Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Bridget L Morse, Nisha Vijay, Marilyn E Morri. γ-Hydroxybutyrate (GHB)-induced respiratory depression: combined receptor-transporter inhibition therapy for treatment in GHB overdose. Molecular pharmacology. vol 82. issue 2. 2012-10-09. PMID:22561075. |
administration of 5 mg/kg sch50911 plus l-lactate further improved respiratory rate compared with the same dose of either agent alone, indicating that gaba(b) and mct inhibitors, alone and in combination, represent potential treatment options for ghb-induced respiratory depression. |
2012-10-09 |
2023-08-12 |
rat |
Amany Mohamed Shalaby, Sahar Mohamed Kama. Effect of rolipram, a phosphodiesterase enzyme type-4 inhibitor, on γ-amino butyric acid content of the frontal cortex in mice exposed to chronic mild stress. Journal of pharmacology & pharmacotherapeutics. vol 3. issue 2. 2012-10-02. PMID:22629087. |
to investigate the alterations in gaba levels by rolipram in the model of depression. |
2012-10-02 |
2023-08-12 |
mouse |
S C Fung, M Fillen. Studies on the mechanism of modulation of [(3)H]noradrenaline release from rat hippocampal synaptosomes by GABA and benzodiazepine receptors. Neurochemistry international. vol 7. issue 1. 2012-10-02. PMID:20492904. |
with [ca(2+)](0) 1 mm 8 br-camp enhanced spontaneous and k(+)-evoked release of [(3)h]noradrenaline, and reversed the depression caused by gaba with bicuculline. |
2012-10-02 |
2023-08-12 |
rat |
S C Fung, M Fillen. Studies on the mechanism of modulation of [(3)H]noradrenaline release from rat hippocampal synaptosomes by GABA and benzodiazepine receptors. Neurochemistry international. vol 7. issue 1. 2012-10-02. PMID:20492904. |
conductance whereas the depression of depolarisation-dependent release of [(3)h]noradrenaline by gaba(b) or benzodiazepine receptors is mediated by a camp-dependent decrease in the voltage-dependent ca(2+) conductance. |
2012-10-02 |
2023-08-12 |
rat |
J G Jefferys, P Mitchell, L O'Hara, C Tiley, J Hardy, S J Jordan, M Lynch, J Wadswort. Ex vivo release of GABA from tetanus toxin-induced chronic epileptic foci decreased during the active seizure phase. Neurochemistry international. vol 18. issue 3. 2012-10-02. PMID:20504714. |
rats which had survived 6-8 weeks, by which time the seizures had ceased, showed a recovery of the ca(2+)-dependent component of the k(+)-evoked release of gaba to control levels, but these rats also exhibited a paradoxical depression of the ca(2+)-independent component of release. |
2012-10-02 |
2023-08-12 |
mouse |
J G Jefferys, P Mitchell, L O'Hara, C Tiley, J Hardy, S J Jordan, M Lynch, J Wadswort. Ex vivo release of GABA from tetanus toxin-induced chronic epileptic foci decreased during the active seizure phase. Neurochemistry international. vol 18. issue 3. 2012-10-02. PMID:20504714. |
the depression of gaba release provides the most likely mechanism for the seizures. |
2012-10-02 |
2023-08-12 |
mouse |
Gareth J Hathway, David Vega-Avelaira, Maria Fitzgeral. A critical period in the supraspinal control of pain: opioid-dependent changes in brainstem rostroventral medulla function in preadolescence. Pain. vol 153. issue 4. 2012-09-12. PMID:22325744. |
rvm microinjection of δ-opioid receptor or gaba(a) receptor agonists, on the other hand, caused reflex depression at both ages. |
2012-09-12 |
2023-08-12 |
rat |
Bao-Hong Lee, Tzu-Ming Pa. Benefit of Monascus-fermented products for hypertension prevention: a review. Applied microbiology and biotechnology. vol 94. issue 5. 2012-09-05. PMID:22526810. |
γ-aminobutyric acid (gaba) has been reported to play a neurotransmitter in the central nervous system thereby exerting an inhibition in nerve impulse, in turn ameliorating depression; in addition, recent study also reveals the anti-hypertensive effect of gaba in vivo. |
2012-09-05 |
2023-08-12 |
Not clear |
Min-Lan Tsai, Melanie Crutchley, Richard Boyce, Jingyi Ma, Francis Boon, D Peter Cain, L Stan Leun. Long-lasting auditory gating deficit accompanied by GABA(B) receptor dysfunction in the hippocampus after early-life limbic seizures in rats. Physiology & behavior. vol 106. issue 4. 2012-09-04. PMID:22504497. |
heterosynaptic electric paired-pulse depression of hippocampal population excitatory postsynaptic potential in freely moving rats, a measure of hippocampal gaba(b)-receptor mediated inhibition, was decreased in seizure as compared to control rats. |
2012-09-04 |
2023-08-12 |
rat |
Kiersten S Smith, Uwe Rudolp. Anxiety and depression: mouse genetics and pharmacological approaches to the role of GABA(A) receptor subtypes. Neuropharmacology. vol 62. issue 1. 2012-08-13. PMID:21810433. |
anxiety and depression: mouse genetics and pharmacological approaches to the role of gaba(a) receptor subtypes. |
2012-08-13 |
2023-08-12 |
mouse |
Kiersten S Smith, Uwe Rudolp. Anxiety and depression: mouse genetics and pharmacological approaches to the role of GABA(A) receptor subtypes. Neuropharmacology. vol 62. issue 1. 2012-08-13. PMID:21810433. |
recent work indicates a role for gaba(a) receptors in physiologically modulating anxiety and depression levels. |
2012-08-13 |
2023-08-12 |
mouse |
Hanns Möhle. The GABA system in anxiety and depression and its therapeutic potential. Neuropharmacology. vol 62. issue 1. 2012-08-13. PMID:21889518. |
in view of the finding that anxiety disorders and major depression share a gabaergic deficit as a common pathophysiology, the gaba hypothesis of depression has found increasing support. |
2012-08-13 |
2023-08-12 |
Not clear |
Julie Espallergues, Takayoshi Mamiya, Monique Vallée, Takenao Koseki, Toshitaka Nabeshima, Jamal Temsamani, Claude Laruelle, Tangui Mauric. The antidepressant-like effects of the 3β-hydroxysteroid dehydrogenase inhibitor trilostane in mice is related to changes in neuroactive steroid and monoamine levels. Neuropharmacology. vol 62. issue 1. 2012-08-13. PMID:21945799. |
these neuroactive steroids are known to regulate neurotransmitters effects in the brain, particularly glutamate, γ-aminobutyric acid (gaba) and serotonin (5-ht), with consequences on mood and depression. |
2012-08-13 |
2023-08-12 |
mouse |
Susan S Girdler, Monica Lindgren, Patrizia Porcu, David R Rubinow, Jacqueline L Johnson, A Leslie Morro. A history of depression in women is associated with an altered GABAergic neuroactive steroid profile. Psychoneuroendocrinology. vol 37. issue 4. 2012-07-16. PMID:21890277. |
the 3α,5α- and 3α,5β-reduced metabolites of progesterone, deoxycorticosterone, and dehydroepiandrosterone (dhea) have potent effects on neurotransmission mediated by gaba(a) receptors, and dysregulation of these receptors has been implicated in depression. |
2012-07-16 |
2023-08-12 |
Not clear |
Graziano Pinna, Ann M Rasmusso. Up-regulation of neurosteroid biosynthesis as a pharmacological strategy to improve behavioural deficits in a putative mouse model of post-traumatic stress disorder. Journal of neuroendocrinology. vol 24. issue 1. 2012-06-01. PMID:21981145. |
in the past decade, clinical studies have suggested that the pharmacological action of ssris may include the ability of these drugs to normalise decreased brain levels of neurosteroids in patients with depression and ptsd; in particular, the progesterone derivative allopregnanolone, which potently, positively and allosterically modulates the action of gaba at gaba(a) receptors. |
2012-06-01 |
2023-08-12 |
mouse |
N I Dubrovin. [Fear memory extinction accelerated by simultaneous activation of GABA(B) and NMDA receptors]. Eksperimental'naia i klinicheskaia farmakologiia. vol 75. issue 2. 2012-05-29. PMID:22550851. |
effects of the n-methyl-d-aspartate (nmda) agonist (d-cycloserine) and gaba(b) agonist (baclofen) on the fear memory extinction as manifested in the passive avoidance reaction in c57bl/6j mice with "behavioral despair" (model of depression) and without previously developed stress have been studied. |
2012-05-29 |
2023-08-12 |
mouse |
Mean-Hwan Kim, Evan Vickers, Henrique von Gersdorf. Patch-clamp capacitance measurements and Ca²⁺ imaging at single nerve terminals in retinal slices. Journal of visualized experiments : JoVE. issue 59. 2012-05-25. PMID:22297269. |
~10 s), gabaergic reciprocal feedback inhibition from amacrine cells undergoes paired-pulse depression via gaba vesicle pool depletion. |
2012-05-25 |
2023-08-12 |
Not clear |
Claire L Padgett, Arnaud L Lalive, Kelly R Tan, Miho Terunuma, Michaelanne B Munoz, Menelas N Pangalos, José Martínez-Hernández, Masahiko Watanabe, Stephen J Moss, Rafael Luján, Christian Lüscher, Paul A Slesinge. Methamphetamine-evoked depression of GABA(B) receptor signaling in GABA neurons of the VTA. Neuron. vol 73. issue 5. 2012-05-01. PMID:22405207. |
methamphetamine-evoked depression of gaba(b) receptor signaling in gaba neurons of the vta. |
2012-05-01 |
2023-08-12 |
mouse |
Ramakrishna Tadavarty, Padmesh S Rajput, Jennifer M Wong, Ujendra Kumar, Bhagavatula R Sastr. Sleep-deprivation induces changes in GABA(B) and mGlu receptor expression and has consequences for synaptic long-term depression. PloS one. vol 6. issue 9. 2012-04-13. PMID:21980366. |
results indicate that mglurs, a release of ca(2+) from intracellular stores and gaba(b)-rs are required for ltd. interestingly, while mglu1rs seem to be involved in both short-term depression and ltd, mglu5rs appear to participate mostly in ltd. cgp 55845, a gaba(b)-r antagonist, partially suppressed ltd in normally sleeping (ns) rats, while completely blocking ltd in sd rats. |
2012-04-13 |
2023-08-12 |
rat |
Yang Li, Shuangyi Fan, Jie Yan, Bo Li, Fang Chen, Jianxia Xia, Zhengping Yu, Zhian H. Adenosine modulates the excitability of layer II stellate neurons in entorhinal cortex through A1 receptors. Hippocampus. vol 21. issue 3. 2012-04-02. PMID:20054814. |
in addition, adenosine reduced the frequency but not the amplitude of miniature epscs and ipscs, suggesting that the global depression of glutamatergic and gabaergic transmission is mediated by a decrease in glutamate and gaba release, respectively. |
2012-04-02 |
2023-08-12 |
Not clear |