| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hirofumi Hayakawa, Toshikazu Samura, Tadanobu Chuyo Kamijo, Yutaka Sakai, Takeshi Aihar. Spatial information enhanced by non-spatial information in hippocampal granule cells. Cognitive neurodynamics. vol 9. issue 1. 2015-06-08. PMID:26052358. |
the dentate gyrus (dg) in the hippocampus receives two types of information from the lateral and medial entorhinal cortices. |
2015-06-08 |
2023-08-13 |
rat |
| Zhen Zhang, Rong Yan, Qi Zhang, Jia Li, Xiaokui Kang, Haining Wang, Linchun Huan, Lin Zhang, Fan Li, Shuyuan Yang, Jianning Zhang, Xinliang Ren, Xinyu Yan. Hes1, a Notch signaling downstream target, regulates adult hippocampal neurogenesis following traumatic brain injury. Brain research. vol 1583. 2015-06-05. PMID:25084035. |
here, we investigate the role of hes1 in regulating neurogenesis in the dg of the adult hippocampus after tbi by up- or downregulating hes1 expression. |
2015-06-05 |
2023-08-13 |
mouse |
| Zhen Zhang, Rong Yan, Qi Zhang, Jia Li, Xiaokui Kang, Haining Wang, Linchun Huan, Lin Zhang, Fan Li, Shuyuan Yang, Jianning Zhang, Xinliang Ren, Xinyu Yan. Hes1, a Notch signaling downstream target, regulates adult hippocampal neurogenesis following traumatic brain injury. Brain research. vol 1583. 2015-06-05. PMID:25084035. |
we show that enhancing hes1 inhibits the proliferation and differentiation of neural precursor cells (npcs) in the dg of the hippocampus soon after tbi. |
2015-06-05 |
2023-08-13 |
mouse |
| Francele Valente Piazza, Ethiane Segabinazi, Lígia Aline Centenaro, Patrícia Severo do Nascimento, Matilde Achaval, Simone Marcuzz. Enriched environment induces beneficial effects on memory deficits and microglial activation in the hippocampus of type 1 diabetic rats. Metabolic brain disease. vol 29. issue 1. 2015-06-02. PMID:24318482. |
thus, our objective was to investigate the influence of the ee on memory deficits, locomotion, corticosterone levels, synaptophysin (syp) protein immunoreactivity, cell survival and microglial activation in the dentate gyrus (dg) of t1dm rat hippocampus. |
2015-06-02 |
2023-08-12 |
rat |
| Maryann Obiorah, Elizabeth McCandlish, Brian Buckley, Emanuel DiCicco-Bloo. Hippocampal developmental vulnerability to methylmercury extends into prepubescence. Frontiers in neuroscience. vol 9. 2015-06-01. PMID:26029035. |
we previously showed that a single low exposure (0.6 μg/gbw) that approaches human exposure reduced hippocampal neurogenesis in the dentate gyrus (dg) 24 h later, producing later proliferation and memory deficits in adolescence. |
2015-06-01 |
2023-08-13 |
human |
| Sandra A Acosta, Naoki Tajiri, Kazutaka Shinozuka, Hiroto Ishikawa, Paul R Sanberg, Juan Sanchez-Ramos, Shijie Song, Yuji Kaneko, Cesar V Borlonga. Combination therapy of human umbilical cord blood cells and granulocyte colony stimulating factor reduces histopathological and motor impairments in an experimental model of chronic traumatic brain injury. PloS one. vol 9. issue 3. 2015-05-29. PMID:24621603. |
results revealed that the rats exposed to tbi treated with saline exhibited widespread neuroinflammation, impaired endogenous neurogenesis in dg and svz, and severe hippocampal cell loss. |
2015-05-29 |
2023-08-12 |
human |
| Sandra A Acosta, Naoki Tajiri, Kazutaka Shinozuka, Hiroto Ishikawa, Paul R Sanberg, Juan Sanchez-Ramos, Shijie Song, Yuji Kaneko, Cesar V Borlonga. Combination therapy of human umbilical cord blood cells and granulocyte colony stimulating factor reduces histopathological and motor impairments in an experimental model of chronic traumatic brain injury. PloS one. vol 9. issue 3. 2015-05-29. PMID:24621603. |
g-csf monotherapy produced partial and short-lived benefits characterized by low levels of neuroinflammation in striatum, dg, svz, and corpus callosum and fornix, a modest neurogenesis, and a moderate reduction of hippocampal cells loss. |
2015-05-29 |
2023-08-12 |
human |
| Katherine E Davis, Sarah Fox, John Gig. Increased hippocampal excitability in the 3xTgAD mouse model for Alzheimer's disease in vivo. PloS one. vol 9. issue 3. 2015-05-29. PMID:24621690. |
here, we tested whether hippocampal synaptic dysfunction accompanies this cognitive deficit by probing dorsal ca1 and dg synaptic responses in anaesthetized, 4-6 month-old 3xtgad mice. |
2015-05-29 |
2023-08-12 |
mouse |
| Yuan Le, Shuli Liu, Mingchao Peng, Chang Tan, Qin Liao, Kaiming Duan, Wen Ouyang, Jianbin Ton. Aging differentially affects the loss of neuronal dendritic spine, neuroinflammation and memory impairment at rats after surgery. PloS one. vol 9. issue 9. 2015-05-28. PMID:25198176. |
we found that (1) in young adult rats, the memory was not significantly affected (p>0.05) 1d, 3d and 7d after partial hepatectomy, but was significantly impaired (p<0.001) in aged rats 1d and 3d post-surgery; (2) in young adult rats, the surgery did not significantly affect the densities of dendritic spines of neurons at ca1, dentate gyrus (dg) and cingulate cortex (p>0.05, respectively) 1d and 3d post-surgery, but the spine densities at ca1 and dg of aged rats were significant reduced 1d and 3d post-surgery (p<0.001, respectively), however this didn't happen at cingulate cortex (p>0.05); (3) in young adult rats, surgery didn't affect the activation of microglia and levels of tnf-α and il-1β at hippocampus (p>0.05), but significantly activated microglia and increased levels of tnf-α and il-1β at hippocampus of aged rats (p<0.05). |
2015-05-28 |
2023-08-13 |
rat |
| Libin Zhou, Zihong Lu, Lin Li, Lei Chen, Jianhua Qi, Ling Che. Pro-neurogenesis and anti-dementia properties of tetradecyl 2,3-dihydroxybenzoate through TrkA receptor-mediated signalling pathways. The international journal of neuropsychopharmacology. vol 17. issue 11. 2015-05-26. PMID:24787365. |
herein, we report that oral administration of abg001 for five days to adult male mice could dose-dependently enhance survival and neurite growth of newborn cells in hippocampal dentate gyrus (dg) without changes in cell proliferation and differentiation of progenitor cells. |
2015-05-26 |
2023-08-13 |
mouse |
| Julia Marschallinger, Monika Krampert, Sebastien Couillard-Despres, Rainer Heuchel, Ulrich Bogdahn, Ludwig Aigne. Age-dependent and differential effects of Smad7ΔEx1 on neural progenitor cell proliferation and on neurogenesis. Experimental gerontology. vol 57. 2015-05-26. PMID:24862634. |
we recently reported that young (3 to 4months old) mice lacking exon 1 of the smad7 gene (s7Δex1 mice) show enhanced proliferation of neural stem and progenitor cells (npcs) in the hippocampal dentate gyrus (dg) and in the subventricular zone (svz) of the lateral ventricles. |
2015-05-26 |
2023-08-13 |
mouse |
| Valentina Corvino, Elisa Marchese, Maria Vittoria Podda, Wanda Lattanzi, Stefano Giannetti, Valentina Di Maria, Sara Cocco, Claudio Grassi, Fabrizio Michetti, Maria Concetta Gelos. The neurogenic effects of exogenous neuropeptide Y: early molecular events and long-lasting effects in the hippocampus of trimethyltin-treated rats. PloS one. vol 9. issue 2. 2015-05-22. PMID:24516629. |
as a functional correlate of the integration of new neurons into the hippocampal network, long-term potentiation recorded in dentate gyrus (dg) in the absence of gabaa receptor blockade was higher in the tmt+npy-treated group than in all other groups. |
2015-05-22 |
2023-08-12 |
rat |
| Diana Xuan Yu, Francesco Paolo Di Giorgio, Jun Yao, Maria Carolina Marchetto, Kristen Brennand, Rebecca Wright, Arianna Mei, Lauren McHenry, David Lisuk, Jaeson Michael Grasmick, Pedro Silberman, Giovanna Silberman, Roberto Jappelli, Fred H Gag. Modeling hippocampal neurogenesis using human pluripotent stem cells. Stem cell reports. vol 2. issue 3. 2015-05-22. PMID:24672753. |
here, we report a differentiation paradigm for hpscs that enriches for hippocampal dentate gyrus (dg) granule neurons. |
2015-05-22 |
2023-08-12 |
human |
| Diana Xuan Yu, Francesco Paolo Di Giorgio, Jun Yao, Maria Carolina Marchetto, Kristen Brennand, Rebecca Wright, Arianna Mei, Lauren McHenry, David Lisuk, Jaeson Michael Grasmick, Pedro Silberman, Giovanna Silberman, Roberto Jappelli, Fred H Gag. Modeling hippocampal neurogenesis using human pluripotent stem cells. Stem cell reports. vol 2. issue 3. 2015-05-22. PMID:24672753. |
this differentiation paradigm recapitulates the expression patterns of key developmental genes during hippocampal neurogenesis, exhibits characteristics of neuronal network maturation, and produces prox1+ neurons that functionally integrate into the dg. |
2015-05-22 |
2023-08-12 |
human |
| P Sampedro-Piquero, Paola De Bartolo, Laura Petrosini, C Zancada-Menendez, J L Arias, A Begeg. Astrocytic plasticity as a possible mediator of the cognitive improvements after environmental enrichment in aged rats. Neurobiology of learning and memory. vol 114. 2015-05-22. PMID:24727294. |
also, we found that aged rats submitted to ee had more gfap immunopositive cells in the dg and more complex astrocytes, revealed by sholl analysis, in all hippocampal subfields with respect to the other experimental conditions. |
2015-05-22 |
2023-08-13 |
rat |
| Jens Stepan, Julien Dine, Matthias Ede. Functional optical probing of the hippocampal trisynaptic circuit in vitro: network dynamics, filter properties, and polysynaptic induction of CA1 LTP. Frontiers in neuroscience. vol 9. 2015-05-22. PMID:25999809. |
especially the hippocampal trisynaptic circuit [entorhinal cortex layer ii → dentate gyrus (dg) → cornu ammonis (ca)-3 → ca1] was studied in great detail because of its seemingly simple connectivity and characteristic structures that are experimentally well accessible. |
2015-05-22 |
2023-08-13 |
Not clear |
| Mohamed Ghilan, Crystal A Bostrom, Brett N Hryciw, Jessica M Simpson, Brian R Christie, Joana Gil-Mohape. YAC128 Huntington's disease transgenic mice show enhanced short-term hippocampal synaptic plasticity early in the course of the disease. Brain research. vol 1581. 2015-05-21. PMID:24949563. |
we show that the yac128 hippocampal dentate gyrus (dg) displays marked reductions in paired-pulse depression both at 3 and 6 months of age. |
2015-05-21 |
2023-08-13 |
mouse |
| Verónica López-Virgen, David Zárate-López, Fabián L Adirsch, Jorge Collas-Aguilar, Óscar González-Pére. [Effects of sleep deprivation in hippocampal neurogenesis]. Gaceta medica de Mexico. vol 151. issue 1. 2015-05-19. PMID:25739489. |
adult neurogenesis in the dentate gyrus (dg) in the hippocampus is a process that involves proliferation, differentiation, maturation, migration, and integration of young neurons in the granular layer of dg. |
2015-05-19 |
2023-08-13 |
Not clear |
| b' Susana Garc\\xc3\\xada-Cerro, Paula Mart\\xc3\\xadnez, Ver\\xc3\\xb3nica Vidal, Andrea Corrales, Jes\\xc3\\xbas Fl\\xc3\\xb3rez, Rebeca Vidal, Noem\\xc3\\xad Rueda, Mar\\xc3\\xada L Arbon\\xc3\\xa9s, Carmen Mart\\xc3\\xadnez-Cu\\xc3\\xa. Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndrome. PloS one. vol 9. issue 9. 2015-05-15. PMID:25188425.' |
concomitant with these functional improvements, normalization of the dyrk1a expression level in ts mice restored the proliferation and differentiation of hippocampal cells in the adult dentate gyrus (dg) and the density of gabaergic and glutamatergic synapse markers in the molecular layer of the hippocampus. |
2015-05-15 |
2023-08-13 |
mouse |
| b' Susana Garc\\xc3\\xada-Cerro, Paula Mart\\xc3\\xadnez, Ver\\xc3\\xb3nica Vidal, Andrea Corrales, Jes\\xc3\\xbas Fl\\xc3\\xb3rez, Rebeca Vidal, Noem\\xc3\\xad Rueda, Mar\\xc3\\xada L Arbon\\xc3\\xa9s, Carmen Mart\\xc3\\xadnez-Cu\\xc3\\xa. Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndrome. PloS one. vol 9. issue 9. 2015-05-15. PMID:25188425.' |
however, normalization of the dyrk1a gene dosage did not affect other structural (e.g., the density of mature hippocampal granule cells, the dg volume and the subgranular zone area) or behavioral (i.e., hyperactivity/attention) alterations found in the ts mouse. |
2015-05-15 |
2023-08-13 |
mouse |