| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gerard W O'Keeffe, Shane V Hegarty, Aideen M Sulliva. Targeting bone morphogenetic protein signalling in midbrain dopaminergic neurons as a therapeutic approach in Parkinson's disease. Neuronal signaling. vol 1. issue 2. 2020-09-28. PMID:32714578. |
targeting bone morphogenetic protein signalling in midbrain dopaminergic neurons as a therapeutic approach in parkinson's disease. |
2020-09-28 |
2023-08-13 |
Not clear |
| Gerard W O'Keeffe, Shane V Hegarty, Aideen M Sulliva. Targeting bone morphogenetic protein signalling in midbrain dopaminergic neurons as a therapeutic approach in Parkinson's disease. Neuronal signaling. vol 1. issue 2. 2020-09-28. PMID:32714578. |
parkinson's disease (pd) is the second most common neurodegenerative disease, characterized by the degeneration of midbrain dopaminergic (mda) neurons and their axons, and aggregation of α-synuclein, which leads to motor and late-stage cognitive impairments. |
2020-09-28 |
2023-08-13 |
Not clear |
| Martina Mazzocchi, Louise M Collins, Aideen M Sullivan, Gerard W O'Keeff. The class II histone deacetylases as therapeutic targets for Parkinson's disease. Neuronal signaling. vol 4. issue 2. 2020-09-28. PMID:32714601. |
the neuropathological hallmarks of pd include progressive degeneration of midbrain dopaminergic neurons, and loss of their axonal projections to the striatum. |
2020-09-28 |
2023-08-13 |
Not clear |
| Emilía Sif Ásgrímsdóttir, Ernest Arena. Midbrain Dopaminergic Neuron Development at the Single Cell Level: Frontiers in cell and developmental biology. vol 8. 2020-09-28. PMID:32733875. |
midbrain dopaminergic neuron development at the single cell level: parkinson's disease (pd) is a progressive neurodegenerative disorder that predominantly affects dopaminergic (da) neurons of the substantia nigra. |
2020-09-28 |
2023-08-13 |
mouse |
| Yannick Vermeiren, Yael Hirschberg, Inge Mertens, Peter P De Dey. Biofluid Markers for Prodromal Parkinson's Disease: Evidence From a Catecholaminergic Perspective. Frontiers in neurology. vol 11. 2020-09-28. PMID:32760338. |
by the time pd manifests with motor signs, 70% of dopaminergic midbrain neurons are lost, and the disease is already in the middle or late stage. |
2020-09-28 |
2023-08-13 |
Not clear |
| Shin Yanagihara, Maki Ikebuchi, Chihiro Mori, Ryosuke O Tachibana, Kazuo Okanoy. Arousal State-Dependent Alterations in Neural Activity in the Zebra Finch VTA/SNc. Frontiers in neuroscience. vol 14. 2020-09-28. PMID:32973441. |
a growing body of evidence indicates that the midbrain dopaminergic system is associated with sleep-wake regulation in mammals. |
2020-09-28 |
2023-08-13 |
Not clear |
| Maria Eleni Karakatsani, Shutao Wang, Gesthimani Samiotaki, Tara Kugelman, Oluyemi O Olumolade, Camilo Acosta, Tao Sun, Yang Han, Hermes A S Kamimura, Vernice Jackson-Lewis, Serge Przedborski, Elisa Konofago. Amelioration of the nigrostriatal pathway facilitated by ultrasound-mediated neurotrophic delivery in early Parkinson's disease. Journal of controlled release : official journal of the Controlled Release Society. vol 303. 2020-09-25. PMID:30953664. |
herein, we show that neither fus applied over both the striatum and the ventral midbrain, without neurotrophic factors, nor intravenous administration of neurotrophic factors (either through protein or gene delivery) without fus, ameliorates the damage to the nigrostriatal dopaminergic pathway in the sub-acute mptp mouse model of early-stage pd. |
2020-09-25 |
2023-08-13 |
mouse |
| GuoQing Wang, YanZhen Zhou, YanYing Wang, DaiDi Li, Jie Liu, Feng Zhan. Age-Associated Dopaminergic Neuron Loss and Midbrain Glia Cell Phenotypic Polarization. Neuroscience. vol 415. 2020-09-23. PMID:31325563. |
this study aimed to investigate the change of glial cells and dopaminergic (da) neuron in midbrain with age. |
2020-09-23 |
2023-08-13 |
rat |
| Khalid I W Kane, Edinson Lucumi Moreno, Siham Hachi, Moriz Walter, Javier Jarazo, Miguel A P Oliveira, Thomas Hankemeier, Paul Vulto, Jens C Schwamborn, Martin Thoma, Ronan M T Flemin. Automated microfluidic cell culture of stem cell derived dopaminergic neurons. Scientific reports. vol 9. issue 1. 2020-09-21. PMID:30741972. |
parkinson's disease is a slowly progressive neurodegenerative disease characterised by dysfunction and death of selectively vulnerable midbrain dopaminergic neurons and the development of human in vitro cellular models of the disease is a major challenge in parkinson's disease research. |
2020-09-21 |
2023-08-13 |
human |
| Khalid I W Kane, Edinson Lucumi Moreno, Siham Hachi, Moriz Walter, Javier Jarazo, Miguel A P Oliveira, Thomas Hankemeier, Paul Vulto, Jens C Schwamborn, Martin Thoma, Ronan M T Flemin. Automated microfluidic cell culture of stem cell derived dopaminergic neurons. Scientific reports. vol 9. issue 1. 2020-09-21. PMID:30741972. |
using this system, we continuously monitored the differentiation of parkinson's disease patient derived human neuroepithelial stem cells into midbrain specific dopaminergic neurons. |
2020-09-21 |
2023-08-13 |
human |
| Grażyna Jerzemowska, Karolina Plucińska, Aleksandra Piwka, Kacper Ptaszek, Magdalena Podlacha, Jolanta Orzeł-Gryglewsk. NMDA receptor modulation of the pedunculopontine tegmental nucleus underlies the motivational drive for feeding induced by midbrain dopaminergic neurons. Brain research. vol 1715. 2020-09-18. PMID:30914249. |
nmda receptor modulation of the pedunculopontine tegmental nucleus underlies the motivational drive for feeding induced by midbrain dopaminergic neurons. |
2020-09-18 |
2023-08-13 |
rat |
| Grażyna Jerzemowska, Karolina Plucińska, Aleksandra Piwka, Kacper Ptaszek, Magdalena Podlacha, Jolanta Orzeł-Gryglewsk. NMDA receptor modulation of the pedunculopontine tegmental nucleus underlies the motivational drive for feeding induced by midbrain dopaminergic neurons. Brain research. vol 1715. 2020-09-18. PMID:30914249. |
we conclude that the level of nmda receptor arousal in the ppn regulates the activity of the midbrain dopaminergic cells, and the ppn-vta circuit may be important in the regulation of motivational aspects of food intake. |
2020-09-18 |
2023-08-13 |
rat |
| Junge Zhu, Shanshan Dou, Yunlu Jiang, Jing Chen, Chunmei Wang, Baohua Chen. Apelin-13 protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through inhibiting endoplasmic reticulum stress and promoting autophagy. Brain research. vol 1715. 2020-09-18. PMID:30914252. |
the dopaminergic neurodegeneration in the substantia nigrapars compacta (snpc) and striatum of the midbrain is the important pathological feature of parkinson's disease (pd). |
2020-09-18 |
2023-08-13 |
mouse |
| Jeroen P H Verharen, Theresia J M Roelofs, Shanice Menting-Henry, Mieneke C M Luijendijk, Louk J M J Vanderschuren, Roger A H Ada. Limbic control over the homeostatic need for sodium. Scientific reports. vol 9. issue 1. 2020-09-14. PMID:30705296. |
we observed that sodium deficiency affected the responses of dopaminergic midbrain neurons to salt tasting, suggesting that these neurons encode appetitive properties of sodium. |
2020-09-14 |
2023-08-13 |
rat |
| J Gendron, C Colace-Sauty, N Beaume, H Cartonnet, J Guegan, D Ulveling, C Pardanaud-Glavieux, I Moszer, H Cheval, P Ravassar. Long non-coding RNA repertoire and open chromatin regions constitute midbrain dopaminergic neuron - specific molecular signatures. Scientific reports. vol 9. issue 1. 2020-09-11. PMID:30723217. |
midbrain dopaminergic (da) neurons are involved in diverse neurological functions, including control of movements, emotions or reward. |
2020-09-11 |
2023-08-13 |
mouse |
| Wafaa Laabbar, Abdeljalil Elgot, Omar Elhiba, Halima Gamran. Curcumin prevents the midbrain dopaminergic innervations and locomotor performance deficiencies resulting from chronic aluminum exposure in rat. Journal of chemical neuroanatomy. vol 100. 2020-09-11. PMID:31170442. |
curcumin prevents the midbrain dopaminergic innervations and locomotor performance deficiencies resulting from chronic aluminum exposure in rat. |
2020-09-11 |
2023-08-13 |
rat |
| Oum Kaltoum Hassani, Vladimir V Rymar, Khanh Q Nguyen, Lia Huo, Jean-François Cloutier, Freda D Miller, Abbas F Sadiko. The noradrenergic system is necessary for survival of vulnerable midbrain dopaminergic neurons: implications for development and Parkinson's disease. Neurobiology of aging. vol 85. 2020-09-11. PMID:31734438. |
the noradrenergic system is necessary for survival of vulnerable midbrain dopaminergic neurons: implications for development and parkinson's disease. |
2020-09-11 |
2023-08-13 |
mouse |
| Oum Kaltoum Hassani, Vladimir V Rymar, Khanh Q Nguyen, Lia Huo, Jean-François Cloutier, Freda D Miller, Abbas F Sadiko. The noradrenergic system is necessary for survival of vulnerable midbrain dopaminergic neurons: implications for development and Parkinson's disease. Neurobiology of aging. vol 85. 2020-09-11. PMID:31734438. |
the cause of midbrain dopaminergic (mda) neuron loss in sporadic parkinson's disease (pd) is multifactorial, involving cell autonomous factors, cell-cell interactions, and the effects of environmental toxins. |
2020-09-11 |
2023-08-13 |
mouse |
| Norman E Taylor, Hu Long, JunZhu Pei, Phanidhar Kukutla, Anthony Phero, Farnaz Hadaegh, Ahmed Abdelnabi, Ken Solt, Gary J Brenne. The rostromedial tegmental nucleus: a key modulator of pain and opioid analgesia. Pain. vol 160. issue 11. 2020-09-10. PMID:31246732. |
this region is composed of gabaergic cells that send afferent projections to the ventral midbrain and synapse onto dopaminergic cells in the vta and substantia nigra. |
2020-09-10 |
2023-08-13 |
Not clear |
| Jun Takahash. Preclinical evaluation of patient-derived cells shows promise for Parkinson's disease. The Journal of clinical investigation. vol 130. issue 2. 2020-09-04. PMID:31929191. |
parkinson's disease (pd) is a neurodegenerative disease caused by the progressive loss of dopaminergic (da) neurons in the midbrain projecting to the striatum, which leads to motor dysfunctions, such as bradykinesia (slowed movement), rigidity, and tremors. |
2020-09-04 |
2023-08-13 |
Not clear |