| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Ma, Ruirui Wang, Jinzhuang Liao, Pengfei Guo, Qiang Wang, Wei L. Xanthohumol overcomes osimertinib resistance via governing ubiquitination-modulated Ets-1 turnover. Cell death discovery. vol 10. issue 1. 2024-10-29. PMID:39468027. |
mechanistically, xanthohumol disrupted the interaction between usp9x and ets-1, and inhibited the phosphorylation of ets-1 at thr38, promoting its degradation, thereby targeting the ets-1/c-met signaling axis and inducing intrinsic apoptosis in osimertinib-resistant nsclc cells. |
2024-10-29 |
2024-10-31 |
mouse |
| Shuhao Gong, Huawei Xiong, Yingchao Lei, Shipeng Huang, Yingdong Ouyang, Chunshui Cao, Ying Wan. Usp9x contributes to the development of sepsis-induced acute kidney injury by promoting inflammation and apoptosis in renal tubular epithelial cells via activation of the TLR4/nf-κb pathway. Renal failure. vol 46. issue 2. 2024-06-14. PMID:38874156. |
usp9x contributes to the development of sepsis-induced acute kidney injury by promoting inflammation and apoptosis in renal tubular epithelial cells via activation of the tlr4/nf-κb pathway. |
2024-06-14 |
2024-06-16 |
rat |
| Shan Xiong, Fengjie Liu, Jingru Sun, Shuaixin Gao, Catherine C L Wong, Ping Tu, Yang Wan. Abrogation of USP9X is a potential strategy to decrease PEG10 levels and impede tumor progression in cutaneous T-cell lymphoma. The Journal of investigative dermatology. 2024-04-27. PMID:38677662. |
moreover, usp9x inhibition conferred tumor cell growth disadvantage and enhanced apoptosis in vitro, an effect that occurred in part through its regulation on peg10. |
2024-04-27 |
2024-04-30 |
Not clear |
| Hongli Gao, Zhiguang Chen, Liang Zhao, Ce Ji, Fei Xin. Cellular functions, molecular signalings and therapeutic applications: Translational potential of deubiquitylating enzyme USP9X as a drug target in cancer treatment. Biochimica et biophysica acta. Reviews on cancer. vol 1879. issue 3. 2024-04-07. PMID:38582329. |
among these dubs, ubiquitin-specific protease 9× (usp9x), a highly conserved member of the usp family, exhibits versatile functions in various cellular processes, including the regulation of cell cycle, protein endocytosis, apoptosis, cell polarity, immunological microenvironment, and stem cell characteristics. |
2024-04-07 |
2024-04-10 |
Not clear |
| Yu-Feng Wan, Chen-Yu Zhang, Xiao-Wen Cheng, Long-Sheng Liu, Tao Zhou, Jun-Kang Gao, Hua-Qing Zhu, Ye-Hai Li. USP9X expression is functionally related to laryngeal cancer. Journal of Cancer. vol 14. issue 4. 2023-04-14. PMID:37057289. |
we speculated that inhibiting usp9x might induce apoptosis in fadu cells by downregulating mcl-1 and upregulating bax protein expression. |
2023-04-14 |
2023-08-14 |
Not clear |
| Naiara Perurena, Rebecca Lock, Rachel A Davis, Srivatsan Raghavan, Natalie F Pilla, Raymond Ng, Patrick Loi, Caroline J Guild, Abigail L Miller, Ewa Sicinska, James M Cleary, Douglas A Rubinson, Brian M Wolpin, Nathanael S Gray, Sandro Santagata, William C Hahn, Jennifer P Morton, Owen J Sansom, Andrew J Aguirre, Karen Cichowsk. USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities. Cell reports. Medicine. 2023-04-08. PMID:37030295. |
specifically, we show that mek inhibitors upregulate the anti-apoptotic protein mcl-1 by triggering an association with its deubiquitinase, usp9x, resulting in acute mcl-1 stabilization and protection from apoptosis. |
2023-04-08 |
2023-08-14 |
Not clear |
| Liu Yang, Siqi Wang, Zengxiang Pan, Xing Du, Qifa L. TGFBR2 is a novel substrate and indirect transcription target of deubiquitylase USP9X in granulosa cells. Journal of cellular physiology. 2022-05-17. PMID:35578792. |
functionally, the maintenance of tgfbr2 by usp9x activates the tgf-β signaling pathway, which further represses gc apoptosis. |
2022-05-17 |
2023-08-13 |
Not clear |
| Liu Yang, Siqi Wang, Zengxiang Pan, Xing Du, Qifa L. TGFBR2 is a novel substrate and indirect transcription target of deubiquitylase USP9X in granulosa cells. Journal of cellular physiology. 2022-05-17. PMID:35578792. |
our study highlights a functional micro-regulatory network composed of deubiquitinase (usp9x), small noncoding rna (mir-143) and the tgf-β signaling pathway, which plays a crucial role in the regulation of gc apoptosis and female fertility. |
2022-05-17 |
2023-08-13 |
Not clear |
| Weiqian Chen, Jingjing Song, Siyu Liu, Bufu Tang, Lin Shen, Jinyu Zhu, Shiji Fang, Fazong Wu, Liyun Zheng, Rongfang Qiu, Chunmiao Chen, Yang Gao, Jianfei Tu, Zhongwei Zhao, Jiansong J. USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bβ via deubiquitinating EGLN3. Journal of biomedical science. vol 28. issue 1. 2021-09-29. PMID:34112167. |
usp9x promotes apoptosis in cholangiocarcinoma by modulation expression of kif1bβ via deubiquitinating egln3. |
2021-09-29 |
2023-08-13 |
Not clear |
| Carolin Golla, Mayas Bilal, Annika Dwucet, Nicolas Bader, Jenson Anthonymuthu, Tim Heiland, Maximilian Pruss, Mike-Andrew Westhoff, Markus David Siegelin, Felix Capanni, Christian Rainer Wirtz, Richard Eric Kast, Marc-Eric Halatsch, Georg Karpel-Massle. Photodynamic Therapy Combined with Bcl-2/Bcl-xL Inhibition Increases the Noxa/Mcl-1 Ratio Independent of Usp9X and Synergistically Enhances Apoptosis in Glioblastoma. Cancers. vol 13. issue 16. 2021-08-30. PMID:34439278. |
photodynamic therapy combined with bcl-2/bcl-xl inhibition increases the noxa/mcl-1 ratio independent of usp9x and synergistically enhances apoptosis in glioblastoma. |
2021-08-30 |
2023-08-13 |
human |
| Wen-Xuan Lu, Guo-Sheng Gan, Bo Yan. Knockdown of USP9X reverses cisplatin resistance by decreasing β-catenin expression in nasopharyngeal carcinoma cells. Neoplasma. vol 68. issue 4. 2021-08-06. PMID:34097426. |
in various cancers, abnormal usp9x expression is involved in tumorigenesis, progression, apoptosis, and metastasis. |
2021-08-06 |
2023-08-13 |
Not clear |
| Wen-Xuan Lu, Guo-Sheng Gan, Bo Yan. Knockdown of USP9X reverses cisplatin resistance by decreasing β-catenin expression in nasopharyngeal carcinoma cells. Neoplasma. vol 68. issue 4. 2021-08-06. PMID:34097426. |
the effects of usp9x on cisplatin resistance, proliferation, apoptosis, and metastasis were examined by cck-8 assay, flow cytometry, wound-healing assay, and transwell chamber assay. |
2021-08-06 |
2023-08-13 |
Not clear |
| Wen-Xuan Lu, Guo-Sheng Gan, Bo Yan. Knockdown of USP9X reverses cisplatin resistance by decreasing β-catenin expression in nasopharyngeal carcinoma cells. Neoplasma. vol 68. issue 4. 2021-08-06. PMID:34097426. |
knockdown of usp9x was able to partially reverse cisplatin resistance, increased cisplatin-induced apoptosis, and decreased the capacities of proliferation, migration, and invasion. |
2021-08-06 |
2023-08-13 |
Not clear |
| Catherine M Nickson, Maria Rita Fabbrizi, Rachel J Carter, Jonathan R Hughes, Andrzej Kacperek, Mark A Hill, Jason L Parson. USP9X Is Required to Maintain Cell Survival in Response to High-LET Radiation. Frontiers in oncology. vol 11. 2021-07-20. PMID:34277417. |
we consequently investigated the mechanism through which this occurs, and demonstrate that an absence of usp9x has no impact on dna damage repair post-irradiation nor on apoptosis, autophagy, or senescence. |
2021-07-20 |
2023-08-13 |
Not clear |
| Harish Potu, Malathi Kandarpa, Luke F Peterson, Alison Durham, Nicholas J Donato, Moshe Talpa. Downregulation of SOX2 by inhibition of Usp9X induces apoptosis in melanoma. Oncotarget. vol 12. issue 3. 2021-02-23. PMID:33613844. |
downregulation of sox2 by inhibition of usp9x induces apoptosis in melanoma. |
2021-02-23 |
2023-08-13 |
Not clear |
| Seok Kim, Seon Min Woo, Kyoung-Jin Min, Seung Un Seo, Tae-Jin Lee, Peter Kubatka, Dong Eun Kim, Taeg Kyu Kwo. WP1130 Enhances TRAIL-Induced Apoptosis through USP9X-Dependent miR-708-Mediated Downregulation of c-FLIP. Cancers. vol 11. issue 3. 2020-10-01. PMID:30862047. |
furthermore, ectopic expression of usp9x prevented c-flip downregulation and apoptosis upon combined treatment. |
2020-10-01 |
2023-08-13 |
mouse |
| Seok Kim, Seon Min Woo, Kyoung-Jin Min, Seung Un Seo, Tae-Jin Lee, Peter Kubatka, Dong Eun Kim, Taeg Kyu Kwo. WP1130 Enhances TRAIL-Induced Apoptosis through USP9X-Dependent miR-708-Mediated Downregulation of c-FLIP. Cancers. vol 11. issue 3. 2020-10-01. PMID:30862047. |
in sum, wp1130 sensitized trail-induced apoptosis through mir-708-mediated downregulation of c-flip by inhibition of usp9x. |
2020-10-01 |
2023-08-13 |
mouse |
| Hiroki Akiyama, Yoshihiro Umezawa, Daisuke Watanabe, Keigo Okada, Shinya Ishida, Ayako Nogami, Osamu Miur. Inhibition of USP9X Downregulates JAK2-V617F and Induces Apoptosis Synergistically with BH3 Mimetics Preferentially in Ruxolitinib-Persistent JAK2-V617F-Positive Leukemic Cells. Cancers. vol 12. issue 2. 2020-09-28. PMID:32050632. |
inhibition of usp9x downregulates jak2-v617f and induces apoptosis synergistically with bh3 mimetics preferentially in ruxolitinib-persistent jak2-v617f-positive leukemic cells. |
2020-09-28 |
2023-08-13 |
Not clear |
| Hiroki Akiyama, Yoshihiro Umezawa, Daisuke Watanabe, Keigo Okada, Shinya Ishida, Ayako Nogami, Osamu Miur. Inhibition of USP9X Downregulates JAK2-V617F and Induces Apoptosis Synergistically with BH3 Mimetics Preferentially in Ruxolitinib-Persistent JAK2-V617F-Positive Leukemic Cells. Cancers. vol 12. issue 2. 2020-09-28. PMID:32050632. |
we here demonstrate that the usp9x inhibitor wp1130 or eoai3402143 (g9) inhibited proliferation and induced apoptosis more efficiently in cells dependent on jak2-v617f than on cytokine-activated jak2. |
2020-09-28 |
2023-08-13 |
Not clear |
| Hiroki Akiyama, Yoshihiro Umezawa, Daisuke Watanabe, Keigo Okada, Shinya Ishida, Ayako Nogami, Osamu Miur. Inhibition of USP9X Downregulates JAK2-V617F and Induces Apoptosis Synergistically with BH3 Mimetics Preferentially in Ruxolitinib-Persistent JAK2-V617F-Positive Leukemic Cells. Cancers. vol 12. issue 2. 2020-09-28. PMID:32050632. |
induction of apoptosis by inhibition of usp9x was mediated through the intrinsic mitochondria-mediated pathway, synergistically enhanced by bh3 mimetics, prevented by overexpression of bcl-xl, and required oxidative stress to activate stress-related map kinases p38 and jnk as well as dna damage responses in hel cells. |
2020-09-28 |
2023-08-13 |
Not clear |