| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kate Hawkins, Meg Watt, Sébastien Gillotin, Maya Hanspal, Martin Helley, Jill Richardson, Nicola Corbett, Janet Brownlee. Disrupting the interaction between AMBRA1 and DLC1 prevents apoptosis while enhancing autophagy and mitophagy. Biology open. 2024-10-29. PMID:39469809. |
disrupting the interaction between ambra1 and dlc1 prevents apoptosis while enhancing autophagy and mitophagy. |
2024-10-29 |
2024-10-31 |
mouse |
| Kate Hawkins, Meg Watt, Sébastien Gillotin, Maya Hanspal, Martin Helley, Jill Richardson, Nicola Corbett, Janet Brownlee. Disrupting the interaction between AMBRA1 and DLC1 prevents apoptosis while enhancing autophagy and mitophagy. Biology open. 2024-10-29. PMID:39469809. |
ambra1 has critical roles in autophagy, mitophagy, cell cycle regulation, neurogenesis and apoptosis. |
2024-10-29 |
2024-10-31 |
mouse |
| Kate Hawkins, Meg Watt, Sébastien Gillotin, Maya Hanspal, Martin Helley, Jill Richardson, Nicola Corbett, Janet Brownlee. Disrupting the interaction between AMBRA1 and DLC1 prevents apoptosis while enhancing autophagy and mitophagy. Biology open. 2024-10-29. PMID:39469809. |
to compare potential ambra1 activation strategies we have designed and validated several previously described mutant constructs in addition to characterising their effects on proliferation, apoptosis, autophagy and mitophagy in shsy5y cells. |
2024-10-29 |
2024-10-31 |
mouse |
| Cuifen Zhang, Ke Wang, Jiahao Tao, Chuangjie Zheng, Linzhu Zha. MYC-dependent MiR-7-5p regulated apoptosis and autophagy in diffuse large B cell lymphoma by targeting AMBRA1. Molecular and cellular biochemistry. 2024-02-23. PMID:38393538. |
myc-dependent mir-7-5p regulated apoptosis and autophagy in diffuse large b cell lymphoma by targeting ambra1. |
2024-02-23 |
2024-02-25 |
Not clear |
| Cuifen Zhang, Ke Wang, Jiahao Tao, Chuangjie Zheng, Linzhu Zha. MYC-dependent MiR-7-5p regulated apoptosis and autophagy in diffuse large B cell lymphoma by targeting AMBRA1. Molecular and cellular biochemistry. 2024-02-23. PMID:38393538. |
these results demonstrate that c-myc-dependent mir-7-5p suppressed autophagy and apoptosis by targeting ambra1 in dlbcl cells. |
2024-02-23 |
2024-02-25 |
Not clear |
| Cuifen Zhang, Ke Wang, Jiahao Tao, Chuangjie Zheng, Linzhu Zha. MYC-dependent MiR-7-5p regulated apoptosis and autophagy in diffuse large B cell lymphoma by targeting AMBRA1. Molecular and cellular biochemistry. 2024-02-23. PMID:38393538. |
mir-7-5p also suppressed autophagy and apoptosis by targeting ambra1 in dlbcl cells. |
2024-02-23 |
2024-02-25 |
Not clear |
| Hui Liu, Wei Lv, Li Ouyang, Li X. Ghrelin alleviates hypoxia/reoxygenation-induced H9C2 injury by activating autophagy and AMPK/ULK1 pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 11. 2023-11-28. PMID:38015515. |
ghrelin overexpression can significantly promote cell survival, reduce apoptosis, activate ampk, ulk1 and ambra1, promote autophagy, increase the expression of lc3bii/lc3bi and beclin-1, reduce the expression of p62, and reduce inflammatory response. |
2023-11-28 |
2023-11-29 |
Not clear |
| Camilla Maria Fontana, Francesca Terrin, Nicola Facchinello, Giacomo Meneghetti, Alberto Dinarello, Lisa Gambarotto, Annalisa Zuccarotto, Micol Caichiolo, Ginevra Brocca, Ranieri Verin, Francesca Nazio, Oliana Carnevali, Francesco Cecconi, Paolo Bonaldo, Luisa Dalla Vall. Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction. Biological research. vol 56. issue 1. 2023-04-27. PMID:37106439. |
ambra1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, by protein-protein interaction, many cellular processes, including autophagy, mitophagy, apoptosis and cell cycle progression. |
2023-04-27 |
2023-08-14 |
zebrafish |
| Xiang Li, Yuan Lyu, Junqi Li, Xinjun Wan. AMBRA1 and its role as a target for anticancer therapy. Frontiers in oncology. vol 12. 2022-10-14. PMID:36237336. |
in this review, we focus on discussing the mechanisms of ambra1 in autophagy, mitophagy, and apoptosis, and particularly the roles of ambra1 in tumorigenesis and targeted therapy. |
2022-10-14 |
2023-08-14 |
human |
| Yan-Qiu Qin, Si-Yu Liu, Mei-Ling Lv, Wei-Liang Su. Ambra1 in cancer: implications for clinical oncology. Apoptosis : an international journal on programmed cell death. 2022-08-22. PMID:35994214. |
in addition, ambra1 is involved in the execution of apoptosis. |
2022-08-22 |
2023-08-14 |
Not clear |
| Wei-Liang Sun, Ling-Yan He, Li Liang, Si-Yu Liu, Jie Luo, Mei-Ling Lv, Zheng-Wen Ca. Ambra1 regulates apoptosis and chemosensitivity in breast cancer cells through the Akt-FoxO1-Bim pathway. Apoptosis : an international journal on programmed cell death. 2022-03-08. PMID:35257265. |
ambra1 regulates apoptosis and chemosensitivity in breast cancer cells through the akt-foxo1-bim pathway. |
2022-03-08 |
2023-08-13 |
Not clear |
| Wei-Liang Sun, Ling-Yan He, Li Liang, Si-Yu Liu, Jie Luo, Mei-Ling Lv, Zheng-Wen Ca. Ambra1 regulates apoptosis and chemosensitivity in breast cancer cells through the Akt-FoxO1-Bim pathway. Apoptosis : an international journal on programmed cell death. 2022-03-08. PMID:35257265. |
autophagy/beclin 1 regulator 1 (ambra1) is a key protein in the crosstalk between autophagy and apoptosis. |
2022-03-08 |
2023-08-13 |
Not clear |
| Wei-Liang Sun, Ling-Yan He, Li Liang, Si-Yu Liu, Jie Luo, Mei-Ling Lv, Zheng-Wen Ca. Ambra1 regulates apoptosis and chemosensitivity in breast cancer cells through the Akt-FoxO1-Bim pathway. Apoptosis : an international journal on programmed cell death. 2022-03-08. PMID:35257265. |
recently, ambra1 has been shown to modulate paclitaxel-induced apoptosis in breast cancer cells via the bim/mitochondrial pathway, thereby modifying the sensitivity of cells to paclitaxel. |
2022-03-08 |
2023-08-13 |
Not clear |
| Wei-Liang Sun, Ling-Yan He, Li Liang, Si-Yu Liu, Jie Luo, Mei-Ling Lv, Zheng-Wen Ca. Ambra1 regulates apoptosis and chemosensitivity in breast cancer cells through the Akt-FoxO1-Bim pathway. Apoptosis : an international journal on programmed cell death. 2022-03-08. PMID:35257265. |
here, we further confirmed that bim plays an indispensable role in ambra1's regulation of apoptosis and chemosensitivity in breast cancer cells. |
2022-03-08 |
2023-08-13 |
Not clear |
| Wanqi Huang, Tianchu Huang, Yusi Liu, Jialin Fu, Xiaowei Wei, Dan Liu, Wei Ma, Hui Gu, Zhengwei Yua. Nuclear factor I-C disrupts cellular homeostasis between autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects. Cell death & disease. vol 13. issue 1. 2021-12-21. PMID:34930914. |
furthermore, mir-200b represses autophagy and triggers apoptosis by directly targeting the autophagy-related gene ambra1 (autophagy/beclin1 regulator 1). |
2021-12-21 |
2023-08-13 |
mouse |
| Yuxia Lin, Changbai Huang, Huixin Gao, Xiaobo Li, Quanshi Lin, Shili Zhou, Zhiting Huo, Yanxia Huang, Chao Liu, Ping Zhan. AMBRA1 promotes apoptosis induced by dsRNA and virus through interacting with and stabilizing MAVS. Journal of cell science. 2021-12-03. PMID:34859815. |
ambra1 promotes apoptosis induced by dsrna and virus through interacting with and stabilizing mavs. |
2021-12-03 |
2023-08-13 |
Not clear |
| Yuxia Lin, Changbai Huang, Huixin Gao, Xiaobo Li, Quanshi Lin, Shili Zhou, Zhiting Huo, Yanxia Huang, Chao Liu, Ping Zhan. AMBRA1 promotes apoptosis induced by dsRNA and virus through interacting with and stabilizing MAVS. Journal of cell science. 2021-12-03. PMID:34859815. |
in current study, we identified activating molecule in beclin1-regulated autophagy protein 1 (ambra1) as a positive regulator of apoptosis triggered by dsrna. |
2021-12-03 |
2023-08-13 |
Not clear |
| Yuxia Lin, Changbai Huang, Huixin Gao, Xiaobo Li, Quanshi Lin, Shili Zhou, Zhiting Huo, Yanxia Huang, Chao Liu, Ping Zhan. AMBRA1 promotes apoptosis induced by dsRNA and virus through interacting with and stabilizing MAVS. Journal of cell science. 2021-12-03. PMID:34859815. |
depletion of ambra1 by gene editing significantly reduced dsrna-induced apoptosis, which was largely restored by trans-complementation of ambra1. |
2021-12-03 |
2023-08-13 |
Not clear |
| Yuxia Lin, Changbai Huang, Huixin Gao, Xiaobo Li, Quanshi Lin, Shili Zhou, Zhiting Huo, Yanxia Huang, Chao Liu, Ping Zhan. AMBRA1 promotes apoptosis induced by dsRNA and virus through interacting with and stabilizing MAVS. Journal of cell science. 2021-12-03. PMID:34859815. |
mechanistically, ambra1 interacts with mitochondrial antiviral-signaling protein (mavs), a key mitochondrial adaptor in the apoptosis pathway induced by dsrna and viral infection. |
2021-12-03 |
2023-08-13 |
Not clear |
| Yuxia Lin, Changbai Huang, Huixin Gao, Xiaobo Li, Quanshi Lin, Shili Zhou, Zhiting Huo, Yanxia Huang, Chao Liu, Ping Zhan. AMBRA1 promotes apoptosis induced by dsRNA and virus through interacting with and stabilizing MAVS. Journal of cell science. 2021-12-03. PMID:34859815. |
the impact of ambra1 on dsrna-induced apoptosis relied on the presence of mavs and caspase-8. |
2021-12-03 |
2023-08-13 |
Not clear |