| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Siavash, N G Nikitakis, J J Sau. Abrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells. British journal of cancer. vol 91. issue 6. 2004-11-26. PMID:15316561. |
targeting of jak signalling using a specific jak inhibitor also abolished stat3 phosphorylation and resulted in apoptosis in oral scc cells. |
2004-11-26 |
2023-08-12 |
human |
| H Siavash, N G Nikitakis, J J Sau. Abrogation of IL-6-mediated JAK signalling by the cyclopentenone prostaglandin 15d-PGJ(2) in oral squamous carcinoma cells. British journal of cancer. vol 91. issue 6. 2004-11-26. PMID:15316561. |
our findings provide the first evidence for 15d-pgj(2)-mediated downregulation of constitutive and il-6-induced jak signalling in cancer and support that jak inhibition and suppression of egfr-independent stat3 activation by 15d-pgj(2) represent a promising approach for induction of apoptosis in oral scc cells. |
2004-11-26 |
2023-08-12 |
human |
| David R Hodge, Weihua Xiao, Li Hua Wang, Dapei Li, William L Farra. Activating mutations in STAT3 and STAT5 differentially affect cellular proliferation and apoptotic resistance in multiple myeloma cells. Cancer biology & therapy. vol 3. issue 2. 2004-11-19. PMID:14726660. |
despite the presence of activated stat3 and stat5a, apoptosis is induced upon exposure to micromolar levels of dexamethasone, and il-6 or igf-1 is still required to rescue the cells. |
2004-11-19 |
2023-08-12 |
Not clear |
| David R Hodge, Weihua Xiao, Li Hua Wang, Dapei Li, William L Farra. Activating mutations in STAT3 and STAT5 differentially affect cellular proliferation and apoptotic resistance in multiple myeloma cells. Cancer biology & therapy. vol 3. issue 2. 2004-11-19. PMID:14726660. |
however, ectopic expression of activated stat3 results in partial rescue from apoptosis of cells treated with fas ligand. |
2004-11-19 |
2023-08-12 |
Not clear |
| James Turkson, Joon S Kim, Shumin Zhang, Jing Yuan, Mei Huang, Matthew Glenn, Eric Haura, Said Sebti, Andrew D Hamilton, Richard Jov. Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity. Molecular cancer therapeutics. vol 3. issue 3. 2004-11-09. PMID:15026546. |
moreover, iss 610 induces cell growth inhibition and apoptosis of src-transformed fibroblasts that contain persistently active stat3. |
2004-11-09 |
2023-08-12 |
mouse |
| Beverly E Barton, James G Karras, Thomas F Murphy, Arnold Barton, Hosea F-S Huan. Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines. Molecular cancer therapeutics. vol 3. issue 1. 2004-11-04. PMID:14749471. |
signal transducer and activator of transcription 3 (stat3) activation in prostate cancer: direct stat3 inhibition induces apoptosis in prostate cancer lines. |
2004-11-04 |
2023-08-12 |
Not clear |
| Beverly E Barton, James G Karras, Thomas F Murphy, Arnold Barton, Hosea F-S Huan. Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines. Molecular cancer therapeutics. vol 3. issue 1. 2004-11-04. PMID:14749471. |
both induction of apoptosis and reduction in intracellular stat3 protein were observed following treatment with antisense stat3 oligonucleotides, while transfection of a dn-stat3 plasmid into both prostate cancer cell lines resulted in loss of viability and onset of apoptosis. |
2004-11-04 |
2023-08-12 |
Not clear |
| Naijie Jing, Yidong Li, Weijun Xiong, Wei Sha, Ling Jing, David J Tweard. G-quartet oligonucleotides: a new class of signal transducer and activator of transcription 3 inhibitors that suppresses growth of prostate and breast tumors through induction of apoptosis. Cancer research. vol 64. issue 18. 2004-11-04. PMID:15374974. |
thus, gq-odn targeting stat3 induces tumor cell apoptosis when delivered into tumor xenografts and represents a novel class of chemotherapeutic agents that holds promise for the systemic treatment of many forms of metastatic cancer. |
2004-11-04 |
2023-08-12 |
mouse |
| Kerstin Nagel-Wolfrum, Claudia Buerger, Ilka Wittig, Karin Butz, Felix Hoppe-Seyler, Bernd Grone. The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells. Molecular cancer research : MCR. vol 2. issue 3. 2004-10-22. PMID:15037656. |
the interaction of specific peptide aptamers with the dna binding domain and the dimerization domain of the transcription factor stat3 inhibits transactivation and induces apoptosis in tumor cells. |
2004-10-22 |
2023-08-12 |
human |
| Nicole Schick, Edward J Oakeley, Nancy E Hynes, Ali Badach. TEL/ETV6 is a signal transducer and activator of transcription 3 (Stat3)-induced repressor of Stat3 activity. The Journal of biological chemistry. vol 279. issue 37. 2004-10-19. PMID:15229229. |
enhanced and prolonged stat3 activity led to cell cycle arrest and apoptosis. |
2004-10-19 |
2023-08-12 |
Not clear |
| Laura Pedranzini, Andrea Leitch, Jacqueline Bromber. Stat3 is required for the development of skin cancer. The Journal of clinical investigation. vol 114. issue 5. 2004-10-14. PMID:15343379. |
inhibition of activated stat3 leads to decreased proliferation and apoptosis of many cancer-derived cell lines, while the introduction of a constitutively activated form of stat3 into immortalized human breast epithelial cells and rodent fibroblasts results in cellular transformation. |
2004-10-14 |
2023-08-12 |
mouse |
| Nalin J Patel, Anne Hansen, Albert L Merati, Joseph E Kerschne. STAT3 activation in recurrent respiratory papillomatosis. Archives of otolaryngology--head & neck surgery. vol 130. issue 9. 2004-10-06. PMID:15381590. |
the activation of signal transducer and activator of transduction (stat) protein is thought to lead to the genesis of neoplasia by promoting cellular growth and preventing apoptosis, and by immune system modulation; stat3 protein has also been implicated in tumor survival and propagation in recurrent respiratory papillomatosis (rrp). |
2004-10-06 |
2023-08-12 |
Not clear |
| Hongwei Gao, Ren-Feng Guo, Cecilia L Speyer, Jayne Reuben, Thomas A Neff, L Marco Hoesel, Niels C Riedemann, Shannon D McClintock, J Vidya Sarma, Nico Van Rooijen, Firas S Zetoune, Peter A War. Stat3 activation in acute lung injury. Journal of immunology (Baltimore, Md. : 1950). vol 172. issue 12. 2004-09-16. PMID:15187153. |
stat3 plays diverse roles in biological processes including cell proliferation, survival, apoptosis, and inflammation. |
2004-09-16 |
2023-08-12 |
rat |
| Shuo Dong, Sai-Juan Chen, David J Tweard. Cross-talk between retinoic acid and STAT3 signaling pathways in acute promyelocytic leukemia. Leukemia & lymphoma. vol 44. issue 12. 2004-09-09. PMID:14959844. |
constitutive stat3 activation has been observed in a number of hematopoietic and non-hematopoietic malignancies where it contributes to apoptosis resistance. |
2004-09-09 |
2023-08-12 |
Not clear |
| Shuo Dong, Sai-Juan Chen, David J Tweard. Cross-talk between retinoic acid and STAT3 signaling pathways in acute promyelocytic leukemia. Leukemia & lymphoma. vol 44. issue 12. 2004-09-09. PMID:14959844. |
these findings support the hypothesis that apoptosis resistance in apl may be mediated through the effects of apl fusion proteins on stat3 signaling and suggest that targeting of stat3 may be a useful adjunctive treatment strategy in apl. |
2004-09-09 |
2023-08-12 |
Not clear |
| Soo Ok Lee, Wei Lou, Candace S Johnson, Donald L Trump, Allen C Ga. Interleukin-6 protects LNCaP cells from apoptosis induced by androgen deprivation through the Stat3 pathway. The Prostate. vol 60. issue 3. 2004-09-03. PMID:15176047. |
interleukin-6 protects lncap cells from apoptosis induced by androgen deprivation through the stat3 pathway. |
2004-09-03 |
2023-08-12 |
Not clear |
| Huamin Wang, Hua Wang, Wei Zhang, Helen J Huang, Warren S L Liao, Gregory N Fulle. Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas. Laboratory investigation; a journal of technical methods and pathology. vol 84. issue 8. 2004-09-02. PMID:15184909. |
as downstream targets of the pten and egfr signaling pathways, akt, nfkappab, and signal transducer and activator of transcription-3 (stat3) have been shown to play important roles in the control of cell proliferation, apoptosis, and oncogenesis. |
2004-09-02 |
2023-08-12 |
human |
| Soo Ok Lee, Wei Lou, Khusroo M Qureshi, Farideh Mehraein-Ghomi, Donald L Trump, Allen C Ga. RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells. The Prostate. vol 60. issue 4. 2004-08-31. PMID:15264241. |
rna interference targeting stat3 inhibits growth and induces apoptosis of human prostate cancer cells. |
2004-08-31 |
2023-08-12 |
human |
| Soo Ok Lee, Wei Lou, Khusroo M Qureshi, Farideh Mehraein-Ghomi, Donald L Trump, Allen C Ga. RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells. The Prostate. vol 60. issue 4. 2004-08-31. PMID:15264241. |
previous studies demonstrated that constitutively activated stat3 plays an important role in the development and progression of prostate cancer by promoting cell proliferation and protecting against apoptosis. |
2004-08-31 |
2023-08-12 |
human |
| Soo Ok Lee, Wei Lou, Khusroo M Qureshi, Farideh Mehraein-Ghomi, Donald L Trump, Allen C Ga. RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells. The Prostate. vol 60. issue 4. 2004-08-31. PMID:15264241. |
the stat3 sirna does not inhibit the proliferation nor induces apoptosis of stat3-inactive human prostate cancer cells. |
2004-08-31 |
2023-08-12 |
human |