| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C J Cruz, R M Beckstea. Quantitative radioimmunocytochemical evidence that haloperidol and SCH 23390 induce opposite changes in substance P levels of rat substantia nigra. Brain research. vol 457. issue 1. 1988-11-23. PMID:2458801. |
chronic blockade of the dopamine (da) d2 receptor by repeated systemic administration of the butyrophenone neuroleptic, haloperidol (hal), is known to lead to a decrease in levels of the neuroactive peptide, substance p (sp), in the rat striatum and substantia nigra (sn). |
1988-11-23 |
2023-08-11 |
rat |
| M Y Globus, R Busto, W D Dietrich, E Martinez, I Valdes, M D Ginsber. Intra-ischemic extracellular release of dopamine and glutamate is associated with striatal vulnerability to ischemia. Neuroscience letters. vol 91. issue 1. 1988-11-23. PMID:2902538. |
we have previously described a marked attenuation of postischemic striatal neuronal death by prior substantia nigra (sn) lesion, and have shown that lowering the brain temperature by only a few degrees during ischemia also confers a marked protective effect. |
1988-11-23 |
2023-08-11 |
rat |
| M Beninato, R F Spence. The cholinergic innervation of the rat substantia nigra: a light and electron microscopic immunohistochemical study. Experimental brain research. vol 72. issue 1. 1988-11-23. PMID:3169185. |
putative cholinergic axons and synaptic endings were demonstrated in the substantia nigra (sn) of the rat by light and electron microscopy on the basis of the localization of choline acetyltransferase (chat) immunoreactivity. |
1988-11-23 |
2023-08-11 |
rat |
| M Y Globus, R Busto, W D Dietrich, E Martinez, I Valdes, M D Ginsber. Effect of ischemia on the in vivo release of striatal dopamine, glutamate, and gamma-aminobutyric acid studied by intracerebral microdialysis. Journal of neurochemistry. vol 51. issue 5. 1988-11-22. PMID:2902196. |
we have previously described a marked attenuation of postischemic striatal neuronal death by prior substantia nigra (sn) lesioning. |
1988-11-22 |
2023-08-11 |
rat |
| K Gal. Progression and generalization of seizure discharge: anatomical and neurochemical substrates. Epilepsia. vol 29 Suppl 2. 1988-11-15. PMID:2844521. |
the substantia nigra (sn) and the area tempestas (at) have been identified as two exemplary substrates for the control of experimental seizures. |
1988-11-15 |
2023-08-11 |
Not clear |
| C Silva-Barrat, S Brailowsky, D Riche, C Menin. Anticonvulsant effects of localized chronic infusions of GABA in cortical and reticular structures of baboons. Experimental neurology. vol 101. issue 3. 1988-10-24. PMID:3416984. |
the gaba infusion has partial anticonvulsant effects when applied to the motor cortex, reticular magnocellular nucleus (rmc), or substantia nigra (sn), but when directed to the prefrontal cortex (area 8) it has no effect. |
1988-10-24 |
2023-08-11 |
Not clear |
| F Gra. [The neuropathology of Parkinson syndrome]. Revue neurologique. vol 144. issue 4. 1988-10-14. PMID:2843979. |
parkinsonism is due to an alteration of the dopaminergic nigro-striatal pathway the main morphological basis of which is a lesion of the substantia nigra (sn). |
1988-10-14 |
2023-08-11 |
Not clear |
| M L Kemel, M Desban, C Gauchy, J Glowinski, M J Besso. Topographical organization of efferent projections from the cat substantia nigra pars reticulata. Brain research. vol 455. issue 2. 1988-09-22. PMID:2456843. |
the topographical organization of the efferent projections from the cat substantia nigra (sn) to the thalamus and the superior colliculus was examined using the anterograde transport of horseradish peroxidase-wheat germ agglutinin (hrp-wga) and of labelled proteins. |
1988-09-22 |
2023-08-11 |
cat |
| M E Old. The response of non-dopamine neurons in substantia nigra and ventral tegmental area to amphetamine and apomorphine during hypermotility: the striatal influence. Brain research. vol 452. issue 1-2. 1988-09-15. PMID:3401732. |
the effects of haloperidol pretreatment in striatum on the motor response, and on concurrently recorded unit responses of nondopamine (da) neurons in substantia nigra (sn) and ventral tegmental area (vta) to systemic amphetamine and apomorphine, were investigated with the objective of determining the role of the striatum in the output of putative da output neurons. |
1988-09-15 |
2023-08-11 |
human |
| S E Brauth, C A Kitt, C R Gerfe. Calcium binding protein in the basal ganglia system of a non-mammalian vertebrate: an immunohistochemical study in the reptile Caiman crocodilus. Brain research. vol 452. issue 1-2. 1988-09-15. PMID:3401743. |
in caiman, calbindin d28k immunoreactivity (cabp) was observed within many neurons of the substantia nigra (sn) but only in the caudal portion of the area ventralis of tsai (avt). |
1988-09-15 |
2023-08-11 |
Not clear |
| H Nabatame, M Sasa, S Takaori, M Kameyam. Muscarinic receptor-mediated inhibition of dopaminergic excitatory input to caudate neurons from the substantia nigra. Japanese journal of pharmacology. vol 46. issue 4. 1988-09-09. PMID:3404769. |
iontophoretic application of carbachol inhibited the spikes elicited by substantia nigra (sn) stimulation in 21 of 24 caudate neurons in which the spikes induced by sn stimulation were inhibited by microiontophoretically applied domperidone, a dopamine d-2 receptor antagonist. |
1988-09-09 |
2023-08-11 |
rat |
| M Sasa, Y Ohno, S Takaor. Presynaptic inhibition of excitatory input from the substantia nigra to caudate nucleus neurons by a substituted quinolinone derivative, 7-[3-(4-(2,3-dimethylphenyl)piperazinyl)propoxy]-2(1H)-quinolinone (OPC-4392). Life sciences. vol 43. issue 3. 1988-08-31. PMID:3398698. |
in the cn neurons of which spikes elicited by stimulation of the pars compacta of substantia nigra (sn) were suppressed by iontophoretically applied domperidone, a dopamine d-2 receptor antagonist, application of opc-4392 (100-200 na) inhibited the spike generation induced by sn stimulation. |
1988-08-31 |
2023-08-11 |
Not clear |
| R G Fariello, T N Ferraro, G T Golden, M DeMatte. Systemic acetyl-L-carnitine elevates nigral levels of glutathione and GABA. Life sciences. vol 43. issue 3. 1988-08-31. PMID:3398700. |
amino acid and reduced glutathione (gsh) levels in substantia nigra (sn) as well as striatal monoamine levels were measured in acetyl-l-carnitine (alcar) treated and control swiss-webster mice. |
1988-08-31 |
2023-08-11 |
mouse |
| G S Robertson, H A Robertso. Evidence that the substantia nigra is a site of action for L-DOPA. Neuroscience letters. vol 89. issue 2. 1988-08-22. PMID:3393296. |
rats with unilateral 6-hydroxydopamine lesions of the substantia nigra (sn) were challenged with l-dopa (25 mg/kg, i.p.). |
1988-08-22 |
2023-08-11 |
rat |
| L C Triarhou, J Norton, B Ghett. Mesencephalic dopamine cell deficit involves areas A8, A9 and A10 in weaver mutant mice. Experimental brain research. vol 70. issue 2. 1988-07-29. PMID:2898380. |
cell counts were obtained in areas a8 (retrorubral nucleus, rrn), a9 (substantia nigra, sn), and a10 (ventral tegmental area, vta). |
1988-07-29 |
2023-08-11 |
mouse |
| b' K Inamura, M L Smith, Y Olsson, B K Siesj\\xc3\\xb. Pathogenesis of substantia nigra lesions following hyperglycemic ischemia: changes in energy metabolites, cerebral blood flow, and morphology of pars reticulata in a rat model of ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 8. issue 3. 1988-06-20. PMID:3366799.' |
in order to study whether the lesion was due to changes occurring during ischemia, local cerebral blood flow (l-cbf) and energy metabolites were measured in the substantia nigra (sn) and in other brain areas. |
1988-06-20 |
2023-08-11 |
human |
| K M Kendrick, E B Keverne, C Chapman, B A Baldwi. Intracranial dialysis measurement of oxytocin, monoamine and uric acid release from the olfactory bulb and substantia nigra of sheep during parturition, suckling, separation from lambs and eating. Brain research. vol 439. issue 1-2. 1988-06-08. PMID:3359176. |
intracranial dialysis was used to measure the release of oxytocin (oxy), monoamines and their metabolites and uric acid (ua) from the substantia nigra (sn) and olfactory bulb (ob) of sheep during parturition, suckling, separation from lambs and eating. |
1988-06-08 |
2023-08-11 |
Not clear |
| b' E F Sperber, B Y Wong, J N Wurpel, S L Mosh\\xc3\\xa. Nigral infusions of muscimol or bicuculline facilitate seizures in developing rats. Brain research. vol 465. issue 1-2. 1988-04-19. PMID:3440204.' |
the substantia nigra (sn) appears to be a crucial site involved in the modification of seizures. |
1988-04-19 |
2023-08-11 |
rat |
| G Waksman, E Hamel, P Delay-Goyet, B P Roque. Neutral endopeptidase-24.11, mu and delta opioid receptors after selective brain lesions: an autoradiographic study. Brain research. vol 436. issue 2. 1988-03-25. PMID:2829989. |
kainic acid injection in the cp induced in the globus pallidus (gp) and substantia nigra (sn) a distant reduction of the 3 opioid markers. |
1988-03-25 |
2023-08-11 |
rat |
| H Arai, D J Sirinathsinghji, P C Emso. Depletion in substance P- and neurokinin A-like immunoreactivity in substantia nigra after ibotenate-induced lesions of striatum. Neuroscience research. vol 5. issue 2. 1988-03-14. PMID:2448711. |
changes in substance p (sp)- and neurokinin a (nka)-like immunoreactivity (li) in the rat substantia nigra (sn) after striatal lesion produced by ibotenate were studied using immunohistochemical methods. |
1988-03-14 |
2023-08-11 |
rat |