| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Clare M Adams, Scott W Hiebert, Christine M Eische. Myc Induces miRNA-Mediated Apoptosis in Response to HDAC Inhibition in Hematologic Malignancies. Cancer research. vol 76. issue 3. 2016-06-28. PMID:26676759. |
taken together, our results reveal a previously unknown mechanism by which myc induces apoptosis independent of the p53 pathway and as a response to hdaci in malignant hematopoietic cells. |
2016-06-28 |
2023-08-13 |
Not clear |
| Yee Ling Wu, Cristina Rad. Molecular fine-tuning of affinity maturation in germinal centers. The Journal of clinical investigation. vol 126. issue 1. 2016-06-20. PMID:26657856. |
they show that mir-155 is highly expressed in positively selected b cells and promotes survival of these cells by orienting the myc transcription program toward survival rather than apoptosis through the inhibition of the transcriptional regulator jarid2. |
2016-06-20 |
2023-08-13 |
Not clear |
| Markus Hart. The Quest for Targets Executing MYC-Dependent Cell Transformation. Frontiers in oncology. vol 6. 2016-06-17. PMID:27313991. |
myc represents a transcription factor with oncogenic potential converting multiple cellular signals into a broad transcriptional response, thereby controlling the expression of numerous protein-coding and non-coding rnas important for cell proliferation, metabolism, differentiation, and apoptosis. |
2016-06-17 |
2023-08-13 |
human |
| Daniel J Murphy, Nathiya Muthalag. BIM's up first. Molecular & cellular oncology. vol 2. issue 2. 2016-06-16. PMID:27308426. |
surprisingly, apoptosis induced by myc in multiple solid tissues does not require p19arf (cdkn2a), whereas puma (bbc3) is required only in the context of sensitization by myc to death induced by dna damage. |
2016-06-16 |
2023-08-13 |
Not clear |
| Taewan Kim, Ri Cui, Young-Jun Jeon, Paolo Fadda, Hansjuerg Alder, Carlo M Croc. MYC-repressed long noncoding RNAs antagonize MYC-induced cell proliferation and cell cycle progression. Oncotarget. vol 6. issue 22. 2016-06-08. PMID:26003165. |
the transcription factor myc is a proto-oncogene regulating cell proliferation, cell cycle, apoptosis and metabolism. |
2016-06-08 |
2023-08-13 |
Not clear |
| Francesca Cottini, Teru Hideshima, Rikio Suzuki, Yu-Tzu Tai, Giampaolo Bianchini, Paul G Richardson, Kenneth C Anderson, Giovanni Tono. Synthetic Lethal Approaches Exploiting DNA Damage in Aggressive Myeloma. Cancer discovery. vol 5. issue 9. 2016-06-01. PMID:26080835. |
we show that oncogenes, such as myc, induce dna damage in multiple myeloma cells not only by increased replicative stress, but also via increased oxidative stress, and that reactive oxygen species-inducer piperlongumine triggers further dna damage and apoptosis. |
2016-06-01 |
2023-08-13 |
Not clear |
| Deepika S Das, Arghya Ray, Yan Song, Paul Richardson, Mohit Trikha, Dharminder Chauhan, Kenneth C Anderso. Synergistic anti-myeloma activity of the proteasome inhibitor marizomib and the IMiD immunomodulatory drug pomalidomide. British journal of haematology. vol 171. issue 5. 2016-05-18. PMID:26456076. |
marizomib plus pomalidomide-induced apoptosis is associated with: (i) activation of caspase-8, caspase-9, caspase-3 and parp cleavage, (ii) downregulation of cereblon (crbn), irf4, myc and mcl1, and (iii) suppression of chymotrypsin-like, caspase-like, and trypsin-like proteasome activities. |
2016-05-18 |
2023-08-13 |
human |
| Huabo Wang, Lokendra Sharma, Jie Lu, Paul Finch, Steven Fletcher, Edward V Prochowni. Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion. Oncotarget. vol 6. issue 18. 2016-05-12. PMID:26036281. |
thirdly, synthetic lethal inhibitors cause the selective apoptosis of myc over-expressing either by promoting mitotic catastrophe or altering myc protein stability. |
2016-05-12 |
2023-08-13 |
human |
| b' Xenia Villalobos, Laura Rodr\\xc3\\xadguez, Anna Sol\\xc3\\xa9, Carolina Lliber\\xc3\\xb3s, N\\xc3\\xbaria Mencia, Carlos J Ciudad, V\\xc3\\xa9ronique No\\xc3\\xa. Effect of Polypurine Reverse Hoogsteen Hairpins on Relevant Cancer Target Genes in Different Human Cell Lines. Nucleic acid therapeutics. vol 25. issue 4. 2016-04-15. PMID:26042602.' |
we designed pprhs against the following genes: bcl2, top1, mtor, mdm2, and myc and tested them for mrna levels, cytotoxicity, and apoptosis in prostate, pancreas, colon, and breast cancer cell lines. |
2016-04-15 |
2023-08-13 |
human |
| b' Xenia Villalobos, Laura Rodr\\xc3\\xadguez, Anna Sol\\xc3\\xa9, Carolina Lliber\\xc3\\xb3s, N\\xc3\\xbaria Mencia, Carlos J Ciudad, V\\xc3\\xa9ronique No\\xc3\\xa. Effect of Polypurine Reverse Hoogsteen Hairpins on Relevant Cancer Target Genes in Different Human Cell Lines. Nucleic acid therapeutics. vol 25. issue 4. 2016-04-15. PMID:26042602.' |
in the case of top1, mdm2, and myc, their corresponding pprhs produced a strong effect in decreasing cell viability and mrna levels and increasing apoptosis in breast cancer cells. |
2016-04-15 |
2023-08-13 |
human |
| b' Xenia Villalobos, Laura Rodr\\xc3\\xadguez, Anna Sol\\xc3\\xa9, Carolina Lliber\\xc3\\xb3s, N\\xc3\\xbaria Mencia, Carlos J Ciudad, V\\xc3\\xa9ronique No\\xc3\\xa. Effect of Polypurine Reverse Hoogsteen Hairpins on Relevant Cancer Target Genes in Different Human Cell Lines. Nucleic acid therapeutics. vol 25. issue 4. 2016-04-15. PMID:26042602.' |
thus, we confirm that the pprh technology is broadly useful to silence the expression of cancer-related genes as demonstrated using target genes involved in metabolism (dhfr), proliferation (mtor), dna topology (top1), lifespan and senescence (telomerase), apoptosis (survivin, bcl2), transcription factors (myc), and proto-oncogenes (mdm2). |
2016-04-15 |
2023-08-13 |
human |
| Roberto Jose Diaz, Brian Golbourn, Claudia Faria, Daniel Picard, David Shih, Denis Raynaud, Michael Leadly, Danielle MacKenzie, Melissa Bryant, Matthew Bebenek, Christian A Smith, Michael D Taylor, Annie Huang, James T Rutk. Mechanism of action and therapeutic efficacy of Aurora kinase B inhibition in MYC overexpressing medulloblastoma. Oncotarget. vol 6. issue 5. 2016-03-28. PMID:25739120. |
lymphoma cells expressing high levels of myc are susceptible to apoptosis following treatment with inhibitors of mitosis. |
2016-03-28 |
2023-08-13 |
mouse |
| Huasong Lu, Yuhua Xue, Yuahua Xue, Guoying K Yu, Carolina Arias, Julie Lin, Susan Fong, Michel Faure, Ben Weisburd, Xiaodan Ji, Alexandre Mercier, James Sutton, Kunxin Luo, Zhenhai Gao, Qiang Zho. Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism. eLife. vol 4. 2016-03-10. PMID:26083714. |
because the i-cdk9-induced myc expression and binding to p-tefb compensate for p-tefb's loss of activity, only simultaneously inhibiting cdk9 and myc/brd4 can efficiently induce growth arrest and apoptosis of cancer cells, suggesting the potential of a combinatorial treatment strategy. |
2016-03-10 |
2023-08-13 |
Not clear |
| Daniela Annibali, Jonathan R Whitfield, Emilia Favuzzi, Toni Jauset, Erika Serrano, Isabel Cuartas, Sara Redondo-Campos, Gerard Folch, Alba Gonzàlez-Juncà, Nicole M Sodir, Daniel Massó-Vallés, Marie-Eve Beaulieu, Lamorna B Swigart, Margaret M Mc Gee, Maria Patrizia Somma, Sergio Nasi, Joan Seoane, Gerard I Evan, Laura Souce. Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis. Nature communications. vol 5. 2016-03-07. PMID:25130259. |
across all these experimental models we find that myc inhibition reduces proliferation, increases apoptosis and remarkably, elicits the formation of multinucleated cells that then arrest or die by mitotic catastrophe, revealing a new role for myc in the proficient division of glioma cells. |
2016-03-07 |
2023-08-13 |
mouse |
| Emma K Baker, Scott Taylor, Ankita Gupte, Phillip P Sharp, Mannu Walia, Nicole C Walsh, Andrew Cw Zannettino, Alistair M Chalk, Christopher J Burns, Carl R Walkle. BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells. Scientific reports. vol 5. 2016-02-29. PMID:25944566. |
bet inhibitors induce apoptosis through a myc independent mechanism and synergise with cdk inhibitors to kill osteosarcoma cells. |
2016-02-29 |
2023-08-13 |
human |
| Jessica Bordini, Maria Teresa Sabrina Bertilaccio, Maurilio Ponzoni, Isabella Fermo, Marta Chesi, P Leif Bergsagel, Clara Camaschella, Alessandro Campanell. Erythroblast apoptosis and microenvironmental iron restriction trigger anemia in the VK*MYC model of multiple myeloma. Haematologica. vol 100. issue 6. 2016-02-12. PMID:25715406. |
erythroblast apoptosis and microenvironmental iron restriction trigger anemia in the vk*myc model of multiple myeloma. |
2016-02-12 |
2023-08-13 |
mouse |
| Yinfei Tan, Eleonora Sementino, Jianming Pei, Yuwaraj Kadariya, Timothy K Ito, Joseph R Test. Co-targeting of Akt and Myc inhibits viability of lymphoma cells from Lck-Dlx5 mice. Cancer biology & therapy. vol 16. issue 4. 2016-01-20. PMID:25793663. |
in contrast, the specific myc inhibitor 10058-f4 caused apoptosis, and when combined with bez235 (≥0.5 µm), an enhanced effect on apoptosis was consistently observed. |
2016-01-20 |
2023-08-13 |
mouse |
| Alper Yetil, Benedict Anchang, Arvin M Gouw, Stacey J Adam, Tahera Zabuawala, Ramya Parameswaran, Jan van Riggelen, Sylvia Plevritis, Dean W Felshe. p19ARF is a critical mediator of both cellular senescence and an innate immune response associated with MYC inactivation in mouse model of acute leukemia. Oncotarget. vol 6. issue 6. 2016-01-12. PMID:25784651. |
addiction to myc is a consequence of both cell-autonomous mechanisms, such as proliferative arrest, cellular senescence, and apoptosis, as well as non-cell autonomous mechanisms, such as shutdown of angiogenesis, and recruitment of immune effectors. |
2016-01-12 |
2023-08-13 |
mouse |
| Xin Li, Xin A Zhang, Xiaoqing Li, Wei Xie, Shiang Huan. MYC-mediated synthetic lethality for treating tumors. Current cancer drug targets. vol 15. issue 2. 2016-01-04. PMID:25553514. |
elevated myc levels lead to dna damage, senescence, and apoptosis. |
2016-01-04 |
2023-08-13 |
mouse |
| Manpreet Kalkat, Pak-Kei Chan, Amanda R Wasylishen, Tharan Srikumar, Sam S Kim, Romina Ponzielli, David P Bazett-Jones, Brian Raught, Linda Z Pen. Identification of c-MYC SUMOylation by mass spectrometry. PloS one. vol 9. issue 12. 2015-12-17. PMID:25522242. |
abrogation of signaling through this residue by substitution with arginine (k326r) has no obvious effects on myc half-life, intracellular localization, transcriptional targets, nor on the biological effects of myc overexpression in two different cell systems assessed for soft agar colony formation, proliferation, and apoptosis. |
2015-12-17 |
2023-08-13 |
Not clear |