| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J B Demoulin, E Van Roost, M Stevens, B Groner, J C Renaul. Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by interleukin-9. The Journal of biological chemistry. vol 274. issue 36. 1999-10-07. PMID:10464327. |
both mutant receptors were able to prevent apoptosis, but only the mutant that activated stat1 and stat3 was able to support induction of granzyme a and l-selectin. |
1999-10-07 |
2023-08-12 |
Not clear |
| J F Bromberg, M H Wrzeszczynska, G Devgan, Y Zhao, R G Pestell, C Albanese, J E Darnel. Stat3 as an oncogene. Cell. vol 98. issue 3. 1999-09-09. PMID:10458605. |
in many human cancers and transformed cell lines, stat3 is persistently activated, and in cell culture, active stat3 is either required for transformation, enhances transformation, or blocks apoptosis. |
1999-09-09 |
2023-08-12 |
mouse |
| S Akir. Functional roles of STAT family proteins: lessons from knockout mice. Stem cells (Dayton, Ohio). vol 17. issue 3. 1999-07-29. PMID:10342556. |
analyses of tissue-specific stat3-deficient mice indicate that stat3 plays a crucial role in a variety of biological functions, including cell growth, suppression of apoptosis, and cell motility. |
1999-07-29 |
2023-08-12 |
mouse |
| M Nielsen, C G Kaestel, K W Eriksen, A Woetmann, T Stokkedal, K Kaltoft, C Geisler, C Röpke, N Odu. Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells. Leukemia. vol 13. issue 5. 1999-06-29. PMID:10374878. |
inhibition of constitutively activated stat3 correlates with altered bcl-2/bax expression and induction of apoptosis in mycosis fungoides tumor cells. |
1999-06-29 |
2023-08-12 |
Not clear |
| M Nielsen, C G Kaestel, K W Eriksen, A Woetmann, T Stokkedal, K Kaltoft, C Geisler, C Röpke, N Odu. Inhibition of constitutively activated Stat3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells. Leukemia. vol 13. issue 5. 1999-06-29. PMID:10374878. |
the decreased ability of stat3 to bind dna precedes dynamic alterations in the expression of anti-apoptotic bcl-2 and pro-apoptotic bax proteins (decreased bcl-2 expression and increased bax expression) and induction of apoptosis. |
1999-06-29 |
2023-08-12 |
Not clear |
| H Akaishi, K Takeda, T Kaisho, R Shineha, S Satomi, J Takeda, S Akir. Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3-deficient T lymphocytes. International immunology. vol 10. issue 11. 1999-03-18. PMID:9846704. |
recently, mice lacking stat3 specifically in t cells have been generated and shown to be defective in il-6-induced proliferation due to the impairment in il-6-mediated prevention of apoptosis. |
1999-03-18 |
2023-08-12 |
mouse |
| K Oritani, Y Tomiyama, P W Kincade, K Aoyama, T Yokota, I Matsumura, Y Kanakura, K Nakajima, T Hirano, Y Matsuzaw. Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells. Blood. vol 93. issue 4. 1999-03-11. PMID:9949178. |
the importance of bcl2 and stat3 on il-6-induced macrophage-differentiation and apoptosis was studied with 1a9-m cells expressing human bcl2 or a dominant-negative form of stat3, respectively. |
1999-03-11 |
2023-08-12 |
human |
| K Oritani, Y Tomiyama, P W Kincade, K Aoyama, T Yokota, I Matsumura, Y Kanakura, K Nakajima, T Hirano, Y Matsuzaw. Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells. Blood. vol 93. issue 4. 1999-03-11. PMID:9949178. |
a dominant-negative form of stat3 inhibited both macrophage-differentiation and apoptosis induced by il-6. |
1999-03-11 |
2023-08-12 |
human |
| R Catlett-Falcone, T H Landowski, M M Oshiro, J Turkson, A Levitzki, R Savino, G Ciliberto, L Moscinski, J L Fernández-Luna, G Nuñez, W S Dalton, R Jov. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity. vol 10. issue 1. 1999-03-03. PMID:10023775. |
constitutive activation of stat3 signaling confers resistance to apoptosis in human u266 myeloma cells. |
1999-03-03 |
2023-08-12 |
human |
| R Catlett-Falcone, T H Landowski, M M Oshiro, J Turkson, A Levitzki, R Savino, G Ciliberto, L Moscinski, J L Fernández-Luna, G Nuñez, W S Dalton, R Jov. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity. vol 10. issue 1. 1999-03-03. PMID:10023775. |
blocking il-6 receptor signaling from janus kinases to the stat3 protein inhibits bcl-xl expression and induces apoptosis, demonstrating that stat3 signaling is essential for the survival of myeloma tumor cells. |
1999-03-03 |
2023-08-12 |
human |
| R Catlett-Falcone, T H Landowski, M M Oshiro, J Turkson, A Levitzki, R Savino, G Ciliberto, L Moscinski, J L Fernández-Luna, G Nuñez, W S Dalton, R Jov. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity. vol 10. issue 1. 1999-03-03. PMID:10023775. |
these findings provide evidence that constitutively activated stat3 signaling contributes to the pathogenesis of multiple myeloma by preventing apoptosis. |
1999-03-03 |
2023-08-12 |
human |
| K Takeda, T Kaisho, N Yoshida, J Takeda, T Kishimoto, S Akir. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. Journal of immunology (Baltimore, Md. : 1950). vol 161. issue 9. 1998-11-18. PMID:9794394. |
stat3 activation is responsible for il-6-dependent t cell proliferation through preventing apoptosis: generation and characterization of t cell-specific stat3-deficient mice. |
1998-11-18 |
2023-08-12 |
mouse |
| K Takeda, T Kaisho, N Yoshida, J Takeda, T Kishimoto, S Akir. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. Journal of immunology (Baltimore, Md. : 1950). vol 161. issue 9. 1998-11-18. PMID:9794394. |
these results demonstrate that stat3 activation is involved in il-6-dependent t cell proliferation through prevention of apoptosis independently of bcl-2. |
1998-11-18 |
2023-08-12 |
mouse |
| S Zushi, Y Shinomura, T Kiyohara, Y Miyazaki, S Kondo, M Sugimachi, Y Higashimoto, S Kanayama, Y Matsuzaw. STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells. International journal of cancer. vol 78. issue 3. 1998-10-28. PMID:9766567. |
we also show that disruption of the stat3 pathway by introduction of a dominant-negative stat3 mutant abolishes the apoptosis resistance against uvc and mmc treatment observed in iec-ras cells without affecting proliferation. |
1998-10-28 |
2023-08-12 |
Not clear |
| T Naka, M Narazaki, M Hirata, T Matsumoto, S Minamoto, A Aono, N Nishimoto, T Kajita, T Taga, K Yoshizaki, S Akira, T Kishimot. Structure and function of a new STAT-induced STAT inhibitor. Nature. vol 387. issue 6636. 1997-07-17. PMID:9202127. |
forced overexpression of ssi-1 complementary dna interfered with il-6- and lif-mediated apoptosis and macrophage differentiation of m1 cells, as well as il-6 induced tyrosine-phosphorylation of a receptor glycoprotein component, gp130, and of stat3. |
1997-07-17 |
2023-08-12 |
Not clear |