| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pinar Eser, Ersoy Kocabicak, Ahmet Bekar, Yasin Teme. The interplay between neuroinflammatory pathways and Parkinson's disease. Experimental neurology. vol 372. 2023-12-08. PMID:38061555. |
parkinson's disease, a progressive neurodegenerative disorder predominantly affecting elderly, is marked by the gradual degeneration of the nigrostriatal dopaminergic pathway, culminating in neuronal loss within the substantia nigra pars compacta (snpc) and dopamine depletion. |
2023-12-08 |
2023-12-17 |
Not clear |
| Vesna Sočan, Klemen Dolinar, Mojca Krža. Transporters involved in adult rat cortical astrocyte dopamine uptake: Kinetics, expression and pharmacological modulation. The European journal of neuroscience. 2023-12-06. PMID:38054361. |
in addition, we were interested in the expression of mrna of dopamine transporters as well as dopamine receptors d1 and d2 and in the effect of dopaminergic drugs on the expression of these transporters and receptors. |
2023-12-06 |
2023-12-10 |
rat |
| Jong Mi Park, Masoud Rahmati, Sang Chul Lee, Jae Il Shin, Yong Wook Ki. Effects of mesenchymal stem cell on dopaminergic neurons, motor and memory functions in animal models of Parkinson's disease: a systematic review and meta-analysis. Neural regeneration research. vol 19. issue 7. 2023-12-05. PMID:38051903. |
parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, and although restoring striatal dopamine levels may improve symptoms, no treatment can cure or reverse the disease itself. |
2023-12-05 |
2023-12-10 |
Not clear |
| Reka Csehi, Viktor Molnar, Mariann Fedor, Vivien Zsumbera, Agnes Palasti, Karoly Acsai, Zoltan Grosz, Gyorgy Nemeth, Maria Judit Molna. The improvement of motor symptoms in Huntington's disease during cariprazine treatment. Orphanet journal of rare diseases. vol 18. issue 1. 2023-12-02. PMID:38041194. |
their emergence is related to alterations in striatal dopaminergic neurotransmission: dopamine levels increase in the early stages of the disease, while more advanced stages are characterised by reduced dopamine levels. |
2023-12-02 |
2023-12-10 |
Not clear |
| Rong-Xin Song, Hui-Tao Miao, Shi-Yan Jia, Wen-Guang Li, Ji-Zhen Liu, Wei Zhang, Bao-Rui Xing, Jian-Yong Zhao, Li-Min Zhang, Xiao-Ming L. Hemorrhagic Shock and Resuscitation Causes Excessive Dopaminergic Signaling in the mPFC and Cognitive Dysfunction. Molecular neurobiology. 2023-12-02. PMID:38041715. |
the hsr caused excessive dopaminergic signaling and cognitive dysfunction in the mpfc, a condition that might be ameliorated using a dopamine d1 receptor inhibitor. |
2023-12-02 |
2023-12-10 |
mouse |
| Masaki Ishikawa, Yasuko Yamamoto, Bolati Wulaer, Kazuo Kunisawa, Hidetsugu Fujigaki, Tatsuya Ando, Hiroki Kimura, Itaru Kushima, Yuko Arioka, Youta Torii, Akihiro Mouri, Norio Ozaki, Toshitaka Nabeshima, Kuniaki Sait. Indoleamine 2,3-dioxygenase 2 deficiency associates with autism-like behavior via dopaminergic neuronal dysfunction. The FEBS journal. 2023-12-01. PMID:38037233. |
both chemogenetic activation of dopaminergic neurons and treatment with methylphenidate, a dopamine reuptake inhibitor, ameliorated the asd-like behavior of ido2 ko mice. |
2023-12-01 |
2023-12-10 |
mouse |
| Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Ki. Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum. Frontiers in public health. vol 11. 2023-12-01. PMID:38026429. |
in conclusion, this study demonstrates that simultaneous exposure to different metals can impact key enzymes involved in dopaminergic and serotonergic neurotransmission processes, leading to disruptions in dopamine and serotonin homeostasis and consequently a range of detrimental neurobehavioral effects. |
2023-12-01 |
2023-12-10 |
mouse |
| Ammara Shaikh, Fairus Ahmad, Seong Lin Teoh, Jaya Kumar, Mohamad Fairuz Yahay. Targeting dopamine transporter to ameliorate cognitive deficits in Alzheimer's disease. Frontiers in cellular neuroscience. vol 17. 2023-12-01. PMID:38026688. |
extensive research has been conducted on dopaminergic neurons, receptors, and dopamine levels as critical factors in cognition and memory in ad. |
2023-12-01 |
2023-12-10 |
Not clear |
| Ammara Shaikh, Fairus Ahmad, Seong Lin Teoh, Jaya Kumar, Mohamad Fairuz Yahay. Targeting dopamine transporter to ameliorate cognitive deficits in Alzheimer's disease. Frontiers in cellular neuroscience. vol 17. 2023-12-01. PMID:38026688. |
recently, a previously overlooked element of the dopaminergic system, the dopamine transporter, has shown significant promise as a more effective target for enhancing cognition while addressing dopaminergic system dysfunction in ad. |
2023-12-01 |
2023-12-10 |
Not clear |
| Yizhou Zhuo, Bin Luo, Xinyang Yi, Hui Dong, Xiaolei Miao, Jinxia Wan, John T Williams, Malcolm G Campbell, Ruyi Cai, Tongrui Qian, Fengling Li, Sophia J Weber, Lei Wang, Bozhi Li, Yu Wei, Guochuan Li, Huan Wang, Yu Zheng, Yulin Zhao, Marina E Wolf, Yingjie Zhu, Mitsuko Watabe-Uchida, Yulong L. Improved green and red GRAB sensors for monitoring dopaminergic activity in vivo. Nature methods. 2023-11-30. PMID:38036855. |
dopamine (da) plays multiple roles in a wide range of physiological and pathological processes via a large network of dopaminergic projections. |
2023-11-30 |
2023-12-10 |
Not clear |
| Dmitrii S Traktirov, Ilya R Nazarov, Valeria S Artemova, Raul R Gainetdinov, Nina S Pestereva, Marina N Karpenk. Alterations in Serotonin Neurotransmission in Hyperdopaminergic Rats Lacking the Dopamine Transporter. Biomedicines. vol 11. issue 11. 2023-11-25. PMID:38001881. |
the observed region-specific changes in the tissue levels of serotonin and in the expression of dopamine and serotonergic metabolism enzymes in rats with an excess of dopamine can indicate important consequences for the pharmacotherapy of drugs that modulate the dopaminergic system. |
2023-11-25 |
2023-11-28 |
rat |
| Miguel Á Luján, Dan P Covey, Reana Young-Morrison, LanYuan Zhang, Andrew Kim, Fiorella Morgado, Sachin Patel, Caroline E Bass, Carlos Paladini, Joseph F Chee. Mobilization of endocannabinoids by midbrain dopamine neurons is required for the encoding of reward prediction. Nature communications. vol 14. issue 1. 2023-11-24. PMID:37985770. |
however, it is not clear whether mobilization of 2-ag specifically from midbrain dopamine neurons is necessary for dopaminergic responses to external stimuli predicting forthcoming reward. |
2023-11-24 |
2023-11-28 |
mouse |
| Laura Dazzi, Fabrizio Sanna, Giuseppe Talani, Valentina Bassareo, Francesca Biggio, Paolo Follesa, Maria Giuseppina Pisu, Patrizia Porcu, Roberta Puliga, Marina Quartu, Mariangela Serra, Maria Pina Serra, Enrico Sann, Elio Acqua. Binge-like administration of alcohol mixed to energy drinks to male adolescent rats severely impacts on mesocortical dopaminergic function in adulthood: A behavioral, neurochemical and electrophysiological study. Neuropharmacology. 2023-11-12. PMID:37952712. |
we did so by measuring: i) physiological sensorimotor gating; ii) voluntary alcohol consumption and dopamine transmission before, during, and after presentation of alcohol; iii) electrophysiological activity of vta dopaminergic neurons and their sensitivity to a challenge with alcohol. |
2023-11-12 |
2023-11-20 |
rat |
| Kyoungjune Pak, Lauri Nummenma. Brain dopamine receptor system is not altered in obesity: Bayesian and frequentist meta-analyses. Human brain mapping. 2023-11-11. PMID:37950852. |
feeding induces dopamine release in the striatum, and a dysfunction of the dopaminergic reward system can lead to overeating, and obesity. |
2023-11-11 |
2023-11-20 |
human |
| Patricia Alejandra Brand-Rubalcava, Aldo Rafael Tejeda-Martínez, Orfil González-Reynoso, Angelica Yanet Nápoles-Medina, Verónica Chaparro-Huerta, Mario Eduardo Flores-Sot. β-Caryophyllene decreases neuroinflammation and exerts neuroprotection of dopaminergic neurons in a model of hemiparkinsonism through inhibition of the NLRP3 inflammasome. Parkinsonism & related disorders. vol 117. 2023-11-04. PMID:37924806. |
parkinson's disease represents a neurodegenerative condition characterized by the progressive loss of dopaminergic neurons within the substantia nigra pars compacta (snpc), resulting in diminished dopamine levels in the striatum (str) and chronic neuroinflammation. |
2023-11-04 |
2023-11-08 |
Not clear |
| Rafael Rivas-Santisteban, Alberto Rico, Ana Muñoz, Ana I Rodriguez, Irene Reyes-Resina, Gemma Navarro, José Luis Labandeira-García, José Luis Lanciego, Rafael Franc. Boolean analysis shows a high proportion of dopamine D Neurobiology of disease. 2023-11-02. PMID:37918757. |
boolean analysis shows a high proportion of dopamine d the antagonistic effect of adenosine on dopaminergic transmission in the basal ganglia indirect motor control pathway is mediated by dopamine d |
2023-11-02 |
2023-11-08 |
Not clear |
| Antonino Natalello, Stefania Brocca, Erika Ponzini, Carlo Santambrogio, Rita Grandor. Modulation of Alpha-Synuclein Conformational Ensemble and Aggregation Pathways by Dopamine and Related Molecules. Frontiers in bioscience (Landmark edition). vol 28. issue 10. 2023-11-02. PMID:37919088. |
dopaminergic neurons are constantly threatened by the thin boundaries between functional α-synuclein (as) structural disorder and pathogenic aggregation, and between dopamine (da) neurotransmitter activity and accumulation of cytotoxic by-products. |
2023-11-02 |
2023-11-08 |
Not clear |
| Hye Yun Kim, Jieun Lee, Hyun-Jin Kim, Byeong Eun Lee, Jaewook Jeong, Eun Jeong Cho, Hyun-Jun Jang, Kyeong Jin Shin, Min Ji Kim, Young Chan Chae, Seung Eun Lee, Kyungjae Myung, Ja-Hyun Baik, Pann-Ghill Suh, Jae-Ick Ki. PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III. Experimental & molecular medicine. 2023-11-01. PMID:37907739. |
we found that cell type-specific deletion of plcγ1 does not adversely affect the development and cellular morphology of midbrain dopamine neurons but does facilitate dopamine release from dopaminergic axon terminals in the striatum. |
2023-11-01 |
2023-11-08 |
mouse |
| Hye Yun Kim, Jieun Lee, Hyun-Jin Kim, Byeong Eun Lee, Jaewook Jeong, Eun Jeong Cho, Hyun-Jun Jang, Kyeong Jin Shin, Min Ji Kim, Young Chan Chae, Seung Eun Lee, Kyungjae Myung, Ja-Hyun Baik, Pann-Ghill Suh, Jae-Ick Ki. PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III. Experimental & molecular medicine. 2023-11-01. PMID:37907739. |
the enhancement of dopamine release was accompanied by increased colocalization of vesicular monoamine transporter 2 (vmat2) at dopaminergic axon terminals. |
2023-11-01 |
2023-11-08 |
mouse |
| Rafael Franco, Joan Serrano-Marín, Gemma Navarro, Rafael Rivas-Santisteba. The NADPH Link between the Renin Angiotensin System and the Antioxidant Mechanisms in Dopaminergic Neurons. Antioxidants (Basel, Switzerland). vol 12. issue 10. 2023-10-30. PMID:37891948. |
the production of ras peptides and the expression of several ras enzymes and receptors in dopaminergic neurons of the substantia nigra has raised expectations in the therapy of parkinson's disease, a neurodegenerative condition characterized by lack of dopamine in the striatum, the motor control region of the mammalian brain. |
2023-10-30 |
2023-11-08 |
Not clear |