| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyle M Sousa, J Carlos Villaescusa, Lukas Cajanek, Jennifer K Ondr, Goncalo Castelo-Branco, Wytske Hofstra, Vitezslav Bryja, Carina Palmberg, Tomas Bergman, Brandon Wainwright, Richard A Lang, Ernest Arena. Wnt2 regulates progenitor proliferation in the developing ventral midbrain. The Journal of biological chemistry. vol 285. issue 10. 2010-04-29. PMID:20018874. |
in agreement with these findings, analysis of the ventral midbrain of developing wnt2-null mice revealed a decrease in progenitor proliferation and neurogenesis that lead to a decrease in the number of postmitotic precursors and dopaminergic neurons. |
2010-04-29 |
2023-08-12 |
mouse |
| David J Brook. Imaging approaches to Parkinson disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 51. issue 4. 2010-04-19. PMID:20351351. |
demonstrating midbrain structural abnormalities with transcranial sonography or diffusion-weighted mri or showing striatal dopamine terminal dysfunction with pet or spect supports the diagnosis and rationalizes the use of dopaminergic medications. |
2010-04-19 |
2023-08-12 |
Not clear |
| Sheng Deng, Hao Deng, Weidong Le, Hongbo Xu, Huarong Yang, Xiong Deng, Hongwei Lv, Wenjie Xie, Shaihong Zhu, Joseph Jankovi. Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease. Neuroscience letters. vol 468. issue 3. 2010-04-06. PMID:19879328. |
the proneural protein neurogenin 2 (neurog2) is a transcription factor of importance for the differentiation and survival of midbrain dopaminergic neurons. |
2010-04-06 |
2023-08-12 |
Not clear |
| Anne K Meyer, Martina Maisel, Andreas Hermann, Katja Stirl, Alexander Storc. Restorative approaches in Parkinson's Disease: which cell type wins the race? Journal of the neurological sciences. vol 289. issue 1-2. 2010-04-05. PMID:19733367. |
parkinson's disease (pd) is a progressive neurodegenerative movement disorder and is characterized by a continuous and selective loss of dopaminergic neurons in the midbrain with a subsequent reduction of the neurotransmitter dopamine in the striatum. |
2010-04-05 |
2023-08-12 |
Not clear |
| Cheryl A Frye, Sandra M Petralia, Madeline E Rhodes, Joseph F DeBol. 6-hydroxydopamine lesions enhance progesterone-facilitated lordosis of rats and hamsters, independent of effects on motor behavior. Physiology & behavior. vol 99. issue 2. 2010-04-05. PMID:19778544. |
this suggests that the dopaminergic output neurons of midbrain vta may play an important role in modulation of p(4)-facilitated sexual lordosis among rodents. |
2010-04-05 |
2023-08-12 |
rat |
| Tomoya Nakatani, Minoru Kumai, Eri Mizuhara, Yasuko Minaki, Yuichi On. Lmx1a and Lmx1b cooperate with Foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon. Developmental biology. vol 339. issue 1. 2010-04-05. PMID:20035737. |
lmx1a and lmx1b cooperate with foxa2 to coordinate the specification of dopaminergic neurons and control of floor plate cell differentiation in the developing mesencephalon. |
2010-04-05 |
2023-08-12 |
mouse |
| Gonçalo Castelo-Branco, Emma R Andersson, Eleonora Minina, Kyle M Sousa, Diogo Ribeiro, Chikara Kokubu, Kenji Imai, Nilima Prakash, Wolfgang Wurst, Ernest Arena. Delayed dopaminergic neuron differentiation in Lrp6 mutant mice. Developmental dynamics : an official publication of the American Association of Anatomists. vol 239. issue 1. 2010-04-02. PMID:19795519. |
wnts are known to bind and activate multiple membrane receptors/coreceptors and to regulate dopaminergic (da) neuron development and ventral midbrain (vm) morphogenesis. |
2010-04-02 |
2023-08-12 |
mouse |
| Sebastian Stuebner, Theresa Faus-Kessler, Thomas Fischer, Wolfgang Wurst, Nilima Prakas. Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect. Developmental dynamics : an official publication of the American Association of Anatomists. vol 239. issue 1. 2010-04-02. PMID:19842188. |
wnt/beta-catenin signaling controls the proper development of the mid-/hindbrain region (mhr) and of midbrain dopaminergic (mda) neurons, but the frizzled (fzd) receptors transducing these signals are still unknown. |
2010-04-02 |
2023-08-12 |
mouse |
| Dennis W Dickson, Hiroshige Fujishiro, Carolyn Orr, Anthony DelleDonne, Keith A Josephs, Roberta Frigerio, Melinda Burnett, Joseph E Parisi, Kevin J Klos, J Eric Ahlsko. Neuropathology of non-motor features of Parkinson disease. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20082965. |
lewy bodies composed of abnormal alpha-synuclein are the histologic hallmark of pd, and their presence beyond midbrain dopaminergic neurons is considered to be the pathologic substrate of many, if not all, of the non-motor manifestations of pd. |
2010-03-31 |
2023-08-12 |
Not clear |
| Yu Luo, Serena Y Kuang, Barry Hoffe. How useful are stem cells in PD therapy? Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20082984. |
clinical symptoms of pd are not manifested until 60-80% of dopaminergic neurons in the midbrain have been affected. |
2010-03-31 |
2023-08-12 |
human |
| E C Hirsc. Iron transport in Parkinson's disease. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20082992. |
using the pd animal model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) intoxication in mice, we showed that dmt1 expression increased in the ventral mesencephalon of intoxicated animals, concomitant with iron accumulation, oxidative stress and dopaminergic cell loss. |
2010-03-31 |
2023-08-12 |
mouse |
| Yasuhiro Tanaka, Tomoyuki Furuyashiki, Toshihiko Momiyama, Hisaaki Namba, Akira Mizoguchi, Tomoyuki Mitsumori, Tetsuro Kayahara, Hitoshi Shichi, Kazushi Kimura, Toshiyuki Matsuoka, Hiroyuki Nawa, Shuh Narumiy. Prostaglandin E receptor EP1 enhances GABA-mediated inhibition of dopaminergic neurons in the substantia nigra pars compacta and regulates dopamine level in the dorsal striatum. The European journal of neuroscience. vol 30. issue 12. 2010-03-30. PMID:20092576. |
further, an ep1 agonist enhanced gaba(a)-mediated inhibitory inputs to snc dopaminergic neurons in midbrain slices. |
2010-03-30 |
2023-08-12 |
mouse |
| June-Hee Park, Grigori Enikolopo. Transient elevation of adult hippocampal neurogenesis after dopamine depletion. Experimental neurology. vol 222. issue 2. 2010-03-26. PMID:20079351. |
degeneration of the midbrain dopaminergic neurons during parkinson's disease (pd) may affect remote regions of the brain that are innervated by the projections of these neurons. |
2010-03-26 |
2023-08-12 |
mouse |
| Y T Cho, J L Fudg. Heterogeneous dopamine populations project to specific subregions of the primate amygdala. Neuroscience. vol 165. issue 4. 2010-03-12. PMID:19914353. |
recent work indicates that the midbrain dopaminergic neurons have heterogeneous receptor and membrane channel profiles, as well as differential physiologic responses to discrete stimuli. |
2010-03-12 |
2023-08-12 |
rat |
| Y T Cho, J L Fudg. Heterogeneous dopamine populations project to specific subregions of the primate amygdala. Neuroscience. vol 165. issue 4. 2010-03-12. PMID:19914353. |
to begin understanding how dopamine affects amygdala physiology and pathology in higher primates, we mapped the inputs from the midbrain dopaminergic neurons to various amygdala nuclei in the monkey using retrograde and anterograde tracing techniques, and single and double immunofluorescence histochemistry for tracer and tyrosine hydroxylase, a dopamine marker. |
2010-03-12 |
2023-08-12 |
rat |
| Andrew J Linsenbardt, Gerald H Wilken, Thomas C Westfall, Heather Macarthu. Cytotoxicity of dopaminochrome in the mesencephalic cell line, MN9D, is dependent upon oxidative stress. Neurotoxicology. vol 30. issue 6. 2010-03-09. PMID:19619580. |
parkinson disease is a specific form of neurodegeneration characterized by a loss of nigra-striatal dopaminergic neurons in the midbrain of humans. |
2010-03-09 |
2023-08-12 |
Not clear |
| Yu Luo, Sara Arezou Sarabi, Cristina Backman, Lufei Shan, Barry Hoffer, Howard Federof. Expression pattern of NuIP gene in adult mouse brain. Brain research. vol 1302. 2010-02-23. PMID:19765553. |
interestingly, nuip is expressed in high levels in midbrain dopaminergic neurons including ventral tegmental area (vta) and substantia nigra (sn) dopaminergic neurons but is not expressed or expressed in low levels in other dopaminergic neurons such as olfactory bulb and hypothalamus. |
2010-02-23 |
2023-08-12 |
mouse |
| Domingo Afonso-Oramas, Ignacio Cruz-Muros, Diego Alvarez de la Rosa, Pedro Abreu, Teresa Giráldez, Javier Castro-Hernández, Josmar Salas-Hernández, José L Lanciego, Manuel Rodríguez, Tomas González-Hernánde. Dopamine transporter glycosylation correlates with the vulnerability of midbrain dopaminergic cells in Parkinson's disease. Neurobiology of disease. vol 36. issue 3. 2010-02-18. PMID:19766189. |
dopamine transporter glycosylation correlates with the vulnerability of midbrain dopaminergic cells in parkinson's disease. |
2010-02-18 |
2023-08-12 |
human |
| C A O'Farrell, K L Martin, M Hutton, M B Delatycki, M R Cookson, P J Lockhar. Mutant torsinA interacts with tyrosine hydroxylase in cultured cells. Neuroscience. vol 164. issue 3. 2010-02-08. PMID:19761814. |
expression of deltae302/303 but not wildtype torsina in primary postnatal midbrain neurons resulted in the formation of intracellular inclusion bodies, predominantly in dopaminergic neurons. |
2010-02-08 |
2023-08-12 |
Not clear |
| Xiao-Qing Zhang, Su-Chun Zhan. Differentiation of neural precursors and dopaminergic neurons from human embryonic stem cells. Methods in molecular biology (Clifton, N.J.). vol 584. 2010-02-05. PMID:19907987. |
identification of the primitive neuroepithelial cells permits efficient patterning of region-specific progenitors and neuronal subtypes such as midbrain dopaminergic neurons. |
2010-02-05 |
2023-08-12 |
mouse |