All Relations between dopaminergic and mesencephalon

Publication Sentence Publish Date Extraction Date Species
N Safreena, Indu C Nair, Goutam Chandr. Therapeutic potential of Parkin and its regulation in Parkinson's disease. Biochemical pharmacology. 2024-11-05. PMID:39500382. parkinson's disease (pd) is a debilitating neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the midbrain substantia nigra, resulting in motor and non-motor symptoms. 2024-11-05 2024-11-08 Not clear
Hyun Jung Kwon, Hyo Young Jung, Soo Young Choi, In Koo Hwang, Dae Won Kim, Min Jea Shi. TAT-PPA1 protects against oxidative stress-induced loss of dopaminergic neurons. Molecular and cellular neurosciences. 2024-11-02. PMID:39488259. parkinson's disease (pd) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn) of the midbrain, resulting in severe motor impairments. 2024-11-02 2024-11-05 Not clear
Mohd Yaseen Malik, Fei Guo, Aman Asif-Malik, Vasileios Eftychidis, Nikolaos Barkas, Elena Eliseeva, Kerstin N Timm, Aleksandra Wolska, David Bergin, Barbara Zonta, Veronika Ratz-Wirsching, Stephan von Hörsten, Mark E Walton, Peter J Magill, Claus Nerlov, Liliana Minichiell. Impaired striatal glutathione-ascorbate metabolism induces transient dopamine increase and motor dysfunction. Nature metabolism. 2024-10-29. PMID:39468205. here, we demonstrate that genetic disruption of ispns function by ntrk2/trkb deletion in mice results in increased striatal dopamine and midbrain dopaminergic neurons, preceding hyperkinetic dysfunction. 2024-10-29 2024-10-31 mouse
Hao Wu, Zhen-Hua Zhang, Ping Zhou, Xin Sui, Xi Liu, Yi Sun, Xin Zhao, Xiao-Ping P. A Single-Cell Atlas of the Substantia Nigra Reveals Therapeutic Effects of Icaritin in a Rat Model of Parkinson's Disease. Antioxidants (Basel, Switzerland). vol 13. issue 10. 2024-10-26. PMID:39456437. degeneration and death of dopaminergic neurons in the substantia nigra of the midbrain are the main pathological changes in parkinson's disease (pd); however, the mechanism underlying the selective vulnerability of specific neuronal populations in pd remains unclear. 2024-10-26 2024-10-29 rat
Heather Lynne Kosakowski, Mark Eldaief, Randy L Buckne. Ventral Striatum is Preferentially Correlated with the Salience Network Including Regions in Dorsolateral Prefrontal Cortex. bioRxiv : the preprint server for biology. 2024-10-17. PMID:39416211. the ventral striatum (vs) receives input from the cerebral cortex and is modulated by midbrain dopaminergic projections in support of processing reward and motivation. 2024-10-17 2024-10-19 human
Min Jung Kim, Daniel J Gibson, Dan Hu, Tomoko Yoshida, Emily Hueske, Ayano Matsushima, Ara Mahar, Cynthia J Schofield, Patlapa Sompolpong, Kathy T Tran, Lin Tian, Ann M Graybie. Dopamine release plateau and outcome signals in dorsal striatum contrast with classic reinforcement learning formulations. Nature communications. vol 15. issue 1. 2024-10-14. PMID:39402067. at most sites, we found no evidence for a transition from outcome signaling to cue signaling, a hallmark of temporal difference reinforcement learning as applied to midbrain dopaminergic neuronal activity. 2024-10-14 2024-10-17 mouse
Astrid M Alsema, Sophie Puvogel, Laura Kracht, Marree J Webster, Cynthia Shannon Weickert, Bart J L Eggen, Iris E C Somme. Schizophrenia-associated changes in neuronal subpopulations in the human midbrain. Brain : a journal of neurology. 2024-10-14. PMID:39397771. dysfunctional gabaergic and dopaminergic neurons are thought to exist in the ventral midbrain of patients with schizophrenia, yet transcriptional changes underpinning these abnormalities have not yet been localized to specific neuronal subsets. 2024-10-14 2024-10-16 human
Astrid M Alsema, Sophie Puvogel, Laura Kracht, Marree J Webster, Cynthia Shannon Weickert, Bart J L Eggen, Iris E C Somme. Schizophrenia-associated changes in neuronal subpopulations in the human midbrain. Brain : a journal of neurology. 2024-10-14. PMID:39397771. in the ventral midbrain, control over dopaminergic activity is maintained by both excitatory (glutamate) and inhibitory (gaba) input neurons. 2024-10-14 2024-10-16 human
Xóchitl Flores-Ponce, Iván Velasc. Dopaminergic neuron metabolism: relevance for understanding Parkinson's disease. Metabolomics : Official journal of the Metabolomic Society. vol 20. issue 6. 2024-10-13. PMID:39397188. dopaminergic neurons from the substantia nigra pars compacta (snc) have a higher susceptibility to aging-related degeneration, compared to midbrain dopaminergic cells present in the ventral tegmental area (vta); the death of dopamine neurons in the snc results in parkinson´s disease (pd). 2024-10-13 2024-10-16 Not clear
Emilía Sif Ásgrímsdóttir, Ernest Arena. Generation of a fluorescent hESC reporter line (Kle033-A-1) for the isolation of distinct midbrain progenitor cell types. Stem cell research. vol 81. 2024-10-09. PMID:39383604. midbrain dopaminergic (mda) neurons derived from human pluripotent stem cells (hpscs) offer a promising cell source for cell replacement therapy in parkinson's disease (pd). 2024-10-09 2024-10-12 human
Azize Yasemin Göks. A review article on the development of dopaminergic neurons and establishment of dopaminergic neuron-based in vitro models by using immortal cell lines or stem cells to study and treat Parkinson's disease. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2024-10-08. PMID:39379284. the primary pathological hallmark of parkinson's disease (pd) is the degeneration of dopaminergic (da) neurons in the substantia nigra pars compacta, a critical midbrain region. 2024-10-08 2024-10-11 Not clear
Can Tao, Guang-Wei Zhang, Wen-Jian Sun, Junxiang J Huang, Li I Zhang, Huizhong Whit Ta. Excitation-inhibition imbalance in medial preoptic area circuits underlies chronic stress-induced depression-like states. Nature communications. vol 15. issue 1. 2024-10-03. PMID:39362860. their projections to ventral tegmental area and periaqueductal gray/dorsal raphe suppress midbrain dopaminergic and serotonergic activity, respectively, and mediate expression of divergent depressive-like symptoms. 2024-10-03 2024-10-07 mouse
Valentina Basso, Máté D Döbrössy, Lachlan H Thompson, Deniz Kirik, Heidi R Fuller, Monte A Gate. State of the Art in Sub-Phenotyping Midbrain Dopamine Neurons. Biology. vol 13. issue 9. 2024-09-28. PMID:39336117. while both groups of dopaminergic neurons are in close proximity in the midbrain and partially overlap, development, function, and impairments in these two classes of neurons are highly diverse. 2024-09-28 2024-10-01 human
Roger A Barker, Philip C Butter. Disease-specific interventions: The use of cell and gene therapies for Parkinson disease. Handbook of clinical neurology. vol 205. 2024-09-28. PMID:39341654. in the case of cell therapies, the ability to make large numbers of authentic midbrain dopaminergic neuroblasts from human pluripotent stem cell sources has turned what was an interesting avenue of research into a major area of investment and trialing, by academics in conjunction with pharma. 2024-09-28 2024-10-01 human
Alessandro Galgani, Marco Scotto, Filippo S Giorg. The Neuroanatomy of Induced Pluripotent Stem Cells: In Vitro Models of Subcortical Nuclei in Neurodegenerative Disorders. Current issues in molecular biology. vol 46. issue 9. 2024-09-27. PMID:39329959. we found that most of the current literature in the field of ipscs and nsss in ndds has focused on midbrain dopaminergic neurons in parkinson's disease, providing interesting results on cellular pathophysiology and even leading to the first human autologous transplantation. 2024-09-27 2024-09-29 human
Hong-Yuan Chu, Liqiang Chen, Hiba Douja Chehad. Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation. Research square. 2024-09-16. PMID:39281856. moreover, it is also unknown whether cortical lewy pathology and midbrain dopaminergic degeneration interact to disrupt cortical function in late-stage. 2024-09-16 2024-09-19 mouse
Hong-Yuan Chu, Liqiang Chen, Hiba Douja Chehad. Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation. Research square. 2024-09-16. PMID:39281856. to begin to address these questions, we injected α-synuclein (αsyn) preformed fibrils (pffs) into the dorsolateral striatum of mice to seed αsyn pathology in the cortical cortex and induce degeneration of midbrain dopaminergic neurons. 2024-09-16 2024-09-19 mouse
M Tatullo, T Cocco, A Ferretta, R Caroppo, B Marrelli, G Spagnuolo, F Paduan. Unveiling the Neurodegenerative Alterations through Oral Stem Cells. Journal of dental research. 2024-09-14. PMID:39275988. parkinson's disease (pd) is a neurodegenerative condition characterized by the progressive and selective loss of dopaminergic (daergic) neurons in the midbrain. 2024-09-14 2024-09-17 human
Shijia Ma, Qianyi Ma, Songhui Hu, Xinlei Mo, Chenze Zhu, Xingxian Zhang, Zetao Jia, Lingjie Tang, Lei Jiang, Yihui Cui, Zhong Chen, Weiwei Hu, Xiangnan Zhan. Deletion of histamine H2 receptor in VTA dopaminergic neurons of mice induces behavior reminiscent of mania. Cell reports. vol 43. issue 9. 2024-09-12. PMID:39264811. histaminergic neurons project dense efferents into the midbrain dopaminergic nuclei. 2024-09-12 2024-09-15 mouse
Kaushik Narasimhan, Abrar Hakami, Giulia Comini, Tommy Patton, Ben Newland, Eilis Dow. Cryogel microcarriers loaded with glial cell line-derived neurotrophic factor enhance the engraftment of primary dopaminergic neurons in a rat model of Parkinson's disease. Journal of neural engineering. 2024-09-04. PMID:39231475. in this context, to develop a proof-of-concept, the aim of this-study was to determine the efficacy of gdnf-loaded cryogel microcarriers by assessing their impact on the survival of, and reinnervation by, primary dopaminergic grafts after intra-striatal delivery in parkinsonian rat brains. approach: rat embryonic day 14 ventral midbrain cells were transplanted into the 6-hydroxydopamine-lesioned striatum either alone, or with gdnf, or with unloaded cryogel microcarriers, or with gdnf-loaded cryogel microcarriers. 2024-09-04 2024-09-08 rat