| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J John Mann, Maria A Oquendo, Kalycia Trishana Watson, Maura Boldrini, Kevin M Malone, Steven P Ellis, Gregory Sullivan, Thomas B Cooper, Shan Xie, Dianne Currie. Anxiety in major depression and cerebrospinal fluid free gamma-aminobutyric acid. Depression and anxiety. vol 31. issue 10. 2015-06-17. PMID:24865448. |
we investigated the relationship of cerebrospinal fluid (csf) free gaba to the anxiety and depression components of a major depressive episode (mde) and to monoamine systems. |
2015-06-17 |
2023-08-13 |
Not clear |
| Georg Northoff, Etienne Sibill. Why are cortical GABA neurons relevant to internal focus in depression? A cross-level model linking cellular, biochemical and neural network findings. Molecular psychiatry. vol 19. issue 9. 2015-06-05. PMID:25048001. |
why are cortical gaba neurons relevant to internal focus in depression? |
2015-06-05 |
2023-08-13 |
human |
| G Northoff, E Sibill. Cortical GABA neurons and self-focus in depression: a model linking cellular, biochemical and neural network findings. Molecular psychiatry. vol 19. issue 9. 2015-06-05. PMID:25237734. |
cortical gaba neurons and self-focus in depression: a model linking cellular, biochemical and neural network findings. |
2015-06-05 |
2023-08-13 |
Not clear |
| Paul E Croarkin, Paul A Nakonezny, Mustafa M Husain, John D Port, Tabatha Melton, Betsy D Kennard, Graham J Emslie, F Andrew Kozel, Zafiris J Daskalaki. Evidence for pretreatment LICI deficits among depressed children and adolescents with nonresponse to fluoxetine. Brain stimulation. vol 7. issue 2. 2015-05-08. PMID:24360599. |
research suggests that alterations in gamma-aminobutyric acid receptor functioning have a role in depression. |
2015-05-08 |
2023-08-12 |
Not clear |
| Bruno D Arbo, Susie Andrade, Gabriela Osterkamp, Rosane Gomez, Maria Flávia M Ribeir. Effect of low doses of progesterone in the expression of the GABA(A) receptor α4 subunit and procaspase-3 in the hypothalamus of female rats. Endocrine. vol 46. issue 3. 2015-04-02. PMID:24366640. |
depression is associated with the several neurotransmitters systems, including gaba and serotonin, and with neurodegeneration and cell death in some brain circuits. |
2015-04-02 |
2023-08-12 |
rat |
| Andrés E Chávez, Vivian M Hernández, Alma Rodenas-Ruano, C Savio Chan, Pablo E Castill. Compartment-specific modulation of GABAergic synaptic transmission by TRPV1 channels in the dentate gyrus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 50. 2015-03-20. PMID:25505315. |
moreover, trpv1-mediated depression occurs independently of gaba release, requires postsynaptic ca(2+) rise and activation of calcineurin, and is likely due to clathrin-dependent internalization of gaba receptors. |
2015-03-20 |
2023-08-13 |
mouse |
| T-S Lee, S Y Quek, K R R Krishna. Molecular imaging for depressive disorders. AJNR. American journal of neuroradiology. vol 35. issue 6 Suppl. 2015-03-12. PMID:24831591. |
mr spectroscopy findings suggest a role for glutamate/glutamine and gamma-aminobutyric acid in depression. |
2015-03-12 |
2023-08-13 |
Not clear |
| Anthony L Gotter, Susan L Garson, Joanne Stevens, Regina L Munden, Steven V Fox, Pamela L Tannenbaum, Lihang Yao, Scott D Kuduk, Terrence McDonald, Jason M Uslaner, Spencer J Tye, Paul J Coleman, Christopher J Winrow, John J Renge. Differential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulators. BMC neuroscience. vol 15. 2015-03-12. PMID:25242351. |
the current standard of care for insomnia includes gamma-aminobutyric acid receptor a (gabaa) activators, which promote sleep as well as general central nervous system depression. |
2015-03-12 |
2023-08-13 |
Not clear |
| Yufeng Xie, Michael F Jackson, John F MacDonal. Calcium-mediated paired pulse depression in juvenile rat dorsal striatum. Neural regeneration research. vol 7. issue 10. 2015-03-04. PMID:25737701. |
in addition, the paired pulse depression was not affected by bath application of gamma-aminobutyric acid type a receptor antagonist or dopamine d1 receptor antagonist. |
2015-03-04 |
2023-08-13 |
rat |
| Anton Dvorzhak, Christoph Gertler, Daniel Harnack, Rosemarie Granty. High frequency stimulation of the subthalamic nucleus leads to presynaptic GABA(B)-dependent depression of subthalamo-nigral afferents. PloS one. vol 8. issue 12. 2015-03-03. PMID:24376521. |
high frequency stimulation of the subthalamic nucleus leads to presynaptic gaba(b)-dependent depression of subthalamo-nigral afferents. |
2015-03-03 |
2023-08-12 |
mouse |
| Anton Dvorzhak, Christoph Gertler, Daniel Harnack, Rosemarie Granty. High frequency stimulation of the subthalamic nucleus leads to presynaptic GABA(B)-dependent depression of subthalamo-nigral afferents. PloS one. vol 8. issue 12. 2015-03-03. PMID:24376521. |
nonetheless, occlusion-negative afferents exhibited signs of presynaptic depression that could be eliminated by blocking gaba(b) receptors with cgp55845 (1 µm). |
2015-03-03 |
2023-08-12 |
mouse |
| Anton Dvorzhak, Christoph Gertler, Daniel Harnack, Rosemarie Granty. High frequency stimulation of the subthalamic nucleus leads to presynaptic GABA(B)-dependent depression of subthalamo-nigral afferents. PloS one. vol 8. issue 12. 2015-03-03. PMID:24376521. |
further analysis of single fiber-activated responses supported the proposal that the heterosynaptic depression of synaptic glutamate release during and after hfs-stn is mainly caused by the tonic release of gaba from co-activated striato-nigral afferents to the snr. |
2015-03-03 |
2023-08-12 |
mouse |
| Luisa Rocha, Mario Alonso-Vanegas, Iris E Martínez-Juárez, Sandra Orozco-Suárez, David Escalante-Santiago, Iris Angélica Feria-Romero, Cecilia Zavala-Tecuapetla, José Miguel Cisneros-Franco, Ricardo Masao Buentello-García, Jesús Cienfuego. GABAergic alterations in neocortex of patients with pharmacoresistant temporal lobe epilepsy can explain the comorbidity of anxiety and depression: the potential impact of clinical factors. Frontiers in cellular neuroscience. vol 8. 2015-01-20. PMID:25601827. |
the present study was designed to identify alterations in the gaba system such as binding to gabaa and gabab receptors and benzodiazepine site, the tissue content of gaba and the expression of the mrna encoding the α1-6, β1-3, and γ gabaa subunits, in the temporal neocortex of surgically treated patients with tle with and without anxiety, and/or depression. |
2015-01-20 |
2023-08-13 |
Not clear |
| Luisa Rocha, Mario Alonso-Vanegas, Iris E Martínez-Juárez, Sandra Orozco-Suárez, David Escalante-Santiago, Iris Angélica Feria-Romero, Cecilia Zavala-Tecuapetla, José Miguel Cisneros-Franco, Ricardo Masao Buentello-García, Jesús Cienfuego. GABAergic alterations in neocortex of patients with pharmacoresistant temporal lobe epilepsy can explain the comorbidity of anxiety and depression: the potential impact of clinical factors. Frontiers in cellular neuroscience. vol 8. 2015-01-20. PMID:25601827. |
neocortex of patients with tle and comorbid anxiety and/or depression showed increased expression of the mrna encoding the γ2-subunit, reduced gabab-induced g-protein activation in spite of elevated gabab binding, and lower tissue content of gaba when compared to autopsy controls. |
2015-01-20 |
2023-08-13 |
Not clear |
| Stephanie C Licata, J Eric Jensen, Nina A Conn, Jeffrey P Winer, Scott E Luka. Zolpidem increases GABA in depressed volunteers maintained on SSRIs. Psychiatry research. vol 224. issue 1. 2014-12-05. PMID:25082715. |
zolpidem elevated gaba levels in both voxels of interest (p<0.05) in the depressed participants, which could imply normalization, given the lower baseline levels associated with depression. |
2014-12-05 |
2023-08-13 |
human |
| Shane A Perrine, Farhad Ghoddoussi, Mark S Michaels, Imran S Sheikh, George McKelvey, Matthew P Gallowa. Ketamine reverses stress-induced depression-like behavior and increased GABA levels in the anterior cingulate: an 11.7 T 1H-MRS study in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 51. 2014-11-25. PMID:24246571. |
these data indicate that stress disrupts gabaergic signaling, which may over time lead to symptoms of depression and ultimately lower basal levels of cortical (1)h-mrs gaba that are seen in humans with depression. |
2014-11-25 |
2023-08-12 |
rat |
| Najwa Ahmed El Zahaf, Abdalla Salem Elhwueg. The effect of GABAmimetics on the duration of immobility in the forced swim test in albino mice. The Libyan journal of medicine. vol 9. 2014-11-03. PMID:24560379. |
studies regarding the role of gamma aminobutyric acid (gaba) in depression are conflicting. |
2014-11-03 |
2023-08-12 |
mouse |
| Steven J Shabel, Christophe D Proulx, Joaquin Piriz, Roberto Malino. Mood regulation. GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment. Science (New York, N.Y.). vol 345. issue 6203. 2014-10-28. PMID:25237099. |
at this synapse, the balance of gaba/glutamate signaling is shifted toward reduced gaba in a model of depression and increased gaba by antidepressant treatment. |
2014-10-28 |
2023-08-13 |
Not clear |
| Anja Froese, Paul Szyszka, Randolf Menze. Effect of GABAergic inhibition on odorant concentration coding in mushroom body intrinsic neurons of the honeybee. Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology. vol 200. issue 3. 2014-10-09. PMID:24362942. |
however, the response dynamic, temporal resolution and paired-pulse depression did not depend on gaba(a) transmission. |
2014-10-09 |
2023-08-12 |
Not clear |
| Corinne A G Lee-Kubli, Nigel A Calcut. Altered rate-dependent depression of the spinal H-reflex as an indicator of spinal disinhibition in models of neuropathic pain. Pain. vol 155. issue 2. 2014-10-06. PMID:24103402. |
rate-dependent depression (rdd), a measure of the change in amplitude of the hoffman reflex over consecutive stimulations, is attenuated in diabetic rats that also exhibit impaired spinal γ-aminobutyric acid (gaba)a receptor function, reduced spinal potassium chloride co-transporter (kcc2) expression, and indices of painful neuropathy. |
2014-10-06 |
2023-08-12 |
rat |