| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sara Nolbrant, Jenelle L Wallace, Jingwen Ding, Tianjia Zhu, Jess L Sevetson, Janko Kajtez, Isabella A Baldacci, Emily K Corrigan, Kaylynn Hoglin, Reed McMullen, Matthew T Schmitz, Arnar Breevoort, Dani Swope, Fengxia Wu, Bryan J Pavlovic, Sofie R Salama, Agnete Kirkeby, Hao Huang, Nathan K Schaefer, Alex A Polle. Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and Vulnerability. bioRxiv : the preprint server for biology. 2024-11-28. PMID:39605599. |
the disproportionate expansion of telencephalic structures during human evolution involved tradeoffs that imposed greater connectivity and metabolic demands on midbrain dopaminergic neurons. |
2024-11-28 |
2024-11-30 |
human |
| You-Yen Lin, De-Maw Chuang, Cheng-Yu Chi, Shih-Ya Hun. Intranasal administration of mesenchymal stem cells overexpressing FGF21 demonstrates therapeutic potential in experimental Parkinson's disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2024-11-28. PMID:39609161. |
parkinson's disease (pd) is a prevalent movement disorder characterized by mitochondrial dysfunction and dopaminergic neuronal loss in the substantia nigra of the midbrain. |
2024-11-28 |
2024-12-01 |
mouse |
| Jintae Kim, Mi-Yoon Chan. Gene Therapy for Parkinson's Disease Using Midbrain Developmental Genes to Regulate Dopaminergic Neuronal Maintenance. International journal of molecular sciences. vol 25. issue 22. 2024-11-27. PMID:39596436. |
gene therapy for parkinson's disease using midbrain developmental genes to regulate dopaminergic neuronal maintenance. |
2024-11-27 |
2024-11-29 |
Not clear |
| Riko Nakanishi, Yuki Kurauchi, Shunsuke Kotani, Natsuko Hitora-Imamura, Takahiro Seki, Hiroshi Katsuk. Structurally Distinct Nurr1 Ligands Exhibit Different Pharmacological Characteristics in Regulating Inflammatory Responses of Microglial BV-2 Cells. Biological & pharmaceutical bulletin. vol 47. issue 11. 2024-11-27. PMID:39603614. |
nurr1 (nr4a2) is a member of nuclear receptor superfamily that regulates gene transcription in midbrain dopaminergic neurons and also inhibits nuclear factor-κb-mediated inflammatory responses in brain microglial cells. |
2024-11-27 |
2024-11-30 |
Not clear |
| Alan D Kaye, Kassady A Perkinson, Noah J Spillers, Alexis J Vega, Caylin J Roberts, Evan M Downs, Melissa M Sheth, David W McGregor, Shahab Ahmadzadeh, Jibin Mathew, Sahar Shekooh. Parkinson's Disease: A Narrative of the Evolving Understanding of the Role of α-Synuclein in Screening. Current issues in molecular biology. vol 46. issue 11. 2024-11-26. PMID:39590351. |
parkinson's disease (pd) is a debilitating neurodegenerative disorder caused by the loss of dopaminergic neurons in the midbrain, leading to symptoms such as tremors, bradykinesia, postural instability, dementia, and depression. |
2024-11-26 |
2024-11-29 |
Not clear |
| Kyriaki Barmpa, Claudia Saraiva, Diego Lopez-Pigozzi, Gemma Gomez-Giro, Elisa Gabassi, Sarah Spitz, Konstanze Brandauer, Juan E Rodriguez Gatica, Paul Antony, Graham Robertson, Rahman Sabahi-Kaviani, Alessandro Bellapianta, Florentia Papastefanaki, Regina Luttge, Ulrich Kubitscheck, Ahmad Salti, Peter Ertl, Mario Bortolozzi, Rebecca Matsas, Frank Edenhofer, Jens C Schwambor. Modeling early phenotypes of Parkinson's disease by age-induced midbrain-striatum assembloids. Communications biology. vol 7. issue 1. 2024-11-23. PMID:39580573. |
parkinson's disease, an aging-associated neurodegenerative disorder, is characterised by nigrostriatal pathway dysfunction caused by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. |
2024-11-23 |
2024-11-26 |
human |
| Özge Düdükcü, Divya D A Raj, Lieke L van de Haar, Laurens M Grossouw, Louisa E Linders, Oxana Garritsen, Youri Adolfs, Nicky C H van Kronenburg, Mark H Broekhoven, Troy H W Kapteijns, Frank J Meye, R Jeroen Pasterkam. Molecular diversity and migration of GABAergic neurons in the developing ventral midbrain. iScience. vol 27. issue 11. 2024-11-21. PMID:39569362. |
dopaminergic neurons in the ventral midbrain (mda) are surrounded by gabaergic neurons. |
2024-11-21 |
2024-11-23 |
mouse |
| Emanuele Frattini, Gaia Faustini, Gianluca Lopez, Emma V Carsana, Mattia Tosi, Ilaria Trezzi, Manuela Magni, Giulia Soldà, Letizia Straniero, Daniele Facchi, Maura Samarani, Mitchell Martá-Ariza, Chiara M G De Luca, Elena Vezzoli, Alessandra Pittaro, Astghik Stepanyan, Rosamaria Silipigni, Isabel Rosety, Jens C Schwamborn, Sergio P Sardi, Fabio Moda, Stefania Corti, Giacomo P Comi, Fabio Blandini, Nicolas X Tritsch, Mario Bortolozzi, Stefano Ferrero, Fulvia M Cribiù, Thomas Wisniewski, Rosanna Asselta, Massimo Aureli, Arianna Bellucci, Alessio Di Fonz. Lewy pathology formation in patient-derived GBA1 Parkinson's disease midbrain organoids. Brain : a journal of neurology. 2024-11-21. PMID:39570889. |
here, we describe an innovative protocol for the generation of human induced pluripotent stem cell-derived midbrain organoids containing dopaminergic neurons with nigral identity that reproduce characteristics of advanced maturation. |
2024-11-21 |
2024-11-24 |
human |
| Tomohiko Yoshizawa, Makoto Funahash. Dopamine release in striatal striosome compartments in response to rewards and aversive outcomes during classical conditioning in mice. Neuroscience research. 2024-11-09. PMID:39515479. |
the striatum consists of two anatomically and neurochemically distinct compartments, striosomes and the matrix, which receive dopaminergic inputs from the midbrain and exhibit distinct dopamine release dynamics in acute brain slices. |
2024-11-09 |
2024-11-17 |
mouse |
| Maxime Vassili Vounatsos, Aryn H Gitti. GPe Projections to the Retrorubral Field Give Rise to Diverging GABAergic and DAergic Circuits. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-11-07. PMID:39510836. |
here, by anatomical and electrophysiological means we investigate the projections of the gpe to the retrorubral field (rrf), a dopaminergic nucleus in the caudal midbrain, in both male and female mice. |
2024-11-07 |
2024-11-16 |
mouse |
| N Safreena, Indu C Nair, Goutam Chandr. Therapeutic potential of Parkin and its regulation in Parkinson's disease. Biochemical pharmacology. 2024-11-05. PMID:39500382. |
parkinson's disease (pd) is a debilitating neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the midbrain substantia nigra, resulting in motor and non-motor symptoms. |
2024-11-05 |
2024-11-08 |
Not clear |
| Hyun Jung Kwon, Hyo Young Jung, Soo Young Choi, In Koo Hwang, Dae Won Kim, Min Jea Shi. TAT-PPA1 protects against oxidative stress-induced loss of dopaminergic neurons. Molecular and cellular neurosciences. 2024-11-02. PMID:39488259. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra (sn) of the midbrain, resulting in severe motor impairments. |
2024-11-02 |
2024-11-05 |
Not clear |
| Mohd Yaseen Malik, Fei Guo, Aman Asif-Malik, Vasileios Eftychidis, Nikolaos Barkas, Elena Eliseeva, Kerstin N Timm, Aleksandra Wolska, David Bergin, Barbara Zonta, Veronika Ratz-Wirsching, Stephan von Hörsten, Mark E Walton, Peter J Magill, Claus Nerlov, Liliana Minichiell. Impaired striatal glutathione-ascorbate metabolism induces transient dopamine increase and motor dysfunction. Nature metabolism. 2024-10-29. PMID:39468205. |
here, we demonstrate that genetic disruption of ispns function by ntrk2/trkb deletion in mice results in increased striatal dopamine and midbrain dopaminergic neurons, preceding hyperkinetic dysfunction. |
2024-10-29 |
2024-10-31 |
mouse |
| Hao Wu, Zhen-Hua Zhang, Ping Zhou, Xin Sui, Xi Liu, Yi Sun, Xin Zhao, Xiao-Ping P. A Single-Cell Atlas of the Substantia Nigra Reveals Therapeutic Effects of Icaritin in a Rat Model of Parkinson's Disease. Antioxidants (Basel, Switzerland). vol 13. issue 10. 2024-10-26. PMID:39456437. |
degeneration and death of dopaminergic neurons in the substantia nigra of the midbrain are the main pathological changes in parkinson's disease (pd); however, the mechanism underlying the selective vulnerability of specific neuronal populations in pd remains unclear. |
2024-10-26 |
2024-10-29 |
rat |
| Heather Lynne Kosakowski, Mark Eldaief, Randy L Buckne. Ventral Striatum is Preferentially Correlated with the Salience Network Including Regions in Dorsolateral Prefrontal Cortex. bioRxiv : the preprint server for biology. 2024-10-17. PMID:39416211. |
the ventral striatum (vs) receives input from the cerebral cortex and is modulated by midbrain dopaminergic projections in support of processing reward and motivation. |
2024-10-17 |
2024-10-19 |
human |
| Min Jung Kim, Daniel J Gibson, Dan Hu, Tomoko Yoshida, Emily Hueske, Ayano Matsushima, Ara Mahar, Cynthia J Schofield, Patlapa Sompolpong, Kathy T Tran, Lin Tian, Ann M Graybie. Dopamine release plateau and outcome signals in dorsal striatum contrast with classic reinforcement learning formulations. Nature communications. vol 15. issue 1. 2024-10-14. PMID:39402067. |
at most sites, we found no evidence for a transition from outcome signaling to cue signaling, a hallmark of temporal difference reinforcement learning as applied to midbrain dopaminergic neuronal activity. |
2024-10-14 |
2024-10-17 |
mouse |
| Astrid M Alsema, Sophie Puvogel, Laura Kracht, Marree J Webster, Cynthia Shannon Weickert, Bart J L Eggen, Iris E C Somme. Schizophrenia-associated changes in neuronal subpopulations in the human midbrain. Brain : a journal of neurology. 2024-10-14. PMID:39397771. |
dysfunctional gabaergic and dopaminergic neurons are thought to exist in the ventral midbrain of patients with schizophrenia, yet transcriptional changes underpinning these abnormalities have not yet been localized to specific neuronal subsets. |
2024-10-14 |
2024-10-16 |
human |
| Astrid M Alsema, Sophie Puvogel, Laura Kracht, Marree J Webster, Cynthia Shannon Weickert, Bart J L Eggen, Iris E C Somme. Schizophrenia-associated changes in neuronal subpopulations in the human midbrain. Brain : a journal of neurology. 2024-10-14. PMID:39397771. |
in the ventral midbrain, control over dopaminergic activity is maintained by both excitatory (glutamate) and inhibitory (gaba) input neurons. |
2024-10-14 |
2024-10-16 |
human |
| Xóchitl Flores-Ponce, Iván Velasc. Dopaminergic neuron metabolism: relevance for understanding Parkinson's disease. Metabolomics : Official journal of the Metabolomic Society. vol 20. issue 6. 2024-10-13. PMID:39397188. |
dopaminergic neurons from the substantia nigra pars compacta (snc) have a higher susceptibility to aging-related degeneration, compared to midbrain dopaminergic cells present in the ventral tegmental area (vta); the death of dopamine neurons in the snc results in parkinson´s disease (pd). |
2024-10-13 |
2024-10-16 |
Not clear |
| Emilía Sif Ásgrímsdóttir, Ernest Arena. Generation of a fluorescent hESC reporter line (Kle033-A-1) for the isolation of distinct midbrain progenitor cell types. Stem cell research. vol 81. 2024-10-09. PMID:39383604. |
midbrain dopaminergic (mda) neurons derived from human pluripotent stem cells (hpscs) offer a promising cell source for cell replacement therapy in parkinson's disease (pd). |
2024-10-09 |
2024-10-12 |
human |