| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ghasem Majdi Yazdi, Gholamhasan Vaezi, Vida Hojati, Mohammad Mohammad-Zade. The Effect of 6-gingerol on Growth Factors and Apoptosis Indices in Rats Exposed to Gold Nanoparticles. Basic and clinical neuroscience. vol 12. issue 3. 2021-12-17. PMID:34917289. |
given the antioxidant properties of gingerol (ging), this study aimed to determine the protective effect of 6-gingerol on hippocampal levels of brain-derived neurotrophic factor (bdnf), nerve growth factor (ngf), dna oxidative damage, and the amount of bax and bcl2 apoptosis indices of rats exposed to aunps. |
2021-12-17 |
2023-08-13 |
rat |
| Ying Yu, Zhaokun Shi, Dan Xu, Ying Li, Jun Qin, Zhaohui Zhang, Hui Wan. Prenatal ethanol exposure increases susceptibility to depression- and anxiety-like behavior in adult female offspring and its underlying mechanism. Reproductive toxicology (Elmsford, N.Y.). vol 96. 2021-12-06. PMID:32497709. |
the latter inhibits the hippocampal bdnf pathway, leading to the disruption of hippocampal neurogenesis, apoptosis and decreased synaptic plasticity. |
2021-12-06 |
2023-08-13 |
rat |
| Ismail S Zaitoun, Yong-Seok Song, Andrew Suscha, Mohamed El Ragaby, Christine M Sorenson, Nader Sheiban. 7, 8-Dihydroxyflavone, a TrkB receptor agonist, provides minimal protection against retinal vascular damage during oxygen-induced ischemic retinopathy. PloS one. vol 16. issue 12. 2021-12-06. PMID:34855884. |
lack of bdnf expression results in increased endothelial cell apoptosis and reduced endothelial cell-cell contact. |
2021-12-06 |
2023-08-13 |
mouse |
| Reza Yakhkeshi, Fatemeh Roshani, Kobra Akhoundzadeh, Sakineh Shafi. Effect of treadmill exercise on serum corticosterone, serum and hippocampal BDNF, hippocampal apoptosis and anxiety behavior in an ovariectomized rat model of post-traumatic stress disorder (PTSD). Physiology & behavior. vol 243. 2021-11-30. PMID:34743976. |
effect of treadmill exercise on serum corticosterone, serum and hippocampal bdnf, hippocampal apoptosis and anxiety behavior in an ovariectomized rat model of post-traumatic stress disorder (ptsd). |
2021-11-30 |
2023-08-13 |
rat |
| Hang Yin, Hao Qin, Tiantian Wang, Qiang Zhuang, Qixia Yan. The Protective Effects of Apremilast Against Oxygen-Glucose Deprivation/Reperfusion (OGD/R)-Induced Inflammation and Apoptosis in Astroglia Mediated by CREB/BDNF. Neurotoxicity research. vol 39. issue 3. 2021-11-29. PMID:33826130. |
in the present study, we employed an in vitro model of ischemic stroke using oxygen-glucose deprivation and reoxygenation (ogd/r)-challenged astrocytes to investigate the effects of apremilast against apoptosis (the flow cytometry assay), cell death (the lactate dehydrogenase release assay), oxidative stress (2', 7' dichlorofluorescin diacetate staining), and the expression of the key neuroprotective factors creb and bdnf (western blot analysis). |
2021-11-29 |
2023-08-13 |
Not clear |
| Hang Yin, Hao Qin, Tiantian Wang, Qiang Zhuang, Qixia Yan. The Protective Effects of Apremilast Against Oxygen-Glucose Deprivation/Reperfusion (OGD/R)-Induced Inflammation and Apoptosis in Astroglia Mediated by CREB/BDNF. Neurotoxicity research. vol 39. issue 3. 2021-11-29. PMID:33826130. |
importantly, we found that creb phosphorylation was required for the increases in bdnf and bcl-2 induced by apremilast as well as the decrease in astrocyte apoptosis. |
2021-11-29 |
2023-08-13 |
Not clear |
| Reza Nasrnezhad, Sohrab Halalkhor, Farzin Sadeghi, Fereshteh Pourabdolhossei. Piperine Improves Experimental Autoimmune Encephalomyelitis (EAE) in Lewis Rats Through its Neuroprotective, Anti-inflammatory, and Antioxidant Effects. Molecular neurobiology. vol 58. issue 11. 2021-11-18. PMID:34338970. |
finally, we found that piperine has anti-apoptotic and neuroprotective effect in eae through reducing caspase-3 (apoptosis marker) and enhancing bdnf and neun expressing cells. |
2021-11-18 |
2023-08-13 |
rat |
| Gino P Asuni, Andrew Speidell, Italo Mocchett. Neuronal apoptosis induced by morphine withdrawal is mediated by the p75 neurotrophin receptor. Journal of neurochemistry. vol 158. issue 2. 2021-11-12. PMID:33742683. |
we have previously shown that morphine withdrawal increases the levels of pro-brain-derived neurotrophic factor (bdnf), a proneurotrophin that promotes neuronal apoptosis through the binding and activation of the pan-neurotrophin receptor p75 (p75ntr). |
2021-11-12 |
2023-08-13 |
mouse |
| L F Zainullina, Yu V Vakhitova, A Yu Lusta, T A Gudasheva, S B Seredeni. Dimeric mimetic of BDNF loop 4 promotes survival of serum-deprived cell through TrkB-dependent apoptosis suppression. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:33833366. |
dimeric mimetic of bdnf loop 4 promotes survival of serum-deprived cell through trkb-dependent apoptosis suppression. |
2021-11-08 |
2023-08-13 |
Not clear |
| Shanshan Liu, Qing Liu, Yanjie Ju, Lei Li. Downregulation of miR-383 reduces depression-like behavior through targeting Wnt family member 2 (Wnt2) in rats. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:33927285. |
downregulation of mir-383 significantly inhibited the apoptosis and inflammatory response of hippocampal neurons, and increased the expression levels of gfap, bdnf and creb which were impacted in depression, as well as neurotransmitters, then attenuated neural injury in rats induced by cums. |
2021-11-08 |
2023-08-13 |
rat |
| Meysam Hassani Moghaddam, Mahdi Eskandarian Boroujeni, Kimia Vakili, Mobina Fathi, Mohammad-Amin Abdollahifar, Neda Eskandari, Tahereh Esmaeilpour, Abbas Aliaghae. Functional and structural alternations in the choroid plexus upon methamphetamine exposure. Neuroscience letters. vol 764. 2021-11-08. PMID:34530114. |
moreover, the upregulation of neurotrophic factors such as bdnf and vegf as well as autophagy and apoptosis gene following meth administration were observed. |
2021-11-08 |
2023-08-13 |
Not clear |
| Xiaomei Yang, Tracey A Martin, Wen Guo Jian. Biological influence of brain-derived neurotrophic factor (BDNF) on colon cancer cells. Experimental and therapeutic medicine. vol 6. issue 6. 2021-10-21. PMID:24255678. |
a set of anti-bdnf ribozymes were used to transfect colon cancer cells in order to generate bdnf knockdown cells to evaluate the effect on growth and apoptosis. |
2021-10-21 |
2023-08-12 |
human |
| Xiaomei Yang, Tracey A Martin, Wen Guo Jian. Biological influence of brain-derived neurotrophic factor (BDNF) on colon cancer cells. Experimental and therapeutic medicine. vol 6. issue 6. 2021-10-21. PMID:24255678. |
it is concluded that bdnf, a neurotrophic growth factor aberrantly expressed in cancers such as colon cancer, has a profound impact on the cellular behavior of colon cancer cells and that bdnf is associated with a reduction in the apoptosis of colon cancer. |
2021-10-21 |
2023-08-12 |
human |
| Ai Chen, Li-Jing Xiong, Yu Tong, Meng Ma. The neuroprotective roles of BDNF in hypoxic ischemic brain injury. Biomedical reports. vol 1. issue 2. 2021-10-21. PMID:24648914. |
we initially examined the background of bdnf, and then focused on its neuroprotective mechanisms against ischemic brain injury, including its involvement in promoting neural regeneration/cognition/memory rehabilitation, angiogenesis within ischemic penumbra and the inhibition of the inflammatory process, neurotoxicity, epilepsy and apoptosis. |
2021-10-21 |
2023-08-12 |
Not clear |
| Chen Xiang-Xin, Tao Tao, Gao Sen, Wang Han, Zhou Xiao-Ming, Gao Yong-Yue, Hang Chun-Hua, Li We. Knock-Down of CD24 in Astrocytes Aggravates Oxyhemoglobin-Induced Hippocampal Neuron Impairment. Neurochemical research. 2021-10-19. PMID:34665391. |
aggravated neuronal apoptosis was induced by the cd24 downregulation in astrocytes, which might be a result of a lower level of brain derived neurotrophic factor (bdnf). |
2021-10-19 |
2023-08-13 |
Not clear |
| Ningning Wang, Bailing Tia. Brain-derived neurotrophic factor in autoimmune inflammatory diseases (Review). Experimental and therapeutic medicine. vol 22. issue 5. 2021-10-12. PMID:34630647. |
besides the role of bdnf in neuron repair, circulatory bdnf also enhances the proliferation and reduces apoptosis of lymphocytes. |
2021-10-12 |
2023-08-13 |
Not clear |
| Xuncui Wang, Wen Xu, Hejuntao Chen, Weizu Li, Weiping Li, Guoqi Zh. Astragaloside IV prevents Aβ Brain research. vol 1747. 2021-10-07. PMID:32739157. |
importantly, exogenous bdnf protected against neurotoxicity and apoptosis induced by aβo, whereas inhibition of pparγ reversed protective effects of as-iv against these outcomes. |
2021-10-07 |
2023-08-13 |
Not clear |
| Yangliang Yang, Jing Yi, Mengzhi Pan, Baoji Hu, Hongwei Dua. Edaravone alleviated propofol-induced neural injury in developing rats by BDNF/TrkB pathway. Journal of cellular and molecular medicine. vol 25. issue 11. 2021-09-30. PMID:33932098. |
additionally, the intraperitoneal injection of edaravone, the intraperitoneal injection of the brain-derived neurotrophic factor (bdnf)-mimicking small compound (7,8 dihydroxyflavone) and the intracranial injection of the exogenous bdnf were all respectively effective in alleviating the propofol-induced neural apoptosis and inflammation in the hippocampus. |
2021-09-30 |
2023-08-13 |
rat |
| Lian Liu, Ming Liu, Wei Zhao, Yuan-Ling Zhao, Yun Wan. Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine. ACS chemical neuroscience. vol 12. issue 18. 2021-09-20. PMID:34448569. |
ma-induced neurotoxicity is related to the down-regulation of bdnf and apoptosis. |
2021-09-20 |
2023-08-13 |
rat |
| Lian Liu, Ming Liu, Wei Zhao, Yuan-Ling Zhao, Yun Wan. Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine. ACS chemical neuroscience. vol 12. issue 18. 2021-09-20. PMID:34448569. |
thp attenuated the ma-induced neurotoxicity by decreasing cam, increasing trkb, phosphorylating akt, up-regulating nf-κb and bdnf, and inhibiting cell apoptosis. |
2021-09-20 |
2023-08-13 |
rat |