| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tetsuro Ago, Junya Kuroda, Jayashree Pain, Cexiong Fu, Hong Li, Junichi Sadoshim. Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. Circulation research. vol 106. issue 7. 2010-04-30. PMID:20185797. |
upregulation of nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. |
2010-04-30 |
2023-08-12 |
Not clear |
| Karen Block, Assaad Eid, Kathy K Griendling, Duck-Yoon Lee, Yohann Wittrant, Yves Gori. Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression. The Journal of biological chemistry. vol 283. issue 35. 2008-10-03. PMID:18559349. |
nox4 nad(p)h oxidase mediates src-dependent tyrosine phosphorylation of pdk-1 in response to angiotensin ii: role in mesangial cell hypertrophy and fibronectin expression. |
2008-10-03 |
2023-08-12 |
Not clear |
| Karen Block, Assaad Eid, Kathy K Griendling, Duck-Yoon Lee, Yohann Wittrant, Yves Gori. Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression. The Journal of biological chemistry. vol 283. issue 35. 2008-10-03. PMID:18559349. |
importantly, inhibition of nox4, src, or pdk-1 prevents the stimulatory effect of ang ii on fibronectin accumulation and cell hypertrophy. |
2008-10-03 |
2023-08-12 |
Not clear |
| Ariel H Polizio, Karina B Balestrasse, Gustavo G Yannarelli, Guillermo O Noriega, Susana Gorzalczany, Carlos Taira, Maria L Tomar. Angiotensin II regulates cardiac hypertrophy via oxidative stress but not antioxidant enzyme activities in experimental renovascular hypertension. Hypertension research : official journal of the Japanese Society of Hypertension. vol 31. issue 2. 2008-05-08. PMID:18360053. |
angiotensin ii induced cardiac hypertrophy and oxidative stress via nox4, p22(phox) and p47(phox), which are components of the nad(p)h oxidase. |
2008-05-08 |
2023-08-12 |
rat |
| Anne Sturrock, Thomas P Huecksteadt, Kimberly Norman, Karl Sanders, Thomas M Murphy, Pasquale Chitano, Kimberly Wilson, John R Hoidal, Thomas P Kenned. Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology. vol 292. issue 6. 2007-07-27. PMID:17369289. |
nox4 mediates tgf-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. |
2007-07-27 |
2023-08-12 |
human |
| Anne Sturrock, Thomas P Huecksteadt, Kimberly Norman, Karl Sanders, Thomas M Murphy, Pasquale Chitano, Kimberly Wilson, John R Hoidal, Thomas P Kenned. Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology. vol 292. issue 6. 2007-07-27. PMID:17369289. |
in this study, we demonstrate that tgf-beta1 is a potent inducer of expression of the nonphagocyte nad(p)h oxidase catalytic homolog nox4, diphenylene iodonium-inhibitable reactive oxygen species production, proliferation, and hypertrophy in cultured human airway smooth muscle cells. |
2007-07-27 |
2023-08-12 |
human |
| Anne Sturrock, Thomas P Huecksteadt, Kimberly Norman, Karl Sanders, Thomas M Murphy, Pasquale Chitano, Kimberly Wilson, John R Hoidal, Thomas P Kenned. Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology. vol 292. issue 6. 2007-07-27. PMID:17369289. |
silencing nox4 prevented tgf-beta1-mediated retinoblastoma protein phosphorylation, proliferation, and cell hypertrophy. |
2007-07-27 |
2023-08-12 |
human |
| Anne Sturrock, Thomas P Huecksteadt, Kimberly Norman, Karl Sanders, Thomas M Murphy, Pasquale Chitano, Kimberly Wilson, John R Hoidal, Thomas P Kenned. Nox4 mediates TGF-beta1-induced retinoblastoma protein phosphorylation, proliferation, and hypertrophy in human airway smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology. vol 292. issue 6. 2007-07-27. PMID:17369289. |
this is the first report to suggest a functional role for nox4 in cell cycle transition and to demonstrate that nox4 influences the pathobiochemistry of asthma by generating reactive oxygen species that promote tgf-beta1-induced proliferation and hypertrophy of human airway smooth muscle. |
2007-07-27 |
2023-08-12 |
human |
| Yves Gorin, Karen Block, James Hernandez, Basant Bhandari, Brent Wagner, Jeffrey L Barnes, Hanna E Abbou. Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. The Journal of biological chemistry. vol 280. issue 47. 2006-02-03. PMID:16135519. |
nox4 nad(p)h oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. |
2006-02-03 |
2023-08-12 |
rat |
| Yves Gorin, Karen Block, James Hernandez, Basant Bhandari, Brent Wagner, Jeffrey L Barnes, Hanna E Abbou. Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. The Journal of biological chemistry. vol 280. issue 47. 2006-02-03. PMID:16135519. |
we investigated the role of the nad(p)h oxidase nox4 in generation of reactive oxygen species (ros), hypertrophy, and fibronectin expression in a rat model of type 1 diabetes induced by streptozotocin. |
2006-02-03 |
2023-08-12 |
rat |
| Yves Gorin, Karen Block, James Hernandez, Basant Bhandari, Brent Wagner, Jeffrey L Barnes, Hanna E Abbou. Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. The Journal of biological chemistry. vol 280. issue 47. 2006-02-03. PMID:16135519. |
these data establish a role for nox4 as the major source of ros in the kidneys during early stages of diabetes and establish that nox4-derived ros mediate renal hypertrophy and increased fibronectin expression. |
2006-02-03 |
2023-08-12 |
rat |
| Yves Gorin, Jill M Ricono, Brent Wagner, Nam-Ho Kim, Basant Bhandari, Goutam Ghosh Choudhury, Hanna E Abbou. Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells. The Biochemical journal. vol 381. issue Pt 1. 2004-11-04. PMID:15027896. |
this pathway involving aa, rac1, nox4, reactive oxygen species and erk1/erk2 may play an important role in ang ii-induced mesangial cell hypertrophy. |
2004-11-04 |
2023-08-12 |
Not clear |
| Yves Gorin, Jill M Ricono, Nam-Ho Kim, Basant Bhandari, Goutam Ghosh Choudhury, Hanna E Abbou. Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells. American journal of physiology. Renal physiology. vol 285. issue 2. 2003-08-19. PMID:12842860. |
n17rac1 or as nox4 abolished ang ii- or aa-induced activation of the hypertrophic kinase akt/pkb. |
2003-08-19 |
2023-08-12 |
Not clear |