| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B D Waterhouse, H C Moises, H H Yeh, H M Geller, D J Woodwar. Comparison of norepinephrine- and benzodiazepine-induced augmentation of Purkinje cell responses to gamma-aminobutyric acid (GABA). The Journal of pharmacology and experimental therapeutics. vol 228. issue 2. 1984-03-20. PMID:6319673. |
doses of gaba sufficient to produce depression of purkinje cell activity in naive rats (4-40 na) suppressed firing rate in all purkinje cells tested in drug-treated animals. |
1984-03-20 |
2023-08-12 |
rat |
| B D Waterhouse, H C Moises, H H Yeh, H M Geller, D J Woodwar. Comparison of norepinephrine- and benzodiazepine-induced augmentation of Purkinje cell responses to gamma-aminobutyric acid (GABA). The Journal of pharmacology and experimental therapeutics. vol 228. issue 2. 1984-03-20. PMID:6319673. |
thus, although flurazepam appears to act independently from the noradrenergic receptor system in augmenting gaba-induced depression of purkinje cell discharge, a reversible subsensitivity to the gaba facilitating effects of both flurazepam and ne can be produced by chronic treatment with this benzodiazepine. |
1984-03-20 |
2023-08-12 |
rat |
| J de Belleroche, I M Gardine. Action of apomorphine, bromocriptine and lergotrile on gamma-aminobutyric acid and acetylcholine release in nucleus accumbens and corpus striatum. Journal of neural transmission. vol 58. issue 3-4. 1984-03-14. PMID:6141217. |
a similar depression of gaba release was obtained in the nucleus accumbens. |
1984-03-14 |
2023-08-12 |
rat |
| R Spehlmann, K Norcros. Decreased sensitivity of neurons in the basolateral amygdala to dopamine and noradrenaline iontophoresis after a kindling stimulus. Experimental neurology. vol 83. issue 1. 1984-02-22. PMID:6690320. |
neuronal excitation by glutamate and depression by gaba were not significantly changed. |
1984-02-22 |
2023-08-12 |
Not clear |
| J Ong, D I Ker. Interactions between GABA and 5-hydroxytryptamine in the guinea-pig ileum. European journal of pharmacology. vol 94. issue 3-4. 1984-02-14. PMID:6317404. |
in isolated segments of the guinea-pig ileum, there was: (a) an early, short-lived (less than 20 s) depression by gamma-aminobutyric acid (gaba) of contractile responses to 5-hydroxytryptamine (5-ht), acetylcholine(ach), or nicotine, also seen with 3-amino-1-propanesulphonic acid (3aps) or muscimol in place of gaba, and sensitive to bicuculline, picrotoxinin or piretanide, and (b) a delayed, longer-lasting (30 s-1 min) depression of responses to 5-ht and nicotine, but not exogenously applied ach, also seen with baclofen and only antagonised by delta-aminovaleric acid (dava). |
1984-02-14 |
2023-08-12 |
Not clear |
| J Ong, D I Ker. Interactions between GABA and 5-hydroxytryptamine in the guinea-pig ileum. European journal of pharmacology. vol 94. issue 3-4. 1984-02-14. PMID:6317404. |
it is concluded that the early, short-lived depression is mediated through gabaa-receptor sites, and the delayed, longer-lasting depression through gabab-receptor sites on neurones of the myenteric plexus; effects consistent with gaba being a neurotransmitter in the enteric nervous system. |
1984-02-14 |
2023-08-12 |
Not clear |
| C Gauchy, M L Kemel, R Romo, A Chéramy, J Glowinski, M J Besso. Effects of nigral application of muscimol on release of [3H] gamma-aminobutyrate and on multiunit activity in various cat thalamic nuclei. Neuroscience. vol 10. issue 3. 1984-01-27. PMID:6646428. |
(1) an increased release of [3h]gaba and a depression of the global multi-unit cellular activity were obtained in the ventralis medialis-ventralis lateralis, the centralis lateralis and the paracentralis nuclei. |
1984-01-27 |
2023-08-12 |
cat |
| L J Herberg, S F William. Anti-conflict and depressant effects by GABA agonists and antagonists, benzodiazepines and non-gabergic anticonvulsants on self-stimulation and locomotor activity. Pharmacology, biochemistry, and behavior. vol 19. issue 4. 1984-01-07. PMID:6139825. |
the facilitatory effects of the benzodiazepines were dramatically enhanced by gaba antagonists (picrotoxin or pentylenetetrazol) even though antagonists on their own produced a dose-dependent depression that was not reversible by other anticonvulsant drugs. |
1984-01-07 |
2023-08-12 |
rat |
| L P Tuff, R J Racine, R Adame. The effects of kindling on GABA-mediated inhibition in the dentate gyrus of the rat. I. Paired-pulse depression. Brain research. vol 277. issue 1. 1984-01-07. PMID:6315140. |
the depression was enhanced by drugs that facilitate or mimic gaba action and attenuated by drugs which block gaba transmission. |
1984-01-07 |
2023-08-12 |
rat |
| F L Eldridge, D E Millhorn, T G Waldrop, J P Kile. Mechanism of respiratory effects of methylxanthines. Respiration physiology. vol 53. issue 2. 1983-12-20. PMID:6579584. |
when administered into the third ventricle, theophylline did not stimulate respiration, but both aminophylline and ethylenediamine, due to the latter's ability to mimic the inhibitory effects on neurons of gamma-aminobutyric acid (gaba), caused significant depression of respiration. |
1983-12-20 |
2023-08-12 |
Not clear |
| J M Lakoski, G K Aghajania. Effects of histamine, H1- and H2-receptor antagonists on the activity of serotonergic neurons in the dorsal raphe nucleus. The Journal of pharmacology and experimental therapeutics. vol 227. issue 2. 1983-12-17. PMID:6138428. |
histamine's effects may, in part, be mediated at a gamma-aminobutyric acid receptor complex as the gamma-aminobutyric acid antagonists bicuculline and picrotoxin rapidly and reversibly antagonized both the histamine- and the cimetidine-induced depression of serotonin cell firing; the glycine antagonist strychnine selectively blocked the inhibitory effect of glycine without altering the histamine-induced response. |
1983-12-17 |
2023-08-12 |
rat |
| W F Simonds, A M Booth, K B Thor, N L Ostrowski, J R Nagel, W C de Groa. Parasympathetic ganglia: naloxone antagonizes inhibition by leucine-enkephalin and GABA. Brain research. vol 271. issue 2. 1983-11-23. PMID:6311333. |
naloxone blocked the depressant effects of the opiates as well as the depression produced by gaba, but did not block the depressant effects of norepinephrine. |
1983-11-23 |
2023-08-12 |
cat |
| J P Gallagher, J Nakamura, P Shinnick-Gallaghe. The effects of temperature, pH and Cl-pump inhibitors on GABA responses recorded from cat dorsal root ganglia. Brain research. vol 267. issue 2. 1983-09-09. PMID:6307467. |
instead we suggest that alkalinization or the putative chloride pump inhibitors affect the chloride channel or some other site associated with the gaba receptor complex and cause the depression we observed. |
1983-09-09 |
2023-08-12 |
cat |
| T Hedner, J Hedner, B Bergman, K Iversen, J Jonaso. Effects of GABA and some GABA analogues on respiratory regulation in the preterm rabbit. Biology of the neonate. vol 43. issue 3-4. 1983-08-11. PMID:6407536. |
our findings demonstrate that gaba and gaba-like drugs cause respiratory depression in the preterm neonate. |
1983-08-11 |
2023-08-12 |
human |
| J Ong, D I Ker. GABAA- and GABAB-receptor-mediated modification of intestinal motility. European journal of pharmacology. vol 86. issue 1. 1983-04-07. PMID:6297929. |
baclofen and gaba, but not 3aps, induced a dose-dependent gabab-receptor mediated depression of electrically elicited twitch contractions of the ileum, unaffected by the gabaa-receptor antagonists or by antagonism of adenosine, adrenergic, opiate or nicotinic receptors. |
1983-04-07 |
2023-08-12 |
Not clear |
| J Ong, D I Ker. GABAA- and GABAB-receptor-mediated modification of intestinal motility. European journal of pharmacology. vol 86. issue 1. 1983-04-07. PMID:6297929. |
in the distal colon, baclofen and gaba caused a bicuculline- and picrotoxinin-insensitive depression of spontaneous cholinergic contractions. |
1983-04-07 |
2023-08-12 |
Not clear |
| H Higashi, S Nish. Effect of barbiturates on the GABA receptor of cat primary afferent neurones. The Journal of physiology. vol 332. 1983-03-17. PMID:6296374. |
barbiturates at these high concentrations initially caused a marked augmentation and prolongation of gaba responses; this was followed by a depression. |
1983-03-17 |
2023-08-12 |
cat |
| P R Hughes, P F Morgan, T W Ston. Inhibitory action of gamma-aminobutyric acid on the excitatory but not inhibitory innervation of the rat anococcygeus muscle. British journal of pharmacology. vol 77. issue 4. 1983-03-11. PMID:7150875. |
2 gaba produced a dose-related depression of the contractile responses to field stimulation. |
1983-03-11 |
2023-08-12 |
rat |
| J L Henr. Effects of intravenously administered enantiomers of baclofen on functionally identified units in lumbar dorsal horn of the spinal cat. Neuropharmacology. vol 21. issue 11. 1983-02-25. PMID:7177338. |
one was a transient (complete within 2 min), non-specific depression of the discharge of synaptically-elicited responses and of the postsynaptic glutamate-evoked excitation; it is reasoned that this effect was due to a postsynaptic action of baclofen and its antagonism by bicuculline suggests it is via classical gaba receptors. |
1983-02-25 |
2023-08-12 |
cat |
| G D Frye, G R Brees. GABAergic modulation of ethanol-induced motor impairment. The Journal of pharmacology and experimental therapeutics. vol 223. issue 3. 1983-01-27. PMID:6292399. |
although gabaergic neurons may be involved in the mechanism underlying ethanol-induced depression of motor coordination, the interaction does not involve a direct activation of gaba receptors by ethanol. |
1983-01-27 |
2023-08-12 |
rat |