| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H B Forrester, C A Vidair, N Albright, C C Ling, W C Dewe. Using computerized video time lapse for quantifying cell death of X-irradiated rat embryo cells transfected with c-myc or c-Ha-ras. Cancer research. vol 59. issue 4. 1999-03-04. PMID:10029087. |
for example, after 9.5 gy, which causes reproductive cell death in 99% of both types of cells, the cumulative percentage of the cells scored as dead in the whole population at 60- 80 h after irradiation, when the maximum amount of cumulative apoptosis occurred, was approximately 60% for rec:myc cells, compared with only approximately 40% for rec:ras cells. |
1999-03-04 |
2023-08-12 |
rat |
| A P Hall, J Irvine, K Blyth, E R Cameron, D E Onions, M E Campbel. Tumours derived from HTLV-I tax transgenic mice are characterized by enhanced levels of apoptosis and oncogene expression. The Journal of pathology. vol 186. issue 2. 1999-03-01. PMID:9924438. |
in situ dna fragment labelling and immunocytochemical analysis of these tumours reveals that they display enhanced levels of apoptosis, which is associated with elevated levels of myc, fos, jun, and p53 protein expression. |
1999-03-01 |
2023-08-12 |
mouse |
| M Volm, J Mattern, R Koomäg. Association between nm23-H1 expression, proliferation and apoptosis in non-small cell lung carcinomas. Clinical & experimental metastasis. vol 16. issue 7. 1999-02-25. PMID:9932606. |
additionally, a direct correlation between apoptosis and nm23-h1 expression or between myc and nm23-h1 expression was found. |
1999-02-25 |
2023-08-12 |
Not clear |
| B Hoffman, D A Lieberman. The proto-oncogene c-myc and apoptosis. Oncogene. vol 17. issue 25. 1999-02-16. PMID:9916997. |
apoptosis associated with inappropriate myc expression limits the tumorigenic effect of the c-myc proto-oncogene. |
1999-02-16 |
2023-08-12 |
Not clear |
| A Tan, H Levrey, C Dahm, V A Polunovsky, J Rubins, P B Bitterma. Lovastatin induces fibroblast apoptosis in vitro and in vivo. A possible therapy for fibroproliferative disorders. American journal of respiratory and critical care medicine. vol 159. issue 1. 1999-02-11. PMID:9872842. |
studies in our laboratory have demonstrated that lovastatin potently induces apoptosis in fibroblasts constitutively expressing myc, and that lung fibroblasts isolated from fibrotic lesions constitutively express growth-promoting genes. |
1999-02-11 |
2023-08-12 |
human |
| A Tan, H Levrey, C Dahm, V A Polunovsky, J Rubins, P B Bitterma. Lovastatin induces fibroblast apoptosis in vitro and in vivo. A possible therapy for fibroproliferative disorders. American journal of respiratory and critical care medicine. vol 159. issue 1. 1999-02-11. PMID:9872842. |
in this study, we sought to determine if nontransformed lung fibroblasts would manifest susceptibility to lovastatin-induced apoptosis similar to that observed in fibroblasts ectopically expressing myc. |
1999-02-11 |
2023-08-12 |
human |
| E K Balcer-Kubiczek, X F Zhang, L H Han, G H Harrison, C C Davis, X J Zhou, V Ioffe, W A McCready, J M Abraham, S J Meltze. BIGEL analysis of gene expression in HL60 cells exposed to X rays or 60 Hz magnetic fields. Radiation research. vol 150. issue 6. 1998-12-14. PMID:9840186. |
dna sequencing revealed that 15 of the 18 cdna clones produced matches with the database for genes related to cell growth, protein synthesis, energy metabolism, oxidative stress or apoptosis (including myc, neuroleukin, copper zinc-dependent superoxide dismutase, tc4 ras-like protein, peptide elongation factor 1alpha, bnip3, gata3, nf45, cytochrome c oxidase ii and triosephosphate isomerase mrnas). |
1998-12-14 |
2023-08-12 |
Not clear |
| C E Nesbit, L E Grove, X Yin, E V Prochowni. Differential apoptotic behaviors of c-myc, N-myc, and L-myc oncoproteins. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 9. issue 9. 1998-12-11. PMID:9751117. |
bcl-2 and bcl-x(l) protected control cells against apoptosis after either il-3 withdrawal or drug exposure, although in some cases this effect could be overridden by myc oncoproteins, particularly n-myc and l-myc. |
1998-12-11 |
2023-08-12 |
Not clear |
| C C Helbing, C L Wellington, M Gogela-Spehar, T Cheng, G G Pinchbeck, R N Johnsto. Quiescence versus apoptosis: Myc abundance determines pathway of exit from the cell cycle. Oncogene. vol 17. issue 12. 1998-11-12. PMID:9794226. |
quiescence versus apoptosis: myc abundance determines pathway of exit from the cell cycle. |
1998-11-12 |
2023-08-12 |
human |
| C C Helbing, C L Wellington, M Gogela-Spehar, T Cheng, G G Pinchbeck, R N Johnsto. Quiescence versus apoptosis: Myc abundance determines pathway of exit from the cell cycle. Oncogene. vol 17. issue 12. 1998-11-12. PMID:9794226. |
surprisingly, serum starvation in the absence of myc overexpression, (which leads to quiescence instead of apoptosis) also causes a marked transient elevation in cdk2 kinase activity, an induction of cdc25a and a delayed increase in p27kip1. |
1998-11-12 |
2023-08-12 |
human |
| A O Hueber, G I Eva. Traps to catch unwary oncogenes. Trends in genetics : TIG. vol 14. issue 9. 1998-11-04. PMID:9769732. |
the myc protein has a well-established role as a component of signal-transduction pathways promoting both proliferation and apoptosis. |
1998-11-04 |
2023-08-12 |
Not clear |
| R Z Orlowski, J R Eswara, A Lafond-Walker, M R Grever, M Orlowski, C V Dan. Tumor growth inhibition induced in a murine model of human Burkitt's lymphoma by a proteasome inhibitor. Cancer research. vol 58. issue 19. 1998-11-03. PMID:9766662. |
fibroblasts transformed with ras and myc, lymphoblasts transformed by c-myc alone, and a burkitt's lymphoma (bl) cell line that overexpresses c-myc were up to 40-fold more susceptible to apoptosis than were either primary rodent fibroblasts or immortalized nontransformed human lymphoblasts, respectively. |
1998-11-03 |
2023-08-12 |
mouse |
| K Braun, G Hölzl, O Pusch, M Hengstschläge. Deregulated expression of CDK2- or CDK3-associated kinase activities enhances c-Myc-induced apoptosis. DNA and cell biology. vol 17. issue 9. 1998-10-28. PMID:9778038. |
however, both molecules heavily elevated the incidence of apoptosis induced by tnf together with myc. |
1998-10-28 |
2023-08-12 |
Not clear |
| Q Guo, J Xie, C V Dang, E T Liu, J M Bisho. Identification of a large Myc-binding protein that contains RCC1-like repeats. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 16. 1998-09-08. PMID:9689053. |
the protooncogene myc plays an important role in the regulation of cellular proliferation, differentiation, and apoptosis and has been implicated in a variety of human tumors. |
1998-09-08 |
2023-08-12 |
human |
| F Zindy, C M Eischen, D H Randle, T Kamijo, J L Cleveland, C J Sherr, M F Rousse. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes & development. vol 12. issue 15. 1998-08-27. PMID:9694806. |
myc signaling via the arf tumor suppressor regulates p53-dependent apoptosis and immortalization. |
1998-08-27 |
2023-08-12 |
mouse |
| F Zindy, C M Eischen, D H Randle, T Kamijo, J L Cleveland, C J Sherr, M F Rousse. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes & development. vol 12. issue 15. 1998-08-27. PMID:9694806. |
myc rapidly activates arf and p53 gene expression in primary mefs and triggers replicative crisis by inducing apoptosis. |
1998-08-27 |
2023-08-12 |
mouse |
| S Gross-Mesilaty, E Reinstein, B Bercovich, K E Tobias, A L Schwartz, C Kahana, A Ciechanove. Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 14. 1998-08-06. PMID:9653139. |
it is possible that in certain cells e6-mediated targeting of myc prevents myc-induced apoptosis and thus ensures maintenance of viral infection. |
1998-08-06 |
2023-08-12 |
human |
| T Hayashi, K Nomata, C C Chang, R J Ruch, J E Trosk. Cooperative effects of v-myc and c-Ha-ras oncogenes on gap junctional intercellular communication and tumorigenicity in rat liver epithelial cells. Cancer letters. vol 128. issue 2. 1998-08-06. PMID:9683275. |
the objective of this study was to isolate and partially characterize several rat liver epithelial cell clones containing myc, ras and myc/ras oncogenes in order to study their roles in apoptosis and to test the hypothesis that gap junctional intercellular communication is necessary for apoptosis in solid tissues and that the loss of junctional communication leads to tumorigenesis. |
1998-08-06 |
2023-08-12 |
rat |
| G N Filippova, A Lindblom, L J Meincke, E M Klenova, P E Neiman, S J Collins, N A Doggett, V V Lobanenko. A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers. Genes, chromosomes & cancer. vol 22. issue 1. 1998-07-22. PMID:9591631. |
the cellular protooncogene myc encodes a nuclear transcription factor that is involved in regulating important cellular functions, including cell cycle progression, differentiation, and apoptosis. |
1998-07-22 |
2023-08-12 |
human |
| I Savini, I D'Angelo, M Annicchiarico-Petruzzelli, L Bellincampi, G Melino, L Aviglian. Ascorbic acid recycling in N-myc amplified human neuroblastoma cells. Anticancer research. vol 18. issue 2A. 1998-06-18. PMID:9615725. |
the present data may explain the ability of the tumor to progress or regress through mechanisms involving both myc oncogene and apoptosis. |
1998-06-18 |
2023-08-12 |
human |