| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yoshiyasu Aoki, Gerald M Feldman, Giovanna Tosat. Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood. vol 101. issue 4. 2003-03-13. PMID:12393476. |
although stat3 activation is known to induce expression of bcl-2 family proteins, pel cell apoptosis was independent of bcl-2, bcl-x(l), or mcl-1 protein expression. |
2003-03-13 |
2023-08-12 |
Not clear |
| Yoshiyasu Aoki, Gerald M Feldman, Giovanna Tosat. Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood. vol 101. issue 4. 2003-03-13. PMID:12393476. |
instead, stat3 inhibition induced transcriptional repression of survivin, a recently identified inhibitor of apoptosis. |
2003-03-13 |
2023-08-12 |
Not clear |
| Yoshiyasu Aoki, Gerald M Feldman, Giovanna Tosat. Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood. vol 101. issue 4. 2003-03-13. PMID:12393476. |
forced overexpression of survivin rescued vg-1 cells from apoptosis induced by stat3 inhibition. |
2003-03-13 |
2023-08-12 |
Not clear |
| Yoshiyasu Aoki, Gerald M Feldman, Giovanna Tosat. Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood. vol 101. issue 4. 2003-03-13. PMID:12393476. |
our findings suggest that activated stat3 signaling directly contributes to malignant progression of pel by preventing apoptosis, acting through the prosurvival protein survivin. |
2003-03-13 |
2023-08-12 |
Not clear |
| Carolina Schere-Levy, Valeria Buggiano, Ana Quaglino, Albana Gattelli, Maria Cecilia Cirio, Isabel Piazzon, Silvia Vanzulli, Edith C Kordo. Leukemia inhibitory factor induces apoptosis of the mammary epithelial cells and participates in mouse mammary gland involution. Experimental cell research. vol 282. issue 1. 2003-01-08. PMID:12490192. |
it has been shown that stat3 is the main factor in signaling the initiation of apoptosis, but the mechanism of its activation remains unclear. |
2003-01-08 |
2023-08-12 |
mouse |
| Carolina Schere-Levy, Valeria Buggiano, Ana Quaglino, Albana Gattelli, Maria Cecilia Cirio, Isabel Piazzon, Silvia Vanzulli, Edith C Kordo. Leukemia inhibitory factor induces apoptosis of the mammary epithelial cells and participates in mouse mammary gland involution. Experimental cell research. vol 282. issue 1. 2003-01-08. PMID:12490192. |
our results also show that lif-induced mammary epithelium apoptosis could be mediated, at least partially, by stat3 activation. |
2003-01-08 |
2023-08-12 |
mouse |
| N G Nikitakis, H Siavash, C Hebert, M A Reynolds, A W Hamburger, J J Sau. 15-PGJ2, but not thiazolidinediones, inhibits cell growth, induces apoptosis, and causes downregulation of Stat3 in human oral SCCa cells. British journal of cancer. vol 87. issue 12. 2003-01-07. PMID:12454768. |
15-pgj2, but not thiazolidinediones, inhibits cell growth, induces apoptosis, and causes downregulation of stat3 in human oral scca cells. |
2003-01-07 |
2023-08-12 |
human |
| Shaik Ohidar Rahaman, Phyllis C Harbor, Olga Chernova, Gene H Barnett, Michael A Vogelbaum, S Jaharul Haqu. Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene. vol 21. issue 55. 2003-01-06. PMID:12466961. |
inhibition of constitutively active stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. |
2003-01-06 |
2023-08-12 |
human |
| Shaik Ohidar Rahaman, Phyllis C Harbor, Olga Chernova, Gene H Barnett, Michael A Vogelbaum, S Jaharul Haqu. Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene. vol 21. issue 55. 2003-01-06. PMID:12466961. |
stat3, a latent transcription factor being activated by aberrant cytokine or growth factor signaling, acts as a suppressor of apoptosis in a number of cancer cells. |
2003-01-06 |
2023-08-12 |
human |
| Shaik Ohidar Rahaman, Phyllis C Harbor, Olga Chernova, Gene H Barnett, Michael A Vogelbaum, S Jaharul Haqu. Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells. Oncogene. vol 21. issue 55. 2003-01-06. PMID:12466961. |
janus kinase inhibitor ag490 inhibits stat3 activation with a concomitant reduction in steady-state levels of bcl-x(l), bcl-2 and mcl-1 proteins and induces apoptosis in u251 cells as revealed by poly (adp-ribose) polymerase cleavage and annexin-v staining. |
2003-01-06 |
2023-08-12 |
human |
| Florian R Greten, Christoph K Weber, Tim F Greten, Günter Schneider, Martin Wagner, Guido Adler, Roland M Schmi. Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis. Gastroenterology. vol 123. issue 6. 2002-12-27. PMID:12454861. |
stat3 and nf-kappab activation prevents apoptosis in pancreatic carcinogenesis. |
2002-12-27 |
2023-08-12 |
mouse |
| Linda B Mora, Ralf Buettner, John Seigne, Jose Diaz, Nazeel Ahmad, Roy Garcia, Tammy Bowman, Robert Falcone, Rita Fairclough, Alan Cantor, Carlos Muro-Cacho, Sandy Livingston, James Karras, Julio Pow-Sang, Richard Jov. Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. Cancer research. vol 62. issue 22. 2002-12-17. PMID:12438264. |
constitutive activation of stat3 in human prostate tumors and cell lines: direct inhibition of stat3 signaling induces apoptosis of prostate cancer cells. |
2002-12-17 |
2023-08-12 |
human |
| Linda B Mora, Ralf Buettner, John Seigne, Jose Diaz, Nazeel Ahmad, Roy Garcia, Tammy Bowman, Robert Falcone, Rita Fairclough, Alan Cantor, Carlos Muro-Cacho, Sandy Livingston, James Karras, Julio Pow-Sang, Richard Jov. Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells. Cancer research. vol 62. issue 22. 2002-12-17. PMID:12438264. |
moreover, the direct inhibition of constitutive stat3 signaling in du145 cells using antisense stat3 oligonucleotides induced growth inhibition and apoptosis. |
2002-12-17 |
2023-08-12 |
human |
| Pedro J Real, Angels Sierra, Ana De Juan, Jose C Segovia, Jose M Lopez-Vega, Jose L Fernandez-Lun. Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells. Oncogene. vol 21. issue 50. 2002-11-19. PMID:12400004. |
in addition, blockade of stat3 activation by treatment with epidermal growth factor receptor and jak2 kinase inhibitors or transfection with a dominant negative stat3, sensitizes 435b cells to chemotherapy-induced apoptosis. |
2002-11-19 |
2023-08-12 |
Not clear |
| Guilian Niu, Tammy Bowman, Mei Huang, Steve Shivers, Douglas Reintgen, Adil Daud, Alfred Chang, Alan Kraker, Richard Jove, Hua Y. Roles of activated Src and Stat3 signaling in melanoma tumor cell growth. Oncogene. vol 21. issue 46. 2002-10-24. PMID:12370822. |
significantly, melanoma cells undergo apoptosis when either src kinase activity or stat3 signaling is inhibited. |
2002-10-24 |
2023-08-12 |
human |
| Hannah Ben-Bassat, Zipora Hartzstark, Rubina Levitzki, Benjamin Y Klein, Zipora Shlomai, Aviv Gazit, Alexander Levitzk. Tyrosine kinase inhibitors suppress the growth of non-hodgkin B lymphomas. The Journal of pharmacology and experimental therapeutics. vol 303. issue 1. 2002-10-21. PMID:12235247. |
agl 2592 induces a dose-dependent and time-dependent inhibition of tyrosine phosphorylation of numerous proteins, including stat3, and an increase of bcl-2 phosphorylation, both biochemical hallmarks of growth inhibition and apoptosis. |
2002-10-21 |
2023-08-12 |
Not clear |
| Ralf Buettner, Linda B Mora, Richard Jov. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 8. issue 4. 2002-08-12. PMID:11948098. |
persistent signaling of specific stats, in particular stat3 and stat5, has been demonstrated to directly contribute to oncogenesis by stimulating cell proliferation and preventing apoptosis. |
2002-08-12 |
2023-08-12 |
human |
| Jianwu Xie, Matthew J LeBaron, Marja T Nevalainen, Hallgeir Ru. Role of tyrosine kinase Jak2 in prolactin-induced differentiation and growth of mammary epithelial cells. The Journal of biological chemistry. vol 277. issue 16. 2002-06-07. PMID:11821424. |
furthermore, suppression of jak2 in hc11 cells was associated with constitutive activation of oncoprotein stat3 and a hyperproliferative phenotype characterized by increased mitotic rate, reduced apoptosis, and reduced contact inhibition. |
2002-06-07 |
2023-08-12 |
mouse |
| A T J Wierenga, J J Schuringa, B J L Eggen, W Kruijer, E Velleng. Downregulation of IL-6-induced STAT3 tyrosine phosphorylation by TGF-beta1 is mediated by caspase-dependent and -independent processes. Leukemia. vol 16. issue 4. 2002-05-07. PMID:11960349. |
the reduced il-6-mediated stat3 tyrosine phosphorylation after pre-treatment with tgf-beta1 was associated with apoptosis and coincided with the degradation of certain cellular proteins, including jak1 and -2 and tyk2, without affecting the erk expression and phosphorylation. |
2002-05-07 |
2023-08-12 |
Not clear |
| A T J Wierenga, J J Schuringa, B J L Eggen, W Kruijer, E Velleng. Downregulation of IL-6-induced STAT3 tyrosine phosphorylation by TGF-beta1 is mediated by caspase-dependent and -independent processes. Leukemia. vol 16. issue 4. 2002-05-07. PMID:11960349. |
furthermore, treatment of aml blasts with the cytostatic agent vp16, as an alternative way to induce apoptosis, resulted in a similar degree of degradation of jak kinases and concomitant reduction of il-6-mediated stat3 tyrosine phosphorylation. |
2002-05-07 |
2023-08-12 |
Not clear |