| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yaghoob Farbood, Sahreh Shabani, Alireza Sarkaki, Seyyed Ali Mard, Akram Ahangarpour, Layasadat Khorsand. Peripheral and central administration of T3 improved the histological changes, memory and the dentate gyrus electrophysiological activity in an animal model of Alzheimer's disease. Metabolic brain disease. vol 32. issue 3. 2018-03-02. PMID:28124751. |
neuronal single unit recording was assessed from hippocampal dg. |
2018-03-02 |
2023-08-13 |
rat |
| Fiorenza Stagni, Alessandra Raspanti, Andrea Giacomini, Sandra Guidi, Marco Emili, Elisabetta Ciani, Alessandro Giuliani, Andrea Bighinati, Laura Calzà, Jacopo Magistretti, Renata Bartesagh. Long-term effect of neonatal inhibition of APP gamma-secretase on hippocampal development in the Ts65Dn mouse model of Down syndrome. Neurobiology of disease. vol 103. 2018-03-02. PMID:28359846. |
we found that in treated ts65dn mice the pool of proliferating cells in the hippocampal dentate gyrus (dg) and total number of granule neurons were still restored as was the number of pre- and postsynaptic terminals in the stratum lucidum of ca3, the site of termination of the mossy fibers from the dg. |
2018-03-02 |
2023-08-13 |
mouse |
| Tie-Yuan Zhang, Christopher L Keown, Xianglan Wen, Junhao Li, Dulcie A Vousden, Christoph Anacker, Urvashi Bhattacharyya, Richard Ryan, Josie Diorio, Nicholas O'Toole, Jason P Lerch, Eran A Mukamel, Michael J Meane. Environmental enrichment increases transcriptional and epigenetic differentiation between mouse dorsal and ventral dentate gyrus. Nature communications. vol 9. issue 1. 2018-02-22. PMID:29352183. |
the hippocampal dentate gyrus (dg) is a major site for experience-dependent plasticity associated with sustained transcriptional alterations, potentially mediated by epigenetic modifications. |
2018-02-22 |
2023-08-13 |
mouse |
| Ling-Yu Yang, Nigel H Greig, Ya-Ni Huang, Tsung-Hsun Hsieh, David Tweedie, Qian-Sheng Yu, Barry J Hoffer, Yu Luo, Yu-Chieh Kao, Jia-Yi Wan. Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury. Neurobiology of disease. vol 96. 2018-02-09. PMID:27553877. |
fluoro-jade c was used to stain hippocampal sub-regions, including ca1 and dentate gyrus (dg), for cellular degeneration. |
2018-02-09 |
2023-08-13 |
rat |
| Tatiana Melnikova, DaMin Park, Lauren Becker, Deidre Lee, Eugenia Cho, Nuzhat Sayyida, Jing Tian, Karen Bandeen-Roche, David R Borchelt, Alena V Savonenk. Sex-related dimorphism in dentate gyrus atrophy and behavioral phenotypes in an inducible tTa:APPsi transgenic model of Alzheimer's disease. Neurobiology of disease. vol 96. 2018-02-09. PMID:27569580. |
both males and females showed atrophy of the dentate gyrus (dg) of the dorsal hippocampus, associated with widening of the pyramidal layer of the ca1 area in both sexes. |
2018-02-09 |
2023-08-13 |
mouse |
| S Y Yau, C A Bostrom, J Chiu, C J Fontaine, S Sawchuk, A Meconi, R C Wortman, E Truesdell, A Truesdell, C Chiu, B N Hryciw, B D Eadie, M Ghilan, B R Christi. Impaired bidirectional NMDA receptor dependent synaptic plasticity in the dentate gyrus of adult female Fmr1 heterozygous knockout mice. Neurobiology of disease. vol 96. 2018-02-09. PMID:27659109. |
we, and others, have recently reported that there is significant impairment in n-methyl-d-aspartate receptor (nmdar)-dependent long-term potentiation (ltp) and long-term depression (ltd) in the hippocampal dentate gyrus (dg) of male fmr1 knock out mice. |
2018-02-09 |
2023-08-13 |
mouse |
| Majid Motaghinejad, Manijeh Motevalian, Fatemeh Babalouei, Mohammad Abdollahi, Mansour Heidari, Zahra Madj. Possible involvement of CREB/BDNF signaling pathway in neuroprotective effects of topiramate against methylphenidate induced apoptosis, oxidative stress and inflammation in isolated hippocampus of rats: Molecular, biochemical and histological evidences. Brain research bulletin. vol 132. 2018-02-09. PMID:28552672. |
expression of total (inactive) and phosphorylated (active) creb and bdnf were also measured in gene and protein levels in dentate gyrus (dg) and ca1 areas of hippocampus. |
2018-02-09 |
2023-08-13 |
rat |
| Jingrui Pan, Lei He, Xiangpen Li, Mei Li, Xiaoni Zhang, Jacob Venesky, Yi Li, Ying Pen. Activating Autophagy in Hippocampal Cells Alleviates the Morphine-Induced Memory Impairment. Molecular neurobiology. vol 54. issue 3. 2018-02-07. PMID:26873855. |
autophagy inhibition by 3-methyladenine obviously aggravates this morphine-induced memory impairment, accompanied with increased cell deaths in stratum pyramidale of hippocampal ca1, ca3, and dg regions and the activation of microglia to induce inflammation in hippocampus, such as upregulated expression of tnf-α, il-1β, il-6, and inos, as well as nf-κb' s activation, while morphine alone promoted microglial immunosuppression in hippocampus with autophagy activation which was also confirmed in primary microglia. |
2018-02-07 |
2023-08-13 |
mouse |
| Yanbo Ma, Takashi Matsuwaki, Keitaro Yamanouchi, Masugi Nishihar. Glucocorticoids Suppress the Protective Effect of Cyclooxygenase-2-Related Signaling on Hippocampal Neurogenesis Under Acute Immune Stress. Molecular neurobiology. vol 54. issue 3. 2018-02-07. PMID:26910812. |
treatment of rats with lps significantly decreased neurogenesis in the dentate gyrus (dg) of the hippocampus, and this inhibitory effect of lps on neurogenesis was reversed by the glucocorticoid receptor antagonist ru486. |
2018-02-07 |
2023-08-13 |
rat |
| Lai-Ling Du, Lin Wang, Xi-Fei Yang, Ping Wang, Xiao-Hong Li, Da-Min Chai, Bing-Jin Liu, Yun Cao, Wei-Qi Xu, Rong Liu, Qing Tian, Jian-Zhi Wang, Xin-Wen Zho. Transient Receptor Potential-canonical 1 is Essential for Environmental Enrichment-Induced Cognitive Enhancement and Neurogenesis. Molecular neurobiology. vol 54. issue 3. 2018-02-07. PMID:26910815. |
interestingly, after the mice were exposed to environmental enrichment (ee) for 4 weeks, trpc1 knockout abolished the ee-induced spatial memory enhancement, ltp induction, and neurogenesis in hippocampal dg subset. |
2018-02-07 |
2023-08-13 |
mouse |
| Lai-Ling Du, Lin Wang, Xi-Fei Yang, Ping Wang, Xiao-Hong Li, Da-Min Chai, Bing-Jin Liu, Yun Cao, Wei-Qi Xu, Rong Liu, Qing Tian, Jian-Zhi Wang, Xin-Wen Zho. Transient Receptor Potential-canonical 1 is Essential for Environmental Enrichment-Induced Cognitive Enhancement and Neurogenesis. Molecular neurobiology. vol 54. issue 3. 2018-02-07. PMID:26910815. |
by stereotaxic infusion of the recombinant adeno-associated viruses (raav)-trpc1 into the hippocampal dg subsets bilaterally, we observed that the ee-associated neurogenesis, ltp induction and the cognitive enhancement were efficiently rescued in trpc1 knockout mice. |
2018-02-07 |
2023-08-13 |
mouse |
| Dinah L Ramos-Ortolaza, Raura J Doreste-Mendez, John K Alvarado-Torres, Annelyn Torres-Revero. Ovarian hormones modify anxiety behavior and glucocorticoid receptors after chronic social isolation stress. Behavioural brain research. vol 328. 2018-02-07. PMID:28408299. |
interestingly, we found a decrease in anxiety behaviors in females in the estrus stage accompanied by a decrease in gr expression in hippocampal dg and ca3. |
2018-02-07 |
2023-08-13 |
rat |
| Thomas R Groves, Jing Wang, Marjan Boerma, Antiño R Alle. Assessment of Hippocampal Dendritic Complexity in Aged Mice Using the Golgi-Cox Method. Journal of visualized experiments : JoVE. issue 124. 2018-02-07. PMID:28671647. |
the data presented show that the golgi staining method effectively stained the mature neurons in the ca1, the ca3, and the dentate gyrus (dg) of the hippocampus. |
2018-02-07 |
2023-08-13 |
mouse |
| D J Hamilton, C M White, C L Rees, D W Wheeler, G A Ascol. Molecular fingerprinting of principal neurons in the rodent hippocampus: A neuroinformatics approach. Journal of pharmaceutical and biomedical analysis. vol 144. 2018-02-05. PMID:28549853. |
here we focus on the principal cell layers of dentate gyrus (dg), ca3, ca2, and ca1, which together contain approximately 90% of hippocampal neurons. |
2018-02-05 |
2023-08-13 |
mouse |
| Joaquín Pardo, Maia Uriarte, Gloria M Cónsole, Paula C Reggiani, Tiago F Outeiro, Gustavo R Morel, Rodolfo G Goy. Insulin-like growth factor-I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats. The European journal of neuroscience. vol 44. issue 4. 2018-02-01. PMID:27188415. |
in the dentate gyrus (dg) of the hippocampus, the igf-i group showed a higher number of immature neurons than the dsred controls. |
2018-02-01 |
2023-08-13 |
rat |
| Min-Shan Lin, Wen-Chao Xiong, Shu-Ji Li, Zhi Gong, Xiong Cao, Xiao-Jing Kuang, Yuan Zhang, Tian-Ming Gao, Naguib Mechawar, Ce Liu, Xin-Hong Zh. α2-glycine receptors modulate adult hippocampal neurogenesis and spatial memory. Developmental neurobiology. vol 77. issue 12. 2018-01-31. PMID:29057625. |
adult hippocampal neurogenesis (ahn) is the process by which new granule cell neurons are added to the dentate gyrus (dg) throughout adulthood. |
2018-01-31 |
2023-08-13 |
mouse |
| Kevin N Hascup, Erin R Hascu. Soluble Amyloid-β42 Stimulates Glutamate Release through Activation of the α7 Nicotinic Acetylcholine Receptor. Journal of Alzheimer's disease : JAD. vol 53. issue 1. 2018-01-29. PMID:27163813. |
because aβ42 binds the α7 nicotinic acetylcholine receptors (α7nachrs) located presynaptically on glutamatergic terminals, involved with hippocampal dependent learning and memory, we examined the effects of the human, monomeric isoform of aβ42 on glutamate release in the dentate gyrus (dg), ca3, and ca1, of isoflurane anesthetized, 6-9 month old male c57bl/6j mice. |
2018-01-29 |
2023-08-13 |
mouse |
| Fang Wang, Rachel A Dian. Temporal context processing within hippocampal subfields. NeuroImage. vol 134. 2018-01-23. PMID:27039142. |
the purpose of the present study is to investigate whether the hippocampal dentate gyrus (dg)/ca3 and ca1 subfields are sensitive to changes in temporal context and, if so, whether the subregions show a linear or threshold-like response to similar temporal contexts. |
2018-01-23 |
2023-08-13 |
human |
| Holly C Hunsberger, Sharay E Setti, Ryan T Heslin, Jorge E Quintero, Greg A Gerhardt, Miranda N Ree. Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models. Journal of visualized experiments : JoVE. issue 123. 2018-01-23. PMID:28518111. |
here, the method described involves anesthetizing rtg(taup301l)4510 mice and using a stereotaxic device to precisely target sub-regions (dg, ca1, and ca3) of the hippocampus. |
2018-01-23 |
2023-08-13 |
mouse |
| Jada Chia-Di Lee, Suk-Yu Yau, Tatia M C Lee, Benson Wui-Man Lau, Kwok-Fai S. Voluntary Wheel Running Reverses the Decrease in Subventricular Zone Neurogenesis Caused by Corticosterone. Cell transplantation. vol 25. issue 11. 2018-01-22. PMID:27393316. |
adult neurogenesis within the dentate gyrus (dg) of the hippocampus can be increased by voluntary exercise but is suppressed under stress, such as with corticosterone (cort). |
2018-01-22 |
2023-08-13 |
rat |