| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ting-Ting Xu, Han Li, Zhao Dai, George K Lau, Ben-Yue Li, Wen-Li Zhu, Xiao-Qi Liu, Hao-Fei Liu, Wei-Wu Cai, Shui-Qing Huang, Qi Wang, Shi-Jie Zhan. Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice. Aging. vol 12. issue 7. 2021-02-25. PMID:32268299. |
in addition, western blot results (bcl-2, bax and caspase-3, nlrp3, il-18, il-1β) showed that spermidine and spermine prevented apoptosis and inflammation, and elevate the expression of neurotrophic factors, including ngf, psd95and psd93 and bdnf in neurons of samp8 mice. |
2021-02-25 |
2023-08-13 |
mouse |
| Efthalia Angelopoulou, Christina Piper. Beneficial Effects of Fingolimod in Alzheimer's Disease: Molecular Mechanisms and Therapeutic Potential. Neuromolecular medicine. vol 21. issue 3. 2021-01-22. PMID:31313064. |
recent in vitro and in vivo evidence indicate that fingolimod may suppress aβ secretion and deposition, inhibit apoptosis and enhance brain-derived neurotrophic factor (bdnf) production. |
2021-01-22 |
2023-08-13 |
Not clear |
| Hugo Talbot, Sofiane Saada, Elodie Barthout, Paul-François Gallet, Nathalie Gachard, Julie Abraham, Arnaud Jaccard, Danielle Troutaud, Fabrice Lalloué, Thomas Naves, Anne-Laure Fauchais, Marie-Odile Jaubertea. BDNF belongs to the nurse-like cell secretome and supports survival of B chronic lymphocytic leukemia cells. Scientific reports. vol 10. issue 1. 2020-12-11. PMID:32724091. |
previously, we demonstrated that brain-derived neurotrophic factor (bdnf) protects b-cll cells from spontaneous apoptosis by activating the oncogenic complex ntsr2-trkb (neurotensin receptor 2-tropomyosin-related kinase receptor b), only overexpressed in b-cll cells, inducing anti-apoptotic protein bcl-2 (b-cell lymphoma 2) expression and src kinase survival signaling pathways. |
2020-12-11 |
2023-08-13 |
Not clear |
| Hugo Talbot, Sofiane Saada, Elodie Barthout, Paul-François Gallet, Nathalie Gachard, Julie Abraham, Arnaud Jaccard, Danielle Troutaud, Fabrice Lalloué, Thomas Naves, Anne-Laure Fauchais, Marie-Odile Jaubertea. BDNF belongs to the nurse-like cell secretome and supports survival of B chronic lymphocytic leukemia cells. Scientific reports. vol 10. issue 1. 2020-12-11. PMID:32724091. |
inhibition of bdnf in co-cultures, enhances b-cll apoptosis, whereas its exogenous recombinant activates pro-survival pathways in b-cll cultured alone (i.e. |
2020-12-11 |
2023-08-13 |
Not clear |
| Hongxia Che, Lingyu Zhang, Lin Ding, Wancui Xie, Xiaoming Jiang, Changhu Xue, Tiantian Zhang, Yuming Wan. EPA-enriched ethanolamine plasmalogen and EPA-enriched phosphatidylethanolamine enhance BDNF/TrkB/CREB signaling and inhibit neuronal apoptosis in vitro and in vivo. Food & function. vol 11. issue 2. 2020-11-23. PMID:32043504. |
in the present study, primary cultured hippocampal neurons and cognitive deficiency rats were used to compare the effects of epa-ppe and epa-pe on brain-derived neurotrophic factor (bdnf)/tropomyosin receptor kinase b (trkb)/camp response element-binding protein (creb) signaling and neuronal apoptosis. |
2020-11-23 |
2023-08-13 |
rat |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
reducing prlr expression and jak2 activity results in an increase in bdnf expression and inhibits the apoptosis of ca3 hippocampal neurons in a chronic mild stress model of depression. |
2020-10-23 |
2023-08-13 |
mouse |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
therefore, the present study was conducted on the effect of prlr gene on brain derived neurotrophic factor (bdnf) expression and hippocampal neuron apoptosis through the establishment of cms-induced depression mouse models, with aims of providing a new and effective therapeutic option for depression. |
2020-10-23 |
2023-08-13 |
mouse |
| Run-Hui Tian, Yang Bai, Jing-Yang Li, Kai-Min Gu. Reducing PRLR expression and JAK2 activity results in an increase in BDNF expression and inhibits the apoptosis of CA3 hippocampal neurons in a chronic mild stress model of depression. Brain research. vol 1725. 2020-10-23. PMID:31545956. |
from the aforementioned findings, we concluded that prlr gene silencing results in the inhibition of hippocampal neuron apoptosis and alleviation of cms-induced depression by inactivating the jak2-stat5 signaling pathway and elevating bdnf expression, providing a new insight for the treatment of depression. |
2020-10-23 |
2023-08-13 |
mouse |
| Xiqiong Han, Bilei Wang, Yuning Sun, Jia Huang, Xin Wang, Wenqi Ma, Yi Zhu, Rongfeng Xu, Hong Jin, Naifeng Li. Metformin Modulates High Glucose-Incubated Human Umbilical Vein Endothelial Cells Proliferation and Apoptosis Through AMPK/CREB/BDNF Pathway. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:30459620. |
in our study, we demonstrated that high glucose (hg) reduced cell proliferation and induced cell apoptosis via changes in bdnf expression and that metformin reversed the effects of hg injury by upregulating bdnf expression. |
2020-10-01 |
2023-08-13 |
human |
| Yu Zhao, Jinling Wang, Jiwei Du, Baixiang Li, Xingchun Gou, Jiannan Liu, Lichao Hou, Hanfei Sang, Bin Den. TAT-Ngn2 Enhances Cognitive Function Recovery and Regulates Caspase-Dependent and Mitochondrial Apoptotic Pathways After Experimental Stroke. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30618628. |
furthermore, tat-ngn2 alleviated hippocampal neuronal damage and apoptosis, and inhibited the cytochrome c (cytc) leak from the mitochondria to the cytoplasm through regulating the expression levels of brain-derived neurotrophic factor (bdnf), phosphorylation tropomyosin-related kinase b (ptrkb), bcl-2, bax and cleaved caspase-3 after reperfusion injury |
2020-10-01 |
2023-08-13 |
mouse |
| Pouneh Kermani, Barbara Hempstea. BDNF Actions in the Cardiovascular System: Roles in Development, Adulthood and Response to Injury. Frontiers in physiology. vol 10. 2020-10-01. PMID:31105581. |
here we review the compartmentally distinct realm of cardiac myocytes, vascular smooth muscle cells, endothelial cells, and hematopoietic cells, focusing upon the actions of bdnf to modulate contractility, migration, neoangiogenesis, apoptosis and survival. |
2020-10-01 |
2023-08-13 |
Not clear |
| Y-H Wang, B-L Huo, C Li, G Ma, W Ca. Knockdown of long noncoding RNA SNHG7 inhibits the proliferation and promotes apoptosis of thyroid cancer cells by downregulating BDNF. European review for medical and pharmacological sciences. vol 23. issue 11. 2020-10-01. PMID:31210313. |
knockdown of long noncoding rna snhg7 inhibits the proliferation and promotes apoptosis of thyroid cancer cells by downregulating bdnf. |
2020-10-01 |
2023-08-13 |
Not clear |
| Lan Wen, Lei Liu, Linyan Tong, Jinfang Li, Keming Zhang, Qinbin Zhang, Changqing L. NDRG4 prevents cerebral ischemia/reperfusion injury by inhibiting neuronal apoptosis. Genes & diseases. vol 6. issue 4. 2020-10-01. PMID:31832525. |
moreover, we found that ndrg4 increased expression of bdnf, which is strongly related to cerebral ischemia and cellular apoptosis. |
2020-10-01 |
2023-08-13 |
rat |
| Lan Wen, Lei Liu, Linyan Tong, Jinfang Li, Keming Zhang, Qinbin Zhang, Changqing L. NDRG4 prevents cerebral ischemia/reperfusion injury by inhibiting neuronal apoptosis. Genes & diseases. vol 6. issue 4. 2020-10-01. PMID:31832525. |
altogether, our findings demonstrate that ndrg4 protects cerebral ir injury by inhibiting cell apoptosis and regulates cerebral cell apoptosis by increasing bdnf expression. |
2020-10-01 |
2023-08-13 |
rat |
| Dian-Wei Liu, Ling Ma, Xu-Hua Zhang, Yun-Yan Wan. Conditioned taste aversion memory extinction temporally induces insular cortical BDNF release and inhibits neuronal apoptosis. Neuropsychiatric disease and treatment. vol 15. 2020-10-01. PMID:31933521. |
conditioned taste aversion memory extinction temporally induces insular cortical bdnf release and inhibits neuronal apoptosis. |
2020-10-01 |
2023-08-13 |
Not clear |
| Feng Guo, Jicheng Lou, Xiaohua Han, Yuguo Deng, Xiaolin Huan. Repetitive Transcranial Magnetic Stimulation Ameliorates Cognitive Impairment by Enhancing Neurogenesis and Suppressing Apoptosis in the Hippocampus in Rats with Ischemic Stroke. Frontiers in physiology. vol 8. 2020-09-30. PMID:28824455. |
our findings suggest that after ischemic stroke, treatment with rtms promoted the functional recovery of cognitive impairments by inhibiting apoptosis and enhancing neurogenesis in the hippocampus and that this mechanism might be mediated by the bdnf signaling pathway. |
2020-09-30 |
2023-08-13 |
rat |
| Parichat On-Ong-Arj, Jintanaporn Wattanathorn, Supaporn Muchimapura, Wipawee Thukham-Me. Yellow Laser Stimulation at GV2 Acupoint Mitigates Apoptosis, Oxidative Stress, Inflammation, and Motor Deficit in Spinal Cord Injury Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2018. 2020-09-30. PMID:30402127. |
therefore, gv2 stimulation by yellow laser might enhance the recovery of spinal cord via the increase in bdnf and the decrease in inflammation, apoptosis, and oxidative stress status in the lesion spinal cord. |
2020-09-30 |
2023-08-13 |
rat |
| I Made Oka Adnyana, Raka Sudewi, Purwa Samatra, Suprapta Suprapt. Balinese Cultivar of Purple Sweet Potato Improved Neurological Score and BDNF and Reduced Caspase-Independent Apoptosis among Wistar Rats with Ischemic Stroke. Open access Macedonian journal of medical sciences. vol 7. issue 1. 2020-09-30. PMID:30740157. |
balinese cultivar of purple sweet potato improved neurological score and bdnf and reduced caspase-independent apoptosis among wistar rats with ischemic stroke. |
2020-09-30 |
2023-08-13 |
rat |
| Huayun Chen, Yanwei Dang, Xiao Liu, Junwei Ren, Hongquan Wan. Exogenous brain-derived neurotrophic factor attenuates neuronal apoptosis and neurological deficits after subarachnoid hemorrhage in rats. Experimental and therapeutic medicine. vol 18. issue 5. 2020-09-30. PMID:31616511. |
brain-derived neurotrophic factor (bdnf) is a growth factor crucial for neuronal survival, while its role in subarachnoid hemorrhage (sah)-induced neuronal apoptosis remains unclear. |
2020-09-30 |
2023-08-13 |
rat |
| Huayun Chen, Yanwei Dang, Xiao Liu, Junwei Ren, Hongquan Wan. Exogenous brain-derived neurotrophic factor attenuates neuronal apoptosis and neurological deficits after subarachnoid hemorrhage in rats. Experimental and therapeutic medicine. vol 18. issue 5. 2020-09-30. PMID:31616511. |
the aim of the present study was to investigate whether administering exogenous bdnf can protect against neuronal apoptosis and neurological deficits following sah in a rat model. |
2020-09-30 |
2023-08-13 |
rat |