| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yaotian Tian, Xinyang Li, Haibo Chen, Wen Su, Shuhua Li, Dandan Zheng, Chunmei Li, Min Che. Altered Nigral Amide Proton Transfer Imaging Signal Concordant With Motor Asymmetry in Parkinson's Disease: A Multipool CEST MRI Study. NMR in biomedicine. vol 38. issue 2. 2024-12-27. PMID:39726050. |
compared with nc, amide proton transfer (apt) was significantly decreased in the more affected sides of substantia nigra (sn) and red nucleus in the pd_ma, pd_sma, and pd_hemi groups. |
2024-12-27 |
2024-12-29 |
Not clear |
| Nehal Shawky Nagy, Mohamed Helal, Eman Sheta Alsawy, Mohamad Moustafa Ali, Soheir Salem Al-Sherif, Amina Essawy Essaw. Paracentrotus lividus sea urchin gonadal extract mitigates neurotoxicity and inflammatory signaling in a rat model of Parkinson's disease. PloS one. vol 19. issue 12. 2024-12-18. PMID:39693313. |
parkinson's disease, characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn), is exacerbated by oxidative stress and neuroinflammation. |
2024-12-18 |
2024-12-21 |
rat |
| Natalie Lipari, Ashley Galfano, Shruti Venkatesh, Han Grezenko, Ivette M Sandoval, Fredric P Manfredsson, Christopher Bisho. The effects of chemogenetic targeting of serotonin-projecting pathways on L-DOPA-induced dyskinesia and psychosis in a bilateral rat model of Parkinson's disease. Frontiers in neural circuits. vol 18. 2024-12-05. PMID:39634948. |
parkinson's disease (pd) is commonly characterized by severe dopamine (da) depletion within the substantia nigra (sn) leading to a myriad of motor and non-motor symptoms. |
2024-12-05 |
2024-12-07 |
rat |
| Piper Schneider, Danielle Goldbaum, Ansh Agarwal, Ashton Taylor, Peyton Sundberg, Eliot L Gardner, Robert Ranaldi, Zhi-Bing You, Ewa Gala. Region-specific neuroadaptations of CRF1 and CRF2 expression following heroin exposure in female rats. Pharmacology, biochemistry, and behavior. 2024-12-03. PMID:39626795. |
heroin-treated rats showed a significant decrease in crf1 receptor protein expression in the ventral tegmental area (vta) and an increase in the nucleus accumbens (nac) but no changes in the prefrontal cortex (pfc), insula, dorsal striatum (dstr), dorsal hippocampus (dhippo), anterior hypothalamus (hypth), amygdala, or substantia nigra (sn) as compared to saline-treated rats. |
2024-12-03 |
2024-12-06 |
rat |
| Leila Maria Guissoni Campos, Gyovanna Sorrentino Dos Santos Campanari, Jeferson Santiago, Eduardo Vinicius Barboza Santos, Alana Cristy Ghiraldelli Santos, Mayara Longui Cabrini, Mauro Audi, Isabela Bazzo Costa, Viviane Canhizares Evangelista de Araujo, Stephannie Monaco Bodra, Maressa Monteiro Pereira Gualassi, Lívia Clemente Motta-Teixeira, Luciana Pinat. Characterization of clock proteins in the substantia nigra and subthalamic nucleus of the Frontiers in neuroanatomy. vol 18. 2024-11-28. PMID:39606564. |
considering that most studies have been conducted in nocturnal rodents, in this study we investigated the presence of per1, per2 and cry1 in neurons of the substantia nigra (sn) and subthalamic nucleus (stn) in a diurnal primate. |
2024-11-28 |
2024-11-30 |
human |
| Hiroshi Sakiyama, Kousuke Baba, Yasuyoshi Kimura, Kotaro Ogawa, Ujiakira Nishiike, Hideki Hayakawa, Miki Yoshida, Cesar Aguirre, Kensuke Ikenaka, Seiichi Nagano, Hideki Mochizuk. Accelerated senescence exacerbates α-synucleinopathy in senescence-accelerated prone 8 mice via persistent neuroinflammation. Neurochemistry international. 2024-11-25. PMID:39586378. |
we injected pff into the substantia nigra (sn) of senescence-accelerated prone 8 (samp8) mice and senescence-accelerated resistant 1 (samr1) mice. |
2024-11-25 |
2024-11-28 |
mouse |
| Jiaqi Wen, Xiaojie Duanmu, Sijia Tan, Chenqing Wu, Xiting Peng, Jianmei Qin, Tao Guo, Shuyue Wang, Haoting Wu, Cheng Zhou, Hui Hong, Weijin Yuan, Qianshi Zheng, Jingjing Wu, Jingwen Chen, Yuelin Fang, Bingting Zhu, Yaping Yan, Jun Tian, Baorong Zhang, Minming Zhang, Xiaojun Guan, Xiaojun X. Spatiotemporal neurodegeneration of the substantia nigra and its connecting cortex and subcortex in Parkinson's disease. European journal of neurology. 2024-11-22. PMID:39575860. |
this study aimed to investigate spatiotemporal neurodegeneration in functional subregions of the substantia nigra (sn) and their connected cortex and subcortex in people with pd. |
2024-11-22 |
2024-11-24 |
Not clear |
| Luiz Fernando A T Pedrão, Pamela O S Medeiros, Estela C Leandro, Barbara Falquett. Parkinson's disease models and death signaling: what do we know until now? Frontiers in neuroanatomy. vol 18. 2024-11-14. PMID:39533977. |
parkinson's disease (pd) is the second neurodegenerative disorder most prevalent in the world, characterized by the loss of dopaminergic neurons in the substantia nigra (sn). |
2024-11-14 |
2024-11-17 |
Not clear |
| Seyed Zanyar Athari, Rana Keyhanmanesh, Fereshteh Farajdokht, Mohammad Karimipour, Negin Azizifar, Soraya Alimohammadi, Gisou Mohadde. AdipoRon improves mitochondrial homeostasis and protects dopaminergic neurons through activation of the AMPK signaling pathway in the 6-OHDA-lesioned rats. European journal of pharmacology. vol 985. 2024-11-13. PMID:39515564. |
after euthanasia, the left substantia nigra (sn) was separated for evaluation of atp, mitochondrial membrane potential (mmp), and protein expressions of ampk, p-ampk, and mitochondrial dynamics markers (mfn-2 and drp-1). |
2024-11-13 |
2024-11-17 |
rat |
| Jin-Sun Park, Yea-Hyun Leem, Do-Yeon Kim, Jae-Min Park, Seong-Eun Kim, Hee-Sun Ki. Neuroprotective and anti-inflammatory effects of the RIPK3 inhibitor GSK872 in an MPTP-induced mouse model of Parkinson's disease. Neurochemistry international. 2024-11-04. PMID:39491747. |
parkinson's disease (pd) is a neurodegenerative disorder triggered by the loss of dopaminergic neurons in the substantia nigra (sn). |
2024-11-04 |
2024-11-06 |
mouse |
| Linglong Xiao, Mengqi Wang, Yifeng Shi, Xinyuejia Huang, Wei Zhang, Yang Wu, Hao Deng, Botao Xiong, Wei Pan, Jie Zhang, Wei Wan. Neuroinflammation-mediated white matter injury in Parkinson's disease and potential therapeutic strategies targeting NLRP3 inflammasome. International immunopharmacology. vol 143. issue Pt 3. 2024-11-03. PMID:39488915. |
most previous studies have focused on neuronal soma in substantia nigra (sn), while wm injury (wmi) in pd has been less studied. |
2024-11-03 |
2024-11-06 |
Not clear |
| Hyun Jung Kwon, Hyo Young Jung, Soo Young Choi, In Koo Hwang, Dae Won Kim, Min Jea Shi. TAT-PPA1 protects against oxidative stress-induced loss of dopaminergic neurons. Molecular and cellular neurosciences. 2024-11-02. PMID:39488259. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn) of the midbrain, resulting in severe motor impairments. |
2024-11-02 |
2024-11-05 |
Not clear |
| Katharina Zühlsdorff, Júlia Sala-Bayo, Sammy Piller, Peter Zhukovsky, Thorsten Lamla, Wiebke Nissen, Moritz von Heimendahl, Serena Deiana, Janet R Nicholson, Trevor W Robbins, Johan Alsiö, Jeffrey W Dalle. Optogenetic activation of mesencephalic projections to the nucleus accumbens shell impairs probabilistic reversal learning by disrupting learning from negative reinforcement. The European journal of neuroscience. 2024-10-31. PMID:39479888. |
optogenetic stimulation of projection neurons from the substantia nigra (sn) to the dms, aligned either with reward receipt or omission or prior to making a choice, had no significant effect on reversal learning. |
2024-10-31 |
2024-11-02 |
rat |
| Qiong Lyu, Rong Chen, Zhengang Qiu, Chuhuai Wang, Rongrong Li. Druggable targets for Parkinson's disease: transcriptomics based Mendelian randomization study. Scientific reports. vol 14. issue 1. 2024-10-29. PMID:39468243. |
first, six geo datasets with transcriptomic data from the substantia nigra (sn) region of the brain were downloaded to find dysregulated druggable genes in pd. |
2024-10-29 |
2024-10-31 |
Not clear |
| Riccardo Rocco Ferrari, Valentina Fantini, Maria Garofalo, Rosalinda Di Gerlando, Francesca Dragoni, Bartolo Rizzo, Erica Spina, Michele Rossi, Chiara Calatozzolo, Xhulja Profka, Mauro Ceroni, Antonio Guaita, Annalisa Davin, Stella Gagliardi, Tino Emanuele Polon. A Map of Transcriptomic Signatures of Different Brain Areas in Alzheimer's Disease. International journal of molecular sciences. vol 25. issue 20. 2024-10-26. PMID:39456899. |
in this study, a whole-transcriptome analysis was carried out on brain samples from the hippocampus (hi), temporal and parietal cortices (tc and pc, respectively), cingulate cortex (cg), and substantia nigra (sn) of six subjects with a definite ad diagnosis and three healthy age-matched controls in duplicate. |
2024-10-26 |
2024-10-29 |
human |
| Xiangbo Zhang, Haiyang Yu, Juan Fen. Emerging role of microglia in inter-cellular transmission of α-synuclein in Parkinson's disease. Frontiers in aging neuroscience. vol 16. 2024-10-24. PMID:39444806. |
the main pathological characteristics of pd are the loss of dopaminergic neurons in the substantia nigra (sn) as well as abnormal aggregation of α-synuclein (α-syn) monomers and oligomers, which results in formation of lewy bodies (lbs). |
2024-10-24 |
2024-10-26 |
Not clear |
| Huifang Wu, Minghao Yan, Tong Wu, Xiaodong Ha. MC-LR disrupts dopamine synthesis in the substantia nigra of midbrain by enhancing the chaperone-mediated autophagy pathway through direct binding to ERK2. Journal of hazardous materials. vol 480. 2024-10-16. PMID:39413523. |
mc-lr could penetrate the blood-brain barrier of mice and accumulate in the substantia nigra (sn) of the midbrain, leading to a reduction in dopamine levels and parkinson's disease (pd)-like motor dysfunction in mice. |
2024-10-16 |
2024-10-19 |
mouse |
| Yueyan Qi, Yuxuan Dong, Jinhu Chen, Siyou Xie, Xin Ma, Xueping Yu, Yang Yu, Yanqin Wan. Lactiplantibacillus plantarum SG5 inhibits neuroinflammation in MPTP-induced PD mice through GLP-1/PGC-1α pathway. Experimental neurology. 2024-10-15. PMID:39406307. |
furthermore, sg5 inhibited mptp-triggered overactivation of microglia and astrocytes in the substantia nigra (sn), attenuated disruption of both blood-brain and intestinal barriers, and suppressed the release of inflammatory factors in the colon and sn. |
2024-10-15 |
2024-10-18 |
mouse |
| Ya Gao, Shuyue Li, Jian Zhang, Yidan Zhang, Yuan Zhao, Shuming Zhang, Lujie Zuo, Guofeng Yan. Atractylenolide-I Ameliorates Motor Deficits and Reduces Inflammation of the Spinal Cord by SIRT1/PGC-1α Pathway in MPTP Subacute Mouse Model of Parkinson's Disease. Neuropsychiatric disease and treatment. vol 20. 2024-10-14. PMID:39399880. |
parkinson's disease (pd) is a neurodegenerative movement disorder that impacts various systems, including the substantia nigra (sn) par compacta (snpc) and extranigral regions like the spinal cord. |
2024-10-14 |
2024-10-16 |
mouse |
| Wen Cheng, Kexin Fang, Xiaorong Ouyang, Lingjing Jin, Yunping Song, Bin Y. Vagus nerve stimulation with a small total charge transfer improves motor behavior and reduces neuroinflammation in a mouse model of Parkinson's disease. Neurochemistry international. vol 180. 2024-10-04. PMID:39362497. |
parkinson's disease (pd) is a common neurodegenerative disease characterized by the loss of dopaminergic (da) neurons in the substantia nigra (sn). |
2024-10-04 |
2024-10-07 |
mouse |