| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Li, Z-X Du, Z-H Zong, B-Q Liu, C Li, Q Zhang, H-Q Wan. PKCδ-mediated phosphorylation of BAG3 at Ser187 site induces epithelial-mesenchymal transition and enhances invasiveness in thyroid cancer FRO cells. Oncogene. vol 32. issue 38. 2013-11-14. PMID:23108398. |
protein kinase c delta (pkcδ) is a serine (ser)/threonine kinase, which regulates numerous cellular processes, including proliferation, differentiation, migration and apoptosis. |
2013-11-14 |
2023-08-12 |
Not clear |
| Daisuke Hibi, Aki Kijima, Yuta Suzuki, Yuji Ishii, Meilan Jin, Yoshiko Sugita-Konishi, Tokuma Yanai, Akiyoshi Nishikawa, Takashi Umemur. Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta mice. Toxicology. vol 304. 2013-04-08. PMID:23261758. |
in the present study, to investigate the effects of p53 knockout on ota-induced mutagenicity, apoptosis, and karyomegaly in renal tubular cells, p53-proficient and p53-deficient gpt delta mice were given 1 and 5mg/kg of ota for 4 weeks. |
2013-04-08 |
2023-08-12 |
mouse |
| Daisuke Hibi, Aki Kijima, Yuta Suzuki, Yuji Ishii, Meilan Jin, Yoshiko Sugita-Konishi, Tokuma Yanai, Akiyoshi Nishikawa, Takashi Umemur. Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta mice. Toxicology. vol 304. 2013-04-08. PMID:23261758. |
incidences of apoptosis and karyomegaly in not only the outer stripe of outer medulla but also the cortex were significantly higher in p53-deficient at 5mg/kg than in p53-proficient gpt delta mice at same dose, which had no change in the cortex, the inner stripe of outer stripe, and the inner medulla. |
2013-04-08 |
2023-08-12 |
mouse |
| Daisuke Hibi, Aki Kijima, Yuta Suzuki, Yuji Ishii, Meilan Jin, Yoshiko Sugita-Konishi, Tokuma Yanai, Akiyoshi Nishikawa, Takashi Umemur. Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta mice. Toxicology. vol 304. 2013-04-08. PMID:23261758. |
additionally, the lower incidence of karyomegaly and apoptosis found in the p53-proficient gpt delta mice suggests that these phenomena may arise from ota-induced dna damage. |
2013-04-08 |
2023-08-12 |
mouse |
| Fabrice Moore, Izortze Santin, Tatiane C Nogueira, Esteban N Gurzov, Lorella Marselli, Piero Marchetti, Decio L Eiziri. The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells. PloS one. vol 7. issue 2. 2012-07-31. PMID:22347430. |
to this end, we presently evaluated the role of the transcription factor ccaat/enhancer binding protein delta (c/ebpδ) on β-cell apoptosis and production of inflammatory mediators in the rat insulinoma ins-1e cells, in purified primary rat β-cells and in human islets. |
2012-07-31 |
2023-08-12 |
human |
| Marie-Michèle Varin, Thomas Guerrier, Valérie Devauchelle-Pensec, Christophe Jamin, Pierre Youinou, Jacques-Olivier Per. In Sjögren's syndrome, B lymphocytes induce epithelial cells of salivary glands into apoptosis through protein kinase C delta activation. Autoimmunity reviews. vol 11. issue 4. 2012-06-06. PMID:22001522. |
in sjögren's syndrome, b lymphocytes induce epithelial cells of salivary glands into apoptosis through protein kinase c delta activation. |
2012-06-06 |
2023-08-12 |
human |
| Felicia Ranta, Johannes Leveringhaus, Dorothea Theilig, Gabriele Schulz-Raffelt, Anita M Hennige, Dominic G Hildebrand, René Handrick, Verena Jendrossek, Fatima Bosch, Klaus Schulze-Osthoff, Hans-Ulrich Häring, Susanne Ullric. Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1. PloS one. vol 6. issue 12. 2012-05-21. PMID:22216119. |
high fat diet-induced hyperglycemia and palmitate-stimulated apoptosis was prevented by specific inhibition of protein kinase c delta (pkcδ) in β-cells. |
2012-05-21 |
2023-08-12 |
Not clear |
| Magali Espinosa, Gisela Ceballos-Cancino, Richard Callaghan, Vilma Maldonado, Nelly Patiño, Víctor Ruíz, Jorge Meléndez-Zajgl. Survivin isoform Delta Ex3 regulates tumor spheroid formation. Cancer letters. vol 318. issue 1. 2012-05-03. PMID:22155745. |
in this study, we sought to analyze survivin delta ex3 expression in a three-dimensional model of avascular tumors and its overexpression effects in processes such as proliferation, clonogenicity and apoptosis. |
2012-05-03 |
2023-08-12 |
human |
| Daisuke Hibi, Yuta Suzuki, Yuji Ishii, Meilan Jin, Maiko Watanabe, Yoshiko Sugita-Konishi, Tokuma Yanai, Takehiko Nohmi, Akiyoshi Nishikawa, Takashi Umemur. Site-specific in vivo mutagenicity in the kidney of gpt delta rats given a carcinogenic dose of ochratoxin A. Toxicological sciences : an official journal of the Society of Toxicology. vol 122. issue 2. 2011-12-19. PMID:21622941. |
in the present study, a 13-week exposure of gpt delta rats to ota at a carcinogenic dose induced karyomegaly and apoptosis at the outer stripe of the outer medulla (om) of the kidney but failed to affect the reporter gene mutations in dna extracted from whole kidneys. |
2011-12-19 |
2023-08-12 |
human |
| Hoi Chin Hew, Hanshao Liu, Zheng-Guang Lu, Junko Kimura, Yoshio Miki, Kiyotsugu Yoshid. Identification of Evi-1 as a novel effector of PKCδ in the apoptotic response to DNA damage. Biochimica et biophysica acta. vol 1809. issue 7. 2011-09-20. PMID:21362509. |
protein kinase c delta (pkcδ), a pkc family isoform, regulates diverse signal transduction pathways during dna damage to induce apoptosis. |
2011-09-20 |
2023-08-12 |
Not clear |
| María Ines Díaz Bessone, Damian E Berardi, Paola B Campodónico, Laura B Todaro, Leonard Lothstein, Elisa D Bal de Kier Joffé, Alejandro J Urtrege. Involvement of PKC delta (PKCδ) in the resistance against different doxorubicin analogs. Breast cancer research and treatment. vol 126. issue 3. 2011-07-15. PMID:20512658. |
it has been proposed that ad 198 induces apoptosis by activating protein kinase c delta (pkcδ); a pkc isoform described as growth inhibitory in a large number of cell types. |
2011-07-15 |
2023-08-12 |
Not clear |
| B L Allen-Petersen, M R Miller, M C Neville, S M Anderson, K I Nakayama, M E Reylan. Loss of protein kinase C delta alters mammary gland development and apoptosis. Cell death & disease. vol 1. 2011-06-23. PMID:21364618. |
loss of protein kinase c delta alters mammary gland development and apoptosis. |
2011-06-23 |
2023-08-12 |
mouse |
| Enos Tangke Arung, Britanto Dani Wicaksono, Yohana Ayupriyanti Handoko, Irawan Wijaya Kusuma, Kuniyoshi Shimizu, Dina Yulia, Ferry Sandr. Cytotoxic effect of artocarpin on T47D cells. Journal of natural medicines. vol 64. issue 4. 2011-06-06. PMID:20544395. |
the mode of action of artocarpin was evaluated by its effect on cell viability, nuclear morphology, cell cycle progression, expression of protein markers for apoptosis, and mitochondrial membrane potential (delta psi m). |
2011-06-06 |
2023-08-12 |
human |
| Anumantha G Kanthasamy, Masashi Kitazawa, Yongjie Yang, Vellareddy Anantharam, Arthi Kanthasam. Environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase C delta (PKCdelta): Implications for neurodegeneration in Parkinson's disease. Molecular brain. vol 1. 2011-05-02. PMID:18945348. |
environmental neurotoxin dieldrin induces apoptosis via caspase-3-dependent proteolytic activation of protein kinase c delta (pkcdelta): implications for neurodegeneration in parkinson's disease. |
2011-05-02 |
2023-08-12 |
Not clear |
| Shuping Yin, Seema Sethi, Kaladhar B Redd. Protein kinase Cδ and caspase-3 modulate TRAIL-induced apoptosis in breast tumor cells. Journal of cellular biochemistry. vol 111. issue 4. 2011-02-07. PMID:20665667. |
this report describes that protein kinase c delta (pkcδ) overexpression prevents trail-induced apoptosis in breast tumor cells; however, the regulatory mechanism(s) involved in this phenomenon is(are) incompletely understood. |
2011-02-07 |
2023-08-12 |
Not clear |
| Yanfen Shi, Yudan Wei, Shanshan Qu, Yang Wang, Yulin Li, Ronggui L. Arsenic induces apoptosis of human umbilical vein endothelial cells through mitochondrial pathways. Cardiovascular toxicology. vol 10. issue 3. 2010-12-08. PMID:20473585. |
to clarify the molecular mechanisms through which arsenic causes injuries to blood vessels, we analyzed the effects of sodium arsenite (naaso(2)) on the apoptosis of human umbilical vein endothelial cells (huvecs), mitochondrial membrane potential (delta psi m), intracellular reactive oxygen species (ros), and the expression of the related genes. |
2010-12-08 |
2023-08-12 |
human |
| Yanfen Shi, Yudan Wei, Shanshan Qu, Yang Wang, Yulin Li, Ronggui L. Arsenic induces apoptosis of human umbilical vein endothelial cells through mitochondrial pathways. Cardiovascular toxicology. vol 10. issue 3. 2010-12-08. PMID:20473585. |
huvecs apoptosis increased and delta psi m decreased in a dose-dependent manner following arsenic treatment. |
2010-12-08 |
2023-08-12 |
human |
| Yanfen Shi, Yudan Wei, Shanshan Qu, Yang Wang, Yulin Li, Ronggui L. Arsenic induces apoptosis of human umbilical vein endothelial cells through mitochondrial pathways. Cardiovascular toxicology. vol 10. issue 3. 2010-12-08. PMID:20473585. |
based on the results, we suggest that the decrease of delta psi m caused by arsenic and the resulting cell apoptosis may contribute to the injuries of blood vessel in arsenism. |
2010-12-08 |
2023-08-12 |
human |
| Rekha Rao, Srilatha Nalluri, Warren Fiskus, Ramesh Balusu, Atul Joshi, Uma Mudunuru, Kathleen M Buckley, Kelly Robbins, Celalettin Ustun, Gary W Reuther, Kapil N Bhall. Heat shock protein 90 inhibition depletes TrkA levels and signaling in human acute leukemia cells. Molecular cancer therapeutics. vol 9. issue 8. 2010-11-26. PMID:20663926. |
exposure to 17-dmag inhibited ngf-induced p-trka, p-akt, and p-erk1/2 levels, as well as induced apoptosis of k562, 32d cells with ectopic expression of wild-type trka or the constitutively active mutant delta trka, and of primary myeloid leukemia cells. |
2010-11-26 |
2023-08-12 |
human |
| Yuko Kumamoto-Yonezawa, Ryohei Sasaki, Yoko Suzuki, Yuki Matsui, Takahiko Hada, Keisuke Uryu, Kazuro Sugimura, Hiromi Yoshida, Yoshiyuki Mizushin. Enhancement of human cancer cell radiosensitivity by conjugated eicosapentaenoic acid - a mammalian DNA polymerase inhibitor. International journal of oncology. vol 36. issue 3. 2010-10-22. PMID:20126977. |
the post-irradiation addition of cepa significantly enhanced hct116 cell radiosensitivity by decreasing the expression of pols beta, delta and epsilon, increasing damaged dna, such as dna double-strand breaks, inhibiting clonogenic survival, and inducing apoptosis. |
2010-10-22 |
2023-08-12 |
human |