| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natalia Siwecka, Grzegorz Galita, Zuzanna Granek, Wojciech Wiese, Ireneusz Majsterek, Wioletta Rozpędek-Kamińsk. IRE1/JNK Is the Leading UPR Pathway in 6-OHDA-Induced Degeneration of Differentiated SH-SY5Y Cells. International journal of molecular sciences. vol 25. issue 14. 2024-07-27. PMID:39062922. |
parkinson's disease (pd) is a neurodegenerative disorder which affects dopaminergic neurons of the midbrain. |
2024-07-27 |
2024-07-29 |
Not clear |
| Elemer Szabad. Three paradoxes related to the mode of action of pramipexole: The path from D2/D3 dopamine receptor stimulation to modification of dopamine-modulated functions. Journal of psychopharmacology (Oxford, England). 2024-07-23. PMID:39041250. |
the functions considered are modulated by midbrain dopaminergic nuclei: locomotion - substantia nigra pars compacta (snc), reinforcement/motivation - ventral tegmental area (vta), sympathetic activity (as reflected in pupil function) - vta; arousal - ventral periaqueductal grey (vpag), with contributions from vta and snc. |
2024-07-23 |
2024-07-25 |
Not clear |
| K Ushna S Islam, Sandra Blaes. The impact of the mesoprefrontal dopaminergic system on the maturation of interneurons in the murine prefrontal cortex. Frontiers in neuroscience. vol 18. 2024-07-22. PMID:39035778. |
this is true both for local interneurons and for innervation from midbrain dopaminergic (mda) neurons. |
2024-07-22 |
2024-07-24 |
mouse |
| Taylor Russo, Markus Riesslan. Lipid accumulation drives cellular senescence in dopaminergic neurons. Aging. vol undefined. 2024-07-21. PMID:39033779. |
parkinson's disease (pd) is an age-related movement disorder caused by the loss of dopaminergic (da) neurons of the substantia nigra pars compacta (snpc) of the midbrain, however, the underlying cause(s) of this da neuron loss in pd is unknown and there are currently no effective treatment options to prevent or slow neuronal loss or the progression of related symptoms. |
2024-07-21 |
2024-07-24 |
Not clear |
| Mia Apuschkin, Hayley B Burm, Jan H Schmidt, Louise J Skov, Rita C Andersen, Carl-Fredrik Bowin, Jonatan F Støier, Kathrine L Jensen, Leonie P Posselt, Oksana Dmytriyeva, Andreas T Sørensen, Kristoffer L Egerod, Birgitte Holst, Mattias Rickhag, Thue W Schwartz, Ulrik Gethe. An atlas of GPCRs in dopamine neurons: Identification of the free fatty acid receptor 4 as a regulator of food and water intake. Cell reports. vol 43. issue 7. 2024-07-14. PMID:39003735. |
midbrain dopaminergic neurons (dans) are subject to extensive metabotropic regulation, but the repertoire of g protein-coupled receptors (gpcrs) present in these neurons has not been mapped. |
2024-07-14 |
2024-07-18 |
mouse |
| Gerard Eric Dwyer, Erik Johnsen, Kenneth Hugdah. NMDAR dysfunction and the regulation of dopaminergic transmission in schizophrenia. Schizophrenia research. vol 271. 2024-07-13. PMID:39002526. |
furthermore, this article presents a model for schizophrenia illustrating how dysfunction in the nrt may interrupt prefrontal regulation of midbrain dopaminergic neurons, and how dysfunction in the pptg may drive increased, irregular burst firing. |
2024-07-13 |
2024-07-16 |
Not clear |
| Joohyun An, Minkyu Shin, Geunyoung Beak, Jinho Yoon, Seewoo Kim, Hyeon-Yeol Cho, Jeong-Woo Cho. Drug Evaluation of Parkinson's Disease Patient-Derived Midbrain Organoids Using Mesoporous Au Nanodot-Patterned 3D Concave Electrode. ACS sensors. 2024-07-02. PMID:38954790. |
after the treatment of pd midbrain organoids with levodopa, the drug for pd, the increase in dopamine level was detected due to the activation of dopaminergic neurons by the drug. |
2024-07-02 |
2024-07-06 |
human |
| Vidhi Bhatt, Halak Shukla, Anand Krishna Tiwar. Parkinson's Disease and Mitotherapy-Based Approaches towards α-Synucleinopathies. Journal of integrative neuroscience. vol 23. issue 6. 2024-06-28. PMID:38940084. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta region of the midbrain and the formation of intracellular protein aggregates known as lewy bodies, of which a major component is the protein α-synuclein. |
2024-06-28 |
2024-06-30 |
Not clear |
| Luke J Vano, Robert A McCutcheon, Grazia Rutigliano, Stephen J Kaar, Valeria Finelli, Giovanna Nordio, George Wellby, Jan Sedlacik, Ben Statton, Eugenii A Rabiner, Rong Ye, Mattia Veronese, Seth C Hopkins, Kenneth S Koblan, Ian P Everall, Oliver D Howe. Mesostriatal Dopaminergic Circuit Dysfunction in Schizophrenia: A Multimodal Neuromelanin-sensitive MRI and [18F]-DOPA PET Study. Biological psychiatry. 2024-06-28. PMID:38942349. |
striatal hyperdopaminergia is implicated in the pathoetiology of schizophrenia, but how this relates to dopaminergic midbrain activity is unclear. |
2024-06-28 |
2024-07-01 |
Not clear |
| Antonio Del Casale, Martina Nicole Modesti, Giovanna Gentile, Cecilia Guariglia, Stefano Ferracuti, Maurizio Simmaco, Marina Borr. Is the Hedgehog Pathway Involved in the Pathophysiology of Schizophrenia? A Systematic Review of Current Evidence of Neural Molecular Correlates and Perspectives on Drug Development. Current issues in molecular biology. vol 46. issue 6. 2024-06-26. PMID:38920990. |
the hh pathway is crucial in the development of midbrain dopaminergic neurons, neuroplasticity mechanisms, regulating astrocyte phenotype and function, brain-derived neurotrophic factor expression, brain glutamatergic neural transmission, and responses to antipsychotics. |
2024-06-26 |
2024-06-29 |
human |
| Stuart B Murray, Joel P Diaz-Fong, Vienna W T Mak, Jamie D Feusne. Assessing midbrain neuromelanin and its relationship to reward learning in anorexia nervosa: Stage 1 of a registered report. Brain and behavior. vol 14. issue 6. 2024-06-20. PMID:38898625. |
neuromelanin-sensitive magnetic resonance imaging (mri) is an emerging method to index midbrain neuromelanin-a by-product of dopaminergic synthesis. |
2024-06-20 |
2024-06-22 |
Not clear |
| Tiziano Balzano, Natalia López-González Del Rey, Noelia Esteban-García, Alejandro Reinares-Sebastián, José A Pineda-Pardo, Inés Trigo-Damas, José A Obeso, Javier Bles. Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates. NPJ Parkinson's disease. vol 10. issue 1. 2024-06-19. PMID:38886348. |
we aimed to investigate the contribution of glial cell activation and immune cell infiltration in the selective vulnerability of ventral dopaminergic neurons within the midbrain in a non-human primate model of pd. |
2024-06-19 |
2024-06-21 |
monkey |
| Tiziano Balzano, Natalia López-González Del Rey, Noelia Esteban-García, Alejandro Reinares-Sebastián, José A Pineda-Pardo, Inés Trigo-Damas, José A Obeso, Javier Bles. Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates. NPJ Parkinson's disease. vol 10. issue 1. 2024-06-19. PMID:38886348. |
higher vascular density within the ventral region of the snc may be a relevant factor for differential vulnerability of dopaminergic neurons in the midbrain. |
2024-06-19 |
2024-06-21 |
monkey |
| Maya Belghazi, Cécile Iborra, Ophélie Toutendji, Manon Lasserre, Dominique Debanne, Jean-Marc Goaillard, Béatrice Marquèze-Poue. High-Resolution Proteomics Unravel a Native Functional Complex of Cav1.3, SK3, and Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in Midbrain Dopaminergic Neurons. Cells. vol 13. issue 11. 2024-06-19. PMID:38891076. |
high-resolution proteomics unravel a native functional complex of cav1.3, sk3, and hyperpolarization-activated cyclic nucleotide-gated channels in midbrain dopaminergic neurons. |
2024-06-19 |
2024-06-21 |
Not clear |
| Maya Belghazi, Cécile Iborra, Ophélie Toutendji, Manon Lasserre, Dominique Debanne, Jean-Marc Goaillard, Béatrice Marquèze-Poue. High-Resolution Proteomics Unravel a Native Functional Complex of Cav1.3, SK3, and Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in Midbrain Dopaminergic Neurons. Cells. vol 13. issue 11. 2024-06-19. PMID:38891076. |
in order to demonstrate the presence of these molecular interactions in situ, we used proximity ligation assay (pla) imaging on midbrain slices containing the substantia nigra, and we could ascertain the presence of these protein complexes specifically in substantia nigra dopaminergic neurons. |
2024-06-19 |
2024-06-21 |
Not clear |
| Shiqiang Zhang, Jingjing Zhang, Yihao Yang, Weidong Zang, Jing Ca. Activation of Pedunculopontine Tegmental Nucleus Alleviates the Pain Induced by the Lesion of Midbrain Dopaminergic Neurons. International journal of molecular sciences. vol 25. issue 11. 2024-06-19. PMID:38891832. |
activation of pedunculopontine tegmental nucleus alleviates the pain induced by the lesion of midbrain dopaminergic neurons. |
2024-06-19 |
2024-06-21 |
mouse |
| Shiqiang Zhang, Jingjing Zhang, Yihao Yang, Weidong Zang, Jing Ca. Activation of Pedunculopontine Tegmental Nucleus Alleviates the Pain Induced by the Lesion of Midbrain Dopaminergic Neurons. International journal of molecular sciences. vol 25. issue 11. 2024-06-19. PMID:38891832. |
the loss of midbrain dopaminergic (da) neurons is the fundamental pathological feature of parkinson's disease (pd). |
2024-06-19 |
2024-06-21 |
mouse |
| Hanieh Javid, Rana Rahimian, Misha Salimi, Elaheh Haghani-Samani, Mona Farhadi, Anahita Torkaman-Boutorab. Fumaria vaillantii extract protects PC12 cells against neurotoxicity induced by 6-OHDA. Molecular biology reports. vol 51. issue 1. 2024-06-17. PMID:38884894. |
parkinson's disease is a neurological disorder caused by the loss of dopaminergic neurons in the midbrain. |
2024-06-17 |
2024-06-19 |
Not clear |
| Huiqing Wang, Wenwei Mao, Yuhan Zhang, Wenhui Feng, Bo Bai, Bingyuan Ji, Jing Chen, Baohua Cheng, Fuling Ya. NOX1 triggers ferroptosis and ferritinophagy, contributes to Parkinson's disease. Free radical biology & medicine. 2024-06-14. PMID:38876456. |
the progressive loss of dopaminergic neurons in the midbrain is the hallmark of parkinson's disease (pd). |
2024-06-14 |
2024-06-17 |
Not clear |
| Tuoying Jiang, Jianan Huang, Bo Xu, Zhen Ge, Yi Li, Leiting Wei, Luyang Yu, Jinying L. Human amniotic epithelial stem cell-derived dopaminergic neuron-like cells ameliorate motor dysfunction in a rat model of Parkinson's disease. Life sciences. 2024-06-11. PMID:38862064. |
parkinson's disease (pd) remains a substantial clinical challenge due to the progressive loss of midbrain dopaminergic (da) neurons in nigrostriatal pathway. |
2024-06-11 |
2024-06-14 |
human |