| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bijaya K Nayak, Karthigayan Shanmugasundaram, William E Friedrichs, Rita C Cavaglierii, Mandakini Patel, Jeffrey Barnes, Karen Bloc. HIF-1 Mediates Renal Fibrosis in OVE26 Type 1 Diabetic Mice. Diabetes. vol 65. issue 5. 2017-06-06. PMID:26908870. |
yc-1 [3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole], an hif-1 inhibitor, reduced whole kidney glomerular hypertrophy, mesangial matrix expansion, extracellular matrix accumulation, and urinary albumin excretion as well as nox4 protein expression and nadph-dependent reactive oxygen species production, while blood glucose levels remained unchanged. |
2017-06-06 |
2023-08-13 |
mouse |
| Yu-Peng Huang, Hong-Yan Jin, Hui-Ping Y. Inhibitory effects of alpha-lipoic acid on oxidative stress in the rostral ventrolateral medulla in rats with salt-induced hypertension. International journal of molecular medicine. vol 39. issue 2. 2017-03-16. PMID:28035366. |
it also decreased the levels of superoxide, nox2, nox4 and mitochondrial mda, and increased the levels of cu/zn‑sod, mitochondrial sod and gsh in the rvlm compared with the rats fed a high-salt diet and not treated with ala. on the whole, our findings indicate that long‑term ala supplementation attenuates hypertensive responses and cardiac hypertrophy by decreasing the expression of nad(p)h subunits (nox2 and nox4), increasing the levels of mitochondrial bioenergetic enzymes, and enhancing the intracellular antioxidant capacity in the rvlm during the development of hypertension. |
2017-03-16 |
2023-08-13 |
rat |
| Young-Hyun You, Tammy Quach, Rintaro Saito, Jessica Pham, Kumar Sharm. Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease. Journal of the American Society of Nephrology : JASN. vol 27. issue 2. 2016-06-07. PMID:26203118. |
we report that podocyte-specific induction of nox4 in vivo was sufficient to recapitulate the characteristic glomerular changes noted with dkd, including glomerular hypertrophy, mesangial matrix accumulation, glomerular basement membrane thickening, albuminuria, and podocyte dropout. |
2016-06-07 |
2023-08-13 |
mouse |
| Shuhui Guo, Xiuping Che. The human Nox4: gene, structure, physiological function and pathological significance. Journal of drug targeting. vol 23. issue 10. 2016-05-16. PMID:25950600. |
expression of nox4 in endothelial cells actively mediated endothelial activation, dysfunction and injury, which contributes to the development of atherosclerosis, hypertension, cardiac hypertrophy and among others. |
2016-05-16 |
2023-08-13 |
human |
| Clintoria R Williams, Brandi M Wynne, Makeeva Walker, Robert S Hoover, Jennifer L Gooc. Compensatory renal hypertrophy following uninephrectomy is calcineurin-independent. Journal of cellular and molecular medicine. vol 18. issue 12. 2015-08-28. PMID:25287476. |
unx induces ~15% increase in the size of the remaining kidney; the data show no change in the generation of reactive oxygen species (ros), nox4 or transforming growth factor-β expression confirming the model as one of compensatory hypertrophy. |
2015-08-28 |
2023-08-13 |
mouse |
| Kimiharu Ambe, Hiroki Watanabe, Shinya Takahashi, Toshihiro Nakagaw. Immunohistochemical localization of Nox1, Nox4 and Mn-SOD in mouse femur during endochondral ossification. Tissue & cell. vol 46. issue 6. 2015-07-14. PMID:25152242. |
nox4 was widely positive from the resting over the hypertrophic cell zone. |
2015-07-14 |
2023-08-13 |
mouse |
| Shao-Qing Zhang, Yi-Ting Sun, Tian-Hua Xu, Xue-Feng Zhang, Ying-Zhong Liu, Ma Jian-Fei Ma, Li-Ning Wang, Li Ya. Protective effect of metformin on renal injury of C57BL/6J mouse treated with high fat diet. Die Pharmazie. vol 69. issue 12. 2015-06-02. PMID:25951664. |
at the end of 12th week, compared with mice on low fat diet (lfd), body weight (bw), the levels of fasting insulin (fins), plasma and renal triglyceride (tg) were higher and plasma high density lipoprotein (hdl) and insulin sensitivity index (isi) were significantly lower, but the levels of fasting blood glycemia (fbg), plasma total cholesterol (tc) and renal tc had no changes; oil red o staining revealed renal lipids deposition, masson staining and he staining revealed glomerular hypertrophy, matrix increasing, and inflammatory cells infiltration in glomerular; the expression of p-ampkα protein decreased and the expression of srebp-1c, tnf-α, nox4 mrna increased significantly in mouse treated with high fat diet (hfd). |
2015-06-02 |
2023-08-13 |
mouse |
| Nynke E Hahn, René J P Musters, Jan M Fritz, Patrick J Pagano, Alexander B A Vonk, Walter J Paulus, Albert C van Rossum, Christof Meischl, Hans W M Niessen, Paul A J Krijne. Early NADPH oxidase-2 activation is crucial in phenylephrine-induced hypertrophy of H9c2 cells. Cellular signalling. vol 26. issue 9. 2015-03-03. PMID:24794531. |
therefore we aimed to determine the involvement of the nox isoforms nox1, nox2 and nox4 in pe-induced cardiomyocyte hypertrophy. |
2015-03-03 |
2023-08-13 |
rat |
| Bin Liu, Xiu-Ju Luo, Zhong-Bao Yang, Jie-Jie Zhang, Ting-Bo Li, Xiao-Jie Zhang, Qi-Lin Ma, Guo-Gang Zhang, Chang-Ping Hu, Jun Pen. Inhibition of NOX/VPO1 pathway and inflammatory reaction by trimethoxystilbene in prevention of cardiovascular remodeling in hypoxia-induced pulmonary hypertensive rats. Journal of cardiovascular pharmacology. vol 63. issue 6. 2015-01-26. PMID:24492474. |
at the end of experiments, the index for pulmonary vascular remodeling and right ventricle hypertrophy, inflammatory cell infiltration in lung tissue, the plasma levels and lung tissue contents of hydrogen peroxide (h(2)o(2)), the mrna and protein levels for nadph oxidases (nox2, nox4) and vascular peroxidase 1 (vpo1) in pulmonary artery or right ventricle were measured. |
2015-01-26 |
2023-08-12 |
rat |
| Bin Liu, Xiu-Ju Luo, Zhong-Bao Yang, Jie-Jie Zhang, Ting-Bo Li, Xiao-Jie Zhang, Qi-Lin Ma, Guo-Gang Zhang, Chang-Ping Hu, Jun Pen. Inhibition of NOX/VPO1 pathway and inflammatory reaction by trimethoxystilbene in prevention of cardiovascular remodeling in hypoxia-induced pulmonary hypertensive rats. Journal of cardiovascular pharmacology. vol 63. issue 6. 2015-01-26. PMID:24492474. |
the results showed that trimethoxystilbene treatment significantly attenuated hypoxia-induced pulmonary vascular remodeling (such as decrease in the ratio of wall thickness to vessel external diameter) and right ventricle hypertrophy (such as decrease in the ratio of right ventricle weight to the length of the tibia), accompanied by downregulation of nox2, nox4, and vpo1 expression in pulmonary artery or right ventricle, decrease in h(2)o(2) production and inflammatory cell infiltration in lung tissue. |
2015-01-26 |
2023-08-12 |
rat |
| Dorota Przybylska, Grazyna Mosienia. [The role of NADPH oxidase NOX4 in regulation of proliferation, senescence and differentiation of the cells]. Postepy biochemii. vol 60. issue 1. 2014-10-20. PMID:25033544. |
it was shown that nox4 has an impact on vasoconstriction, atherosclerosis development, vascular cells hypertrophy, apoptosis and differentiation. |
2014-10-20 |
2023-08-13 |
human |
| Si-Yu Zeng, Xi Chen, Shao-Rui Chen, Qin Li, Yu-Hua Wang, Jian Zou, Wei-Wei Cao, Jia-Ni Luo, Hui Gao, Pei-Qing Li. Upregulation of Nox4 promotes angiotensin II-induced epidermal growth factor receptor activation and subsequent cardiac hypertrophy by increasing ADAM17 expression. The Canadian journal of cardiology. vol 29. issue 10. 2013-11-26. PMID:23850346. |
upregulation of nox4 promotes angiotensin ii-induced epidermal growth factor receptor activation and subsequent cardiac hypertrophy by increasing adam17 expression. |
2013-11-26 |
2023-08-12 |
Not clear |
| Si-Yu Zeng, Xi Chen, Shao-Rui Chen, Qin Li, Yu-Hua Wang, Jian Zou, Wei-Wei Cao, Jia-Ni Luo, Hui Gao, Pei-Qing Li. Upregulation of Nox4 promotes angiotensin II-induced epidermal growth factor receptor activation and subsequent cardiac hypertrophy by increasing ADAM17 expression. The Canadian journal of cardiology. vol 29. issue 10. 2013-11-26. PMID:23850346. |
in this study, we aimed to confirm the important role of nicotinamide adenine dinucleotide phosphate oxidase 4 (nox4) in ang ii-induced egfr activation and subsequent cardiac hypertrophy by upregulating expression of a disintegrin and metalloproteinase (mmp)-17 (adam17). |
2013-11-26 |
2023-08-12 |
Not clear |
| Yong Wang, Chun Li, Yuli Ouyang, Tianjiao Shi, Xiaomin Yang, Junda Yu, Qi Qiu, Jing Han, Yan Wu, Binghua Tang, Wei Wan. QSYQ Attenuates Oxidative Stress and Apoptosis Induced Heart Remodeling Rats through Different Subtypes of NADPH-Oxidase. Evidence-based complementary and alternative medicine : eCAM. vol 2013. 2013-07-17. PMID:23861715. |
moreover, nox4 was another key targets to inhibit the p53 and caspase3, thus to reduce the hypertrophy and apoptosis, and eventually provide a synergetic cardiac protective effect. |
2013-07-17 |
2023-08-12 |
rat |
| Shouji Matsushima, Junya Kuroda, Tetsuro Ago, Peiyong Zhai, Ji Yeon Park, Lai-Hua Xie, Bin Tian, Junichi Sadoshim. Increased oxidative stress in the nucleus caused by Nox4 mediates oxidation of HDAC4 and cardiac hypertrophy. Circulation research. vol 112. issue 4. 2013-04-16. PMID:23271793. |
increased oxidative stress in the nucleus caused by nox4 mediates oxidation of hdac4 and cardiac hypertrophy. |
2013-04-16 |
2023-08-12 |
Not clear |
| Yasuhiro Maejima, Junya Kuroda, Shouji Matsushima, Tetsuro Ago, Junichi Sadoshim. Regulation of myocardial growth and death by NADPH oxidase. Journal of molecular and cellular cardiology. vol 50. issue 3. 2011-06-09. PMID:21215757. |
although nox2 plays an important role in mediating angiotensin ii-induced cardiac hypertrophy, nox4 mediates cardiac hypertrophy and heart failure in response to pressure overload. |
2011-06-09 |
2023-08-12 |
Not clear |
| Yasuhiro Maejima, Junya Kuroda, Shouji Matsushima, Tetsuro Ago, Junichi Sadoshim. Regulation of myocardial growth and death by NADPH oxidase. Journal of molecular and cellular cardiology. vol 50. issue 3. 2011-06-09. PMID:21215757. |
expression of nox4 is upregulated by hypertrophic stimuli, and nox4 in mitochondria plays an essential role in mediating oxidative stress during pressure overload-induced cardiac hypertrophy. |
2011-06-09 |
2023-08-12 |
Not clear |
| Junya Kuroda, Junichi Sadoshim. NADPH oxidase and cardiac failure. Journal of cardiovascular translational research. vol 3. issue 4. 2010-11-16. PMID:20559780. |
nox4 is localized primarily at mitochondria in cardiac myocytes, and upregulation of nox4 hypertrophic stimuli enhances o(2)(-) production, apoptosis, and mitochondrial dysfunction, thereby playing an important role in mediating cardiac dysfunction. |
2010-11-16 |
2023-08-12 |
Not clear |
| Junya Kuroda, Junichi Sadoshim. NADPH oxidase and cardiac failure. Journal of cardiovascular translational research. vol 3. issue 4. 2010-11-16. PMID:20559780. |
since nox4 could be a key molecule mediating oxidative stress and pathological hypertrophy, it may serve as an important target of heart failure treatment. |
2010-11-16 |
2023-08-12 |
Not clear |
| Junya Kuroda, Tetsuro Ago, Shouji Matsushima, Peiyong Zhai, Michael D Schneider, Junichi Sadoshim. NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 35. 2010-11-15. PMID:20713697. |
in response to pressure overload (po), however, increases in nox4 expression and o(2)(-) production in mitochondria were abolished in c-nox4(-/-) mice, and c-nox4(-/-) mice exhibited significantly attenuated cardiac hypertrophy, interstitial fibrosis and apoptosis, and better cardiac function compared with wt mice. |
2010-11-15 |
2023-08-12 |
mouse |