| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Muhyaddin, P J Roberts, G N Woodruf. Presynaptic gamma-aminobutyric acid receptors in the rat anococcygeus muscle and their antagonism by 5-aminovaleric acid. British journal of pharmacology. vol 77. issue 1. 1982-12-21. PMID:6289954. |
3 the maximum response to gaba was a 56.8% depression of twitch response, with an ec50 of 0.68 microm. |
1982-12-21 |
2023-08-12 |
rat |
| K Kasa, S Otsuki, M Yamamoto, M Sato, H Kuroda, N Ogaw. Cerebrospinal fluid gamma-aminobutyric acid and homovanillic acid in depressive disorders. Biological psychiatry. vol 17. issue 8. 1982-12-02. PMID:7115838. |
gamma-aminobutyric acid (gaba) and homovanillic acid (hva) levels were determined in the lumbar cerebrospinal fluid (csf) of hospitalized patients suffering from depression and in a control group. |
1982-12-02 |
2023-08-12 |
Not clear |
| K Kasa, S Otsuki, M Yamamoto, M Sato, H Kuroda, N Ogaw. Cerebrospinal fluid gamma-aminobutyric acid and homovanillic acid in depressive disorders. Biological psychiatry. vol 17. issue 8. 1982-12-02. PMID:7115838. |
both mean csf gaba and hva levels in the patients with depression were significantly lower than those of the control group (p less than 0.05, p less than 0.01, respectively). |
1982-12-02 |
2023-08-12 |
Not clear |
| K Kasa, S Otsuki, M Yamamoto, M Sato, H Kuroda, N Ogaw. Cerebrospinal fluid gamma-aminobutyric acid and homovanillic acid in depressive disorders. Biological psychiatry. vol 17. issue 8. 1982-12-02. PMID:7115838. |
no positive correlation was found between the changes in csf gaba and hva levels in the patients with depression. |
1982-12-02 |
2023-08-12 |
Not clear |
| W Lösche. Cardiovascular effects of GABA, GABA-aminotransferase inhibitors and valproic acid following systemic administration in rats, cats and dogs: pharmacological approach to localize the site of action. Archives internationales de pharmacodynamie et de therapie. vol 257. issue 1. 1982-10-29. PMID:6810779. |
the prolonged cardiovascular depression in response to gaba could be attenuated by subsequent administration of picrotoxin and bicuculline as well as by alpha-methyltyrosine, corynanthine, chlorpromazine and tripelennamine. |
1982-10-29 |
2023-08-12 |
rat |
| W Lösche. Cardiovascular effects of GABA, GABA-aminotransferase inhibitors and valproic acid following systemic administration in rats, cats and dogs: pharmacological approach to localize the site of action. Archives internationales de pharmacodynamie et de therapie. vol 257. issue 1. 1982-10-29. PMID:6810779. |
it is concluded that gaba, gaba-t inhibitors and vpa may induce cardiovascular depression at least in part by activation of gaba receptors and that the response is mediated predominantly by the central adrenergic system. |
1982-10-29 |
2023-08-12 |
rat |
| V Chan-Palay, M Ito, P Tongroach, M Sakurai, S Pala. Inhibitory effects of motilin, somatostatin, [Leu]enkephalin, [Met]enkephalin, and taurine on neurons of the lateral vestibular nucleus: interactions with gamma-aminobutyric acid. Proceedings of the National Academy of Sciences of the United States of America. vol 79. issue 10. 1982-09-17. PMID:6124970. |
when gaba was administered together with motilin, [met]enkephalin, or somatostatin, the effects of the peptide and gaba were additive, producing depression greater than that with application of either substance alone. |
1982-09-17 |
2023-08-12 |
Not clear |
| V Chan-Palay, M Ito, P Tongroach, M Sakurai, S Pala. Inhibitory effects of motilin, somatostatin, [Leu]enkephalin, [Met]enkephalin, and taurine on neurons of the lateral vestibular nucleus: interactions with gamma-aminobutyric acid. Proceedings of the National Academy of Sciences of the United States of America. vol 79. issue 10. 1982-09-17. PMID:6124970. |
at low iontophoretic currents, [leu]enkephalin antagonized the action of gaba, producing a depression less than that of gaba alone and of considerably slower onset, suggesting an additional modulatory effect. |
1982-09-17 |
2023-08-12 |
Not clear |
| J M Wojtowicz, R A Nicol. Selective action of piretanide on primary afferent GABA responses in the frog spinal cord. Brain research. vol 236. issue 1. 1982-06-24. PMID:6279234. |
the depression of gaba responses on dorsal root ganglion cells was accompanied by a large decrease in the conductance change elicited by gaba. |
1982-06-24 |
2023-08-12 |
Not clear |
| F Petty, M A Schlesse. Plasma GABA in affective illness. A preliminary investigation. Journal of affective disorders. vol 3. issue 4. 1982-03-13. PMID:6459350. |
plasma gaba levels in secondary depression and in bipolar depression were similar to control. |
1982-03-13 |
2023-08-12 |
Not clear |
| K A Yamada, P Hamosh, R A Gilli. Respiratory depression produced by activation of GABA receptors in hindbrain of cat. Journal of applied physiology: respiratory, environmental and exercise physiology. vol 51. issue 5. 1982-01-09. PMID:6271715. |
respiratory depression produced by activation of gaba receptors in hindbrain of cat. |
1982-01-09 |
2023-08-12 |
cat |
| K A Yamada, P Hamosh, R A Gilli. Respiratory depression produced by activation of GABA receptors in hindbrain of cat. Journal of applied physiology: respiratory, environmental and exercise physiology. vol 51. issue 5. 1982-01-09. PMID:6271715. |
these results indicate that activation of gaba receptors causes respiratory depression and suggest that gaba may be an important neurotransmitter in cns neural pathways involved in regulating respiratory activity. |
1982-01-09 |
2023-08-12 |
cat |
| Z Jian. A comparison of the effects of flurazepam on gamma-aminobutyric acid mediated depression of cerebellar and cerebral cortical neurons. Canadian journal of physiology and pharmacology. vol 59. issue 6. 1982-01-09. PMID:7296372. |
a comparison of the effects of flurazepam on gamma-aminobutyric acid mediated depression of cerebellar and cerebral cortical neurons. |
1982-01-09 |
2023-08-12 |
rat |
| Z Jian. A comparison of the effects of flurazepam on gamma-aminobutyric acid mediated depression of cerebellar and cerebral cortical neurons. Canadian journal of physiology and pharmacology. vol 59. issue 6. 1982-01-09. PMID:7296372. |
with standard extracellular recording and microiontophoretic techniques, the effects of flurazepam on gamma-aminobutyric acid (gaba) evoked depression of cerebellar and cerebral cortical neurons in rats have been studied. |
1982-01-09 |
2023-08-12 |
rat |
| F Petty, A D Sherma. GABAergic modulation of learned helplessness. Pharmacology, biochemistry, and behavior. vol 15. issue 4. 1981-12-22. PMID:6117082. |
these three findings along with those of prior experiments, suggest a controlling role for gaba in the learned helplessness model of depression. |
1981-12-22 |
2023-08-12 |
Not clear |
| J Hedner, T Hedner, B Bergman, D Lundber. Respiratory depression by GABA-ergic drugs in the preterm rabbit. Journal of developmental physiology. vol 2. issue 6. 1981-10-25. PMID:6114974. |
central gaba neurons may thus be involved in the pathogenesis of neonatal respiratory depression and irregular breathing. |
1981-10-25 |
2023-08-12 |
rabbit |
| P A Kelly, J McCulloc. Heterogeneous depression of glucose utilization in the caudate nucleus by GABA agonists. Brain research. vol 209. issue 2. 1981-07-09. PMID:6261871. |
heterogeneous depression of glucose utilization in the caudate nucleus by gaba agonists. |
1981-07-09 |
2023-08-12 |
rat |
| T G Smart, A Constant. A re-examination of the GABA-inhibitory action of bicuculline on lobster muscle. European journal of pharmacology. vol 70. issue 1. 1981-06-23. PMID:7215440. |
if bicuculline was assumed to be a pure non-competitive antagonist, then the observed depression of the gaba curves at high gaba concentrations was underestimated. |
1981-06-23 |
2023-08-12 |
lobster |
| J Davie. Selective depression of synaptic excitation in cat spinal neurones by baclofen: an iontophoretic study. British journal of pharmacology. vol 72. issue 2. 1981-06-13. PMID:7214103. |
6 comparison of baclofen with a number of other substances indicates that the depression of noncholinergic, excitatory, synaptic responses is unlikely to involve an interaction of this agent with receptors for monoamines, 5-hydroxytryptamine or the inhibitory amino acids, gamma-aminobutyric acid and glycine. |
1981-06-13 |
2023-08-12 |
cat |
| R D Allan, R H Evans, G A Johnsto. gamma-Aminobutyric acid agonists: an in vitro comparison between depression of spinal synaptic activity and depolarization of spinal root fibres in the rat. British journal of pharmacology. vol 70. issue 4. 1981-05-21. PMID:6258682. |
gamma-aminobutyric acid agonists: an in vitro comparison between depression of spinal synaptic activity and depolarization of spinal root fibres in the rat. |
1981-05-21 |
2023-08-12 |
rat |