| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mei-Ping Zhu, Bing-Yi Zhang, Ting Lian, Yuan-Jia Tan, Lin-Lin Chang, Pan Xu, Jin-Yi Zhang, Yan-Huan Du, Zhen-Yu Xiong, Qiong Du, Shi-Zhong Zhan. Involvement of mitochondrial TRPV3 in cardiac hypertrophy induced by pressure overload in rats. Sheng li xue bao : [Acta physiologica Sinica]. vol 76. issue 5. 2024-10-29. PMID:39468807. |
these results suggest that mitochondrial trpv3 in cardiomyocytes exacerbates mitochondrial dysfunction by up-regulating nox4, thereby participating in the process of pressure overload-induced myocardial hypertrophy. |
2024-10-29 |
2024-10-31 |
rat |
| Ji-Young Kang, Dasom Mun, Yumin Chun, Da-Seul Park, Hyoeun Kim, Nuri Yun, Boyoung Joun. Engineered small extracellular vesicle-mediated NOX4 siRNA delivery for targeted therapy of cardiac hypertrophy. Journal of extracellular vesicles. vol 12. issue 10. 2023-10-05. PMID:37795828. |
engineered small extracellular vesicle-mediated nox4 sirna delivery for targeted therapy of cardiac hypertrophy. |
2023-10-05 |
2023-10-07 |
mouse |
| Ji-Young Kang, Dasom Mun, Yumin Chun, Da-Seul Park, Hyoeun Kim, Nuri Yun, Boyoung Joun. Engineered small extracellular vesicle-mediated NOX4 siRNA delivery for targeted therapy of cardiac hypertrophy. Journal of extracellular vesicles. vol 12. issue 10. 2023-10-05. PMID:37795828. |
furthermore, to treat cardiac hypertrophy, cevs are loaded with nadph oxidase 4 (nox4) sirna (sinox4). |
2023-10-05 |
2023-10-07 |
mouse |
| James P Teuber, Kobina Essandoh, Scott L Hummel, Nageswara R Madamanchi, Matthew J Brod. NADPH Oxidases in Diastolic Dysfunction and Heart Failure with Preserved Ejection Fraction. Antioxidants (Basel, Switzerland). vol 11. issue 9. 2022-09-23. PMID:36139898. |
nox2 and nox4, for example, regulate distinct redox signaling mechanisms in cardiac myocytes pertinent to the onset and progression of cardiac hypertrophy and heart failure. |
2022-09-23 |
2023-08-14 |
Not clear |
| Hong-Li Gao, Xiao-Jing Yu, Han-Bo Hu, Qian-Wen Yang, Kai-Li Liu, Yan-Mei Chen, Yan Zhang, Dong-Dong Zhang, Hua Tian, Guo-Qing Zhu, Jie Qi, Yu-Ming Kan. Apigenin Improves Hypertension and Cardiac Hypertrophy Through Modulating NADPH Oxidase-Dependent ROS Generation and Cytokines in Hypothalamic Paraventricular Nucleus. Cardiovascular toxicology. vol 21. issue 9. 2021-11-15. PMID:34076830. |
the results showed that after pvn infusion of apigenin, the mean arterial pressure (map), heart rate, plasma norepinephrine (ne), beta 1 receptor in kidneys, level of phosphorylation of pka in the ventricular tissue and cardiac hypertrophy, perivascular fibrosis, heart level of oxidative stress, pvn levels of oxidative stress, interleukin 1β (il-1β), interleukin 6 (il-6), inos, monocyte chemotactic protein 1 (mcp-1), tyrosine hydroxylase (th), nox2 and nox4 were attenuated and pvn levels of interleukin 10 (il-10), superoxide dismutase 1 (cu/zn-sod) and the 67-kda isoform of glutamate decarboxylase (gad67) were increased. |
2021-11-15 |
2023-08-13 |
rat |
| Kosuke Okabe, Shouji Matsushima, Soichiro Ikeda, Masataka Ikeda, Akihito Ishikita, Tomonori Tadokoro, Nobuyuki Enzan, Taishi Yamamoto, Masashi Sada, Hiroko Deguchi, Keisuke Shinohara, Tomomi Ide, Hiroyuki Tsutsu. DPP (Dipeptidyl Peptidase)-4 Inhibitor Attenuates Ang II (Angiotensin II)-Induced Cardiac Hypertrophy via GLP (Glucagon-Like Peptide)-1-Dependent Suppression of Nox (Nicotinamide Adenine Dinucleotide Phosphate Oxidase) 4-HDAC (Histone Deacetylase) 4 Pathway. Hypertension (Dallas, Tex. : 1979). vol 75. issue 4. 2021-03-31. PMID:32160098. |
nox4 (nadph [nicotinamide adenine dinucleotide phosphate] oxidase 4) is a major source of oxidative stress and is intimately involved in cardiac hypertrophy. |
2021-03-31 |
2023-08-13 |
mouse |
| Kosuke Okabe, Shouji Matsushima, Soichiro Ikeda, Masataka Ikeda, Akihito Ishikita, Tomonori Tadokoro, Nobuyuki Enzan, Taishi Yamamoto, Masashi Sada, Hiroko Deguchi, Keisuke Shinohara, Tomomi Ide, Hiroyuki Tsutsu. DPP (Dipeptidyl Peptidase)-4 Inhibitor Attenuates Ang II (Angiotensin II)-Induced Cardiac Hypertrophy via GLP (Glucagon-Like Peptide)-1-Dependent Suppression of Nox (Nicotinamide Adenine Dinucleotide Phosphate Oxidase) 4-HDAC (Histone Deacetylase) 4 Pathway. Hypertension (Dallas, Tex. : 1979). vol 75. issue 4. 2021-03-31. PMID:32160098. |
however, its effects on nox4 in cardiac hypertrophy are still unclear. |
2021-03-31 |
2023-08-13 |
mouse |
| Kosuke Okabe, Shouji Matsushima, Soichiro Ikeda, Masataka Ikeda, Akihito Ishikita, Tomonori Tadokoro, Nobuyuki Enzan, Taishi Yamamoto, Masashi Sada, Hiroko Deguchi, Keisuke Shinohara, Tomomi Ide, Hiroyuki Tsutsu. DPP (Dipeptidyl Peptidase)-4 Inhibitor Attenuates Ang II (Angiotensin II)-Induced Cardiac Hypertrophy via GLP (Glucagon-Like Peptide)-1-Dependent Suppression of Nox (Nicotinamide Adenine Dinucleotide Phosphate Oxidase) 4-HDAC (Histone Deacetylase) 4 Pathway. Hypertension (Dallas, Tex. : 1979). vol 75. issue 4. 2021-03-31. PMID:32160098. |
we investigated whether dpp-4 inhibitor could ameliorate cardiac hypertrophy by regulating nox4 and its downstream targets. |
2021-03-31 |
2023-08-13 |
mouse |
| Kosuke Okabe, Shouji Matsushima, Soichiro Ikeda, Masataka Ikeda, Akihito Ishikita, Tomonori Tadokoro, Nobuyuki Enzan, Taishi Yamamoto, Masashi Sada, Hiroko Deguchi, Keisuke Shinohara, Tomomi Ide, Hiroyuki Tsutsu. DPP (Dipeptidyl Peptidase)-4 Inhibitor Attenuates Ang II (Angiotensin II)-Induced Cardiac Hypertrophy via GLP (Glucagon-Like Peptide)-1-Dependent Suppression of Nox (Nicotinamide Adenine Dinucleotide Phosphate Oxidase) 4-HDAC (Histone Deacetylase) 4 Pathway. Hypertension (Dallas, Tex. : 1979). vol 75. issue 4. 2021-03-31. PMID:32160098. |
it also significantly suppressed ang ii-induced increases in nox4 mrna, 4-hydroxy-2-nonenal, and phosphorylation of hdac4 (histone deacetylase 4), a downstream target of nox4 and a crucial suppressor of cardiac hypertrophy, in the heart. |
2021-03-31 |
2023-08-13 |
mouse |
| Kosuke Okabe, Shouji Matsushima, Soichiro Ikeda, Masataka Ikeda, Akihito Ishikita, Tomonori Tadokoro, Nobuyuki Enzan, Taishi Yamamoto, Masashi Sada, Hiroko Deguchi, Keisuke Shinohara, Tomomi Ide, Hiroyuki Tsutsu. DPP (Dipeptidyl Peptidase)-4 Inhibitor Attenuates Ang II (Angiotensin II)-Induced Cardiac Hypertrophy via GLP (Glucagon-Like Peptide)-1-Dependent Suppression of Nox (Nicotinamide Adenine Dinucleotide Phosphate Oxidase) 4-HDAC (Histone Deacetylase) 4 Pathway. Hypertension (Dallas, Tex. : 1979). vol 75. issue 4. 2021-03-31. PMID:32160098. |
exendin-3 (150 pmol/kg per minute), a glp-1 (glucagon-like peptide 1) receptor antagonist, abrogated these inhibitory effects of teneligliptin on nox4, 4-hydroxy-2-nonenal, phosphorylation of hdac4, and cardiac hypertrophy. |
2021-03-31 |
2023-08-13 |
mouse |
| Kosuke Okabe, Shouji Matsushima, Soichiro Ikeda, Masataka Ikeda, Akihito Ishikita, Tomonori Tadokoro, Nobuyuki Enzan, Taishi Yamamoto, Masashi Sada, Hiroko Deguchi, Keisuke Shinohara, Tomomi Ide, Hiroyuki Tsutsu. DPP (Dipeptidyl Peptidase)-4 Inhibitor Attenuates Ang II (Angiotensin II)-Induced Cardiac Hypertrophy via GLP (Glucagon-Like Peptide)-1-Dependent Suppression of Nox (Nicotinamide Adenine Dinucleotide Phosphate Oxidase) 4-HDAC (Histone Deacetylase) 4 Pathway. Hypertension (Dallas, Tex. : 1979). vol 75. issue 4. 2021-03-31. PMID:32160098. |
in cultured neonatal cardiomyocytes, exendin-4 (100 nmol/l, 24 hours), a glp-1 receptor agonist, ameliorated ang ii-induced cardiomyocyte hypertrophy and decreased in nox4, 4-hydroxy-2-nonenal, and phosphorylation of hdac4. |
2021-03-31 |
2023-08-13 |
mouse |
| Eduardo Pena, Patricia Siques, Julio Brito, Silvia M Arribas, Rainer Böger, Juliane Hannemann, Fabiola León-Velarde, M Carmen González, M Rosario López, Ángel Luis López de Pabl. Nox2 Upregulation and p38α MAPK Activation in Right Ventricular Hypertrophy of Rats Exposed to Long-Term Chronic Intermittent Hypobaric Hypoxia. International journal of molecular sciences. vol 21. issue 22. 2021-03-03. PMID:33202984. |
measurements in the rv included the following: hypertrophy, nox2, nox4, p22phox, lox-1 and hif-1α expression, lipid peroxidation and h |
2021-03-03 |
2023-08-13 |
rat |
| Si-Yu Zeng, Li Yang, Hui-Qin Lu, Qiu-Jiang Yan, Ling Gao, Xu-Ping Qi. Rutaecarpine prevents hypertensive cardiac hypertrophy involving the inhibition of Nox4-ROS-ADAM17 pathway. Journal of cellular and molecular medicine. vol 23. issue 6. 2020-07-06. PMID:30953402. |
our previous study indicated that nadph oxidase 4 (nox4) promotes angiotensin ii (ang ii)-induced cardiac hypertrophy through the pathway between reactive oxygen species (ros) and a disintegrin and metalloproteinase-17 (adam17) in primary cardiomyocytes. |
2020-07-06 |
2023-08-13 |
rat |
| Tae Hyun Youm, Sun-Hee Woo, Eun-Soo Kwon, Sung Sup Par. NADPH Oxidase 4 Contributes to Myoblast Fusion and Skeletal Muscle Regeneration. Oxidative medicine and cellular longevity. vol 2019. 2020-04-27. PMID:31827673. |
insulin-like growth factor 1 induces muscle hypertrophy via nox4, but its function in myoblast fusion remains elusive. |
2020-04-27 |
2023-08-13 |
Not clear |
| Renuga D Rajaram, Romain Dissard, Vincent Jaquet, Sophie de Seigneu. Potential benefits and harms of NADPH oxidase type 4 in the kidneys and cardiovascular system. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 34. issue 4. 2020-01-06. PMID:29931336. |
diabetes elevates nox4 expression in podocytes and mesangial cells, which was shown to damage glomeruli leading to podocyte loss, mesangial cell hypertrophy and matrix accumulation. |
2020-01-06 |
2023-08-13 |
mouse |
| Jingni He, Xiaohui Li, Hui Luo, Tangzhiming Li, Lin Zhao, Qiangqiang Qi, Yuwei Liu, Zaixin Y. Galectin-3 mediates the pulmonary arterial hypertension-induced right ventricular remodeling through interacting with NADPH oxidase 4. Journal of the American Society of Hypertension : JASH. vol 11. issue 5. 2018-03-26. PMID:28431936. |
in the monocrotaline-induced pah rat models of right ventricular hypertrophy and fibrosis, the gal-3 and nox4 expressions were both significantly upregulated compared with the controls. |
2018-03-26 |
2023-08-13 |
human |
| Jun Feng, Hua-Wen Chen, Li-Juan Pi, Jin Wang, Da-Qian Zha. Protective effect of tanshinone IIA against cardiac hypertrophy in spontaneously hypertensive rats through inhibiting the Cys-C/Wnt signaling pathway. Oncotarget. vol 8. issue 6. 2018-02-20. PMID:28053285. |
compared with the cardiac hypertrophy group, the sbp, hw/bw, lvw/bw, swelling degree of myocardial cells, col1a1 and col3a1 mrna expressions, serum ctni and adma levels, and the cys-c/wnt signaling pathway-related proteins and nox4 expressions in the low- and high-dose tanshinone iia groups were decreased, but the endothelial no synthase (enos), phosphorylated enos (ser1177) and no expressions were increased. |
2018-02-20 |
2023-08-13 |
rat |
| Tomohiro Tanno, Hirofumi Tomita, Ikuyo Narita, Takahiko Kinjo, Kimitaka Nishizaki, Hiroaki Ichikawa, Yoshihiro Kimura, Makoto Tanaka, Tomohiro Osanai, Ken Okumur. Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression. Journal of cardiovascular pharmacology. vol 67. issue 6. 2017-09-11. PMID:26886190. |
these findings indicate that olm treatment inhibits cardiac hypertrophy independently of blood pressure, not only through its original at1r blockade but partly through enhancement of ace2/ang(1-7)/mas axis and suppression of nox4 expression. |
2017-09-11 |
2023-08-13 |
mouse |
| Li Chen, Mingyue Zhao, Junli Li, Yu Wang, Qinxue Bao, Siyuan Wu, Xueqin Deng, Xiaoju Tang, Wenchao Wu, Xiaojing Li. Critical role of X-box binding protein 1 in NADPH oxidase 4-triggered cardiac hypertrophy is mediated by receptor interacting protein kinase 1. Cell cycle (Georgetown, Tex.). vol 16. issue 4. 2017-06-19. PMID:27929749. |
nadph oxidase 4 (nox4) and the nox4-related redox signaling are implicated in cardiac hypertrophy. |
2017-06-19 |
2023-08-13 |
rat |
| Li Chen, Mingyue Zhao, Junli Li, Yu Wang, Qinxue Bao, Siyuan Wu, Xueqin Deng, Xiaoju Tang, Wenchao Wu, Xiaojing Li. Critical role of X-box binding protein 1 in NADPH oxidase 4-triggered cardiac hypertrophy is mediated by receptor interacting protein kinase 1. Cell cycle (Georgetown, Tex.). vol 16. issue 4. 2017-06-19. PMID:27929749. |
gene silencing of nox4 by specific small interfering rna (sirna) significantly blocked the upregulation of nox4, generation of ros, splicing of xbp1 and activation of the ripk1-related nf-κb signaling, meanwhile attenuated cardiomyocyte hypertrophy. |
2017-06-19 |
2023-08-13 |
rat |