| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Isabelle R de Luzy, Jonathan C Niclis, Carlos W Gantner, Jessica A Kauhausen, Cameron P J Hunt, Charlotte Ermine, Colin W Pouton, Lachlan H Thompson, Clare L Paris. Isolation of LMX1a Ventral Midbrain Progenitors Improves the Safety and Predictability of Human Pluripotent Stem Cell-Derived Neural Transplants in Parkinsonian Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 48. 2020-07-02. PMID:31641054. |
human pluripotent stem cells (hpscs) are a promising resource for the replacement of degenerated ventral midbrain dopaminergic (vmda) neurons in parkinson's disease. |
2020-07-02 |
2023-08-13 |
human |
| Fanni F Geibl, Martin T Henrich, Wolfgang H Oerte. Mesencephalic and extramesencephalic dopaminergic systems in Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 126. issue 4. 2020-06-26. PMID:30643975. |
despite the central role of da in the pathogenesis of pd, dopaminergic systems outside of the midbrain have not been systematically investigated for lewy body pathology or neurodegeneration. |
2020-06-26 |
2023-08-13 |
Not clear |
| Rubén Fernández-Santiago, Angelika Merkel, Giancarlo Castellano, Simon Heath, Ángel Raya, Eduard Tolosa, María-José Martí, Antonella Consiglio, Mario Ezquerr. Whole-genome DNA hyper-methylation in iPSC-derived dopaminergic neurons from Parkinson's disease patients. Clinical epigenetics. vol 11. issue 1. 2020-06-26. PMID:31337434. |
parkinson's disease (pd) is characterized by the loss of midbrain dopaminergic neurons (dan). |
2020-06-26 |
2023-08-13 |
Not clear |
| Olga Gorelenkova Miller, John J Mieya. Critical Roles of Glutaredoxin in Brain Cells-Implications for Parkinson's Disease. Antioxidants & redox signaling. vol 30. issue 10. 2020-06-24. PMID:29183158. |
recent advances: in postmortem midbrain pd samples, grx1 was decreased relative to controls, specifically within dopaminergic neurons. |
2020-06-24 |
2023-08-13 |
human |
| Sabine Morris Hey, Pia Jensen, Matias Ryding, Alberto Martínez Serrano, Bjarne W Kristensen, Morten Meye. Nonhypoxic pharmacological stabilization of Hypoxia Inducible Factor 1α: Effects on dopaminergic differentiation of human neural stem cells. The European journal of neuroscience. vol 49. issue 4. 2020-06-22. PMID:30471165. |
parkinson's disease is a neurodegenerative disease resulting in degeneration of midbrain dopaminergic neurons. |
2020-06-22 |
2023-08-13 |
human |
| Yixi Chen, Karamjit Singh Dolt, Marco Kriek, Terry Baker, Patrick Downey, Nicola J Drummond, Maurice A Canham, Ammar Natalwala, Susan Rosser, Tilo Kunat. Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated deletion of the SNCA gene. The European journal of neuroscience. vol 49. issue 4. 2020-06-22. PMID:30472757. |
authentic midbrain dopaminergic (mda) neuronal precursors can be differentiated from human embryonic stem cells (hescs) and human induced pluripotent stem cells (ipscs). |
2020-06-22 |
2023-08-13 |
human |
| Qian Zhang, Changpeng Hu, Jingbin Huang, Wuyi Liu, Wenjing Lai, Faning Leng, Qin Tang, Yali Liu, Qing Wang, Min Zhou, Fangfang Sheng, Guobing Li, Rong Zhan. ROCK1 induces dopaminergic nerve cell apoptosis via the activation of Drp1-mediated aberrant mitochondrial fission in Parkinson's disease. Experimental & molecular medicine. vol 51. issue 10. 2020-06-15. PMID:31578315. |
dopamine deficiency is mainly caused by apoptosis of dopaminergic nerve cells in the substantia nigra of the midbrain and the striatum and is an important pathologic basis of parkinson's disease (pd). |
2020-06-15 |
2023-08-13 |
Not clear |
| Wei Zheng, Zhiguo Che. Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies. Journal of visualized experiments : JoVE. issue 149. 2020-06-12. PMID:31355797. |
parkinson's disease (pd) is caused by degeneration of dopaminergic (da) neurons at the substantia nigra pars compacta (snpc) in the ventral mesencephalon (vm). |
2020-06-12 |
2023-08-13 |
mouse |
| Tanusree Das, Jaclyn J Hwang, Kathleen L Posto. Episodic recognition memory and the hippocampus in Parkinson's disease: A review. Cortex; a journal devoted to the study of the nervous system and behavior. vol 113. 2020-06-08. PMID:30660957. |
the hallmark pathophysiology includes the development of neuronal lewy bodies in the substantia nigra of the midbrain with subsequent loss of dopaminergic neurons. |
2020-06-08 |
2023-08-13 |
Not clear |
| Laura Masullo, Marco Tripod. Goal-Oriented Behaviour: The Ventral Tegmental Area in Motivated Movements. Current biology : CB. vol 29. issue 19. 2020-06-05. PMID:31593666. |
the ventral tegmental area is a midbrain region known for the involvement of its dopaminergic neurons in encoding reward-related features, value and motivational states. |
2020-06-05 |
2023-08-13 |
Not clear |
| James Wt Kusena, Robert J Thomas, Mark J McCall, Samantha L Wilso. From protocol to product: ventral midbrain dopaminergic neuron differentiation for the treatment of Parkinson's disease. Regenerative medicine. vol 14. issue 11. 2020-06-05. PMID:31718456. |
this report summaries key milestones in specifically for ventral midbrain dopaminergic neuroprogenitor differentiation and key translational considerations and recommendations to enable successful, robust and reproducible current cell therapy product-manufacturing. |
2020-06-05 |
2023-08-13 |
Not clear |
| Fabien Menardy, Andrés Pablo Varani, Adèle Combes, Clément Léna, Daniela Pop. Functional Alteration of Cerebello-Cerebral Coupling in an Experimental Mouse Model of Parkinson's Disease. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 4. 2020-06-02. PMID:30715237. |
in parkinson's disease, the degeneration of the midbrain dopaminergic neurons is consistently associated with modified metabolic activity in the cerebellum. |
2020-06-02 |
2023-08-13 |
mouse |
| Fabien Menardy, Andrés Pablo Varani, Adèle Combes, Clément Léna, Daniela Pop. Functional Alteration of Cerebello-Cerebral Coupling in an Experimental Mouse Model of Parkinson's Disease. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 4. 2020-06-02. PMID:30715237. |
here we examined the functional reorganization taking place in the cerebello-cerebral circuit in a murine model of parkinson's disease with 6-ohda lesion of midbrain dopaminergic neurons. |
2020-06-02 |
2023-08-13 |
mouse |
| Dominique Leitner, Mahesh Ramamoorthy, Marion Dejosez, Thomas P Zwak. Immature mDA neurons ameliorate motor deficits in a 6-OHDA Parkinson's disease mouse model and are functional after cryopreservation. Stem cell research. vol 41. 2020-06-02. PMID:31731178. |
parkinson's disease is associated with the loss of dopaminergic neurons in the midbrain. |
2020-06-02 |
2023-08-13 |
mouse |
| Dominique Leitner, Mahesh Ramamoorthy, Marion Dejosez, Thomas P Zwak. Immature mDA neurons ameliorate motor deficits in a 6-OHDA Parkinson's disease mouse model and are functional after cryopreservation. Stem cell research. vol 41. 2020-06-02. PMID:31731178. |
however, this approach has been limited by difficulties in scaling up on-demand production of midbrain dopaminergic (mda) neurons from pluripotent stem cells. |
2020-06-02 |
2023-08-13 |
mouse |
| Christa Überbacher, Julia Obergasteiger, Mattia Volta, Serena Venezia, Stefan Müller, Isabella Pesce, Sara Pizzi, Giulia Lamonaca, Anne Picard, Giada Cattelan, Giorgio Malpeli, Michele Zoli, Dayne Beccano-Kelly, Rowan Flynn, Richard Wade-Martins, Peter P Pramstaller, Andrew A Hicks, Sally A Cowley, Corrado Cort. Application of CRISPR/Cas9 editing and digital droplet PCR in human iPSCs to generate novel knock-in reporter lines to visualize dopaminergic neurons. Stem cell research. vol 41. 2020-06-02. PMID:31733438. |
derivation of midbrain dopaminergic (daergic) neurons from hipscs of pd patients represents the only option to model physiological processes in a cell type that is not otherwise accessible from human patients. |
2020-06-02 |
2023-08-13 |
human |
| Akanksha Mishra, Sonu Singh, Virendra Tiwari, Swati Chaturvedi, M Wahajuddin, Shubha Shukl. Dopamine receptor activation mitigates mitochondrial dysfunction and oxidative stress to enhance dopaminergic neurogenesis in 6-OHDA lesioned rats: A role of Wnt signalling. Neurochemistry international. vol 129. 2020-06-01. PMID:31078578. |
nigral dopaminergic (daergic) cell degeneration and depletion of dopamine neurotransmitter in the midbrain are cardinal features of parkinson's disease (pd). |
2020-06-01 |
2023-08-13 |
rat |
| Nicolas Mallet, Lorena Delgado, Marine Chazalon, Cristina Miguelez, Jérôme Baufreto. Cellular and Synaptic Dysfunctions in Parkinson's Disease: Stepping out of the Striatum. Cells. vol 8. issue 9. 2020-05-26. PMID:31470672. |
this network is also the region primarily affected by the degeneration of midbrain dopaminergic neurons localized in the substantia nigra pars compacta (snc). |
2020-05-26 |
2023-08-13 |
Not clear |
| Brónagh McCoy, Sara Jahfari, Gwenda Engels, Tomas Knapen, Jan Theeuwe. Dopaminergic medication reduces striatal sensitivity to negative outcomes in Parkinson's disease. Brain : a journal of neurology. vol 142. issue 11. 2020-05-26. PMID:31603493. |
reduced levels of dopamine in parkinson's disease contribute to changes in learning, resulting from the loss of midbrain neurons that transmit a dopaminergic teaching signal to the striatum. |
2020-05-26 |
2023-08-13 |
human |
| Jeffrey S Schweitzer, Bin Song, Todd M Herrington, Tae-Yoon Park, Nayeon Lee, Sanghyeok Ko, Jeha Jeon, Young Cha, Kyungsang Kim, Quanzheng Li, Claire Henchcliffe, Michael Kaplitt, Carolyn Neff, Otto Rapalino, Hyemyung Seo, In-Hee Lee, Jisun Kim, Taewoo Kim, Gregory A Petsko, Jerome Ritz, Bruce M Cohen, Sek-Won Kong, Pierre Leblanc, Bob S Carter, Kwang-Soo Ki. Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson's Disease. The New England journal of medicine. vol 382. issue 20. 2020-05-22. PMID:32402162. |
we report the implantation of patient-derived midbrain dopaminergic progenitor cells, differentiated in vitro from autologous induced pluripotent stem cells (ipscs), in a patient with idiopathic parkinson's disease. |
2020-05-22 |
2023-08-13 |
mouse |