| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryuta Kuwamizu, Yudai Yamazaki, Naoki Aoike, Dongmin Lee, Hideaki Soy. Resting-state blink rate does not increase following very-light-intensity exercise, but individual variation predicts executive function enhancement levels. Journal of physiological anthropology. vol 44. issue 1. 2025-04-15. PMID:40229907. |
recently, our rodent study demonstrated that exercise, even at light-intensity, activates the midbrain dopaminergic neurons. |
2025-04-15 |
2025-04-17 |
Not clear |
| Fumino Fujiyama, Fuyuki Karub. [Analysis of Nigral Dopamine Neuron Projections]. Brain and nerve = Shinkei kenkyu no shinpo. vol 77. issue 4. 2025-04-13. PMID:40222740. |
environmental adaptation requires reward prediction errors to be transmitted to the striatum by dopaminergic neurons in the substantia nigra pars compacta of the midbrain. |
2025-04-13 |
2025-04-16 |
Not clear |
| Pretty Garg, Mathias Bähr, Sebastian Kügle. Differentiation of Mature Dopaminergic Neurons from Human Induced Pluripotent Stem Cells. Methods in molecular biology (Clifton, N.J.). vol 2910. 2025-04-12. PMID:40220093. |
dopaminergic (da) neurons are one such neuronal subtype that is largely present in the midbrain region of the human brain and controls several functions like voluntary movement, reward, addiction, and stress. |
2025-04-12 |
2025-04-15 |
human |
| Mehwish Mehreen, Mehak Ali, Huraira Tariq, Aneeqa Noor, Sara Mumtaz, Saima Zafa. Chenodeoxycholic Acid-Mediated neuroprotection via α-synuclein and BDNF Modulation in MPTP-Induced mouse model of Parkinson's disease. Neuroscience. 2025-04-04. PMID:40185387. |
furthermore, the effective defense against mptp-induced dopaminergic degeneration was provided by cdca by improving the morphological and histological features of neurons in the midbrain, hippocampus, cortex and cerebellum. |
2025-04-04 |
2025-04-08 |
mouse |
| Xinjie Liu, Zijian Zheng, Cheng Xue, Xiangrong Wang, Jianwei Li, Zheng Liu, Wenqiang Xin, Xinping Xu, Dongwei Zhou, Longping Yao, Guohui L. LRRK2 Mediates α-Synuclein-Induced Neuroinflammation and Ferroptosis through the p62-Keap1-Nrf2 Pathway in Parkinson's Disease. Inflammation. 2025-04-01. PMID:40169487. |
furthermore, conditioned medium from lrrk2-inhibited microglia conferred neuroprotective effects on cultured neurons, highlighting the therapeutic potential of targeting lrrk2 in microglia.importantly, these in vitro findings were corroborated in the mptp-induced pd mouse model, where lrrk2 inhibition led to diminished microglial activation, decreased apoptosis of midbrain dopaminergic neurons, and upregulation of the p62-keap1-nrf2 pathway.our study fills a critical gap in understanding the microglial mechanisms mediated by lrrk2 and provides novel insights into the pathogenesis of pd. |
2025-04-01 |
2025-04-04 |
mouse |
| Weifeng Xu, Meiting Wang, Xiaodan Li, Rongyan He, Ren-Bo Ding, Jiaolin Bao, Dongting Zhangsun, Sulan Lu. α-Conotoxin TxIB Reversed Nicotine-Induced Locomotor Sensitization and Nicotine-Enhanced Dopaminergic Activity in Mice. Marine drugs. vol 23. issue 3. 2025-03-26. PMID:40137295. |
a significant contributor to nicotine addiction is its interaction with α6β2* nachrs located on midbrain dopaminergic neurons, which leads to an increase in dopamine (da) release. |
2025-03-26 |
2025-03-28 |
mouse |
| Sazan Ismael, Sarah Baitamouni, Daewoo Le. Neuroprotective Role of Cyclic AMP Signaling in Dopaminergic Degeneration Induced by a Parkinson's Disease Toxin, Rotenone. NeuroSci. vol 6. issue 1. 2025-03-26. PMID:40137868. |
parkinson's disease (pd) is a progressive neurodegenerative disorder characterized by the selective loss of dopaminergic (da) neurons in the midbrain. |
2025-03-26 |
2025-03-30 |
Not clear |
| Zhao Li, Jinhai Duan, AnQi Cao, Zhuo Gong, Hao Liu, Danyang Shen, Tonglin Ye, Shunyan Zhu, Qikai Cen, Shuaiyin He, Yongqian He, Canbing Zheng, Xian Li. Activating Wnt1/β-Catenin signaling pathway to restore Otx2 expression in the dopaminergic neurons of ventral midbrain. Experimental neurology. 2025-03-15. PMID:40089003. |
activating wnt1/β-catenin signaling pathway to restore otx2 expression in the dopaminergic neurons of ventral midbrain. |
2025-03-15 |
2025-03-18 |
mouse |
| Zhao Li, Jinhai Duan, AnQi Cao, Zhuo Gong, Hao Liu, Danyang Shen, Tonglin Ye, Shunyan Zhu, Qikai Cen, Shuaiyin He, Yongqian He, Canbing Zheng, Xian Li. Activating Wnt1/β-Catenin signaling pathway to restore Otx2 expression in the dopaminergic neurons of ventral midbrain. Experimental neurology. 2025-03-15. PMID:40089003. |
otx2 plays a critical role in the differentiation of midbrain dopaminergic neurons (mdans) during midbrain development. |
2025-03-15 |
2025-03-18 |
mouse |
| Nathany da Silva Nogueira, Taynan Motta Portal, Thuany da Silva Nogueira, Aurenita Emile Sá Miranda, Eldo Campos, Cintia Monteiro de Barro. Neuronal degeneration, mitochondrial dysfunction, and disturbance of movements induced by rotenone in the ascidian Styela plicata. Neurotoxicology. 2025-03-12. PMID:40074177. |
parkinson's disease (pd), a movement disorder caused by dopaminergic degeneration in the midbrain, has been induced in various organisms after injection of different neurotoxins, such as rotenone (rot), which affect mitochondrial complex i. |
2025-03-12 |
2025-03-15 |
Not clear |
| Amalie Holm Nygaard, Alrik L Schörling, Zehra Abay-Nørgaard, Erno Hänninen, Yuan Li, Adrian Santonja, Gaurav Singh Rathore, Alison Salvador, Charlotte Rusimbi, Katrine Bech Lauritzen, Yu Zhang, Agnete Kirkeb. Patterning effects of FGF17 and cAMP on generation of dopaminergic progenitors for cell replacement therapy in Parkinson's disease. Stem cells (Dayton, Ohio). 2025-03-12. PMID:40071608. |
cell replacement therapies using human pluripotent stem cell-derived ventral midbrain (vm) dopaminergic (da) progenitors are currently in clinical trials for treatment of parkinson's disease (pd). |
2025-03-12 |
2025-03-14 |
human |
| Francesca Montarolo, Sarah Thielens, Maria Bove, Antonio Bertolotto, Filippo Tempia, Eriola Hoxh. NURR1 Deficiency Is Associated to Altered Microglial Phenotype in Male Mice. Molecular neurobiology. 2025-03-07. PMID:40055293. |
the transcription factor nuclear receptor related 1 (nurr1) regulates the development and maintenance of midbrain dopaminergic (mda) neurons, which control voluntary movement, motivation, and reward. |
2025-03-07 |
2025-03-12 |
mouse |
| Tsering Yangzom, Anbin Chen, Kristina Xiao Lian. Generation of 3D Midbrain Organoids from Human-Induced Pluripotent Stem Cells. Journal of visualized experiments : JoVE. issue 216. 2025-03-03. PMID:40029817. |
a notable outcome of this methodology is the effective differentiation of ipscs into dopaminergic neurons, which are characteristic of the midbrain. |
2025-03-03 |
2025-03-14 |
human |
| Leah C Beauchamp, Laura J Ellett, Sydney M A Juan, Xiang M Liu, Cameron P J Hunt, Clare L Parish, Laura H Jacobson, Claire E Shepherd, Glenda M Halliday, Ashley I Bush, Laura J Vella, David I Finkelstein, Kevin J Barnha. Evidence of COMT dysfunction in the olfactory bulb in Parkinson's disease. Acta neuropathologica. vol 149. issue 1. 2025-03-02. PMID:40024917. |
in contrast to the loss of dopaminergic neurons in the midbrain, we observed an increase in tyrosine hydroxylase-positive neurons in the parkinson's disease olfactory bulb, suggesting a potential role for dopamine in the hyposmia associated with the condition. |
2025-03-02 |
2025-03-05 |
human |
| Nicole C Miranda, Yasmin C Aquino, Tainá O Macedo, Luiz M Oliveira, Kairo A Albernaz-Mariano, Carolina D Munhoz, Jan-Marino Ramirez, Thiago S Moreira, Ana C Takakur. Role of substantia Nigra dopaminergic neurons in respiratory modulation and limitations of levodopa in Parkinson's disease. Experimental neurology. vol 387. 2025-03-01. PMID:40021074. |
the substantia nigra pars compacta (snpc), a midbrain region enriched with dopaminergic neurons projecting to the dorsal striatum, is essential for motor control and has been implicated in respiratory modulation. |
2025-03-01 |
2025-03-04 |
mouse |
| Fariba Akbari Gavabari, Mohsen Rastegari-Pouyani, Saeid Afshar, Mehrdokht Mazdeh, Armin Bahramian, Siamak Shahidi, Elahe Talebi-Ghane, Mahsa Chalabi, Mohammad Mahdi Eftekharia. Expression levels of protein inhibitor of activated STAT (PIAS) family genes in Parkinson's disease patients: results from a case-control study. Acta neurologica Belgica. 2025-02-27. PMID:40016540. |
parkinson's disease (pd) is one of the most common progressive neurological disorders characterized by the loss of dopaminergic neurons in the substantia nigra of the midbrain. |
2025-02-27 |
2025-03-02 |
Not clear |
| Manal M Khowdiary, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Ali K Albuhadily, Ahmed A Elhenawy, Ahmad O Babalghith, Mustafa M Shokr, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batih. Dysregulation of serotonergic neurotransmission in Parkinson disease: A key duet. European journal of pharmacology. 2025-02-23. PMID:39988096. |
however, motor symptoms in pd are developed due to degeneration of the dopaminergic neurons in the substantia nigra pars compacta (snpc) of midbrain. |
2025-02-23 |
2025-02-26 |
Not clear |
| Manal M Khowdiary, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Ali K Albuhadily, Ahmed A Elhenawy, Ahmad O Babalghith, Mustafa M Shokr, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batih. Dysregulation of serotonergic neurotransmission in Parkinson disease: A key duet. European journal of pharmacology. 2025-02-23. PMID:39988096. |
the pd neuropathology is related to the progressive loss of the dopaminergic neurons in the snpc of midbrain. |
2025-02-23 |
2025-02-26 |
Not clear |
| Xinyue Wang, Gaoying Sun, Mingming Tang, Da Li, Jianhuan Qi, Chuanyue Wang, Yukai Wang, Baoyang H. Human Midbrain Organoids Enriched With Dopaminergic Neurons for Long-Term Functional Evaluation. Cell proliferation. 2025-02-20. PMID:39973567. |
human midbrain organoids enriched with dopaminergic neurons for long-term functional evaluation. |
2025-02-20 |
2025-02-23 |
human |
| Xinyue Wang, Gaoying Sun, Mingming Tang, Da Li, Jianhuan Qi, Chuanyue Wang, Yukai Wang, Baoyang H. Human Midbrain Organoids Enriched With Dopaminergic Neurons for Long-Term Functional Evaluation. Cell proliferation. 2025-02-20. PMID:39973567. |
human midbrain organoids with functional dopaminergic (da) neurons are invaluable for the therapeutic development of parkinson's disease (pd). |
2025-02-20 |
2025-02-23 |
human |