| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Meloche, J Landry, J Huot, F Houle, F Marceau, E Giasso. p38 MAP kinase pathway regulates angiotensin II-induced contraction of rat vascular smooth muscle. American journal of physiology. Heart and circulatory physiology. vol 279. issue 2. 2000-09-12. PMID:10924074. |
angiotensin ii (ang ii) is a multifunctional hormone that exerts potent vasoconstrictor and hypertrophic effects on vascular smooth muscle. |
2000-09-12 |
2023-08-12 |
rat |
| Y Arata, E Geshi, A Nomizo, S Aoki, T Katagir. Alterations in sarcoplasmic reticulum and angiotensin II receptor type 1 gene expression in spontaneously hypertensive rat hearts. Japanese circulation journal. vol 63. issue 5. 2000-08-29. PMID:10943616. |
these results suggest that in the early stage of hypertension in shr ang ii may stimulate hypertrophy in the cardiomyocytes through the at1, which is not downregulated by a high concentration of ang ii. |
2000-08-29 |
2023-08-12 |
rat |
| S A Katz, J A Opsahl, S E Wernsing, L M Forbis, J Smith, L J Helle. Myocardial renin is neither necessary nor sufficient to initiate or maintain ventricular hypertrophy. American journal of physiology. Regulatory, integrative and comparative physiology. vol 278. issue 3. 2000-06-20. PMID:10712275. |
myocardial and plasma renin and angiotensinogen were measured in rats during initiation and maintenance of ventricular hypertrophy associated with doca implants and 1% nacl drinking water, with and without the at(1) ang ii receptor blocker losartan. |
2000-06-20 |
2023-08-12 |
rat |
| H Aoki, M Richmond, S Izumo, J Sadoshim. Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro. The Biochemical journal. vol 347 Pt 1. 2000-06-05. PMID:10727428. |
we examined the role of extracellular signal-regulated protein kinase (erk), c-jun n-terminal kinase (jnk) and p38 map kinase in angiotensin ii (ang ii)-induced hypertrophy compared with phenylephrine-induced hypertrophy in neonatal rat cardiac myocytes. |
2000-06-05 |
2023-08-12 |
rat |
| H Aoki, M Richmond, S Izumo, J Sadoshim. Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro. The Biochemical journal. vol 347 Pt 1. 2000-06-05. PMID:10727428. |
pd98059 did not affect other markers of ang ii-induced hypertrophy, such as skeletal alpha-actin and c-fos expression, increases in the rate of protein synthesis or rapid sarcomeric actin organization. |
2000-06-05 |
2023-08-12 |
rat |
| H Aoki, M Richmond, S Izumo, J Sadoshim. Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro. The Biochemical journal. vol 347 Pt 1. 2000-06-05. PMID:10727428. |
the ras/erk pathway selectively mediates anf expression in various phenotypes observed in ang ii-induced hypertrophy. |
2000-06-05 |
2023-08-12 |
rat |
| M Hou, E Pantev, S Möller, D Erlinge, L Edvinsso. Angiotensin II type 1 receptors stimulate protein synthesis in human cardiac fibroblasts via a Ca2+-sensitive PKC-dependent tyrosine kinase pathway. Acta physiologica Scandinavica. vol 168. issue 2. 2000-04-21. PMID:10712568. |
there were no significant alterations of cell number or total protein content, suggesting that ang ii stimulated protein synthesis but did not induce hypertrophy. |
2000-04-21 |
2023-08-12 |
human |
| M Hou, E Pantev, S Möller, D Erlinge, L Edvinsso. Angiotensin II type 1 receptors stimulate protein synthesis in human cardiac fibroblasts via a Ca2+-sensitive PKC-dependent tyrosine kinase pathway. Acta physiologica Scandinavica. vol 168. issue 2. 2000-04-21. PMID:10712568. |
in summary, ang ii stimulates protein synthesis through at1 receptors in human cardiac fibroblasts, but has no hypertrophic or hyperplastic effect. |
2000-04-21 |
2023-08-12 |
human |
| D Lang, S I Mosfer, A Shakesby, F Donaldson, M J Lewi. Coronary microvascular endothelial cell redox state in left ventricular hypertrophy : the role of angiotensin II. Circulation research. vol 86. issue 4. 2000-04-11. PMID:10700452. |
left ventricular hypertrophy (lvh) is associated with elevated plasma angiotensin ii (ang ii) levels and endothelial dysfunction. |
2000-04-11 |
2023-08-12 |
Not clear |
| M J Servant, P Coulombe, B Turgeon, S Meloch. Differential regulation of p27(Kip1) expression by mitogenic and hypertrophic factors: Involvement of transcriptional and posttranscriptional mechanisms. The Journal of cell biology. vol 148. issue 3. 2000-04-07. PMID:10662779. |
in contrast, angiotensin ii (ang ii) induces cellular hypertrophy as a result of increased protein synthesis, but is unable to drive cells into s phase. |
2000-04-07 |
2023-08-12 |
rat |
| J Higaki, M Aoki, R Morishita, I Kida, Y Taniyama, N Tomita, K Yamamoto, A Moriguchi, Y Kaneda, T Ogihar. In vivo evidence of the importance of cardiac angiotensin-converting enzyme in the pathogenesis of cardiac hypertrophy. Arteriosclerosis, thrombosis, and vascular biology. vol 20. issue 2. 2000-03-03. PMID:10669640. |
angiotensin ii (ang ii) stimulates cardiac hypertrophy as well as the production of extracellular matrix. |
2000-03-03 |
2023-08-12 |
human |
| J Higaki, M Aoki, R Morishita, I Kida, Y Taniyama, N Tomita, K Yamamoto, A Moriguchi, Y Kaneda, T Ogihar. In vivo evidence of the importance of cardiac angiotensin-converting enzyme in the pathogenesis of cardiac hypertrophy. Arteriosclerosis, thrombosis, and vascular biology. vol 20. issue 2. 2000-03-03. PMID:10669640. |
however, it is still unclear whether ang ii exerts a direct effect on cardiac hypertrophy independent of its effect on blood pressure or the circulating renin-angiotensin system. |
2000-03-03 |
2023-08-12 |
human |
| J Higaki, M Aoki, R Morishita, I Kida, Y Taniyama, N Tomita, K Yamamoto, A Moriguchi, Y Kaneda, T Ogihar. In vivo evidence of the importance of cardiac angiotensin-converting enzyme in the pathogenesis of cardiac hypertrophy. Arteriosclerosis, thrombosis, and vascular biology. vol 20. issue 2. 2000-03-03. PMID:10669640. |
although ace inhibitors and/or ang ii receptor antagonists have regressed cardiac hypertrophy, classic pharmacological experiments cannot exclude the contribution of hemodynamics and the circulating renin-angiotensin system. |
2000-03-03 |
2023-08-12 |
human |
| S B Parker, A D Dobrian, S S Wade, R L Prewit. AT(1) receptor inhibition does not reduce arterial wall hypertrophy or PDGF-A expression in renal hypertension. American journal of physiology. Heart and circulatory physiology. vol 278. issue 2. 2000-03-02. PMID:10666094. |
to separate the role of ang ii from pressure in hypertrophy of the vascular wall in one-kidney, one-clip (1k1c) hypertension, experimental and sham-operated rats were given the at(1)-receptor antagonist losartan (20 mg x kg(-1) x day(-1)) or tap water for 14 days. |
2000-03-02 |
2023-08-12 |
rat |
| S B Parker, A D Dobrian, S S Wade, R L Prewit. AT(1) receptor inhibition does not reduce arterial wall hypertrophy or PDGF-A expression in renal hypertension. American journal of physiology. Heart and circulatory physiology. vol 278. issue 2. 2000-03-02. PMID:10666094. |
these observations demonstrate that effects of ang ii mediated through the at(1) receptor are not necessary for hypertrophy of the vascular wall during 1k1c hypertension or expression of pdgf-a. |
2000-03-02 |
2023-08-12 |
rat |
| H Kawano, R J Cody, K Graf, S Goetze, Y Kawano, J Schnee, R E Law, W A Hsue. Angiotensin II enhances integrin and alpha-actinin expression in adult rat cardiac fibroblasts. Hypertension (Dallas, Tex. : 1979). vol 35. issue 1 Pt 2. 2000-02-07. PMID:10642310. |
these results suggest that integrins and alpha-actinin are upregulated by ang ii and in left ventricular hypertrophy and that the block of expression of these proteins through inhibition of the at(1) receptor is associated with attenuation of the hypertrophic response. |
2000-02-07 |
2023-08-12 |
rat |
| H Kawano, R J Cody, K Graf, S Goetze, Y Kawano, J Schnee, R E Law, W A Hsue. Angiotensin II enhances integrin and alpha-actinin expression in adult rat cardiac fibroblasts. Hypertension (Dallas, Tex. : 1979). vol 35. issue 1 Pt 2. 2000-02-07. PMID:10642310. |
ang ii induces integrin and alpha-actinin expression in cardiac fibroblasts that is associated with adhesion and left ventricular hypertrophy and blocked through inhibition of the at(1) receptor. |
2000-02-07 |
2023-08-12 |
rat |
| T Yamakawa, S Tanaka, K Numaguchi, Y Yamakawa, E D Motley, S Ichihara, T Inagam. Involvement of Rho-kinase in angiotensin II-induced hypertrophy of rat vascular smooth muscle cells. Hypertension (Dallas, Tex. : 1979). vol 35. issue 1 Pt 2. 2000-02-07. PMID:10642317. |
angiotensin ii (ang ii) is now believed to play a critical role in the pathogenesis of hypertrophy and/or hyperplasia of vascular smooth muscle cells (vsmcs). |
2000-02-07 |
2023-08-12 |
rat |
| T Yamakawa, S Tanaka, K Numaguchi, Y Yamakawa, E D Motley, S Ichihara, T Inagam. Involvement of Rho-kinase in angiotensin II-induced hypertrophy of rat vascular smooth muscle cells. Hypertension (Dallas, Tex. : 1979). vol 35. issue 1 Pt 2. 2000-02-07. PMID:10642317. |
however, little is known about the role of rho-kinase in ang ii-induced vascular hypertrophy in vsmcs. |
2000-02-07 |
2023-08-12 |
rat |
| T Yamakawa, S Tanaka, K Numaguchi, Y Yamakawa, E D Motley, S Ichihara, T Inagam. Involvement of Rho-kinase in angiotensin II-induced hypertrophy of rat vascular smooth muscle cells. Hypertension (Dallas, Tex. : 1979). vol 35. issue 1 Pt 2. 2000-02-07. PMID:10642317. |
these observations suggest that the rho, rho-kinase, and c-fos pathways may play a role in ang ii-induced hypertrophic changes of vsmcs through a novel pathway. |
2000-02-07 |
2023-08-12 |
rat |