| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daisuke Yamada, Satoshi Watanabe, Kohichi Kawahara, Takehiko Maed. Plexin A1 signaling confers malignant phenotypes in lung cancer cells. Biochemical and biophysical research communications. vol 480. issue 1. 2017-06-06. PMID:27717823. |
we found that plxna1 knockdown did not affect apoptosis but resulted in decreased cell proliferation and reductions in mrna expression levels of proliferation-marker genes, such as ccnd1, pcna, and myc. |
2017-06-06 |
2023-08-13 |
Not clear |
| Jiang-Ping Wang, Yong Jiao, Cheng-Yuan Wang, Zhi-Bin Xu, Bo Zhan. Rb knockdown accelerates bladder cancer progression through E2F3 activation. International journal of oncology. vol 50. issue 1. 2017-04-04. PMID:27922689. |
interestingly, rb silence results in e2f3, myc and mtor signaling pathway activation, contributing to bladder cancer cell proliferation and apoptosis suppression mainly through caspase-3 inhibition in vitro and in vivo. |
2017-04-04 |
2023-08-13 |
human |
| b' Matja\\xc5\\xbe Novak, Bojana \\xc5\\xbdegura, \\xc5\\xa0pela Baebler, Alja \\xc5\\xa0tern, Ana Rotter, Katja Stare, Metka Filipi\\xc4\\x8. Influence of selected anti-cancer drugs on the induction of DNA double-strand breaks and changes in gene expression in human hepatoma HepG2 cells. Environmental science and pollution research international. vol 23. issue 15. 2017-03-21. PMID:26392091.' |
the analysis of the changes in the expression of genes involved in the response to dna damage (cdkn1a, gadd45a, mdm2), apoptosis (bax, bcl2) and oncogenesis (myc, jun) showed that 5-fu, cddp and et upregulated the genes involved in dna damage response, while the anti-apoptotic gene bcl2 and oncogene myc were downregulated. |
2017-03-21 |
2023-08-13 |
human |
| Gebang Wang, Huan Wang, Chenlei Zhang, Tieqin Liu, Qingchang Li, Xuyong Lin, Jingwei Xie, Hongxu Li. Rac3 regulates cell proliferation through cell cycle pathway and predicts prognosis in lung adenocarcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 9. 2017-02-14. PMID:27402308. |
silencing of rac3 significantly induced cell growth inhibition, colony formation decrease, cell cycle arrest, and apoptosis of lung adenocarcinoma cell lines, which accompanied by obvious downregulation of ccnd1, myc, and tfdp1 of cell cycle pathway involving in the tumorigenesis of lung adenocarcinoma based on the gene expression microarray. |
2017-02-14 |
2023-08-13 |
Not clear |
| Yuma Nonomiya, Kohji Noguchi, Noritaka Tanaka, Takahiro Kasagaki, Kazuhiro Katayama, Yoshikazu Sugimot. Effect of AKT3 expression on MYC- and caspase-8-dependent apoptosis caused by polo-like kinase inhibitors in HCT 116 cells. Cancer science. vol 107. issue 12. 2017-02-06. PMID:27699933. |
expression of p-gp conferred resistance to plkis, and plki-induced apoptosis was dependent on myc and caspase-8 in hct 116 cells. |
2017-02-06 |
2023-08-13 |
human |
| Yuma Nonomiya, Kohji Noguchi, Noritaka Tanaka, Takahiro Kasagaki, Kazuhiro Katayama, Yoshikazu Sugimot. Effect of AKT3 expression on MYC- and caspase-8-dependent apoptosis caused by polo-like kinase inhibitors in HCT 116 cells. Cancer science. vol 107. issue 12. 2017-02-06. PMID:27699933. |
collectively, these results indicate that myc, caspase-8, p-gp, and akt3 play critical roles in plki-induced apoptosis. |
2017-02-06 |
2023-08-13 |
human |
| Marcela Cristina Robaina, Roberta Soares Faccion, Luciano Mazzoccoli, Lidia Maria M Rezende, Eduardo Queiroga, Carlos E Bacchi, Andrei Thomas-Tikhonenko, Claudete Esteves Klum. miR-17-92 cluster components analysis in Burkitt lymphoma: overexpression of miR-17 is associated with poor prognosis. Annals of hematology. vol 95. issue 6. 2017-01-27. PMID:27044389. |
recently, myc has been shown to maintain the neoplastic state via the mir-17-92 microrna cluster that suppresses chromatin regulatory genes and the apoptosis regulator bim. |
2017-01-27 |
2023-08-13 |
Not clear |
| Yunwei Li, Dongyang Yu, Weiwei Sheng, He Song, Yuji Li, Ming Don. Co-expression of FOXL1 and PP2A inhibits proliferation inducing apoptosis in pancreatic cancer cells via promoting TRAIL and reducing phosphorylated MYC. Oncology reports. vol 35. issue 4. 2016-12-26. PMID:26820810. |
co-expression of foxl1 and pp2a inhibits proliferation inducing apoptosis in pancreatic cancer cells via promoting trail and reducing phosphorylated myc. |
2016-12-26 |
2023-08-13 |
human |
| Yunwei Li, Dongyang Yu, Weiwei Sheng, He Song, Yuji Li, Ming Don. Co-expression of FOXL1 and PP2A inhibits proliferation inducing apoptosis in pancreatic cancer cells via promoting TRAIL and reducing phosphorylated MYC. Oncology reports. vol 35. issue 4. 2016-12-26. PMID:26820810. |
in conclusion, the adenovirus‑mediated co‑expression of foxl1 and pp2a with the 2a peptide linker exterts synergistic suppression of pancreatic cancer cells via inhibiting the growth and promoting apoptosis of cancer cells, probably via upregulating trail and reducing the phosphorylation of myc. |
2016-12-26 |
2023-08-13 |
human |
| Yong Zhang, Zheng Peng, Yunshan Zhao, Lin Che. microRNA-25 Inhibits Cell Apoptosis of Human Gastric Adenocarcinoma Cell Line AGS via Regulating CCNE1 and MYC. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2016-12-26. PMID:27120728. |
microrna-25 inhibits cell apoptosis of human gastric adenocarcinoma cell line ags via regulating ccne1 and myc. |
2016-12-26 |
2023-08-13 |
human |
| Heidi M Haikala, Juha Klefström, Martin Eilers, Katrin E Wies. MYC-induced apoptosis in mammary epithelial cells is associated with repression of lineage-specific gene signatures. Cell cycle (Georgetown, Tex.). vol 15. issue 3. 2016-12-13. PMID:26873145. |
apoptosis caused by deregulated myc expression is a prototype example of intrinsic tumor suppression. |
2016-12-13 |
2023-08-13 |
human |
| Heidi M Haikala, Juha Klefström, Martin Eilers, Katrin E Wies. MYC-induced apoptosis in mammary epithelial cells is associated with repression of lineage-specific gene signatures. Cell cycle (Georgetown, Tex.). vol 15. issue 3. 2016-12-13. PMID:26873145. |
however, it is still unclear how supraphysiological myc expression levels engage specific sets of target genes to promote apoptosis. |
2016-12-13 |
2023-08-13 |
human |
| Michala Prause, Christopher Michael Mayer, Caroline Brorsson, Klaus Stensgaard Frederiksen, Nils Billestrup, Joachim Størling, Thomas Mandrup-Poulse. JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression. Journal of diabetes research. vol 2016. 2016-12-13. PMID:26962537. |
jnk1 deficient insulin-producing cells are protected against interleukin-1β-induced apoptosis associated with abrogated myc expression. |
2016-12-13 |
2023-08-13 |
Not clear |
| Michala Prause, Christopher Michael Mayer, Caroline Brorsson, Klaus Stensgaard Frederiksen, Nils Billestrup, Joachim Størling, Thomas Mandrup-Poulse. JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression. Journal of diabetes research. vol 2016. 2016-12-13. PMID:26962537. |
jnk1 knockdown prevented il-1β-induced ins-1 cell apoptosis associated with decreased 46 kda isoform jnk protein phosphorylation and attenuated myc expression. |
2016-12-13 |
2023-08-13 |
Not clear |
| Michala Prause, Christopher Michael Mayer, Caroline Brorsson, Klaus Stensgaard Frederiksen, Nils Billestrup, Joachim Størling, Thomas Mandrup-Poulse. JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression. Journal of diabetes research. vol 2016. 2016-12-13. PMID:26962537. |
transient knockdown of myc also prevented il-1β-induced apoptosis as well as caspase 3 cleavage. |
2016-12-13 |
2023-08-13 |
Not clear |
| Jiannong Li, Bin Fang, Fumi Kinose, Yun Bai, Jae-Young Kim, Yian A Chen, Uwe Rix, John M Koomen, Eric B Haur. Target Identification in Small Cell Lung Cancer via Integrated Phenotypic Screening and Activity-Based Protein Profiling. Molecular cancer therapeutics. vol 15. issue 2. 2016-11-03. PMID:26772203. |
we next extended the platform to a second compound that had activity in sclc cell lines lacking c-myc amplification and identified tank-binding kinase 1, a kinase that affects cell viability, polo-like kinase-1 signaling, g2-m arrest, and apoptosis in sclc cells lacking myc amplification. |
2016-11-03 |
2023-08-13 |
Not clear |
| Qingqing Cai, L Jeffrey Medeiros, Xiaolu Xu, Ken H Youn. MYC-driven aggressive B-cell lymphomas: biology, entity, differential diagnosis and clinical management. Oncotarget. vol 6. issue 36. 2016-10-19. PMID:26416427. |
myc encodes a helix-loop-helix transcription factor that accentuates many cellular functions including proliferation, growth and apoptosis. |
2016-10-19 |
2023-08-13 |
Not clear |
| Nourdine Hamdane, Chelsea Herdman, Jean-Clement Mars, Victor Stefanovsky, Michel G Tremblay, Tom Mos. Depletion of the cisplatin targeted HMGB-box factor UBF selectively induces p53-independent apoptotic death in transformed cells. Oncotarget. vol 6. issue 29. 2016-08-16. PMID:26317157. |
apoptosis is not affected by homozygous deletion of the p53 gene and occurs equally in cells transformed by sv40 t antigens, by myc or by a combination of ras & myc oncogenes. |
2016-08-16 |
2023-08-13 |
Not clear |
| Huabo Wang, Peter Teriete, Angela Hu, Dhanya Raveendra-Panickar, Kelsey Pendelton, John S Lazo, Julie Eiseman, Toril Holien, Kristine Misund, Ganna Oliynyk, Marie Arsenian-Henriksson, Nicholas D P Cosford, Anders Sundan, Edward V Prochowni. Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids. Oncotarget. vol 6. issue 32. 2016-08-12. PMID:26474287. |
as with other myc inhibitors, these analogs rapidly reduced the abundance of myc protein and provoked a global energy crisis marked by atp depletion, neutral lipid accumulation, amp-activated protein kinase activation, cell cycle arrest and apoptosis. |
2016-08-12 |
2023-08-13 |
human |
| Clare M Adams, Scott W Hiebert, Christine M Eische. Myc Induces miRNA-Mediated Apoptosis in Response to HDAC Inhibition in Hematologic Malignancies. Cancer research. vol 76. issue 3. 2016-06-28. PMID:26676759. |
myc induces mirna-mediated apoptosis in response to hdac inhibition in hematologic malignancies. |
2016-06-28 |
2023-08-13 |
Not clear |