| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Saba Nayar, Joana Campos, Charlotte G Smith, Valentina Iannizzotto, David H Gardner, Serena Colafrancesco, Elena Pipi, Florian Kollert, Kelly J Hunter, Charlotte Brewer, Christopher Dominic Buckley, Simon J Bowman, Roberta Priori, Guido Valesini, Maria Juarez, William A Fahy, Benjamin A Fisher, Andrew Payne, Rodger A Allen, Francesca Baron. Phosphatidylinositol 3-kinase delta pathway: a novel therapeutic target for Sjögren's syndrome. Annals of the rheumatic diseases. vol 78. issue 2. 2019-10-28. PMID:30472652. |
the phosphatidylinositol 3-kinase delta isoform (pi3kδ) belongs to an intracellular lipid kinase family that regulate lymphocyte metabolism, survival, proliferation, apoptosis and migration and has been successfully targeted in b-cell malignancies. |
2019-10-28 |
2023-08-13 |
Not clear |
| Xiao-Li Xie, Wen-Tao Zhou, Kai-Kai Zhang, Yue Yuan, En-Ming Qiu, Ya-Wen Shen, Qi Wan. PCB52 induces hepatotoxicity in male offspring through aggravating loss of clearance capacity and activating the apoptosis: Sex-biased effects on rats. Chemosphere. vol 227. 2019-06-27. PMID:31003123. |
moreover, over-expressed peroxisome proliferator-activated receptor delta and mitogen-activated protein kinase 9 might activate apoptosis, which was verified by the augments of cleaved poly adp-ribose polymerase 1 and caspase 3 in pcb52-treated male offspring. |
2019-06-27 |
2023-08-13 |
rat |
| Kira G Slepchenko, Justin M Holub, Yang V L. Intracellular zinc increase affects phosphorylation state and subcellular localization of protein kinase C delta (δ). Cellular signalling. vol 44. 2019-06-26. PMID:29414441. |
protein kinase c delta (pkcδ) is a ser/thr-specific kinase involved in many fundamental cellular processes including growth, differentiation and apoptosis. |
2019-06-26 |
2023-08-13 |
Not clear |
| M Soltanineghad, S Roshan-Milani, E Saboory, F Kheradmand, M Pourheydar, B Pourheydar, M Motazakker, L Chodar. Opioid-mediated Sertoli cells apoptosis is involved in testicular homeostasis and/or reproductive dysfunction. Bratislavske lekarske listy. vol 120. issue 4. 2019-06-26. PMID:31023050. |
here, the effects of damgo (mu opioid receptor's agonist), dpdpe (delta opioid receptor's agonist) and dyn 1-9 (kappa opioid receptor's agonist) on sertoli cell viability and apoptosis were investigated. |
2019-06-26 |
2023-08-13 |
Not clear |
| Gunnar F Kwakye, Jessica A Jiménez, Morgan G Thomas, Brett A Kingsley, Matthew McIIvin, Mak A Saito, Edmund M Korle. Heterozygous huntingtin promotes cadmium neurotoxicity and neurodegeneration in striatal cells via altered metal transport and protein kinase C delta dependent oxidative stress and apoptosis signaling mechanisms. Neurotoxicology. vol 70. 2019-03-18. PMID:30399392. |
heterozygous huntingtin promotes cadmium neurotoxicity and neurodegeneration in striatal cells via altered metal transport and protein kinase c delta dependent oxidative stress and apoptosis signaling mechanisms. |
2019-03-18 |
2023-08-13 |
mouse |
| M Grant Liska, Marci G Crowley, Trenton Lippert, Sydney Corey, Cesar V Borlonga. Delta Opioid Receptor and Peptide: A Dynamic Therapy for Stroke and Other Neurological Disorders. Handbook of experimental pharmacology. vol 247. 2019-01-22. PMID:28315071. |
delta opioid agonists such as (d-ala2, d-leu5) enkephalin (dadle) have been shown to promote neuronal survival and decrease apoptosis, resulting in a substantial amount of research for its application as a neurological therapeutic. |
2019-01-22 |
2023-08-13 |
Not clear |
| Cai-Hua Chen, Jing Pan, Yu-Qin Di, Wen Liu, Li Hou, Jin-Xing Wang, Xiao-Fan Zha. Protein kinase C delta phosphorylates ecdysone receptor B1 to promote gene expression and apoptosis under 20-hydroxyecdysone regulation. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 34. 2018-07-26. PMID:28790182. |
protein kinase c delta phosphorylates ecdysone receptor b1 to promote gene expression and apoptosis under 20-hydroxyecdysone regulation. |
2018-07-26 |
2023-08-13 |
Not clear |
| A K Gopal, M A Fanale, C H Moskowitz, A R Shustov, S Mitra, W Ye, A Younes, A J Moskowit. Phase II study of idelalisib, a selective inhibitor of PI3Kδ, for relapsed/refractory classical Hodgkin lymphoma. Annals of oncology : official journal of the European Society for Medical Oncology. vol 28. issue 5. 2018-03-02. PMID:28327905. |
the phosphatidylinositol-3-kinase delta (pi3kδ) inhibitor idelalisib has been shown to block downstream intracellular signaling, reduce the production of prosurvival chemokines and induce apoptosis in classical hodgkin lymphoma (hl) cell lines. |
2018-03-02 |
2023-08-13 |
Not clear |
| Neha Kapila, Ankita Sharma, Amit Kishore, Monika Sodhi, Pawan K Tripathi, Ashok K Mohanty, Manishi Mukes. Impact of Heat Stress on Cellular and Transcriptional Adaptation of Mammary Epithelial Cells in Riverine Buffalo (Bubalus Bubalis). PloS one. vol 11. issue 9. 2018-01-29. PMID:27682256. |
the overrepresented pathways across all time points were; electron transport chain, cytochrome p450, apoptosis, mapk, fas and stress induction of hsp regulation, delta notch signaling, apoptosis modulation by hsp70, egfr1 signaling, cytokines and inflammatory response, oxidative stress, tnf-alpha and nf- kb signaling pathway. |
2018-01-29 |
2023-08-13 |
cattle |
| M A Rosales-Reynoso, L I Wence-Chavez, A R Arredondo-Valdez, S Dumois-Petersen, P Barros-Núñez, M P Gallegos-Arreola, S E Flores-Martínez, J Sánchez-Coron. Protective role of +294 T/C (rs2016520) polymorphism of PPARD in Mexican patients with colorectal cancer. Genetics and molecular research : GMR. vol 16. issue 1. 2017-03-16. PMID:28128413. |
ppard encodes for peroxisome proliferator-activated receptor delta, which plays a significant role in controlling lipid metabolism, atherosclerosis, inflammation, cancer growth, progression, and apoptosis. |
2017-03-16 |
2023-08-13 |
Not clear |
| Nurmaa Dashzeveg, Satomi Yogosawa, Kiyotsugu Yoshid. Transcriptional induction of protein kinase C delta by p53 tumor suppressor in the apoptotic response to DNA damage. Cancer letters. vol 374. issue 1. 2016-07-13. PMID:26884258. |
protein kinase c delta (pkcδ) also induces apoptosis via various mechanisms including modification of p53. |
2016-07-13 |
2023-08-13 |
human |
| Gay Carter, Rekha Patel, André Apostolatos, Michel Murr, Denise R Cooper, Niketa A Pate. Protein kinase C delta (PKCδ) splice variant modulates senescence via hTERT in adipose-derived stem cells. Stem cell investigation. vol 1. 2016-06-30. PMID:27358850. |
protein kinase c delta (pkcδ) is alternatively spliced and has important roles in apoptosis. |
2016-06-30 |
2023-08-13 |
human |
| Ayca Kiykim, Ismail Ogulur, Safa Baris, Elisabeth Salzer, Elif Karakoc-Aydiner, Ahmet Oguzhan Ozen, Wojciech Garncarz, Tatjana Hirschmugl, Ana Krolo, Ayse Deniz Yucelten, Kaan Boztug, Isil B Barla. Potentially Beneficial Effect of Hydroxychloroquine in a Patient with a Novel Mutation in Protein Kinase Cδ Deficiency. Journal of clinical immunology. vol 35. issue 6. 2016-06-20. PMID:26233237. |
protein kinase c delta (prkcd) has essential functions in controlling b-cell proliferation and apoptosis, development of b-cell tolerance and nk-cell cytolitic activity. |
2016-06-20 |
2023-08-13 |
human |
| M M Varin, T Guerrier, V Devauchelle, P Youinou, J-O Per. B lymphocytes induce epithelial cells of salivary glands into apoptosis through protein kinase C delta activation. Bulletin du Groupement international pour la recherche scientifique en stomatologie & odontologie. vol 50. issue 2. 2016-04-22. PMID:22750714. |
b lymphocytes induce epithelial cells of salivary glands into apoptosis through protein kinase c delta activation. |
2016-04-22 |
2023-08-12 |
Not clear |
| Udayakumar Karunakaran, Si Jun Park, Do Youn Jun, Taebo Sim, Keun-Gyu Park, Myoung Ok Kim, In Kyu Le. Non-receptor tyrosine kinase inhibitors enhances β-cell survival by suppressing the PKCδ signal transduction pathway in streptozotocin-induced β-cell apoptosis. Cellular signalling. vol 27. issue 6. 2015-12-21. PMID:25683919. |
stz treatment causes apoptosis of ins-1 cells by activation of intracellular ros, c-jun n-terminal kinase (jnk), caspase 3, and caspase 3-dependent activation of protein kinase c delta (pkcδ). |
2015-12-21 |
2023-08-13 |
mouse |
| Aldo J Montano-Loza, Albert J Czaj. Cell mediators of autoimmune hepatitis and their therapeutic implications. Digestive diseases and sciences. vol 60. issue 6. 2015-08-10. PMID:25487192. |
natural killer t cells can expand the regulatory t cell population; gamma delta lymphocytes can secrete interleukin-10, stimulate hepatic regeneration, and induce the apoptosis of hepatic stellate cells; and antigen-specific regulatory t cells can dampen immune cell proliferation and function. |
2015-08-10 |
2023-08-13 |
Not clear |
| Sergio Carracedo, Frank Sacher, Gudrun Brandes, Ursula Braun, Michael Leitge. Redundant role of protein kinase C delta and epsilon during mouse embryonic development. PloS one. vol 9. issue 8. 2015-04-23. PMID:25084151. |
protein kinase c delta and epsilon are mediators of important cellular events, such as cell proliferation, migration or apoptosis. |
2015-04-23 |
2023-08-13 |
mouse |
| Fang Cui, Xiuli Li, Xiangyu Zhu, Lili Huang, Yongfang Huang, Caiying Mao, Qi Yan, Jianhong Zhu, Wenxia Zhao, Hong Sh. MiR-125b inhibits tumor growth and promotes apoptosis of cervical cancer cells by targeting phosphoinositide 3-kinase catalytic subunit delta. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 30. issue 5. 2014-09-08. PMID:23160634. |
mir-125b inhibits tumor growth and promotes apoptosis of cervical cancer cells by targeting phosphoinositide 3-kinase catalytic subunit delta. |
2014-09-08 |
2023-08-12 |
Not clear |
| Meaghan Staples, Sandra Acosta, Naoki Tajiri, Mibel Pabon, Yuji Kaneko, Cesar V Borlonga. Delta opioid receptor and its peptide: a receptor-ligand neuroprotection. International journal of molecular sciences. vol 14. issue 9. 2014-03-19. PMID:23979422. |
additionally, delta opioid agonists such as (d-ala 2, d-leu 5) enkephalin (dadle) have been shown to decrease apoptosis and promote neuronal survival. |
2014-03-19 |
2023-08-12 |
Not clear |
| Yong-Li Zhang, Xiang-Sheng Wang, Wei Fang, Xiao-Yan Cai, Hong-Zhi Li, Jian-Wen Mao, Xiao-Bao Jin, Yin-Liang Bai, Jia-Zheng L. In vitro study of the cytotoxicities of two mixed-ligand oxovanadium complexes on human hepatoma cells. Die Pharmazie. vol 68. issue 10. 2014-01-16. PMID:24273888. |
in addition, the anti-proliferative mechanism of the complexes was analyzed by cell cycle analysis and an apoptosis assay and by detecting the mitochondrial membrane potential (delta psi m). |
2014-01-16 |
2023-08-12 |
human |