| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Janjuree Netsawang, Sansanee Noisakran, Chunya Puttikhunt, Watchara Kasinrerk, Wiyada Wongwiwat, Prida Malasit, Pa-thai Yenchitsomanus, Thawornchai Limjindapor. Nuclear localization of dengue virus capsid protein is required for DAXX interaction and apoptosis. Virus research. vol 147. issue 2. 2010-02-17. PMID:19944121. |
stable hepg2 cells constitutively expressing denv c, denv c (delta 85-100) and denv c (delta 73-100) were constructed to clarify whether nuclear translocation of denv c affected apoptosis in liver cell line. |
2010-02-17 |
2023-08-12 |
Not clear |
| Emmalene J Bartlett, Ann-Marie Cruz, Jim Boonyaratanakornkit, Janice Esker, Adam Castaño, Mario H Skiadopoulos, Peter L Collins, Brian R Murphy, Alexander C Schmid. A novel human parainfluenza virus type 1 (HPIV1) with separated P and C genes is useful for generating C gene mutants for evaluation as live-attenuated virus vaccine candidates. Vaccine. vol 28. issue 3. 2010-02-03. PMID:19857454. |
rhpiv1-c(delta 84-85)+p and an additional mutant, rhpiv1-c(delta 169-170)+p, were found to replicate to similar titers in vitro and to activate the type i ifn and apoptosis responses to a similar degree as rhpiv1-c+p. |
2010-02-03 |
2023-08-12 |
human |
| Feng-Hou Gao, Ying-Li Wu, Meng Zhao, Chuan-Xu Liu, Li-Shun Wang, Guo-Qiang Che. Protein kinase C-delta mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction. Experimental cell research. vol 315. issue 19. 2010-01-19. PMID:19747914. |
we reported previously that nsc606985, a camptothecin analogue, induces apoptosis of acute myeloid leukemia (aml) cells through proteolytic activation of protein kinase c delta (deltapkc-delta). |
2010-01-19 |
2023-08-12 |
Not clear |
| Yong-Lie Zhou, Ya-Ping Lü, Wei-Xiao Hu, Lian-Nü Qiu, Wen-Song Wang, Jian-Dong Liu, Jian-Guo W. [ZGDHu-1-inducing apoptosis of SHI-1 leukemia cells and its molecular mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 15. issue 3. 2009-12-11. PMID:17605850. |
different concentrations of zgdhu-1 and different times of culture were used to treat shi-1 cells; the apoptosis of shi-1 cells was analyzed by morphology, dna agarose gel electrophoresis, dna content detection, annexin-v/pi and hoechst33258 labeling method, the mitochondrial transmembrane potential (delta psi m) were measured by dihydrorhodamin 123, and expressions of bcl-2, bax, fas, p53 and mitochondrial membrane protein were analyzed by flow cytometry, while the bcl-2, bax and p53 gene were analyzed by rt-pcr. |
2009-12-11 |
2023-08-12 |
human |
| Susanne Oesch, Dagmar Walter, Marco Wachtel, Kathya Pretre, Maria Salazar, Manuel Guzmán, Guillermo Velasco, Beat W Schäfe. Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma. Molecular cancer therapeutics. vol 8. issue 7. 2009-10-19. PMID:19509271. |
our study shows that treatment with the cannabinoid receptor agonists hu210 and delta(9)-tetrahydrocannabinol lowers the viability of translocation-positive rhabdomyosarcoma cells through the induction of apoptosis. |
2009-10-19 |
2023-08-12 |
Not clear |
| Sudarshana Purkayastha, Suraj Shawn Fernando, Souleymane Diallo, Leah Cohen, Buddima Ranasinghe, Kelly Levano, Probal Banerje. Regulation of protein kinase C isozymes during early postnatal hippocampal development. Brain research. vol 1288. 2009-10-15. PMID:19591813. |
neurogenesis), following which pkcalpha (and the beta, gamma, or delta isozymes) could guide maturation or apoptosis. |
2009-10-15 |
2023-08-12 |
mouse |
| Laura DePalatis, Colleen M Almgren, Jypji Patmastan, Mark Troyer, Todd Woodrich, Charles L Brook. Structure and function of a new class of human prolactin antagonists. Protein expression and purification. vol 66. issue 2. 2009-09-30. PMID:19236917. |
we have compared the antagonist activities of g129r and delta 41-52 hprls to induce apoptosis in jurkat cells, a human lymphoid cell line displaying an autocrine/paracrine hprl/receptor system. |
2009-09-30 |
2023-08-12 |
human |
| Laura DePalatis, Colleen M Almgren, Jypji Patmastan, Mark Troyer, Todd Woodrich, Charles L Brook. Structure and function of a new class of human prolactin antagonists. Protein expression and purification. vol 66. issue 2. 2009-09-30. PMID:19236917. |
delta 41-52 hprl induces apoptosis in a time and dose-dependent fashion. |
2009-09-30 |
2023-08-12 |
human |
| Laura DePalatis, Colleen M Almgren, Jypji Patmastan, Mark Troyer, Todd Woodrich, Charles L Brook. Structure and function of a new class of human prolactin antagonists. Protein expression and purification. vol 66. issue 2. 2009-09-30. PMID:19236917. |
we conclude delta 41-52 hprl is a lead compound of a new class of hprl antagonists capable at low concentrations of inducing apoptosis in human cells expressing an autocrine/paracrine hprl/receptor system. |
2009-09-30 |
2023-08-12 |
human |
| J Wang, X F Wang, L G Zhang, S Y Xie, Z L Li, Y J Li, H H Li, F Jia. Involvement of the mitochondrial pathway in p53-independent apoptosis induced by p28GANK knockdown in Hep3B cells. Cytogenetic and genome research. vol 125. issue 2. 2009-09-17. PMID:19729910. |
since p38 can signal to bax, its activation may lead to mitochondrial transmembrane potential (delta psi m) loss, cytochrome c release from mitochondria to cytosol, and caspase-9 activation, eventually triggering the mitochondrial pathway of apoptosis. |
2009-09-17 |
2023-08-12 |
human |
| Naiara Beraza, Yann Malato, Leif E Sander, Malika Al-Masaoudi, Julia Freimuth, Dieter Riethmacher, Gregory J Gores, Tania Roskams, Christian Liedtke, Christian Trautwei. Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damage. The Journal of experimental medicine. vol 206. issue 8. 2009-08-14. PMID:19635861. |
we show that nemo(delta hepa) mice were resistant to fas-mediated apoptosis but hypersensitive to tumor necrosis factor-related apoptosis-inducing ligand (trail) as the result of a strong up-regulation of its receptor dr5 on hepatocytes. |
2009-08-14 |
2023-08-12 |
mouse |
| Zhao-zhe Liu, Jie-peng Chen, Su-lan Zhao, Chang-ling L. [Apoptosis-inducing effect of alternol on mouse lymphocyte leukemia cells and its mechanism]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 42. issue 12. 2009-08-10. PMID:18338638. |
the increase of reactive oxygen species (ros) production was found after cells were exposed to alternol for 6 h, while the decrease of mitochondrial transmembrane potential (delta psi m) was not found until cells were exposed to alternol for 24 h. furthermore, the level of bcel-2 and bcl-2/bax was down-regulated, while the level of caspase-3 and caspase-9 but not caspase-8 was up-regulated when alternol was added for 72 h. in summary, the results suggested that alternol could inhibit the proliferation of l1210 cells and induce apoptosis of l1210 cells, which was mediated by mitochondria-dependent pathway. |
2009-08-10 |
2023-08-12 |
mouse |
| Quan Li, Eisuke F Sato, Xiaoping Zhu, Masayasu Inou. A simultaneous release of SOD1 with cytochrome c regulates mitochondria-dependent apoptosis. Molecular and cellular biochemistry. vol 322. issue 1-2. 2009-08-05. PMID:19002561. |
however, mntbap inhibited the apoptosis induced by staurosporine but not by actinomycin d. mntbap failed to inhibit delta psi decrease and release of sod1 and cytochrome c induced by actinomycin d. moreover, 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (dids), an inhibitor of voltage-dependent anion channel (vdac), inhibited the release of the two proteins and apoptosis induced by staurosporine but not actinomycin d. these results suggest that ros plays an important role in mitochondria-dependent but not mitochondria-independent apoptosis and that the release of sod1 increases the susceptibility of mitochondria to oxidative stress, thereby enhancing a vicious cycle leading to apoptosis. |
2009-08-05 |
2023-08-12 |
Not clear |
| Hyo Jung Kim, Min Young Kim, Hana Jin, Hyun Joon Kim, Sang Soo Kang, Hye Jung Kim, Jae Heun Lee, Ki Churl Chang, Jin-Yong Hwang, Chihiro Yabe-Nishimura, Jin-Hoi Kim, Han Geuk Se. Peroxisome proliferator-activated receptor {delta} regulates extracellular matrix and apoptosis of vascular smooth muscle cells through the activation of transforming growth factor-{beta}1/Smad3. Circulation research. vol 105. issue 1. 2009-08-03. PMID:19461048. |
peroxisome proliferator-activated receptor {delta} regulates extracellular matrix and apoptosis of vascular smooth muscle cells through the activation of transforming growth factor-{beta}1/smad3. |
2009-08-03 |
2023-08-12 |
mouse |
| Elaine M Reno, James M Haughian, Twila A Jackson, Alicia M Thorne, Andrew P Bradfor. c-Jun N-terminal kinase regulates apoptosis in endometrial cancer cells. Apoptosis : an international journal on programmed cell death. vol 14. issue 6. 2009-07-23. PMID:19424800. |
knockdown of protein kinase c delta (pkcdelta) also attenuated apoptosis in endometrial cancer cells and inhibited the sustained, uv-mediated jnk activation in hec-50, but not ishikawa cells. |
2009-07-23 |
2023-08-12 |
Not clear |
| Ying Zheng, Li-Shun Wang, Li Xia, Yu-Hui Han, Shi-Hua Liao, Xiao-Ling Wang, Jin-Ke Cheng, Guo-Qiang Che. NDRG1 is down-regulated in the early apoptotic event induced by camptothecin analogs: the potential role in proteolytic activation of PKC delta and apoptosis. Proteomics. vol 9. issue 8. 2009-07-20. PMID:19322780. |
ndrg1 is down-regulated in the early apoptotic event induced by camptothecin analogs: the potential role in proteolytic activation of pkc delta and apoptosis. |
2009-07-20 |
2023-08-12 |
Not clear |
| Ying Zheng, Li-Shun Wang, Li Xia, Yu-Hui Han, Shi-Hua Liao, Xiao-Ling Wang, Jin-Ke Cheng, Guo-Qiang Che. NDRG1 is down-regulated in the early apoptotic event induced by camptothecin analogs: the potential role in proteolytic activation of PKC delta and apoptosis. Proteomics. vol 9. issue 8. 2009-07-20. PMID:19322780. |
we previously reported that nsc606985, a new camptothecin analog, induces apoptosis of acute myeloid leukemic cells, which is triggered by proteolytic activation of protein kinase c delta (pkc delta). |
2009-07-20 |
2023-08-12 |
Not clear |
| Ying Zheng, Li-Shun Wang, Li Xia, Yu-Hui Han, Shi-Hua Liao, Xiao-Ling Wang, Jin-Ke Cheng, Guo-Qiang Che. NDRG1 is down-regulated in the early apoptotic event induced by camptothecin analogs: the potential role in proteolytic activation of PKC delta and apoptosis. Proteomics. vol 9. issue 8. 2009-07-20. PMID:19322780. |
with the ectopic expression of ndrg1, the proteolytic activation of pkc delta in nsc606985-treated leukemic cells was delayed and the cells were less sensitive to apoptosis. |
2009-07-20 |
2023-08-12 |
Not clear |
| Ying Zheng, Li-Shun Wang, Li Xia, Yu-Hui Han, Shi-Hua Liao, Xiao-Ling Wang, Jin-Ke Cheng, Guo-Qiang Che. NDRG1 is down-regulated in the early apoptotic event induced by camptothecin analogs: the potential role in proteolytic activation of PKC delta and apoptosis. Proteomics. vol 9. issue 8. 2009-07-20. PMID:19322780. |
on the contrary, the suppression of ndrg1 expression by specific small interfering rna significantly enhanced nsc606985-induced activation of pkc delta and apoptosis of u937 cells. |
2009-07-20 |
2023-08-12 |
Not clear |
| Ying Zheng, Li-Shun Wang, Li Xia, Yu-Hui Han, Shi-Hua Liao, Xiao-Ling Wang, Jin-Ke Cheng, Guo-Qiang Che. NDRG1 is down-regulated in the early apoptotic event induced by camptothecin analogs: the potential role in proteolytic activation of PKC delta and apoptosis. Proteomics. vol 9. issue 8. 2009-07-20. PMID:19322780. |
in summary, our study suggests that the down-regulation of ndrg1 is involved in proteolytic activation of pkc delta during apoptosis induction, which would shed new light on the understanding the apoptotic process initiated by camptothecin. |
2009-07-20 |
2023-08-12 |
Not clear |