| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gerardo Mendez-Victoriano, Yunting Zhu, Frank Middleton, Paul T Massa, Kachikwulu Ajulu, Maree J Webster, Cynthia S Weicker. Increased Parenchymal Macrophages are associated with decreased Tyrosine Hydroxylase mRNA levels in the Substantia Nigra of people with Schizophrenia and Bipolar Disorder. Psychiatry research. vol 340. 2024-08-17. PMID:39153291. |
we provide the first quantitative and molecular evidence of an increase in the density of parenchymal macrophages in the midbrain of major mental illnesses and show that the presence of these macrophages may negatively impact dopaminergic neurons. |
2024-08-17 |
2024-08-20 |
Not clear |
| Wenjuan Zhang, Hao Peng, Daihe Yang, Guohua Song, Juan He, Yun Zhou, Cao Huang, Bo Huan. Absence of motor impairments or pathological changes in TMEM230 knockout rats. Neuroscience letters. 2024-08-06. PMID:39106917. |
parkinson's disease (pd), which is the second most common neurodegenerative disorder, is characterized by progressive movement impairment and loss of midbrain dopaminergic neurons in the substantia nigra. |
2024-08-06 |
2024-08-09 |
rat |
| Liqiang Chen, Hiba Douja Chehade, Hong-Yuan Ch. Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation. bioRxiv : the preprint server for biology. 2024-08-02. PMID:39091827. |
moreover, it is also unknown whether cortical lewy pathology and midbrain dopaminergic degeneration interact to disrupt cortical function in late-stage. |
2024-08-02 |
2024-08-05 |
mouse |
| Liqiang Chen, Hiba Douja Chehade, Hong-Yuan Ch. Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation. bioRxiv : the preprint server for biology. 2024-08-02. PMID:39091827. |
to begin to address these questions, we injected α-synuclein (αsyn) preformed fibrils (pffs) into the dorsolateral striatum of mice to seed αsyn pathology in the cortical cortex and induce degeneration of midbrain dopaminergic neurons. |
2024-08-02 |
2024-08-05 |
mouse |
| Congmin Wang, Yu Hei, Yu Liu, Akhilesh Kumar Bajpai, Yuhe Li, Yawen Guan, Fuyi Xu, Cuifang Ya. Systems genetics identifies methionine as a high risk factor for Alzheimer's disease. Frontiers in neuroscience. vol 18. 2024-07-31. PMID:39081851. |
gene enrichment analysis indicated that the genes associated with the concentration of methionine in the midbrain are involved in the dopaminergic synaptic signaling pathway. |
2024-07-31 |
2024-08-02 |
mouse |
| Natalia Siwecka, Grzegorz Galita, Zuzanna Granek, Wojciech Wiese, Ireneusz Majsterek, Wioletta Rozpędek-Kamińsk. IRE1/JNK Is the Leading UPR Pathway in 6-OHDA-Induced Degeneration of Differentiated SH-SY5Y Cells. International journal of molecular sciences. vol 25. issue 14. 2024-07-27. PMID:39062922. |
parkinson's disease (pd) is a neurodegenerative disorder which affects dopaminergic neurons of the midbrain. |
2024-07-27 |
2024-07-29 |
Not clear |
| Elemer Szabad. Three paradoxes related to the mode of action of pramipexole: The path from D2/D3 dopamine receptor stimulation to modification of dopamine-modulated functions. Journal of psychopharmacology (Oxford, England). 2024-07-23. PMID:39041250. |
the functions considered are modulated by midbrain dopaminergic nuclei: locomotion - substantia nigra pars compacta (snc), reinforcement/motivation - ventral tegmental area (vta), sympathetic activity (as reflected in pupil function) - vta; arousal - ventral periaqueductal grey (vpag), with contributions from vta and snc. |
2024-07-23 |
2024-07-25 |
Not clear |
| K Ushna S Islam, Sandra Blaes. The impact of the mesoprefrontal dopaminergic system on the maturation of interneurons in the murine prefrontal cortex. Frontiers in neuroscience. vol 18. 2024-07-22. PMID:39035778. |
this is true both for local interneurons and for innervation from midbrain dopaminergic (mda) neurons. |
2024-07-22 |
2024-07-24 |
mouse |
| Taylor Russo, Markus Riesslan. Lipid accumulation drives cellular senescence in dopaminergic neurons. Aging. vol undefined. 2024-07-21. PMID:39033779. |
parkinson's disease (pd) is an age-related movement disorder caused by the loss of dopaminergic (da) neurons of the substantia nigra pars compacta (snpc) of the midbrain, however, the underlying cause(s) of this da neuron loss in pd is unknown and there are currently no effective treatment options to prevent or slow neuronal loss or the progression of related symptoms. |
2024-07-21 |
2024-07-24 |
Not clear |
| Mia Apuschkin, Hayley B Burm, Jan H Schmidt, Louise J Skov, Rita C Andersen, Carl-Fredrik Bowin, Jonatan F Støier, Kathrine L Jensen, Leonie P Posselt, Oksana Dmytriyeva, Andreas T Sørensen, Kristoffer L Egerod, Birgitte Holst, Mattias Rickhag, Thue W Schwartz, Ulrik Gethe. An atlas of GPCRs in dopamine neurons: Identification of the free fatty acid receptor 4 as a regulator of food and water intake. Cell reports. vol 43. issue 7. 2024-07-14. PMID:39003735. |
midbrain dopaminergic neurons (dans) are subject to extensive metabotropic regulation, but the repertoire of g protein-coupled receptors (gpcrs) present in these neurons has not been mapped. |
2024-07-14 |
2024-07-18 |
mouse |
| Gerard Eric Dwyer, Erik Johnsen, Kenneth Hugdah. NMDAR dysfunction and the regulation of dopaminergic transmission in schizophrenia. Schizophrenia research. vol 271. 2024-07-13. PMID:39002526. |
furthermore, this article presents a model for schizophrenia illustrating how dysfunction in the nrt may interrupt prefrontal regulation of midbrain dopaminergic neurons, and how dysfunction in the pptg may drive increased, irregular burst firing. |
2024-07-13 |
2024-07-16 |
Not clear |
| Joohyun An, Minkyu Shin, Geunyoung Beak, Jinho Yoon, Seewoo Kim, Hyeon-Yeol Cho, Jeong-Woo Cho. Drug Evaluation of Parkinson's Disease Patient-Derived Midbrain Organoids Using Mesoporous Au Nanodot-Patterned 3D Concave Electrode. ACS sensors. 2024-07-02. PMID:38954790. |
after the treatment of pd midbrain organoids with levodopa, the drug for pd, the increase in dopamine level was detected due to the activation of dopaminergic neurons by the drug. |
2024-07-02 |
2024-07-06 |
human |
| Vidhi Bhatt, Halak Shukla, Anand Krishna Tiwar. Parkinson's Disease and Mitotherapy-Based Approaches towards α-Synucleinopathies. Journal of integrative neuroscience. vol 23. issue 6. 2024-06-28. PMID:38940084. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta region of the midbrain and the formation of intracellular protein aggregates known as lewy bodies, of which a major component is the protein α-synuclein. |
2024-06-28 |
2024-06-30 |
Not clear |
| Luke J Vano, Robert A McCutcheon, Grazia Rutigliano, Stephen J Kaar, Valeria Finelli, Giovanna Nordio, George Wellby, Jan Sedlacik, Ben Statton, Eugenii A Rabiner, Rong Ye, Mattia Veronese, Seth C Hopkins, Kenneth S Koblan, Ian P Everall, Oliver D Howe. Mesostriatal Dopaminergic Circuit Dysfunction in Schizophrenia: A Multimodal Neuromelanin-sensitive MRI and [18F]-DOPA PET Study. Biological psychiatry. 2024-06-28. PMID:38942349. |
striatal hyperdopaminergia is implicated in the pathoetiology of schizophrenia, but how this relates to dopaminergic midbrain activity is unclear. |
2024-06-28 |
2024-07-01 |
Not clear |
| Antonio Del Casale, Martina Nicole Modesti, Giovanna Gentile, Cecilia Guariglia, Stefano Ferracuti, Maurizio Simmaco, Marina Borr. Is the Hedgehog Pathway Involved in the Pathophysiology of Schizophrenia? A Systematic Review of Current Evidence of Neural Molecular Correlates and Perspectives on Drug Development. Current issues in molecular biology. vol 46. issue 6. 2024-06-26. PMID:38920990. |
the hh pathway is crucial in the development of midbrain dopaminergic neurons, neuroplasticity mechanisms, regulating astrocyte phenotype and function, brain-derived neurotrophic factor expression, brain glutamatergic neural transmission, and responses to antipsychotics. |
2024-06-26 |
2024-06-29 |
human |
| Stuart B Murray, Joel P Diaz-Fong, Vienna W T Mak, Jamie D Feusne. Assessing midbrain neuromelanin and its relationship to reward learning in anorexia nervosa: Stage 1 of a registered report. Brain and behavior. vol 14. issue 6. 2024-06-20. PMID:38898625. |
neuromelanin-sensitive magnetic resonance imaging (mri) is an emerging method to index midbrain neuromelanin-a by-product of dopaminergic synthesis. |
2024-06-20 |
2024-06-22 |
Not clear |
| Tiziano Balzano, Natalia López-González Del Rey, Noelia Esteban-García, Alejandro Reinares-Sebastián, José A Pineda-Pardo, Inés Trigo-Damas, José A Obeso, Javier Bles. Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates. NPJ Parkinson's disease. vol 10. issue 1. 2024-06-19. PMID:38886348. |
we aimed to investigate the contribution of glial cell activation and immune cell infiltration in the selective vulnerability of ventral dopaminergic neurons within the midbrain in a non-human primate model of pd. |
2024-06-19 |
2024-06-21 |
monkey |
| Tiziano Balzano, Natalia López-González Del Rey, Noelia Esteban-García, Alejandro Reinares-Sebastián, José A Pineda-Pardo, Inés Trigo-Damas, José A Obeso, Javier Bles. Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates. NPJ Parkinson's disease. vol 10. issue 1. 2024-06-19. PMID:38886348. |
higher vascular density within the ventral region of the snc may be a relevant factor for differential vulnerability of dopaminergic neurons in the midbrain. |
2024-06-19 |
2024-06-21 |
monkey |
| Maya Belghazi, Cécile Iborra, Ophélie Toutendji, Manon Lasserre, Dominique Debanne, Jean-Marc Goaillard, Béatrice Marquèze-Poue. High-Resolution Proteomics Unravel a Native Functional Complex of Cav1.3, SK3, and Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in Midbrain Dopaminergic Neurons. Cells. vol 13. issue 11. 2024-06-19. PMID:38891076. |
high-resolution proteomics unravel a native functional complex of cav1.3, sk3, and hyperpolarization-activated cyclic nucleotide-gated channels in midbrain dopaminergic neurons. |
2024-06-19 |
2024-06-21 |
Not clear |
| Maya Belghazi, Cécile Iborra, Ophélie Toutendji, Manon Lasserre, Dominique Debanne, Jean-Marc Goaillard, Béatrice Marquèze-Poue. High-Resolution Proteomics Unravel a Native Functional Complex of Cav1.3, SK3, and Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels in Midbrain Dopaminergic Neurons. Cells. vol 13. issue 11. 2024-06-19. PMID:38891076. |
in order to demonstrate the presence of these molecular interactions in situ, we used proximity ligation assay (pla) imaging on midbrain slices containing the substantia nigra, and we could ascertain the presence of these protein complexes specifically in substantia nigra dopaminergic neurons. |
2024-06-19 |
2024-06-21 |
Not clear |