| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T Unge. Neurohormonal modulation in cardiovascular disease. American heart journal. vol 139. issue 1 Pt 2. 2000-01-19. PMID:10618581. |
recent data, however, suggest that ang ii also contributes to cell proliferation, left ventricular hypertrophy, vascular media hypertrophy, neointima formation in atherosclerosis, and nephrosclerosis by stimulation of at(1) receptors. |
2000-01-19 |
2023-08-12 |
Not clear |
| K C Wollert, H Drexle. The renin-angiotensin system and experimental heart failure. Cardiovascular research. vol 43. issue 4. 2000-01-14. PMID:10615411. |
experimental studies suggest that the renin-angiotensin system (ras) and its primary effector peptide, angiotensin ii (ang ii), are involved in the pathophysiology of cardiac hypertrophy and failure. |
2000-01-14 |
2023-08-12 |
mouse |
| K C Wollert, H Drexle. The renin-angiotensin system and experimental heart failure. Cardiovascular research. vol 43. issue 4. 2000-01-14. PMID:10615411. |
in neonatal cardiac myocytes, ang ii induces a hypertrophic response via the at1-receptor. |
2000-01-14 |
2023-08-12 |
mouse |
| K C Wollert, H Drexle. The renin-angiotensin system and experimental heart failure. Cardiovascular research. vol 43. issue 4. 2000-01-14. PMID:10615411. |
in the neonatal system, ang ii appears to be a major autocrine/paracrine mediator of cardiac myocyte hypertrophy in response to passive mechanical stretch. |
2000-01-14 |
2023-08-12 |
mouse |
| K C Wollert, H Drexle. The renin-angiotensin system and experimental heart failure. Cardiovascular research. vol 43. issue 4. 2000-01-14. PMID:10615411. |
in this paper, we review recent experimental evidence suggesting a critical role for the ras in cardiac hypertrophy and failure with special emphasis on the putative role of ang ii and ang ii-receptor signaling in cardiac myocytes. |
2000-01-14 |
2023-08-12 |
mouse |
| T Nunohiro, N Ashizawa, K Graf, W A Hsueh, K Yan. Angiotensin II promotes integrin-mediated collagen gel contraction by adult rat cardiac fibroblasts. Japanese heart journal. vol 40. issue 4. 2000-01-05. PMID:10611911. |
angiotensin ii (ang ii) directly promotes these changes in cardiac fibroblasts and thus, plays critical roles in cardiac hypertrophy and wound healing. |
2000-01-05 |
2023-08-12 |
rat |
| A Ciechanowic. [Molecular mechanisms of nephro-protective action of enalapril in experimental chronic renal failure]. Annales Academiae Medicae Stetinensis. vol Suppl 52. 1999-12-30. PMID:10589103. |
locally increased synthesis of angiotensin ii (ang ii) in the kidney has been linked to glomerular hypertrophy, glomerulosclerosis and tubulo-interstitial fibrosis observed in chronic renal failure after subtotal nephrectomy. |
1999-12-30 |
2023-08-12 |
rat |
| A Dang, D Zheng, B Wang, Y Zhang, P Zhang, M Xu, G Liu, L Li. The role of the renin-angiotensin and cardiac sympathetic nervous systems in the development of hypertension and left ventricular hypertrophy in spontaneously hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension. vol 22. issue 3. 1999-11-09. PMID:10515445. |
otherwise, the left ventricular tissue ang ii concentrations were significantly higher in shr than in wky rats at the late stage (from 15 to 28 wk), which may have contributed to the late-stage cardiac hypertrophy. |
1999-11-09 |
2023-08-12 |
rat |
| G P Rossi, A Sacchetto, M Cesari, A C Pessin. Interactions between endothelin-1 and the renin-angiotensin-aldosterone system. Cardiovascular research. vol 43. issue 2. 1999-11-08. PMID:10536660. |
endogenously produced et-1 was found to contribute to the hypertrophic response of cardiomyocytes to ang ii and thereby to cardiac hypertrophy. |
1999-11-08 |
2023-08-12 |
rat |
| C A van Kesteren, J J Saris, D H Dekkers, J M Lamers, P R Saxena, M A Schalekamp, A H Danse. Cultured neonatal rat cardiac myocytes and fibroblasts do not synthesize renin or angiotensinogen: evidence for stretch-induced cardiomyocyte hypertrophy independent of angiotensin II. Cardiovascular research. vol 43. issue 1. 1999-11-04. PMID:10536699. |
the hypertrophic response of cardiomyocytes exposed to mechanical stretch is assumed to depend on the release of angiotensin (ang) ii from these cells. |
1999-11-04 |
2023-08-12 |
rat |
| P B Timmerman. Angiotensin II receptor antagonists: an emerging new class of cardiovascular therapeutics. Hypertension research : official journal of the Japanese Society of Hypertension. vol 22. issue 2. 1999-10-19. PMID:10487332. |
the predominant role of the at1 receptor in mediating the pathophysiological role of ang ii underlies the effectiveness of this novel class of agents to lower arterial blood pressure, reduce pre- and afterload, inhibit sympathetic nervous system activity and prevent cardiovascular hypertrophy and cardiac failure induced by inappropriate control of the raas. |
1999-10-19 |
2023-08-12 |
Not clear |
| P Lijnen, V Petro. Antagonism of the renin-angiotensin system, hypertrophy and gene expression in cardiac myocytes. Methods and findings in experimental and clinical pharmacology. vol 21. issue 5. 1999-10-13. PMID:10420393. |
the ang ii-induced hypertrophic effect also depends on the existence of nonmyocytes in a cardiocyte culture. |
1999-10-13 |
2023-08-12 |
rat |
| R C Braun-Dullaeus, M J Mann, A Ziegler, H E von der Leyen, V J Dza. A novel role for the cyclin-dependent kinase inhibitor p27(Kip1) in angiotensin II-stimulated vascular smooth muscle cell hypertrophy. The Journal of clinical investigation. vol 104. issue 6. 1999-10-13. PMID:10491417. |
angiotensin ii (ang ii) has been shown to stimulate either hypertrophy or hyperplasia. |
1999-10-13 |
2023-08-12 |
Not clear |
| R C Braun-Dullaeus, M J Mann, A Ziegler, H E von der Leyen, V J Dza. A novel role for the cyclin-dependent kinase inhibitor p27(Kip1) in angiotensin II-stimulated vascular smooth muscle cell hypertrophy. The Journal of clinical investigation. vol 104. issue 6. 1999-10-13. PMID:10491417. |
the role of p27(kip1) in modulating the hypertrophic response of vsmcs to ang ii was further tested by antisense oligodeoxynucleotide (odn) inhibition of p27(kip1) expression. |
1999-10-13 |
2023-08-12 |
Not clear |
| R C Braun-Dullaeus, M J Mann, A Ziegler, H E von der Leyen, V J Dza. A novel role for the cyclin-dependent kinase inhibitor p27(Kip1) in angiotensin II-stimulated vascular smooth muscle cell hypertrophy. The Journal of clinical investigation. vol 104. issue 6. 1999-10-13. PMID:10491417. |
ang ii stimulation of quiescent cells in which p27(kip1) levels are high results in hypertrophy but promotes hyperplasia when levels of p27(kip1) are low, as in the presence of other growth factors. |
1999-10-13 |
2023-08-12 |
Not clear |
| X Zhou, L Che. [Effect of calcium and angiotensin II receptor on angiotensin II-stimulated protein synthesis in neonatal myocardial cells]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. vol 19. issue 1. 1999-10-05. PMID:10453550. |
these results indicated that the hypertrophic effect of ang ii on the myocytes was mediated by ang ii receptor and depended on increase in [ca2+]i and may be associated with enhanced expression of c-fos. |
1999-10-05 |
2023-08-12 |
Not clear |
| Z Cao, R Dean, L Wu, D Casley, M E Coope. Role of angiotensin receptor subtypes in mesenteric vascular proliferation and hypertrophy. Hypertension (Dallas, Tex. : 1979). vol 34. issue 3. 1999-09-30. PMID:10489386. |
the aim of this study was to explore the regulation of angiotensin receptors after chronic infusion with angiotensin ii (ang ii) and to clarify the relative roles of the angiotensin type 1 (at(1)) and type 2 (at(2)) receptors in the mediation of ang ii-induced mesenteric vascular hypertrophy. |
1999-09-30 |
2023-08-12 |
rat |
| G Wolf, R Kalluri, F N Ziyadeh, E G Neilson, R A Stah. Angiotensin II induces alpha3(IV) collagen expression in cultured murine proximal tubular cells. Proceedings of the Association of American Physicians. vol 111. issue 4. 1999-09-22. PMID:10417744. |
angiotensin ii (ang ii) induces cellular hypertrophy of cultured proximal tubular cells from various species. |
1999-09-22 |
2023-08-12 |
Not clear |
| R Malhotra, J Sadoshima, F C Brosius, S Izum. Mechanical stretch and angiotensin II differentially upregulate the renin-angiotensin system in cardiac myocytes In vitro. Circulation research. vol 85. issue 2. 1999-08-12. PMID:10417395. |
mechanical stretch of neonatal rat cardiac myocytes in vitro causes secretion of angiotensin ii (ang ii), which in turn plays a pivotal role in mechanical stretch-induced hypertrophy. |
1999-08-12 |
2023-08-12 |
rat |
| P Lijnen, V Petro. Renin-angiotensin system, hypertrophy and gene expression in cardiac myocytes. Journal of molecular and cellular cardiology. vol 31. issue 5. 1999-07-07. PMID:10336836. |
the ang ii-induced hypertrophic effect also depends on the existence of non-myocytes in a cardiocyte culture. |
1999-07-07 |
2023-08-12 |
rat |