| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John Anto Pulikkan, Mahesh Hegde, Hafiz Mohd Ahmad, Houda Belaghzal, Anuradha Illendula, Jun Yu, Kelsey O'Hagan, Jianhong Ou, Carsten Muller-Tidow, Scot A Wolfe, Lihua Julie Zhu, Job Dekker, John Hackett Bushweller, Lucio Hernán Castill. CBFβ-SMMHC Inhibition Triggers Apoptosis by Disrupting MYC Chromatin Dynamics in Acute Myeloid Leukemia. Cell. vol 174. issue 1. 2019-03-21. PMID:29958106. |
upon pharmacologic inhibition of the cbfβ-smmhc/runx1 interaction, runx1 shows increased binding at three myc distal enhancers, where it represses myc expression by mediating the replacement of the swi/snf complex component brg1 with the polycomb-repressive complex component ring1b, leading to apoptosis. |
2019-03-21 |
2023-08-13 |
mouse |
| M S Webb, A L Miller, T L Howard, B H Johnson, S Chumakov, Y Fofanov, T Nguyen-Vu, C Y Lin, E B Thompso. Sequential gene regulatory events leading to glucocorticoid-evoked apoptosis of CEM human leukemic cells:interactions of MAPK, MYC and glucocorticoid pathways. Molecular and cellular endocrinology. vol 471. 2019-03-08. PMID:29596968. |
sequential gene regulatory events leading to glucocorticoid-evoked apoptosis of cem human leukemic cells:interactions of mapk, myc and glucocorticoid pathways. |
2019-03-08 |
2023-08-13 |
human |
| M S Webb, A L Miller, T L Howard, B H Johnson, S Chumakov, Y Fofanov, T Nguyen-Vu, C Y Lin, E B Thompso. Sequential gene regulatory events leading to glucocorticoid-evoked apoptosis of CEM human leukemic cells:interactions of MAPK, MYC and glucocorticoid pathways. Molecular and cellular endocrinology. vol 471. 2019-03-08. PMID:29596968. |
myc levels and the balance of activities between the three major groups of mapks are known important regulators of glucocorticoid-driven apoptosis in several lymphoid cell systems. |
2019-03-08 |
2023-08-13 |
human |
| b' A Esteve-Arenys, J G Valero, A Chamorro-Jorganes, D Gonzalez, V Rodriguez, I Dlouhy, I Salaverria, E Campo, D Colomer, A Martinez, G Rymkiewicz, P P\\xc3\\xa9rez-Gal\\xc3\\xa1n, A Lopez-Guillermo, G Rou\\xc3\\xa. The BET bromodomain inhibitor CPI203 overcomes resistance to ABT-199 (venetoclax) by downregulation of BFL-1/A1 in in vitro and in vivo models of MYC+/BCL2+ double hit lymphoma. Oncogene. vol 37. issue 14. 2019-03-07. PMID:29353886.' |
upon cpi203 treatment, simultaneous downregulation of myc and bfl-1 further overcomes resistance to abt-199 both in vitro and in vivo, engaging synergistic caspase-mediated apoptosis in dhl cultures and tumor xenografts. |
2019-03-07 |
2023-08-13 |
mouse |
| Nicholas T Jacob, Pedro O Miranda, Ryan J Shirey, Ritika Gautam, Bin Zhou, M Elena de Orbe Izquierdo, Mark S Hixon, Jonathan R Hart, Lynn Ueno, Peter K Vogt, Kim D Jand. Synthetic molecules for disruption of the MYC protein-protein interface. Bioorganic & medicinal chemistry. vol 26. issue 14. 2019-02-04. PMID:30037753. |
myc is a key transcriptional regulator involved in cellular proliferation and has established roles in transcriptional elongation and initiation, microrna regulation, apoptosis, and pluripotency. |
2019-02-04 |
2023-08-13 |
Not clear |
| Esther J Y Kim, Minna-Liisa Anko, Christoffer Flensberg, Ian J Majewski, Fan-Suo Geng, Jaber Firas, David C S Huang, Mark F van Delft, Joan K Heat. BAK/BAX-Mediated Apoptosis Is a Myc-Induced Roadblock to Reprogramming. Stem cell reports. vol 10. issue 2. 2019-01-17. PMID:29358089. |
thus, the propensity for myc overexpression to elicit apoptosis creates a significant roadblock to reprogramming under oksm conditions. |
2019-01-17 |
2023-08-13 |
mouse |
| Lavinia A Carabet, Nada Lallous, Eric Leblanc, Fuqiang Ban, Helene Morin, Sam Lawn, Fariba Ghaidi, Joseph Lee, Ian G Mills, Martin E Gleave, Paul S Rennie, Artem Cherkaso. Computer-aided drug discovery of Myc-Max inhibitors as potential therapeutics for prostate cancer. European journal of medicinal chemistry. vol 160. 2018-12-11. PMID:30326371. |
to elicit its oncogenic effects, myc must form a heterodimer with its partner max, which together bind dna and activate transcription of a spectrum of target genes that promote cell growth, proliferation, metabolism, and apoptosis while blocking differentiation. |
2018-12-11 |
2023-08-13 |
human |
| U Sh Kuzmina, L F Zainullina, S V Sadovnikov, V A Vakhitov, Yu V Vakhitov. NMDA Receptors Regulate Genes Responsible for Major Immune Functions of Mononuclears in Human Peripheral Blood. Bulletin of experimental biology and medicine. vol 165. issue 2. 2018-11-14. PMID:29923004. |
the genes, whose expression changed in response to blockade of nmda receptors in mononuclears, encode the products involved in regulation of the major functions of immune cells, such as proliferation (il4, vcam1, and cdkn2a), apoptosis (bax, myc, cdkn2a, hspb1, and cadd45a), activation (il4r, il4, vcam1, and cdkn2a), and differentiation (il4, vcam1, and bax). |
2018-11-14 |
2023-08-13 |
human |
| Saeed Hassani, Parisa Ghaffari, Bahram Chahardouli, Kamran Alimoghaddam, Ardeshir Ghavamzadeh, Shaban Alizadeh, Seyed H Ghaffar. Disulfiram/copper causes ROS levels alteration, cell cycle inhibition, and apoptosis in acute myeloid leukaemia cell lines with modulation in the expression of related genes. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 99. 2018-10-15. PMID:29902866. |
these were associated with the increased expression of foxo tumor suppressors, decreased expression of the myc oncogene and the modulation of their known target genes related to the cell cycle and apoptosis. |
2018-10-15 |
2023-08-13 |
cat |
| Z J Pei, Z G Zhang, A X Hu, F Yang, Y Ga. miR-122-5p inhibits tumor cell proliferation and induces apoptosis by targeting MYC in gastric cancer cells. Die Pharmazie. vol 72. issue 6. 2018-08-22. PMID:29442023. |
mir-122-5p inhibits tumor cell proliferation and induces apoptosis by targeting myc in gastric cancer cells. |
2018-08-22 |
2023-08-13 |
human |
| Z J Pei, Z G Zhang, A X Hu, F Yang, Y Ga. miR-122-5p inhibits tumor cell proliferation and induces apoptosis by targeting MYC in gastric cancer cells. Die Pharmazie. vol 72. issue 6. 2018-08-22. PMID:29442023. |
on the other hand, cells apoptosis research showed that mir-122-5p induced apoptosis by targeting myc in scg7901 cells. |
2018-08-22 |
2023-08-13 |
human |
| Z J Pei, Z G Zhang, A X Hu, F Yang, Y Ga. miR-122-5p inhibits tumor cell proliferation and induces apoptosis by targeting MYC in gastric cancer cells. Die Pharmazie. vol 72. issue 6. 2018-08-22. PMID:29442023. |
finally, in this study, mir-122-5p was confirmed inhibiting tumor gc cells proliferation and inducing cells apoptosis by targeting myc. |
2018-08-22 |
2023-08-13 |
human |
| Lufang Wang, Yanyan Zhao, Qiong Wu, Yifu Guan, Xin W. Therapeutic effects of β-elemene via attenuation of the Wnt/β-catenin signaling pathway in cervical cancer cells. Molecular medicine reports. vol 17. issue 3. 2018-08-16. PMID:29363722. |
the expression levels of cyclin‑dependent kinase inhibitor 2b (p15), cyclin d1, cellular tumor antigen p53, apoptosis regulator bcl‑2 (bcl‑2), apoptosis regulator bax (bax), 72 kda type iv collagenase (mmp‑2), matrix metalloproteinase‑9 (mmp‑9), β‑catenin, transcription factor 7 (tcf7), and myc proto‑oncogene protein (c‑myc) were analyzed via western blotting. |
2018-08-16 |
2023-08-13 |
human |
| Masanori Kawano, Kazuhiro Tanaka, Ichiro Itonaga, Tatsuya Iwasaki, Hiroshi Tsumur. MicroRNA-20b promotes cell proliferation via targeting of TGF-β receptor II and upregulates MYC expression in Ewing's sarcoma cells. International journal of oncology. vol 51. issue 6. 2018-07-23. PMID:29039480. |
because downstream tgfbr2 and tgf-β signaling regulate cell cycle, apoptosis, and tumor proliferation via myc, our findings may contribute to new targeted therapies for es. |
2018-07-23 |
2023-08-13 |
human |
| Chengle Zhuang, Xinbo Huang, Changshui Zhuang, Xiaomin Luo, Xiaowei Zhang, Zhiming Cai, Yaoting Gu. Synthetic regulatory RNAs selectively suppress the progression of bladder cancer. Journal of experimental & clinical cancer research : CR. vol 36. issue 1. 2018-07-19. PMID:29084575. |
without the arna, mrna and protein levels of myc, cell growth, cell apoptosis and cell migration were no significance in two bladder cancer cell lines, t24 and 5637, and human foreskin fibroblast (hff) cells. |
2018-07-19 |
2023-08-13 |
human |
| Rui-Fang Fan, Ying Lu, Zhi-Gang Fang, Xiao-Yan Guo, Yu-Xin Chen, Yi-Chuan Xu, Ya-Mei Lei, Ke-Fang Liu, Dong-Jun Lin, Ling-Ling Liu, Xiang-Fu Li. PIM-1 kinase inhibitor SMI-4a exerts antitumor effects in chronic myeloid leukemia cells by enhancing the activity of glycogen synthase kinase 3β. Molecular medicine reports. vol 16. issue 4. 2018-05-21. PMID:28849186. |
in addition, the downstream gene expression of apoptosis regulator bax and poly(adp‑ribose) polymerase‑1 was upregulated, and apoptosis regulator bcl‑2 and myc proto‑oncogene protein expression levels were downregulated. |
2018-05-21 |
2023-08-13 |
Not clear |
| Jinghang Zhang, Na Song, Dan Zang, Jian Yu, Jinsong Li, Wenyu Di, Ruina Guo, Weixing Zhao, Haijun Wan. c-Myc promotes tumor proliferation and anti‑apoptosis by repressing p21 in rhabdomyosarcomas. Molecular medicine reports. vol 16. issue 4. 2018-05-14. PMID:28765944. |
v-myc avian myelocytomatosis viral oncogene homolog (c-myc) is an important member protein of the myc family that is important in cell cycle progression, apoptosis and tumorigenesis. |
2018-05-14 |
2023-08-13 |
Not clear |
| Munir A Al-Zeer, Audrey Xavier, Mohammad Abu Lubad, Janine Sigulla, Mirjana Kessler, Robert Hurwitz, Thomas F Meye. Chlamydia trachomatis Prevents Apoptosis Via Activation of PDPK1-MYC and Enhanced Mitochondrial Binding of Hexokinase II. EBioMedicine. vol 23. 2018-05-11. PMID:28803120. |
strikingly, preventing the hkii interaction with mitochondria using exogenous peptides triggers apoptosis of infected cells as does inhibiting either pdpk1 or myc, which also disrupts intracellular development of chlamydia trachomatis. |
2018-05-11 |
2023-08-13 |
human |
| Wen Zhao, RuiYue Qiu, Pan Li, Jin Yan. PIM1: a promising target in patients with triple-negative breast cancer. Medical oncology (Northwood, London, England). vol 34. issue 8. 2018-04-16. PMID:28721678. |
recently, the cooperation of pim1 and myc was identified involved in cell proliferation, migration and apoptosis of tnbcs, which has been reported in hematological malignancy and prostatic cancer. |
2018-04-16 |
2023-08-13 |
mouse |
| Ka Kui Chan, Kyle B Matchett, Jonathan A Coulter, Hiu-Fung Yuen, Cian M McCrudden, Shu-Dong Zhang, Gareth W Irwin, Matthew A Davidson, Thomas Rülicke, Sophie Schober, Ludger Hengst, Heidelinde Jaekel, Angela Platt-Higgins, Philip S Rudland, Ken I Mills, Perry Maxwell, Mohamed El-Tanani, Terence R Lappi. Erythropoietin drives breast cancer progression by activation of its receptor EPOR. Oncotarget. vol 8. issue 24. 2018-04-04. PMID:28418910. |
epor knockdown abrogated human tumor cell growth, induced apoptosis through bim, reduced invasiveness, and caused downregulation of myc expression. |
2018-04-04 |
2023-08-13 |
human |