| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ji-Wei Tan, Juan Ji An, Hannah Deane, Haifei Xu, Guey-Ying Liao, Baoji X. Neurotrophin-3 from the dentate gyrus supports postsynaptic sites of mossy fiber-CA3 synapses and hippocampus-dependent cognitive functions. Molecular psychiatry. 2024-01-11. PMID:38212372. |
at the center of the hippocampal tri-synaptic loop are synapses formed between mossy fiber (mf) terminals from granule cells in the dentate gyrus (dg) and proximal dendrites of ca3 pyramidal neurons. |
2024-01-11 |
2024-01-14 |
mouse |
| Marijke Vergaelen, Simona Manzella, Kristl Vonck, Erine Craey, Jeroen Spanoghe, Mathieu Sprengers, Evelien Carrette, Wytse Jan Wadman, Jean Delbeke, Paul Boon, Lars Emil Larsen, Robrecht Raed. Increased Dentate Gyrus Excitability in the Intrahippocampal Kainic Acid Mouse Model for Temporal Lobe Epilepsy. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203829. |
we recorded field postsynaptic potentials (fpsps) after electrical stimulation in the ca1 region and in the dentate gyrus (dg) of hippocampal slices of ihka and healthy mice using a multielectrode array (mea). |
2024-01-11 |
2024-01-13 |
mouse |
| Marijke Vergaelen, Simona Manzella, Kristl Vonck, Erine Craey, Jeroen Spanoghe, Mathieu Sprengers, Evelien Carrette, Wytse Jan Wadman, Jean Delbeke, Paul Boon, Lars Emil Larsen, Robrecht Raed. Increased Dentate Gyrus Excitability in the Intrahippocampal Kainic Acid Mouse Model for Temporal Lobe Epilepsy. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203829. |
these results point to increased neuronal excitability in the dg but not in the ca1 region of the hippocampus of ihka mice. |
2024-01-11 |
2024-01-13 |
mouse |
| Marijke Vergaelen, Simona Manzella, Kristl Vonck, Erine Craey, Jeroen Spanoghe, Mathieu Sprengers, Evelien Carrette, Wytse Jan Wadman, Jean Delbeke, Paul Boon, Lars Emil Larsen, Robrecht Raed. Increased Dentate Gyrus Excitability in the Intrahippocampal Kainic Acid Mouse Model for Temporal Lobe Epilepsy. International journal of molecular sciences. vol 25. issue 1. 2024-01-11. PMID:38203829. |
this method, in which the excitability of hippocampal slices from ihka mice is investigated using a mea, can now be further explored as a potential new model to screen for new interventions that can restore dg function and potentially lead to novel therapies for mtle. |
2024-01-11 |
2024-01-13 |
mouse |
| He Huang, Ning Wang, Jia-Tao Lin, Yong-Kang Qiu, Wei-Feng Wu, Qiang Liu, Chen Chen, Hai-Bi Wang, Yan-Ping Liu, Wei Dong, Jie Wan, Hui Zheng, Cheng-Hua Zhou, Yu-Qing W. Repeated Ketamine Anesthesia during the Neonatal Period Impairs Hippocampal Neurogenesis and Long-Term Neurocognitive Function by Inhibiting Mfn2-Mediated Mitochondrial Fusion in Neural Stem Cells. Molecular neurobiology. 2024-01-10. PMID:38200350. |
for the interventional study, lentivirus (lv) overexpressing mfn2 (lv-mfn2) or control lv vehicle was microinjected into the hippocampal dentate gyrus (dg) 4 days before ketamine administration. |
2024-01-10 |
2024-01-13 |
rat |
| He Huang, Ning Wang, Jia-Tao Lin, Yong-Kang Qiu, Wei-Feng Wu, Qiang Liu, Chen Chen, Hai-Bi Wang, Yan-Ping Liu, Wei Dong, Jie Wan, Hui Zheng, Cheng-Hua Zhou, Yu-Qing W. Repeated Ketamine Anesthesia during the Neonatal Period Impairs Hippocampal Neurogenesis and Long-Term Neurocognitive Function by Inhibiting Mfn2-Mediated Mitochondrial Fusion in Neural Stem Cells. Molecular neurobiology. 2024-01-10. PMID:38200350. |
preconditioning with lv-mfn2 improved long-term cognitive dysfunction after repeated neonatal ketamine exposure by reversing the inhibitory effect of ketamine on synaptic plasticity in the hippocampal dg. |
2024-01-10 |
2024-01-13 |
rat |
| Shahab Ghaderi, Parsa Gholipour, Alireza Komaki, Siamak Shahidi, Faezeh Seif, Mohammad Bahrami-Tapehebur, Iraj Salehi, Mohammad Zarei, Abdolrahman Sarihi, Masome Rashn. Underlying mechanisms behind the neuroprotective effect of vanillic acid against diabetes-associated cognitive decline: An in vivo study in a rat model. Phytotherapy research : PTR. 2024-01-08. PMID:38185917. |
long-term potentiation (ltp) was induced at hippocampal dentate gyrus (dg) synapses in response to high-frequency stimulation (hfs) applied to the perforant pathway (pp) to evaluate synaptic plasticity. |
2024-01-08 |
2024-01-10 |
rat |
| Chi Xu, Jiayu Ye, Yanting Sun, Xiujian Sun, Jing-Gen Li. The Antidepressant Effect of Magnolol on Depression-Like Behavior of CORT-Treated Mice. Journal of molecular neuroscience : MN. vol 74. issue 1. 2024-01-06. PMID:38183534. |
prevented cort-induced depression-like behavior and reduced cort-induced dynorphin (dyn a) elevation in the hippocampal ventral dg. |
2024-01-06 |
2024-01-09 |
mouse |
| Chi Xu, Jiayu Ye, Yanting Sun, Xiujian Sun, Jing-Gen Li. The Antidepressant Effect of Magnolol on Depression-Like Behavior of CORT-Treated Mice. Journal of molecular neuroscience : MN. vol 74. issue 1. 2024-01-06. PMID:38183534. |
the present study demonstrated that magnolol could ameliorate cort-induced depression-like behaviors, by modulating the dyn a/kor system in the ventral dg of the hippocampus. |
2024-01-06 |
2024-01-09 |
mouse |
| Nicholas Chalmers, Evangelia Masouti, Ruth Beckervordersandfort. Astrocytes in the adult dentate gyrus-balance between adult and developmental tasks. Molecular psychiatry. 2024-01-04. PMID:38177351. |
in this review, we focus on astrocytes of the hippocampal dentate gyrus (dg), and discuss specific features of the astrocytic compartment that may allow the execution of both tasks. |
2024-01-04 |
2024-01-07 |
Not clear |
| Nicholas Chalmers, Evangelia Masouti, Ruth Beckervordersandfort. Astrocytes in the adult dentate gyrus-balance between adult and developmental tasks. Molecular psychiatry. 2024-01-04. PMID:38177351. |
the diversity and dynamic of astrocytes in the adult dg implicate a vital contribution to hippocampal plasticity and represent an interesting model to uncover mechanisms how astrocytes simultaneously fulfill developmental and adult tasks. |
2024-01-04 |
2024-01-07 |
Not clear |
| Oier Pastor-Alonso, Anum Syeda Zahra, Bente Kaske, Fernando García-Moreno, Felix Tetzlaff, Enno Bockelmann, Vanessa Grunwald, Soraya Martín-Suárez, Kristoffer Riecken, Otto Wilhelm Witte, Juan Manuel Encinas, Anja Urbac. Generation of adult hippocampal neural stem cells occurs in the early postnatal dentate gyrus and depends on cyclin D2. The EMBO journal. 2024-01-04. PMID:38177500. |
lifelong hippocampal neurogenesis is maintained by a pool of multipotent adult neural stem cells (anscs) residing in the subgranular zone of the dentate gyrus (dg). |
2024-01-04 |
2024-01-07 |
mouse |
| Rong-Xin Zou, Xiaozhen Gu, Chenqing Huang, Hui-Li Wang, Xiang-Tao Che. Chronic Pb exposure impairs learning and memory abilities by inhibiting excitatory projection neuro-circuit of the hippocampus in mice. Toxicology. 2023-12-31. PMID:38160928. |
in conclusion, our data indicated that pb significantly impaired the excitatory connections from ec to the hippocampus (ca1 and dg), providing a novel neuro-circuitry basis for pb neurotoxicity. |
2023-12-31 |
2024-01-05 |
mouse |
| Kim Ngan Hoang, Yushan Huang, Esther Fujiwara, Nikolai Malykhi. Effects of healthy aging and mnemonic strategies on verbal memory performance across the adult lifespan: Mediating role of posterior hippocampus. Hippocampus. 2023-12-25. PMID:38145465. |
in this study, we aimed to understand the contributions of hippocampal anteroposterior subregions (head, body, tail) and subfields (cornu ammonis 1-3 [ca1-3], dentate gyrus [dg], and subiculum [sub]) and encoding strategies to the age-related verbal memory decline. |
2023-12-25 |
2023-12-27 |
human |
| Kim Ngan Hoang, Yushan Huang, Esther Fujiwara, Nikolai Malykhi. Effects of healthy aging and mnemonic strategies on verbal memory performance across the adult lifespan: Mediating role of posterior hippocampus. Hippocampus. 2023-12-25. PMID:38145465. |
while total ca1-3 and dg volumes did not show direct or indirect effects on verbal memory, exploratory analyses with dg and ca1-3 volumes within the hippocampal body subregion suggested an indirect effect of age-related volumetric reduction on verbal memory performance through semantic clustering. |
2023-12-25 |
2023-12-27 |
human |
| b' Andrijana Stanisavljevi\\xc4\\x87 Ili\\xc4\\x87, Sne\\xc5\\xbeana \\xc4\\x90or\\xc4\\x91evi\\xc4\\x87, Drago\\xc5\\xa1 Inta, Stefan Borgwardt, Dragana Filipovi\\xc4\\x8. Olanzapine Effects on Parvalbumin/GAD67 Cell Numbers in Layers/Subregions of Dorsal Hippocampus of Chronically Socially Isolated Rats. International journal of molecular sciences. vol 24. issue 24. 2023-12-23. PMID:38139008.' |
we determined the effect of olz on pv-positive (+) and glutamate decarboxylase 67 (gad67) + cell numbers in the layers of dorsal hippocampus (dhipp) cornu ammonis (ca1-ca3) and dentate gyrus (dg) subregions in rats exposed to chronic social isolation (csis), which is an animal model of depression. |
2023-12-23 |
2023-12-25 |
rat |
| Jasmin A Strickland, Joseph M Austen, Rolf Sprengel, David J Sanderso. Knockout of NMDARs in CA1 and dentate gyrus fails to impair temporal control of conditioned behavior in mice. Hippocampus. 2023-12-23. PMID:38140716. |
we tested the prediction that hippocampal nmda receptors are required for learning about time by testing mice that lack postembryonal nmdars in the ca1 and dentate gyrus (dg) hippocampal subfields on three different appetitive temporal learning procedures. |
2023-12-23 |
2023-12-25 |
mouse |
| Hirofumi Hirakawa, Takeshi Terao, Koji Hatano, Masanao Shirahama, Tsuyoshi Kugimiya, Kentaro Kohno, Hiroyuki Matsuta, Tsuyoshi Shimomura, Minoru Fujik. Increased volume of the left hippocampal dentate gyrus after 4 weeks of bright light exposure in patients with mood disorders: a randomized controlled study. Translational psychiatry. vol 13. issue 1. 2023-12-15. PMID:38102115. |
bright light exposure (bl) induces neurogenesis in the rat hippocampal dentate gyrus (dg). |
2023-12-15 |
2023-12-18 |
human |
| Su-Hyun Kim, Chong-Hyun Ki. Neuronal IGF-1 overexpression restores hippocampal newborn cell survival and recent CFC memory consolidation in Ca Brain research. 2023-12-14. PMID:38097125. |
neuronal igf-1 overexpression restores hippocampal newborn cell survival and recent cfc memory consolidation in ca insulin-like growth factor-1 (igf-1) exogenously supplied in the brain was shown to enhance the survival of hippocampal dentate gyrus (dg) newborn cells and some cognitive functions of mice. |
2023-12-14 |
2023-12-17 |
mouse |
| Kaige Liu, Yue Qu, Bozhi Li, Ningxi Zeng, Gaolei Yao, Xiaofeng Wu, Hanfang Xu, Can Yan, Lili W. GRP94 in cerebrospinal fluid may contribute to a potential biomarker of depression: Based on proteomics. Journal of psychiatric research. vol 169. 2023-12-11. PMID:38081093. |
flx significantly increased neuronal numbers in dentate gyrus (dg) and ca3 regions of hippocampus. |
2023-12-11 |
2023-12-17 |
rat |