| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nills Diaz, Susan Minton, Charles Cox, Tammy Bowman, Tanya Gritsko, Roy Garcia, Ibrahim Eweis, Marek Wloch, Sandy Livingston, Ed Seijo, Alan Cantor, Ji-Hyun Lee, Craig A Beam, Daniel Sullivan, Richard Jove, Carlos A Muro-Cach. Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 12. issue 1. 2006-02-09. PMID:16397019. |
constitutive activation of signal transducer and activator of transcription 3 (stat3) protein has been observed in a wide variety of tumors, including breast cancer, and contributes to oncogenesis at least in part by prevention of apoptosis. |
2006-02-09 |
2023-08-12 |
Not clear |
| Eric B Haura, Zhong Zheng, Lanxi Song, Alan Cantor, Gerold Beple. Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 11. issue 23. 2006-01-24. PMID:16322287. |
we evaluated stat3 activation in early stage non-small cell lung cancers (nsclc) and how this relates to upstream epidermal growth factor receptor (egfr) activation, tumor apoptosis, and prognosis. |
2006-01-24 |
2023-08-12 |
Not clear |
| Marc Boelhauve, Fred Sinowatz, Eckhard Wolf, Fabíola F Paula-Lope. Maturation of bovine oocytes in the presence of leptin improves development and reduces apoptosis of in vitro-produced blastocysts. Biology of reproduction. vol 73. issue 4. 2006-01-23. PMID:15958729. |
transcript levels of the genes encoding leptin receptor (lepr), signal transducer and activator of transcription (stat3), bcl2 associated x-protein (bax), and baculoviral inhibitor of apoptosis protein repeat-containing 4 (birc4, also known as xiap), were determined by reverse transcriptase-quantitative polymerase chain reaction analysis of expanded and hatched blastocysts. |
2006-01-23 |
2023-08-12 |
cattle |
| Marc Boelhauve, Fred Sinowatz, Eckhard Wolf, Fabíola F Paula-Lope. Maturation of bovine oocytes in the presence of leptin improves development and reduces apoptosis of in vitro-produced blastocysts. Biology of reproduction. vol 73. issue 4. 2006-01-23. PMID:15958729. |
in conclusion, leptin improved the ability of the oocyte to sustain embryonic development and had long-term effects on blastocyst apoptosis and transcript abundance of lepr, stat3, and apoptosis-associated genes. |
2006-01-23 |
2023-08-12 |
cattle |
| Wangrong Wen, Shengting Chen, Yan Cao, Yonghua Zhu, Yukiyo Yamamot. HIV-1 infection initiates changes in the expression of a wide array of genes in U937 promonocytes and HUT78 T cells. Virus research. vol 113. issue 1. 2005-12-27. PMID:15885842. |
these genes encode a host of proteins with divergent functions in a variety of cellular processes including apoptosis (fas, fas ligand, pin, hsp90beta, bcl-2, bcl-x), cell signal transduction (ras, rgs1, irf-1, stat3), receptor-mediated signaling transduction (cd71, cd69, cd3delta), cell cycle and growth (c-myc, cytokines, kinase), transcriptional regulation (ews, creb-2), and chemotaxis (beta-chemokines, rantes), supporting the general effects of hiv-1 infection on cells of different origin. |
2005-12-27 |
2023-08-12 |
human |
| Adina Vultur, Rozanne Arulanandam, James Turkson, Guilian Niu, Richard Jove, Leda Rapti. Stat3 is required for full neoplastic transformation by the Simian Virus 40 large tumor antigen. Molecular biology of the cell. vol 16. issue 8. 2005-12-12. PMID:15917293. |
inhibition of src activity led to stat3 down-regulation as well as apoptosis of sparsely growing, tag-transformed cells. |
2005-12-12 |
2023-08-12 |
Not clear |
| Adina Vultur, Rozanne Arulanandam, James Turkson, Guilian Niu, Richard Jove, Leda Rapti. Stat3 is required for full neoplastic transformation by the Simian Virus 40 large tumor antigen. Molecular biology of the cell. vol 16. issue 8. 2005-12-12. PMID:15917293. |
direct stat3 inhibition on the other hand induced apoptosis very effectively in confluent cells, which could have significant therapeutic implications. |
2005-12-12 |
2023-08-12 |
Not clear |
| Sheng-Hua Wu, Chao Lu, Ling Dong, Guo-Ping Zhou, Zha-Guang He, Zi-Qing Che. High dose of lipoxin A4 induces apoptosis in rat renal interstitial fibroblasts. Prostaglandins, leukotrienes, and essential fatty acids. vol 73. issue 2. 2005-12-05. PMID:15936930. |
rat renal interstitial fibroblasts (nrk-49f cells) were exposed to lxa4 in 5% fcs for 24 h. lxa4 at 0.1 and 1 microm induced 9.83% and 33.82% apoptosis of the cells, respectively, upregulated the expression of calpain 10 and smac, the levels of [ca2+]i and activity of caspase-3, and downregulated the activity of stat3 and threonine phosphorylated akt1. |
2005-12-05 |
2023-08-12 |
rat |
| Mrinal K Ghosh, Pankaj Sharma, Phyllis C Harbor, Shaik O Rahaman, S Jaharul Haqu. PI3K-AKT pathway negatively controls EGFR-dependent DNA-binding activity of Stat3 in glioblastoma multiforme cells. Oncogene. vol 24. issue 49. 2005-12-01. PMID:16007122. |
blockade of egfr activation inhibited the activation of both akt and stat3 in u87 and d54 gbm cells and induced spontaneous apoptosis, which were associated with reduction in the steady-state level of mcl-1. |
2005-12-01 |
2023-08-12 |
Not clear |
| James Turkson, Shumin Zhang, Linda B Mora, Audrey Burns, Said Sebti, Richard Jov. A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells. The Journal of biological chemistry. vol 280. issue 38. 2005-11-28. PMID:16046414. |
a novel platinum compound inhibits constitutive stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells. |
2005-11-28 |
2023-08-12 |
mouse |
| James Turkson, Shumin Zhang, Linda B Mora, Audrey Burns, Said Sebti, Richard Jov. A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells. The Journal of biological chemistry. vol 280. issue 38. 2005-11-28. PMID:16046414. |
in human and mouse tumor cell lines with constitutively active stat3, is3 295 selectively attenuated stat3 signaling, thereby inducing cell growth arrest at g0/g1 phase and apoptosis. |
2005-11-28 |
2023-08-12 |
mouse |
| Peter Stärkel, Christine De Saeger, Isabelle Leclercq, Alastair Strain, Yves Horsman. Deficient Stat3 DNA-binding is associated with high Pias3 expression and a positive anti-apoptotic balance in human end-stage alcoholic and hepatitis C cirrhosis. Journal of hepatology. vol 43. issue 4. 2005-11-28. PMID:16098628. |
in vitro and animal data suggest that alcohol and hepatitis c virus (hcv) proteins might interfere with stat3 signaling, a potential regulator of liver cell apoptosis and proliferation. |
2005-11-28 |
2023-08-12 |
human |
| Anette Weber, Ulrich R Hengge, Walter Bardenheuer, Iris Tischoff, Florian Sommerer, Annett Markwarth, Andreas Dietz, Christian Wittekind, Andrea Tannapfe. SOCS-3 is frequently methylated in head and neck squamous cell carcinoma and its precursor lesions and causes growth inhibition. Oncogene. vol 24. issue 44. 2005-11-15. PMID:16007169. |
overexpression of wild-type socs-3 in carcinoma cells with methylated socs-3 resulted in the induction of apoptosis and growth suppression as well as downregulation of stat3, bcl-2 as well as bcl-xl. |
2005-11-15 |
2023-08-12 |
Not clear |
| Shahab Uddin, Azhar R Hussain, Pulicat S Manogaran, Khaled Al-Hussein, Leonidas C Platanias, Marina I Gutierrez, Kishor G Bhati. Curcumin suppresses growth and induces apoptosis in primary effusion lymphoma. Oncogene. vol 24. issue 47. 2005-11-15. PMID:16044161. |
altogether, our findings suggest a novel function for curcumin, acting as a suppressor of jak-1 and stat3 activation in pel cells, leading to inhibition of proliferation and induction of caspase-dependent apoptosis. |
2005-11-15 |
2023-08-12 |
Not clear |
| Stefania Militi, Caterina Chiapparino, Ugo Testa, Paolo Carminati, Rita De Santis, Ottaviano Serlupi-Crescenz. Role of IL-6 and CD23 in the resistance to growth arrest and apoptosis in LCL41 B lymphoma cells. Cytokine. vol 31. issue 4. 2005-11-07. PMID:16009564. |
however, this inhibition is associated with marginal induction of apoptosis and with minor decrease of cell proliferation, contrary to the effect of the jak kinase inhibitor ag490, which down-regulates both proliferation and stat3 activation. |
2005-11-07 |
2023-08-12 |
Not clear |
| Stefania Militi, Caterina Chiapparino, Ugo Testa, Paolo Carminati, Rita De Santis, Ottaviano Serlupi-Crescenz. Role of IL-6 and CD23 in the resistance to growth arrest and apoptosis in LCL41 B lymphoma cells. Cytokine. vol 31. issue 4. 2005-11-07. PMID:16009564. |
inhibition of stat3 activation is therefore not sufficient to prevent proliferation and to induce apoptosis in these cells. |
2005-11-07 |
2023-08-12 |
Not clear |
| A Leela Kumari, A Mubarak Ali, Suvendu Das, B V V Pardhasaradhi, Ch Varalakshmi, Ashok Kha. Role of STAT3 and NFkappaB signaling in the serum factor-induced apoptosis in AK-5 cells. Biochemical and biophysical research communications. vol 336. issue 3. 2005-11-01. PMID:16153599. |
role of stat3 and nfkappab signaling in the serum factor-induced apoptosis in ak-5 cells. |
2005-11-01 |
2023-08-12 |
rat |
| A Leela Kumari, A Mubarak Ali, Suvendu Das, B V V Pardhasaradhi, Ch Varalakshmi, Ashok Kha. Role of STAT3 and NFkappaB signaling in the serum factor-induced apoptosis in AK-5 cells. Biochemical and biophysical research communications. vol 336. issue 3. 2005-11-01. PMID:16153599. |
our results demonstrate downregulation of a transcription factor, stat3, as a critical regulator of sf-induced apoptosis in bc-8 cells. |
2005-11-01 |
2023-08-12 |
rat |
| A Leela Kumari, A Mubarak Ali, Suvendu Das, B V V Pardhasaradhi, Ch Varalakshmi, Ashok Kha. Role of STAT3 and NFkappaB signaling in the serum factor-induced apoptosis in AK-5 cells. Biochemical and biophysical research communications. vol 336. issue 3. 2005-11-01. PMID:16153599. |
sf induced apoptosis in bc-8 cells mediated through downregulation of stat3 and elevated nfkappab activity is abrogated by treatment with mapk inhibitors-pd98059 and sb203580. |
2005-11-01 |
2023-08-12 |
rat |
| Li-fang Gao, De-qi Xu, Lian-ji Wen, Xing-yi Zhang, Yue-ting Shao, Xue-jian Zha. Inhibition of STAT3 expression by siRNA suppresses growth and induces apoptosis in laryngeal cancer cells. Acta pharmacologica Sinica. vol 26. issue 3. 2005-10-25. PMID:15715937. |
inhibition of stat3 expression by sirna suppresses growth and induces apoptosis in laryngeal cancer cells. |
2005-10-25 |
2023-08-12 |
human |