| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Min Hyung Seo, Sujung Ye. Acupuncture regulates α-synuclein expression via Acupuncture in medicine : journal of the British Medical Acupuncture Society. 2025-03-25. PMID:40130647. |
acupuncture regulates α-synuclein expression via parkinson's disease (pd) is a neurodegenerative disorder that is characterized by a substantial loss of dopaminergic cells in the substantia nigra (sn) and the formation of intracellular lewy bodies, which are mainly composed of α-synuclein (α-syn). |
2025-03-25 |
2025-03-27 |
Not clear |
| Minxia Xiu, Yanhong Liu, Zhaobo Wang, Jing Zhang, Yaying Shi, Junxia Xie, Limin Sh. Abnormal iron metabolism in the zona incerta in Parkinson's disease mice. Journal of neural transmission (Vienna, Austria : 1996). 2025-03-22. PMID:40119221. |
parkinson's disease (pd) is characterized by the loss of dopaminergic neurons in the substantia nigra (sn) and abnormal iron metabolism. |
2025-03-22 |
2025-03-25 |
mouse |
| Jihu Zhao, Deyuan Zhu, Yue Chen, Pengju Ma, Suya Li, Shifei Ye, Wei Cao, Shuai Han, Yibin Fan. T-type calcium channels attenuate anxiety in MPTP-treated mice through modulating burst firing of dopaminergic neuron. Neuropharmacology. 2025-03-21. PMID:40118209. |
however, the effects of t-vgcc on dopaminergic (daergic) neurons in the substantia nigra (sn) remain unclear. |
2025-03-21 |
2025-03-24 |
mouse |
| Rebecca R Valentino, Shunsuke Koga, Alexandra I Soto-Beasley, Daisuke Ono, Mikolaj A Wieczorek, Patrick W Johnson, Launia J White, Molly M Watkins, Melissa E Murray, Koji Kasanuki, Pamela J McLean, Wolfdieter Springer, Ryan J Uitti, Julie A Fields, Hugo Botha, Vijay K Ramanan, Kejal Kantarci, Val J Lowe, Clifford R Jack, Jose Bras, Rita Guerreiro, Nilufer Ertekin-Taner, Rodolfo Savica, Jonathan Graff-Radford, Ronald C Petersen, Joseph E Parisi, R Ross Reichard, Neill R Graff-Radford, Tanis J Ferman, Bradley F Boeve, Zbigniew K Wszolek, Dennis W Dickson, Michael G Heckman, Owen A Ros. Genome-wide association study of neuropathological features in Lewy body disease. Brain : a journal of neurology. 2025-03-17. PMID:40091616. |
the 11 neuropathological outcomes included braak neurofibrillary tangle (nft) stage, thal amyloid phase, lbd subtype, lewy body (lb) counts in five different brain regions, dorsolateral and ventromedial putaminal tyrosine hydroxylase immunoreactivity (th-ir), and neuronal loss in the ventrolateral part of the substantia nigra (sn). |
2025-03-17 |
2025-03-20 |
Not clear |
| Mehrdad Mozafar, Zobeydeh Dehghan Manshadi, Zohreh Molaei, Hedye Babaei, Meysam Mansouri, Sahba Shahbazi, Shayan Shakeri, Hanieh Mirhosseini, David Gulisashvili, Mahsa Mayel. Microstructural patterns in substantia nigra subregions are associated with depression and olfactory impairments in Parkinson's disease. Clinical neurology and neurosurgery. vol 251. 2025-03-13. PMID:40080943. |
the link between non-motor symptoms, particularly depression, and olfactory dysfunction, and substantia nigra (sn) subregions has been studied less. |
2025-03-13 |
2025-03-16 |
Not clear |
| Vipul Sharma, Bhat Zada Unjum Saqib, Khadga Raj Ara. Leptin as a potential neuroprotective target in Parkinson's Disease: Exploring its role in Neuroinflammation, oxidative Stress, and dopaminergic neurodegeneration. Neuroscience. 2025-03-10. PMID:40064367. |
parkinson's disease (pd) is the second most commonneurodegenerative disease, characterized bybradykinesia, resting tremor, stiffness, and postural instabilityresulting due to the progressive loss ofdopaminergic neurons in the substantia nigra (sn). |
2025-03-10 |
2025-03-13 |
Not clear |
| Francesca Montarolo, Sarah Thielens, Maria Bove, Antonio Bertolotto, Filippo Tempia, Eriola Hoxh. NURR1 Deficiency Is Associated to Altered Microglial Phenotype in Male Mice. Molecular neurobiology. 2025-03-07. PMID:40055293. |
the present work demonstrates that nurr1 deficiency determines a reduction in the number of microglial cells specifically in the substantia nigra (sn), without altering their morphological activation state. |
2025-03-07 |
2025-03-12 |
mouse |
| Irum Waheed, Talal Sikandri, Sumbal Zaheen, Muhammad Mahtab Aslam Khan Khakwani, Zhaowu An, Tingting Liu, Chaoyang Zhu, Jianshe We. Evaluating the Molecular Interactions between Type 2 Diabetes Mellitus and Parkinson's Disease: Role of Antidiabetic Drugs as Promising Therapeutics. ACS chemical neuroscience. 2025-03-05. PMID:40042145. |
it inhibits neuronal function through disrupted insulin signaling and oxidative stress, which ultimately lead to the loss of dopaminergic neurons in the substantia nigra (sn). |
2025-03-05 |
2025-03-07 |
Not clear |
| Mart Kals, Anu Reigo, Maris Teder-Laving, Mariliis Vaht, Tiit Nikopensius, Andres Metspalu, Toomas Toomso. Polygenic Risk Score Combined with Transcranial Sonography Refines Parkinson's Disease Risk Prediction. Movement disorders clinical practice. 2025-02-28. PMID:40019135. |
dopaminergic neuron depletion in the substantia nigra (sn) and the pathological aggregation of α-synuclein are the neuropathological hallmarks of parkinson's disease (pd). |
2025-02-28 |
2025-03-02 |
Not clear |
| Chenxi Ni, Lina Chen, Ruolan Lin, Wan-Yi Zheng, Yiting Cai, Guoen Cai, Yuqi Zeng, Qinyong Ye, Rifeng Jiang, Yì Xiáng J Wán. Diffusion tensor image analysis along the perivascular space and quantitative susceptibility mapping in the diagnosis and severity assessment of Parkinson's disease. Quantitative imaging in medicine and surgery. vol 15. issue 2. 2025-02-25. PMID:39995711. |
increased iron accumulation measured by quantitative susceptibility mapping (qsm) has been observed in various brain regions, especially substantia nigra (sn), in parkinson's disease (pd). |
2025-02-25 |
2025-02-27 |
Not clear |
| Weiling Cheng, Wei Zeng, Jiali Guo, Jiankun Dai, Fuqing Zhou, Fangjun Li, Xin Fan. Radiomics analysis of substantia nigra on multi-echo susceptibility map-weighted imaging for differentiating Parkinson's disease from atypical parkinsonian syndromes. Acta radiologica (Stockholm, Sweden : 1987). 2025-02-24. PMID:39992089. |
while the "swallow tail" sign observed in the substantia nigra (sn) on susceptibility map-weighted imaging (smwi) serves as an effective marker for differentiating patients with parkinson's disease (pd) from healthy individuals, its visual assessment proves inadequate in differentiating pd from atypical parkinson syndromes (aps). |
2025-02-24 |
2025-02-26 |
Not clear |
| Sayan Chatterjee, Arvind Verma, Harsh Thakkar, Ravi P Shah, Amit Khairna. Glycated α-Synuclein Renders Glial Cell Activation and Induces Degeneration of Dopaminergic Neurons: A Potential Implication for the Development of Parkinson's Disease. ACS chemical biology. 2025-02-21. PMID:39982250. |
the gly-α-syn (2 μg/μl) was injected stereotaxically in the substantia nigra (sn) of icr mice (3-4 months) and compared with the normal α-syn, d ribose, and tris-hcl/artificial csf groups. |
2025-02-21 |
2025-02-23 |
mouse |
| Feng Xue, Mei Zhang, Rui-Yue Zhao, Xiao-Wen Wang, Yu Gu, Ye Yang, Wen-Fang Che. Dectin-1 participates in neuroinflammation and dopaminergic neurodegeneration through synergistic signaling crosstalk with TLR4. Brain, behavior, and immunity. 2025-02-20. PMID:39978698. |
inhibition of dectin-1 by laminarin (lam) attenuated lps-induced dopaminergic neuronal damage in substantia nigra (sn) and behavioral deficits, and promoted the phenotypic transformation of microglia from m1 to m2. |
2025-02-20 |
2025-02-23 |
mouse |
| Alyssa M Wilson, Michelle M Jacobs, Tova Y Lambert, Aditi Valada, Gregory Meloni, Evan Gilmore, Jacinta Murray, Susan Morgello, Schahram Akbaria. Transcriptional impacts of substance use disorder and HIV on human ventral midbrain neurons and microglia. bioRxiv : the preprint server for biology. 2025-02-20. PMID:39974894. |
here, we profile, at single nucleus resolution, the substantia nigra (sn) transcriptomes of 90 postmortem donors in the context of chronic hiv and opioid/cocaine sud, including 67 prospectively characterized pwh. |
2025-02-20 |
2025-02-23 |
human |
| Sophie Sun, Victoria Madge, Jelena Djordjevic, Jean-François Gagnon, D Louis Collins, Alain Dagher, Madeleine Shar. Selective Effects of Substantia Nigra and Locus Coeruleus Degeneration on Cognition in Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. 2025-02-13. PMID:39945211. |
the substantia nigra (sn) and locus coeruleus (lc) are among the first brain regions to degenerate in parkinson's disease (pd). |
2025-02-13 |
2025-02-15 |
Not clear |
| Jacopo Pasquini, Michael J Firbank, Laura Best, Victoria Foster, Charlotte Stewart, Vincenzo Silani, Rory Durcan, Gemma Roberts, George Petrides, Roberto Ceravolo, David J Brooks, Kirstie N Anderson, Nicola Paves. Substantia nigra and locus coeruleus microstructural abnormalities in isolated rapid eye movement sleep behaviour disorder and Parkinson's disease. Brain communications. vol 7. issue 1. 2025-02-10. PMID:39926608. |
substantia nigra (sn) and locus coeruleus (lc) are two catecholaminergic, neuromelanin-rich nuclei that are affected in parkinson's disease (pd) and may show neuroimaging abnormalities before the onset of motor manifestations. |
2025-02-10 |
2025-02-13 |
human |
| Emily N Hilz, Cameron Schnurer, Swati Bhamidipati, Jahnabi Deka, Lindsay M Thompson, Andrea C Gor. Cognitive effects of early life exposure to PCBs in rats: Sex-specific behavioral, hormonal and neuromolecular mechanisms involving the brain dopamine system. Hormones and behavior. vol 169. 2025-02-09. PMID:39923265. |
following these tests, rats were euthanized, and serum estradiol (e2), da cells in the midbrain ventral tegmental area (vta) and substantia nigra (sn), and gene expression from those combined midbrain nuclei were measured. |
2025-02-09 |
2025-02-13 |
rat |
| Rana M Merghany, Salma A El-Sawi, Asmaa F Aboul Naser, Mohamed A Salem, Shahira M Ezzat, Sherifa F A Moustafa, Meselhy R Meselh. Pelargonium graveolens Attenuates Rotenone-Induced Parkinson's Disease in a Rat Model: Role of MAO-B Inhibition and In Silico Study. Molecular neurobiology. 2025-02-08. PMID:39921688. |
parkinson's disease (pd), the second most common neurodegenerative condition, is primarily characterized by motor dysfunctions due to dopaminergic neuronal loss in the substantia nigra (sn), with oxidative stress playing a significant role in its progression. |
2025-02-08 |
2025-02-11 |
rat |
| Ankumoni Dutta, Rubina Roy, Mritunjay Pandey, Sushila Chhetry, Banashree Chetia Phukan, Abhideep Roy, Pallab Bhattacharya, Anupom Bora. Arsenic-induced mice model of Parkinson's disease: Revealing the neurotoxicity of arsenic through mitochondrial complexes inhibition and dopaminergic neurodegeneration in the substantia nigra region of brain. Brain research. 2025-02-05. PMID:39909295. |
however, the impact of arsenic toxicity on the dopaminergic neurons of substantia nigra (sn), the hallmark region which degenerates in pd, has not been shown yet. |
2025-02-05 |
2025-02-08 |
mouse |
| Samantha Edwards, Frances Corrigan, Lyndsey Collins-Prain. Lasting Impact: Exploring the Brain Mechanisms that Link Traumatic Brain Injury to Parkinson's Disease. Molecular neurobiology. 2025-02-01. PMID:39891816. |
of note, many key parallels have been identified between the pathologies of pd and tbi; in particular, pd is characterised by loss of dopaminergic neurons from the substantia nigra (sn), accompanied by broader changes to dopaminergic signalling, disruption of the locus coeruleus (lc) and noradrenergic system, and accumulation of aggregated α-synuclein in lewy bodies, which spreads in a stereotypical pattern throughout the brain. |
2025-02-01 |
2025-02-04 |
Not clear |