| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicola Simola, Annalisa Pinna, Sandro Fen. Pharmacological therapy of Parkinson's disease: current options and new avenues. Recent patents on CNS drug discovery. vol 5. issue 3. 2011-01-31. PMID:20726838. |
parkinson's disease is a neurodegenerative pathology which affects the dopaminergic neurons in the mesencephalon, leading to a progressive and relentless motor disability and to non-motor symptoms of different severity. |
2011-01-31 |
2023-08-12 |
Not clear |
| Collin J Lobb, Carlos A Paladin. Application of a NMDA receptor conductance in rat midbrain dopaminergic neurons using the dynamic clamp technique. Journal of visualized experiments : JoVE. issue 46. 2011-01-31. PMID:21206469. |
application of a nmda receptor conductance in rat midbrain dopaminergic neurons using the dynamic clamp technique. |
2011-01-31 |
2023-08-12 |
rat |
| Carol A Seger, Earl K Mille. Category learning in the brain. Annual review of neuroscience. vol 33. 2011-01-27. PMID:20572771. |
it is subserved by plasticity in many neural systems, including neocortical regions (sensory, prefrontal, parietal, and motor cortex), the medial temporal lobe, the basal ganglia, and midbrain dopaminergic systems. |
2011-01-27 |
2023-08-12 |
Not clear |
| Oliver Cooper, Gunnar Hargus, Michela Deleidi, Alexandra Blak, Teresia Osborn, Elizabeth Marlow, Kristen Lee, Adam Levy, Eduardo Perez-Torres, Alyssa Yow, Ole Isacso. Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid. Molecular and cellular neurosciences. vol 45. issue 3. 2011-01-21. PMID:20603216. |
differentiation of human es and parkinson's disease ips cells into ventral midbrain dopaminergic neurons requires a high activity form of shh, fgf8a and specific regionalization by retinoic acid. |
2011-01-21 |
2023-08-12 |
human |
| Oliver Cooper, Gunnar Hargus, Michela Deleidi, Alexandra Blak, Teresia Osborn, Elizabeth Marlow, Kristen Lee, Adam Levy, Eduardo Perez-Torres, Alyssa Yow, Ole Isacso. Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid. Molecular and cellular neurosciences. vol 45. issue 3. 2011-01-21. PMID:20603216. |
the cardinal motor symptoms of parkinson's disease (pd) are caused by the vulnerability to dysfunction and degeneration of ventral midbrain (vm) dopaminergic (da) neurons. |
2011-01-21 |
2023-08-12 |
human |
| R Rössler, E Boddeke, S Copra. Differentiation of non-mesencephalic neural stem cells towards dopaminergic neurons. Neuroscience. vol 170. issue 2. 2011-01-20. PMID:20643196. |
it is generally thought that in vitro differentiation of neural stem cells into meso-diencephalic dopaminergic neurons, requires recapitulation of dopaminergic differentiation pathway normally occurring in the ventral mesencephalon during embryogenesis. |
2011-01-20 |
2023-08-12 |
human |
| Enza Lonardo, Clare L Parish, Salvatore Ponticelli, Daniela Marasco, Diogo Ribeiro, Menotti Ruvo, Sandro De Falco, Ernest Arenas, Gabriella Minchiott. A small synthetic cripto blocking Peptide improves neural induction, dopaminergic differentiation, and functional integration of mouse embryonic stem cells in a rat model of Parkinson's disease. Stem cells (Dayton, Ohio). vol 28. issue 8. 2011-01-13. PMID:20641036. |
interestingly, genetic ablation of cripto results in increased neuralization and midbrain dopaminergic (da) differentiation of mescs, as well as improved da cell replacement therapy (crt) in a model of parkinson's disease (pd). |
2011-01-13 |
2023-08-12 |
mouse |
| Anna Y Kuznetsova, Marco A Huertas, Alexey S Kuznetsov, Carlos A Paladini, Carmen C Canavie. Regulation of firing frequency in a computational model of a midbrain dopaminergic neuron. Journal of computational neuroscience. vol 28. issue 3. 2011-01-11. PMID:20217204. |
dopaminergic (da) neurons of the mammalian midbrain exhibit unusually low firing frequencies in vitro. |
2011-01-11 |
2023-08-12 |
Not clear |
| Magdalena Misiak, Cordian Beyer, Susanne Arnol. Gender-specific role of mitochondria in the vulnerability of 6-hydroxydopamine-treated mesencephalic neurons. Biochimica et biophysica acta. vol 1797. issue 6-7. 2011-01-10. PMID:20416276. |
besides the known effects of 6-ohda on mitochondria and neuronal survivability, we aimed to demonstrate that the mitochondrial neurotoxin affects the morphology and survival of primary dopaminergic and non-dopaminergic neurons in the mesencephalon in a gender-specific manner by influencing the transcription of mitochondrial genes, atp and reactive oxygen species production. |
2011-01-10 |
2023-08-12 |
Not clear |
| Collin J Lobb, Charles J Wilson, Carlos A Paladin. A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons. Journal of neurophysiology. vol 104. issue 1. 2011-01-07. PMID:20445035. |
a dynamic role for gaba receptors on the firing pattern of midbrain dopaminergic neurons. |
2011-01-07 |
2023-08-12 |
human |
| Hitoshi Morikawa, Richard A Morriset. Ethanol action on dopaminergic neurons in the ventral tegmental area: interaction with intrinsic ion channels and neurotransmitter inputs. International review of neurobiology. vol 91. 2010-12-21. PMID:20813245. |
the dopaminergic system originating in the midbrain ventral tegmental area (vta) has been extensively studied over the past decades as a critical neural substrate involved in the development of alcoholism and addiction to other drugs of abuse. |
2010-12-21 |
2023-08-12 |
Not clear |
| Daniel P Eisenberg, Philip D Kohn, Erica B Baller, Joel A Bronstein, Joseph C Masdeu, Karen F Berma. Seasonal effects on human striatal presynaptic dopamine synthesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 44. 2010-12-08. PMID:21048126. |
past studies in rodents have demonstrated circannual variation in central dopaminergic activity as well as a host of compelling interactions between melatonin--a scotoperiod-responsive neurohormone closely tied to seasonal adaptation--and dopamine in the striatum and in midbrain neuronal populations with striatal projections. |
2010-12-08 |
2023-08-12 |
human |
| Kathleen A Maguire-Zeiss, Howard J Federof. Future directions for immune modulation in neurodegenerative disorders: focus on Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 117. issue 8. 2010-11-30. PMID:20549523. |
when activated, microglia release pro-inflammatory diffusible mediators that promote dysfunction and contribute to the death of the pd vulnerable dopaminergic neurons in the midbrain. |
2010-11-30 |
2023-08-12 |
Not clear |
| Manisha Nautiyal, Andrew J Sweatt, James A MacKenzie, R Mark Payne, Sylvia Szucs, Reuben Matalon, Reidar Wallin, Susan M Hutso. Neuronal localization of the mitochondrial protein NIPSNAP1 in rat nervous system. The European journal of neuroscience. vol 32. issue 4. 2010-11-30. PMID:20646061. |
dopaminergic neurons in midbrain and noradrenergic neurons in the brainstem, which are affected in pku, also express nipsnap1. |
2010-11-30 |
2023-08-12 |
mouse |
| Kerstin Krauel, Hendrik C Feldhaus, Andrea Simon, Claudia Rehe, Martin Glaser, Hans-Henning Flechtner, Hans-Jochen Heinze, Ludwig Niehau. Increased echogenicity of the substantia nigra in children and adolescents with attention-deficit/hyperactivity disorder. Biological psychiatry. vol 68. issue 4. 2010-11-22. PMID:20227683. |
recent neurobiological models on attention-deficit/hyperactivity disorder (adhd) as well as findings from imaging studies suggest a crucial involvement of dopaminergic midbrain nuclei, especially the substantia nigra (sn), in the pathogenesis of adhd symptoms. |
2010-11-22 |
2023-08-12 |
Not clear |
| Michelle E Page, Li Bao, Pierrette Andre, Joshua Pelta-Heller, Emily Sluzas, Pedro Gonzalez-Alegre, Alexey Bogush, Loren E Khan, Lorraine Iacovitti, Margaret E Rice, Michelle E Ehrlic. Cell-autonomous alteration of dopaminergic transmission by wild type and mutant (DeltaE) TorsinA in transgenic mice. Neurobiology of disease. vol 39. issue 3. 2010-11-16. PMID:20460154. |
we utilized the tyrosine hydroxylase (th) promoter to direct transgene expression specifically to dopaminergic neurons of the midbrain to identify cell-autonomous abnormalities. |
2010-11-16 |
2023-08-12 |
mouse |
| Gunasingh Masilamoni, John Votaw, Leonard Howell, Rosa M Villalba, Mark Goodman, Ronald J Voll, Jeffrey Stehouwer, Thomas Wichmann, Yoland Smit. (18)F-FECNT: validation as PET dopamine transporter ligand in parkinsonism. Experimental neurology. vol 226. issue 2. 2010-11-12. PMID:20832405. |
the goal of this study is to validate the use of (18)f-fecnt as a pet radiotracer to assess the degree of striatal dopamine terminals denervation and midbrain dopaminergic cell loss in mptp-treated parkinsonian monkeys. |
2010-11-12 |
2023-08-12 |
monkey |
| Gunasingh Masilamoni, John Votaw, Leonard Howell, Rosa M Villalba, Mark Goodman, Ronald J Voll, Jeffrey Stehouwer, Thomas Wichmann, Yoland Smit. (18)F-FECNT: validation as PET dopamine transporter ligand in parkinsonism. Experimental neurology. vol 226. issue 2. 2010-11-12. PMID:20832405. |
postmortem stereological cell counts of dopaminergic neurons in the ventral midbrain, and intensity measurements of dat and tyrosine hydroxylase (th) immunoreactivity in the striatum were performed and correlated with striatal and ventral midbrain pet data. |
2010-11-12 |
2023-08-12 |
monkey |
| Gunasingh Masilamoni, John Votaw, Leonard Howell, Rosa M Villalba, Mark Goodman, Ronald J Voll, Jeffrey Stehouwer, Thomas Wichmann, Yoland Smit. (18)F-FECNT: validation as PET dopamine transporter ligand in parkinsonism. Experimental neurology. vol 226. issue 2. 2010-11-12. PMID:20832405. |
three additional monkeys were used as controls for midbrain dopaminergic cell counts, and striatal dat or th immunoreactivity measurements. |
2010-11-12 |
2023-08-12 |
monkey |
| Gunasingh Masilamoni, John Votaw, Leonard Howell, Rosa M Villalba, Mark Goodman, Ronald J Voll, Jeffrey Stehouwer, Thomas Wichmann, Yoland Smit. (18)F-FECNT: validation as PET dopamine transporter ligand in parkinsonism. Experimental neurology. vol 226. issue 2. 2010-11-12. PMID:20832405. |
the (18)f-fecnt binding potential of the ventral midbrain and striatal regions was tightly correlated with postmortem stereological cell counts of nigral dopaminergic neurons (r²=0.91), and striatal dat (r²=0.83) or th (r²=0.88) immunoreactivity intensity measurements. |
2010-11-12 |
2023-08-12 |
monkey |