| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoyang Ling, Marina Konopleva, Zhihong Zeng, Vivian Ruvolo, L Clifton Stephens, Wendy Schober, Teresa McQueen, Martin Dietrich, Timothy L Madden, Michael Andreef. The novel triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid inhibits metastatic murine breast tumor growth through inactivation of STAT3 signaling. Cancer research. vol 67. issue 9. 2007-06-18. PMID:17483332. |
in vitro, after treatment of 4t1 cells with 500 nmol/l cddo-me for 2 h, we found (a) inactivation of stat3, (b) inactivation of src and akt, (c) 4-fold reduction of c-myc mrna levels, (d) accumulation of cells in g(2)-m cell cycle phase, (e) abrogation of invasive growth of 4t1 cells, and (f) lack of apoptosis induction. |
2007-06-18 |
2023-08-12 |
mouse |
| A Iwamaru, S Szymanski, E Iwado, H Aoki, T Yokoyama, I Fokt, K Hess, C Conrad, T Madden, R Sawaya, S Kondo, W Priebe, Y Kond. A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. Oncogene. vol 26. issue 17. 2007-05-31. PMID:17043651. |
a novel inhibitor of the stat3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. |
2007-05-31 |
2023-08-12 |
mouse |
| A Iwamaru, S Szymanski, E Iwado, H Aoki, T Yokoyama, I Fokt, K Hess, C Conrad, T Madden, R Sawaya, S Kondo, W Priebe, Y Kond. A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. Oncogene. vol 26. issue 17. 2007-05-31. PMID:17043651. |
a selective inhibitor of stat3 phosphorylation, ag490, has been shown to inhibit growth and induce apoptosis in some cancer cell types. |
2007-05-31 |
2023-08-12 |
mouse |
| Daniela Baus, Edith Pfitzne. Specific function of STAT3, SOCS1, and SOCS3 in the regulation of proliferation and survival of classical Hodgkin lymphoma cells. International journal of cancer. vol 118. issue 6. 2007-05-29. PMID:16206268. |
specific downregulation of stat3 by sirna expression decreased cell proliferation and induced apoptosis. |
2007-05-29 |
2023-08-12 |
Not clear |
| Natalia Cuesta, Quan M Nhu, Enrique Zudaire, Swamy Polumuri, Frank Cuttitta, Stefanie N Voge. IFN regulatory factor-2 regulates macrophage apoptosis through a STAT1/3- and caspase-1-dependent mechanism. Journal of immunology (Baltimore, Md. : 1950). vol 178. issue 6. 2007-05-22. PMID:17339457. |
using microarray gene expression profiling of liver rna samples derived from irf-2(+/+) and irf-2(-/-) mice treated with saline or lps, we identified >40 genes that were significantly down-regulated in irf-2(-/-) mice, including stat3, which has been reported to regulate apoptosis. |
2007-05-22 |
2023-08-12 |
mouse |
| Natalia Cuesta, Quan M Nhu, Enrique Zudaire, Swamy Polumuri, Frank Cuttitta, Stefanie N Voge. IFN regulatory factor-2 regulates macrophage apoptosis through a STAT1/3- and caspase-1-dependent mechanism. Journal of immunology (Baltimore, Md. : 1950). vol 178. issue 6. 2007-05-22. PMID:17339457. |
pharmacologic inhibition of stat3 and caspase-1 abolished gliotoxin-induced apoptosis in irf-2(-/-) macrophages. |
2007-05-22 |
2023-08-12 |
mouse |
| Fatih Uckun, Zahide Ozer, Alexei Vassile. Bruton's tyrosine kinase prevents activation of the anti-apoptotic transcription factor STAT3 and promotes apoptosis in neoplastic B-cells and B-cell precursors exposed to oxidative stress. British journal of haematology. vol 136. issue 4. 2007-04-24. PMID:17367410. |
bruton's tyrosine kinase prevents activation of the anti-apoptotic transcription factor stat3 and promotes apoptosis in neoplastic b-cells and b-cell precursors exposed to oxidative stress. |
2007-04-24 |
2023-08-12 |
human |
| Fatih Uckun, Zahide Ozer, Alexei Vassile. Bruton's tyrosine kinase prevents activation of the anti-apoptotic transcription factor STAT3 and promotes apoptosis in neoplastic B-cells and B-cell precursors exposed to oxidative stress. British journal of haematology. vol 136. issue 4. 2007-04-24. PMID:17367410. |
the present study examined whether btk mediates apoptosis during oxidative stress by interfering with the anti-apoptotic function of signal transducer and activator of transcription 3 (stat3). |
2007-04-24 |
2023-08-12 |
human |
| Fatih Uckun, Zahide Ozer, Alexei Vassile. Bruton's tyrosine kinase prevents activation of the anti-apoptotic transcription factor STAT3 and promotes apoptosis in neoplastic B-cells and B-cell precursors exposed to oxidative stress. British journal of haematology. vol 136. issue 4. 2007-04-24. PMID:17367410. |
similarly, while the btk-positive nalm-6 human leukaemic b-cell precursor cell line showed no stat3 activation after pv treatment and was exquisitely sensitive to pv-induced apoptosis, pv failed to induce apoptosis in btk-deficient ramos-1 human lymphoma b-cells that showed a robust stat3 response. |
2007-04-24 |
2023-08-12 |
human |
| Fatih Uckun, Zahide Ozer, Alexei Vassile. Bruton's tyrosine kinase prevents activation of the anti-apoptotic transcription factor STAT3 and promotes apoptosis in neoplastic B-cells and B-cell precursors exposed to oxidative stress. British journal of haematology. vol 136. issue 4. 2007-04-24. PMID:17367410. |
these results provide unprecedented biochemical and genetic evidence for a unique mode of cross-talk that occurs between btk and stat3 pathways during oxidative stress, whereby btk may trigger apoptosis via negative regulation of the anti-apoptotic stat3 activity. |
2007-04-24 |
2023-08-12 |
human |
| Mazen Kurdi, George W Boo. Jak inhibition, but not Stat1 knockdown, blocks the synergistic effect of IFN-gamma on Fas-induced apoptosis of A549 human non-small cell lung cancer cells. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 27. issue 1. 2007-04-05. PMID:17266440. |
because stat1 and stat3 often elicit opposite effects, we assessed whether stat1 would couple to a549 cell apoptosis. |
2007-04-05 |
2023-08-12 |
human |
| Mazen Kurdi, George W Boo. Jak inhibition, but not Stat1 knockdown, blocks the synergistic effect of IFN-gamma on Fas-induced apoptosis of A549 human non-small cell lung cancer cells. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. vol 27. issue 1. 2007-04-05. PMID:17266440. |
knockdown of stat1 or stat3 with small interfering rna (sirna), separately or together, did not inhibit apoptosis, although a paninhibitor of jak1 did. |
2007-04-05 |
2023-08-12 |
human |
| Anjana Bhardwaj, Gautam Sethi, Saroj Vadhan-Raj, Carlos Bueso-Ramos, Yasunari Takada, Upasna Gaur, Asha S Nair, Shishir Shishodia, Bharat B Aggarwa. Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood. vol 109. issue 6. 2007-04-02. PMID:17164350. |
resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of stat3 and nuclear factor-kappab-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. |
2007-04-02 |
2023-08-12 |
human |
| Anjana Bhardwaj, Gautam Sethi, Saroj Vadhan-Raj, Carlos Bueso-Ramos, Yasunari Takada, Upasna Gaur, Asha S Nair, Shishir Shishodia, Bharat B Aggarwa. Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood. vol 109. issue 6. 2007-04-02. PMID:17164350. |
when we examined cd138(+) plasma cells from patients with mm, resveratrol inhibited constitutive activation of both nf-kappab and stat3, leading to down-regulation of cell proliferation and potentiation of apoptosis induced by bortezomib and thalidomide. |
2007-04-02 |
2023-08-12 |
human |
| B Mohana Kumar, Hai-Feng Jin, Jung-Gon Kim, Sun-A Ock, Yonggeun Hong, S Balasubramanian, Sang-Yong Choe, Gyu-Jin Rh. Differential gene expression patterns in porcine nuclear transfer embryos reconstructed with fetal fibroblasts and mesenchymal stem cells. Developmental dynamics : an official publication of the American Association of Anatomists. vol 236. issue 2. 2007-04-02. PMID:17191234. |
alterations in the expression pattern of genes implicated in transcription and pluripotency (oct4, stat3, nanog), dna methylation (dnmt1, dnmt3a), histone deacetylation (hdac2), growth factor signaling, and imprinting (igf2, igf2r) and apoptosis (bax, bcl2) regulation were observed in nt embryos. |
2007-04-02 |
2023-08-12 |
Not clear |
| Bharat B Aggarwal, Gautam Sethi, Kwang Seok Ahn, Santosh K Sandur, Manoj K Pandey, Ajaikumar B Kunnumakkara, Bokyung Sung, Haruyo Ichikaw. Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution. Annals of the New York Academy of Sciences. vol 1091. 2007-03-28. PMID:17341611. |
its role in cancer is indicated by numerous avenues of evidence, including the following: stat3 is constitutively active in tumor cells; stat3 is activated by growth factors (e.g., egf, tgf-alpha, il-6, hepatocyte growth factor) and oncogenic kinases (e.g., src); stat3 regulates the expression of genes that mediate proliferation (e.g., c-myc and cyclin d1), suppress apoptosis (e.g., bcl-x(l) and survivin), or promote angiogenesis (e.g, vegf); stat3 activation has been linked with chemoresistance and radioresistance; and chemopreventive agents have been shown to suppress stat3 activation. |
2007-03-28 |
2023-08-12 |
Not clear |
| Jinxia Deng, Fedora Grande, Nouri Neamat. Small molecule inhibitors of Stat3 signaling pathway. Current cancer drug targets. vol 7. issue 1. 2007-03-20. PMID:17305481. |
compelling evidence from mechanistic studies with antisense, rna interference (rnai), peptides, and small molecular inhibitors indicate that blocking stat3 signaling can lead to successful suppression of tumor cell growth and apoptosis. |
2007-03-20 |
2023-08-12 |
Not clear |
| Sweeta R Choudhari, Muhammad A Khan, Genesis Harris, Donald Picker, Gary S Jacob, Timothy Block, Kunwar Shailubha. Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod. Molecular cancer therapeutics. vol 6. issue 1. 2007-03-16. PMID:17237271. |
deactivation of akt and stat3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, atiprimod. |
2007-03-16 |
2023-08-12 |
Not clear |
| Sweeta R Choudhari, Muhammad A Khan, Genesis Harris, Donald Picker, Gary S Jacob, Timothy Block, Kunwar Shailubha. Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod. Molecular cancer therapeutics. vol 6. issue 1. 2007-03-16. PMID:17237271. |
in this study, we report that atiprimod selectively inhibited proliferation and induced apoptosis in hcc cells that expressed either hepatitis b virus (hbv) or hepatitis c virus, through deactivation of protein kinase b (akt) and signal transducers and activators of transcription 3 (stat3) signaling. |
2007-03-16 |
2023-08-12 |
Not clear |
| Benjamin Barré, Arnaud Vigneron, Neil Perkins, Igor B Roninson, Erick Gamelin, Olivier Coquere. The STAT3 oncogene as a predictive marker of drug resistance. Trends in molecular medicine. vol 13. issue 1. 2007-03-09. PMID:17118707. |
constitutive activation of stat3 (signal transducer and activator of transcription) has been reported in several primary cancers and tumor cell lines where it induces cell transformation through a combined inhibition of apoptosis and cell-cycle activation. |
2007-03-09 |
2023-08-12 |
Not clear |