| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gerardo G Mackenzie, Nina Queisser, Manuel L Wolfson, Cesar G Fraga, Ana M Adamo, Patricia I Oteiz. Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells. International journal of cancer. vol 123. issue 1. 2008-06-02. PMID:18386790. |
therefore, the current goal in hl treatment is to find new therapies that specifically target the deregulated signaling cascades, such as nf-kappab and stat3, which cause hodgkin and reed-sternberg (h-rs) cell proliferation and resistance of apoptosis. |
2008-06-02 |
2023-08-12 |
Not clear |
| Gerardo G Mackenzie, Nina Queisser, Manuel L Wolfson, Cesar G Fraga, Ana M Adamo, Patricia I Oteiz. Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells. International journal of cancer. vol 123. issue 1. 2008-06-02. PMID:18386790. |
curcumin is incorporated into h-rs cells and acts inhibiting both nf-kappab and stat3 activation, leading to a decreased expression of proteins involved in cell proliferation and apoptosis, e.g. |
2008-06-02 |
2023-08-12 |
Not clear |
| Yalai Bai, Usman Ahmad, Yinong Wang, Jie H Li, Jonathan C Choy, Richard W Kim, Nancy Kirkiles-Smith, Stephen E Maher, James G Karras, C Frank Bennett, Alfred L M Bothwell, Jordan S Pober, George Tellide. Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation. The Journal of biological chemistry. vol 283. issue 11. 2008-05-20. PMID:18192275. |
interferon-gamma induces x-linked inhibitor of apoptosis-associated factor-1 and noxa expression and potentiates human vascular smooth muscle cell apoptosis by stat3 activation. |
2008-05-20 |
2023-08-12 |
mouse |
| Yalai Bai, Usman Ahmad, Yinong Wang, Jie H Li, Jonathan C Choy, Richard W Kim, Nancy Kirkiles-Smith, Stephen E Maher, James G Karras, C Frank Bennett, Alfred L M Bothwell, Jordan S Pober, George Tellide. Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation. The Journal of biological chemistry. vol 283. issue 11. 2008-05-20. PMID:18192275. |
stat3 activation by ifn-gamma sensitized vsmcs to apoptosis triggered by both death receptor- and mitochondrial-mediated pathways. |
2008-05-20 |
2023-08-12 |
mouse |
| Hui-Fang Xie, Ru-Xiang Xu, Ji-Peng Wei, Xiao-Dan Jiang, Zhen-Hua Li. [P-JAK2 and P-STAT3 protein expression and cell apoptosis following focal cerebral ischemia-reperfusion injury in rats]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 27. issue 2. 2008-05-15. PMID:17355939. |
to investigate the changes in phosphorylated jak2 and stat3 protein expression of and cell apoptosis following focal cerebral ischemia-reperfusion injury in rats. |
2008-05-15 |
2023-08-12 |
rat |
| Shigetoshi Sano, Keith Syson Chan, John DiGiovann. Impact of Stat3 activation upon skin biology: a dichotomy of its role between homeostasis and diseases. Journal of dermatological science. vol 50. issue 1. 2008-04-22. PMID:17601706. |
it was shown that stat3 activation contributed to skin wound healing, keratinocyte migration, hair follicle growth, and resistance to uv irradiation-induced apoptosis. |
2008-04-22 |
2023-08-12 |
mouse |
| Jianzhong Wang, Chun Ouyang, Xiangmei Chen, Bo Fu, Yang Lu, Quan Hon. STAT3 inhibits apoptosis of human renal tubular epithelial cells induced by ATP depletion/recovery. Nephron. Experimental nephrology. vol 108. issue 1. 2008-04-14. PMID:18097150. |
stat3 inhibits apoptosis of human renal tubular epithelial cells induced by atp depletion/recovery. |
2008-04-14 |
2023-08-12 |
human |
| Jianzhong Wang, Chun Ouyang, Xiangmei Chen, Bo Fu, Yang Lu, Quan Hon. STAT3 inhibits apoptosis of human renal tubular epithelial cells induced by ATP depletion/recovery. Nephron. Experimental nephrology. vol 108. issue 1. 2008-04-14. PMID:18097150. |
in the in vitro model of renal ischemic injury, we explored the role of the stat3, a major component of the stat family, in apoptosis of human proximal tubular epithelial cell (hkc) induced by atp depletion/recovery. |
2008-04-14 |
2023-08-12 |
human |
| Corina Borghouts, Christian Kunz, Natalia Delis, Bernd Grone. Monomeric recombinant peptide aptamers are required for efficient intracellular uptake and target inhibition. Molecular cancer research : MCR. vol 6. issue 2. 2008-04-09. PMID:18314488. |
we show that treatment of glioblastoma cells, expressing constitutively activated stat3, with the purified peptide aptamers strongly inhibits stat3 signaling, causing cell growth arrest and inducing apoptosis. |
2008-04-09 |
2023-08-12 |
human |
| Rebecka Hellsten, Martin Johansson, Anna Dahlman, Nishtman Dizeyi, Olov Sterner, Anders Bjartel. Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3. The Prostate. vol 68. issue 3. 2008-04-01. PMID:18163422. |
stat3 signaling may be an interesting target for cancer therapy since inhibition of this pathway mediates growth inhibition and apoptosis of these cells. |
2008-04-01 |
2023-08-12 |
Not clear |
| B Belinda Ding, J Jessica Yu, Raymond Y-L Yu, Lourdes M Mendez, Rita Shaknovich, Yonghui Zhang, Giorgio Cattoretti, B Hilda Y. Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas. Blood. vol 111. issue 3. 2008-03-26. PMID:17951530. |
most importantly, inactivating stat3 by either ag490 or small interference rna in abc-dlbcl cells inhibits cell proliferation and triggers apoptosis. |
2008-03-26 |
2023-08-12 |
Not clear |
| Khandaker Al Zaid Siddiquee, James Turkso. STAT3 as a target for inducing apoptosis in solid and hematological tumors. Cell research. vol 18. issue 2. 2008-03-25. PMID:18227858. |
stat3 as a target for inducing apoptosis in solid and hematological tumors. |
2008-03-25 |
2023-08-12 |
human |
| Tin Lap Lee, Jason Yeh, Jay Friedman, Bin Yan, Xinping Yang, Ning T Yeh, Carter Van Waes, Zhong Che. A signal network involving coactivated NF-kappaB and STAT3 and altered p53 modulates BAX/BCL-XL expression and promotes cell survival of head and neck squamous cell carcinomas. International journal of cancer. vol 122. issue 9. 2008-03-18. PMID:18172861. |
over-expression of p53 together with inhibition of nf-kappab or stat3 induced greater increase in the bax/bcl-xl ratio and apoptosis than modulation of these transcription factors individually. |
2008-03-18 |
2023-08-12 |
Not clear |
| Ana Quaglino, Carolina Schere-Levy, Leonardo Romorini, Roberto P Meiss, Edith C Kordo. Mouse mammary tumors display Stat3 activation dependent on leukemia inhibitory factor signaling. Breast cancer research : BCR. vol 9. issue 5. 2008-03-11. PMID:17925034. |
it has been demonstrated that leukemia inhibitory factor (lif) induces epithelium apoptosis through stat3 activation during mouse mammary gland involution. |
2008-03-11 |
2023-08-12 |
mouse |
| Akiko Onishi, Qianming Chen, Joseph O Humtsoe, Randall H Krame. STAT3 signaling is induced by intercellular adhesion in squamous cell carcinoma cells. Experimental cell research. vol 314. issue 2. 2008-03-05. PMID:17961551. |
in squamous cell carcinoma of the head and neck (hnscc), stat3 signaling has been shown to inhibit apoptosis and induce a more aggressive phenotype through the activation of specific signaling pathways. |
2008-03-05 |
2023-08-12 |
Not clear |
| Qiang Cui, Wei Jiang, Yingxin Wang, Chen Lv, Jingjing Luo, Wei Zhang, Fang Lin, Yuexiang Yin, Rong Cai, Ping Wei, Cheng Qia. Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma. Hepatology (Baltimore, Md.). vol 47. issue 1. 2008-03-04. PMID:17935223. |
the constitutive activation of signal transducer and activator of transcription 3 (stat3) participates in carcinogenesis through up-regulation of genes encoding apoptosis inhibitors and cell cycle regulators, such as bcl-xl, cyclins d1 and d2, and c-myc. |
2008-03-04 |
2023-08-12 |
Not clear |
| Stephanie Kreis, Georg A Munz, Serge Haan, Peter C Heinrich, Iris Behrman. Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases. Molecular cancer research : MCR. vol 5. issue 12. 2008-03-04. PMID:18171991. |
although stat3 activation was completely blocked with jak inhibitor i and to a lesser extent with the common jak inhibitor ag490, only the latter compound markedly decreased proliferation and induced apoptosis. |
2008-03-04 |
2023-08-12 |
Not clear |
| Hiroyuki Fuke, Katsuya Shiraki, Kazushi Sugimoto, Junichiro Tanaka, Tetsuya Beppu, Kentaro Yoneda, Norihiko Yamamoto, Keiichi Ito, Masahiro Masuya, Yoshiyuki Take. Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells. Biochemical and biophysical research communications. vol 363. issue 3. 2008-02-11. PMID:17904524. |
signal transducer and activator of transcription 3 (stat3) is constitutively activated in various cancers and plays a crucial role in oncogensis, including the activation of genes encoding apoptosis inhibitors and cell-cycle regulators. |
2008-02-11 |
2023-08-12 |
human |
| Hiroyuki Fuke, Katsuya Shiraki, Kazushi Sugimoto, Junichiro Tanaka, Tetsuya Beppu, Kentaro Yoneda, Norihiko Yamamoto, Keiichi Ito, Masahiro Masuya, Yoshiyuki Take. Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells. Biochemical and biophysical research communications. vol 363. issue 3. 2008-02-11. PMID:17904524. |
jak inhibitor ag490 inhibited activation of stat3 and markedly reduced cell viability without significant apoptosis. |
2008-02-11 |
2023-08-12 |
human |
| Olga A Timofeeva, Vadim Gaponenko, Stephen J Lockett, Sergey G Tarasov, Sheng Jiang, Christopher J Michejda, Alan O Perantoni, Nadya I Tarasov. Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target. ACS chemical biology. vol 2. issue 12. 2008-01-31. PMID:18154267. |
activated stat3 may participate in oncogenesis by stimulating cell proliferation and resisting apoptosis, as well as promoting tumor angiogenesis, invasion, and migration. |
2008-01-31 |
2023-08-12 |
Not clear |