| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anupama Kotha, Madhavi Sekharam, Lucia Cilenti, Khandaker Siddiquee, Annette Khaled, Antonis S Zervos, Bradford Carter, James Turkson, Richard Jov. Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. Molecular cancer therapeutics. vol 5. issue 3. 2006-05-26. PMID:16546976. |
resveratrol inhibits src and stat3 signaling and induces the apoptosis of malignant cells containing activated stat3 protein. |
2006-05-26 |
2023-08-12 |
mouse |
| Anupama Kotha, Madhavi Sekharam, Lucia Cilenti, Khandaker Siddiquee, Annette Khaled, Antonis S Zervos, Bradford Carter, James Turkson, Richard Jov. Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. Molecular cancer therapeutics. vol 5. issue 3. 2006-05-26. PMID:16546976. |
analyses of resveratrol-treated malignant cells harboring constitutively-active stat3 reveal irreversible cell cycle arrest of v-src-transformed mouse fibroblasts (nih3t3/v-src), human breast (mda-mb-231), pancreatic (panc-1), and prostate carcinoma (du145) cell lines at the g0-g1 phase or at the s phase of human breast cancer (mda-mb-468) and pancreatic cancer (colo-357) cells, and loss of viability due to apoptosis. |
2006-05-26 |
2023-08-12 |
mouse |
| Soon-Tae Lee, Kon Chu, Dong-In Sinn, Keun-Hwa Jung, Eun-Hee Kim, Se-Jeong Kim, Jeong-Min Kim, Song-Yi Ko, Manho Kim, Jae-Kyu Ro. Erythropoietin reduces perihematomal inflammation and cell death with eNOS and STAT3 activations in experimental intracerebral hemorrhage. Journal of neurochemistry. vol 96. issue 6. 2006-05-10. PMID:16539688. |
these data suggests that epo treatment in ich induces better functional recovery with reducing perihematomal inflammation and apoptosis, coupled with activations of enos, stat3 and erk. |
2006-05-10 |
2023-08-12 |
human |
| Kathrine Abell, Christine J Watso. The Jak/Stat pathway: a novel way to regulate PI3K activity. Cell cycle (Georgetown, Tex.). vol 4. issue 7. 2006-05-04. PMID:15970662. |
stat3 is essential for the induction of apoptosis and, in the absence of stat3 or lif, expression of the p55alpha and p50alpha subunits is abrogated. |
2006-05-04 |
2023-08-12 |
mouse |
| Naijie Jing, Qiqing Zhu, Ping Yuan, Yidong Li, Li Mao, David J Tweard. Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer. Molecular cancer therapeutics. vol 5. issue 2. 2006-05-04. PMID:16505101. |
signal transducer and activator of transcription 3 (stat3) is a critical mediator of oncogenic signaling activated frequently in many types of human cancer where it contributes to tumor cell growth and resistance to apoptosis. |
2006-05-04 |
2023-08-12 |
mouse |
| James V Alvarez, Heidi Greulich, William R Sellers, Matthew Meyerson, David A Fran. Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor. Cancer research. vol 66. issue 6. 2006-05-03. PMID:16540667. |
inhibiting stat3 function increases apoptosis of these cells, suggesting that stat3 is necessary for their survival. |
2006-05-03 |
2023-08-12 |
human |
| Jalal Ahmed-Choudhury, Kevin T Williams, Lawrence S Young, David H Adams, Simon C Affor. CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2. Cellular signalling. vol 18. issue 4. 2006-04-18. PMID:15970430. |
cd40 mediated human cholangiocyte apoptosis requires jak2 dependent activation of stat3 in addition to activation of jnk1/2 and erk1/2. |
2006-04-18 |
2023-08-12 |
human |
| Jalal Ahmed-Choudhury, Kevin T Williams, Lawrence S Young, David H Adams, Simon C Affor. CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2. Cellular signalling. vol 18. issue 4. 2006-04-18. PMID:15970430. |
because stat3 has been implicated in liver regeneration we investigated this signalling pathway during cd40 mediated cholangiocyte apoptosis. |
2006-04-18 |
2023-08-12 |
human |
| Jalal Ahmed-Choudhury, Kevin T Williams, Lawrence S Young, David H Adams, Simon C Affor. CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2. Cellular signalling. vol 18. issue 4. 2006-04-18. PMID:15970430. |
in conclusion, induction of cd40-mediated cholangiocyte apoptosis requires jak2-mediated phosphorylation of stat3 as well as sustained jnk1/2, erk1/2 activation. |
2006-04-18 |
2023-08-12 |
human |
| Li Hua Wang, Xiao Yi Yang, Xiaohu Zhang, William L Farra. Nuclear receptors as negative modulators of STAT3 in multiple myeloma. Cell cycle (Georgetown, Tex.). vol 4. issue 2. 2006-03-31. PMID:15655377. |
particularly, stat3 activated by il-6 has a key role in preventing apoptosis and stimulating growth of multiple myeloma cells. |
2006-03-31 |
2023-08-12 |
Not clear |
| Tin Lap Lee, Jason Yeh, Carter Van Waes, Zhong Che. Epigenetic modification of SOCS-1 differentially regulates STAT3 activation in response to interleukin-6 receptor and epidermal growth factor receptor signaling through JAK and/or MEK in head and neck squamous cell carcinomas. Molecular cancer therapeutics. vol 5. issue 1. 2006-03-10. PMID:16432158. |
pharmacologic inhibitors of jak and mek and expression of socs-1 following demethylation or transient transfection inhibited stat3 activation and cell proliferation and induced cell apoptosis in corresponding cell lines. |
2006-03-10 |
2023-08-12 |
human |
| Joo Eun Jung, Hyun Gyu Lee, Ik Hyun Cho, Doo Hyun Chung, Sun-Hee Yoon, Young Mok Yang, Jung Weon Lee, Seongwon Choi, Jong-Wan Park, Sang-Kyu Ye, Myung-Hee Chun. STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 10. 2006-03-06. PMID:15919761. |
therefore, these findings provide compelling evidence that a causal relationship exists between stat3 activation and hif-1-dependent angiogenesis and suggest that therapeutic modalities designed to disrupt stat3 signaling hold considerable promise for the blocking tumor growth and enhancing apoptosis of cancer cells and tissues. |
2006-03-06 |
2023-08-12 |
human |
| Sujoy Bhattacharya, Ramesh M Ray, Leonard R Johnso. STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells. The Biochemical journal. vol 392. issue Pt 2. 2006-02-23. PMID:16048438. |
the aim of the present study was to clarify the role of stat3 signalling in the protection of polyamine-depleted intestinal epithelial cells against tnf-alpha (tumour necrosis factor-alpha)-induced apoptosis. |
2006-02-23 |
2023-08-12 |
Not clear |
| Sujoy Bhattacharya, Ramesh M Ray, Leonard R Johnso. STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells. The Biochemical journal. vol 392. issue Pt 2. 2006-02-23. PMID:16048438. |
inhibition of stat3 activation by ag490 or cell-membrane-permeant inhibitory peptide (ppylktk; where py represents phospho-tyr) increased the sensitivity of polyamine-depleted cells to apoptosis. |
2006-02-23 |
2023-08-12 |
Not clear |
| Sujoy Bhattacharya, Ramesh M Ray, Leonard R Johnso. STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells. The Biochemical journal. vol 392. issue Pt 2. 2006-02-23. PMID:16048438. |
these results suggest that activation of stat3 in response to polyamine depletion increases the transcription and subsequent expression of anti-apoptotic bcl-2 and iap family proteins and thereby promotes survival of cells against tnf-alpha-induced apoptosis. |
2006-02-23 |
2023-08-12 |
Not clear |
| Qingde Zhou, Salomon Ama. Identification of proteins differentially expressed in human monocytes exposed to Porphyromonas gingivalis and its purified components by high-throughput immunoblotting. Infection and immunity. vol 74. issue 2. 2006-02-22. PMID:16428770. |
the expression of proteins involved in gene transcription (e.g., monocyte enhancer factor 2d [mef2d], signal transducer and activator of transcription 1 [stat1], stat3, stat6, and il enhancer binding factors [ilf3]), of protein kinases (e.g., mitogen-activated protein kinase 3 [mapk3], map3k8, double-stranded rna-activated protein kinase [prkr], and map2k4), and of proteins involved in immune responses (e.g., tnf super family member 6 [tnfsf6] and interferon-induced protein with tetratricopeptide repeat 4 [ifit4]), apoptosis (e.g., genes associated with retinoid interferon-induced mortality 19 [grim19]), and other fundamental cellular processes (e.g., clathrin heavy-chain polypeptide, culreticulin, and ras-associated protein rab27a) was found to be modulated differentially by p. gingivalis, lps, and fima. |
2006-02-22 |
2023-08-12 |
human |
| Michal Marzec, Monika Kasprzycka, Andrzej Ptasznik, Pawel Wlodarski, Qian Zhang, Niels Odum, Mariusz A Wasi. Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3. Laboratory investigation; a journal of technical methods and pathology. vol 85. issue 12. 2006-02-16. PMID:16170336. |
inhibition of alk enzymatic activity in t-cell lymphoma cells induces apoptosis and suppresses proliferation and stat3 phosphorylation independently of jak3. |
2006-02-16 |
2023-08-12 |
Not clear |
| Michal Marzec, Monika Kasprzycka, Andrzej Ptasznik, Pawel Wlodarski, Qian Zhang, Niels Odum, Mariusz A Wasi. Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3. Laboratory investigation; a journal of technical methods and pathology. vol 85. issue 12. 2006-02-16. PMID:16170336. |
the inhibition of npm/alk activity resulted in malignant t cells in suppression of their growth, induction of apoptosis and inhibition of tyrosine phosphorylation of stat3, the key effector of the npm/alk-induced oncogenesis. |
2006-02-16 |
2023-08-12 |
Not clear |
| Tanya Gritsko, Ann Williams, James Turkson, Satoshi Kaneko, Tammy Bowman, Mei Huang, Sangkil Nam, Ibrahim Eweis, Nils Diaz, Daniel Sullivan, Sean Yoder, Steve Enkemann, Steven Eschrich, Ji-Hyun Lee, Craig A Beam, Jin Cheng, Susan Minton, Carlos A Muro-Cacho, Richard Jov. Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 12. issue 1. 2006-02-09. PMID:16397018. |
persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. |
2006-02-09 |
2023-08-12 |
human |
| Tanya Gritsko, Ann Williams, James Turkson, Satoshi Kaneko, Tammy Bowman, Mei Huang, Sangkil Nam, Ibrahim Eweis, Nils Diaz, Daniel Sullivan, Sean Yoder, Steve Enkemann, Steven Eschrich, Ji-Hyun Lee, Craig A Beam, Jin Cheng, Susan Minton, Carlos A Muro-Cacho, Richard Jov. Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 12. issue 1. 2006-02-09. PMID:16397018. |
to gain a better understanding of the role of constitutive stat3 signaling in breast cancer progression, we evaluated the expression profile of potential stat3-regulated genes that may confer resistance to apoptosis. |
2006-02-09 |
2023-08-12 |
human |