| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B M Iritani, R N Eisenma. c-Myc enhances protein synthesis and cell size during B lymphocyte development. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 23. 1999-12-13. PMID:10557294. |
members of the myc family of nuclear protooncogenes play roles in cell proliferation, differentiation, and apoptosis. |
1999-12-13 |
2023-08-12 |
mouse |
| C Bouchard, K Thieke, A Maier, R Saffrich, J Hanley-Hyde, W Ansorge, S Reed, P Sicinski, J Bartek, M Eiler. Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27. The EMBO journal. vol 18. issue 19. 1999-12-02. PMID:10508165. |
primary mouse fibroblasts that are cyclin d2-deficient undergo accelerated senescence in culture and are not immortalized by myc; induction of apoptosis by myc is unimpaired in such cells. |
1999-12-02 |
2023-08-12 |
mouse |
| J J Jacobs, B Scheijen, J W Voncken, K Kieboom, A Berns, M van Lohuize. Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. Genes & development. vol 13. issue 20. 1999-11-15. PMID:10541554. |
others have shown that part of myc's ability to induce apoptosis depends on induction of p19arf. |
1999-11-15 |
2023-08-12 |
mouse |
| J J Jacobs, B Scheijen, J W Voncken, K Kieboom, A Berns, M van Lohuize. Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF. Genes & development. vol 13. issue 20. 1999-11-15. PMID:10541554. |
furthermore, bmi-1 collaborates with myc in enhancing proliferation and transformation of primary embryo fibroblasts (mefs) in an ink4a-arf dependent manner, by prohibiting myc-mediated induction of p19arf and apoptosis. |
1999-11-15 |
2023-08-12 |
mouse |
| F Vega, A Panizo, J Pardo-Mindán, J Die. Susceptibility to apoptosis measured by MYC, BCL-2, and BAX expression in arterioles and capillaries of adult spontaneously hypertensive rats. American journal of hypertension. vol 12. issue 8 Pt 1. 1999-10-19. PMID:10480475. |
susceptibility to apoptosis measured by myc, bcl-2, and bax expression in arterioles and capillaries of adult spontaneously hypertensive rats. |
1999-10-19 |
2023-08-12 |
rat |
| U Galderisi, G Di Bernardo, M Cipollaro, F P Jori, E Piegari, A Cascino, G Peluso, M A Melon. Induction of apoptosis and differentiation in neuroblastoma and astrocytoma cells by the overexpression of Bin1, a novel Myc interacting protein. Journal of cellular biochemistry. vol 74. issue 3. 1999-09-27. PMID:10412034. |
induction of apoptosis and differentiation in neuroblastoma and astrocytoma cells by the overexpression of bin1, a novel myc interacting protein. |
1999-09-27 |
2023-08-12 |
Not clear |
| U Galderisi, G Di Bernardo, M Cipollaro, F P Jori, E Piegari, A Cascino, G Peluso, M A Melon. Induction of apoptosis and differentiation in neuroblastoma and astrocytoma cells by the overexpression of Bin1, a novel Myc interacting protein. Journal of cellular biochemistry. vol 74. issue 3. 1999-09-27. PMID:10412034. |
since myc family genes play a regulatory role in the proliferation, differentiation, and apoptosis of the nervous system, we studied the effects of the overexpression of the myc-interacting protein, bin1, in neuroblastoma and astrocytoma cell lines, which were chosen as neural cell system models. |
1999-09-27 |
2023-08-12 |
Not clear |
| N Gündoguş-Ozcanli, C Sayilir, W E Cris. Effects of polyamines, polyamine synthesis inhibitors, and polyamine analogs on casein kinase II using Myc oncoprotein as substrate. Biochemical pharmacology. vol 58. issue 2. 1999-08-05. PMID:10423165. |
polyamines, casein kinase ii (ckii), and the myc oncogene are directly involved in the regulation of molecular events in cell proliferation, differentiation, and apoptosis. |
1999-08-05 |
2023-08-12 |
Not clear |
| S T Lee, K P Hoeflich, G W Wasfy, J R Woodgett, B Leber, D W Andrews, D W Hedley, L Z Pen. Bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by Myc but not etoposide in Rat-1 fibroblasts. Oncogene. vol 18. issue 23. 1999-06-30. PMID:10376530. |
bcl-2 targeted to the endoplasmic reticulum can inhibit apoptosis induced by myc but not etoposide in rat-1 fibroblasts. |
1999-06-30 |
2023-08-12 |
Not clear |
| G F Claassen, S R Han. Myc-mediated transformation: the repression connection. Oncogene. vol 18. issue 19. 1999-06-25. PMID:10378689. |
myc is an important regulator of many cellular processes, including growth promotion, differentiation, and apoptosis. |
1999-06-25 |
2023-08-12 |
Not clear |
| D Sakamuro, G C Prendergas. New Myc-interacting proteins: a second Myc network emerges. Oncogene. vol 18. issue 19. 1999-06-25. PMID:10378691. |
the n-terminal domain (ntd), which includes the evolutionarily conserved and functionally crucial myc box sequences (mb1 and mb2), contains the transcription activation domain (tad) of c-myc as well as regions required for transcriptional repression, cell cycle regulation, transformation, and apoptosis. |
1999-06-25 |
2023-08-12 |
human |
| B Lüscher, L G Larsso. The basic region/helix-loop-helix/leucine zipper domain of Myc proto-oncoproteins: function and regulation. Oncogene. vol 18. issue 19. 1999-06-25. PMID:10378692. |
interestingly myc can also sensitize cells to apoptosis, suggesting that this protein is part of a life-and-death switch. |
1999-06-25 |
2023-08-12 |
Not clear |
| K Inoue, M F Roussel, C J Sher. Induction of ARF tumor suppressor gene expression and cell cycle arrest by transcription factor DMP1. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 7. 1999-05-12. PMID:10097151. |
unlike genes such as myc, adenovirus e1a, and e2f-1, which, when overexpressed, activate the arf-p53 pathway and trigger apoptosis, dmp1, like arf itself, does not induce programmed cell death. |
1999-05-12 |
2023-08-12 |
mouse |
| S Cory, D L Vaux, A Strasser, A W Harris, J M Adam. Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation. Cancer research. vol 59. issue 7 Suppl. 1999-04-22. PMID:10197581. |
insights from bcl-2 and myc: malignancy involves abrogation of apoptosis as well as sustained proliferation. |
1999-04-22 |
2023-08-12 |
mouse |
| K K Papas, L Sun, E S Roos, J S Gounarides, M Shapiro, C M Nali. Change in lactate production in Myc-transformed cells precedes apoptosis and can be inhibited by Bcl-2 overexpression. FEBS letters. vol 446. issue 2-3. 1999-04-20. PMID:10100870. |
recently, the increased susceptibility to stress-induced apoptosis associated with myc transfection has been linked to the overexpression of the ldh-a gene. |
1999-04-20 |
2023-08-12 |
Not clear |
| E Weber, R K Ravi, E S Knudsen, J R Williams, L E Dillehay, B D Nelkin, G P Kalemkerian, J R Feramisco, M Mabr. Retinoic acid-mediated growth inhibition of small cell lung cancer cells is associated with reduced myc and increased p27Kip1 expression. International journal of cancer. vol 80. issue 6. 1999-03-25. PMID:10074929. |
we found that ectopic expression of p27kip1 induced growth inhibition in both h209 and h82 cells, and that sustained myc expression in h209-rar-beta cells promoted the induction of apoptosis upon ra addition. |
1999-03-25 |
2023-08-12 |
human |
| A Sugiyama, K Noguchi, C Kitanaka, N Katou, F Tashiro, T Ono, M C Yoshida, Y Kuchin. Molecular cloning and chromosomal mapping of mouse intronless myc gene acting as a potent apoptosis inducer. Gene. vol 226. issue 2. 1999-03-16. PMID:9931502. |
molecular cloning and chromosomal mapping of mouse intronless myc gene acting as a potent apoptosis inducer. |
1999-03-16 |
2023-08-12 |
mouse |
| A Sugiyama, K Noguchi, C Kitanaka, N Katou, F Tashiro, T Ono, M C Yoshida, Y Kuchin. Molecular cloning and chromosomal mapping of mouse intronless myc gene acting as a potent apoptosis inducer. Gene. vol 226. issue 2. 1999-03-16. PMID:9931502. |
our previous findings suggest that the activation of the rat intronless myc gene provides a selective advantage in tumor suppression through apoptosis induction. |
1999-03-16 |
2023-08-12 |
mouse |
| A Sugiyama, K Noguchi, C Kitanaka, N Katou, F Tashiro, T Ono, M C Yoshida, Y Kuchin. Molecular cloning and chromosomal mapping of mouse intronless myc gene acting as a potent apoptosis inducer. Gene. vol 226. issue 2. 1999-03-16. PMID:9931502. |
in the present study, to examine whether intronless myc gene acting as an apoptosis inducer is evolutionarily conserved in mammalian cells, we isolated the mouse intronless myc gene and characterized it. |
1999-03-16 |
2023-08-12 |
mouse |
| H B Forrester, C A Vidair, N Albright, C C Ling, W C Dewe. Using computerized video time lapse for quantifying cell death of X-irradiated rat embryo cells transfected with c-myc or c-Ha-ras. Cancer research. vol 59. issue 4. 1999-03-04. PMID:10029087. |
the loss of clonogenic survival of x-irradiated (9.5 or 2.5 gy) rec:myc cells was attributed almost entirely to the cells dying by apoptosis, with almost all of the apoptosis occurring after the progeny had divided from one to four times. |
1999-03-04 |
2023-08-12 |
rat |