| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David A Vogelsang, Daniella J Furman, Derek E Nee, Ioannis Pappas, Robert L White, Andrew S Kayser, Mark D'Esposit. Dopamine Modulates Effective Connectivity in Frontal Cortex. Journal of cognitive neuroscience. 2023-10-30. PMID:37902578. |
using a randomized, double-blind, within-subject design, we analyzed resting-state fmri data of 66 healthy young participants who were scanned once each after administration of bromocriptine (a dopamine agonist with preferential affinity for d2 receptor), tolcapone (an inhibitor of catechol-o-methyltransferase), and placebo, to determine whether dopaminergic stimulation modulated effective functional connectivity between hierarchically organized frontal regions in the left hemisphere. |
2023-10-30 |
2023-11-08 |
human |
| Priya Rathor, Ratnasekhar C. Metabolic Basis of Circadian Dysfunction in Parkinson's Disease. Biology. vol 12. issue 10. 2023-10-27. PMID:37887004. |
impaired α-synuclein secretion and dopamine release may cause mitochondrial dysfunction and perturb energy metabolism, subsequently altering the activity and survival of dopaminergic neurons, thus perpetuating the neurodegenerative process in pd. |
2023-10-27 |
2023-11-08 |
human |
| M López-Aguirre, M Matarazzo, J Blesa, M H G Monje, R Rodríguez-Rojas, A Sánchez-Ferro, J A Obeso, J A Pineda-Pard. Dopaminergic denervation and associated MRI microstructural changes in the nigrostriatal projection in early Parkinson's disease patients. NPJ Parkinson's disease. vol 9. issue 1. 2023-10-20. PMID:37852988. |
loss of dopaminergic neurons in the substantia nigra pars compacta (snc) and a profound reduction of striatal dopamine are two hallmarks of parkinson's disease (pd). |
2023-10-20 |
2023-11-08 |
human |
| Lin Zhou, Rongjie Yang, Xinru Li, Nuo Dong, Boyu Zhu, Jingjing Wang, Xingyu Lin, Bin S. COF-Coated Microelectrode for Space-Confined Electrochemical Sensing of Dopamine in Parkinson's Disease Model Mouse Brain. Journal of the American Chemical Society. 2023-10-20. PMID:37859408. |
parkinson's disease (pd) is a progressive neurodegenerative disorder causing the loss of dopaminergic neurons in the substantia nigra and the drastic depletion of dopamine (da) in the striatum; thus, da can act as a marker for pd diagnosis and therapeutic evaluation. |
2023-10-20 |
2023-11-08 |
mouse |
| Jeonghyun Park, Eunsoo Moon, Hyun Ju Lim, Kyungwon Kim, Yoo Rha Hong, Jung Hyun Le. Changes of Locomotor Activity by Dopamine D2, D3 Agonist Quinpirole in Mice Using Home-cage Monitoring System. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology. vol 21. issue 4. 2023-10-20. PMID:37859441. |
: as dopamine is closely linked to locomotor activities, animal studies on locomotor activities using dopaminergic agents were widely done. |
2023-10-20 |
2023-11-08 |
mouse |
| Elena Contaldi, Silvia Gallo, Lucia Corrado, Sandra D'Alfonso, Luca Magistrell. Parkinsonism in SCA19/22: Dopamine Transporter Imaging in an Italian Family Harboring a Novel Mutation. Cerebellum (London, England). 2023-10-19. PMID:37857779. |
patients underwent dopamine transporter single-photon emission computed tomography to assess dopaminergic degeneration. |
2023-10-19 |
2023-11-08 |
Not clear |
| Merlin Monzel, Jana Karneboge, Martin Reute. The role of dopamine in visual imagery-An experimental pharmacological study. Journal of neuroscience research. 2023-10-18. PMID:37849328. |
additional exploratory analyses will use genetic data to investigate possible effects of variations on dopaminergic gene loci (e.g., dat1) on dopamine levels and strength of mental imagery. |
2023-10-18 |
2023-11-08 |
human |
| Iman Touati, Mohnad Abdalla, Yassir Boulaamane, Nawal Al-Hoshani, Abdulaziz Alouffi, Mohammed Reda Britel, Amal Maurad. Identification of novel dual acting ligands targeting the adenosine A2A and serotonin 5-HT1A receptors. Journal of biomolecular structure & dynamics. 2023-10-18. PMID:37850444. |
pd is the second most ubiquitous neurological disorder after alzheimer's disease, characterized by the depletion of dopamine in the central nervous system due to the impairment of dopaminergic neurons, leading to involuntary movements or dyskinesia. |
2023-10-18 |
2023-11-08 |
Not clear |
| Sairam Ramesh, Arosh S Perera Molligoda Arachchig. Depletion of dopamine in Parkinson's disease and relevant therapeutic options: A review of the literature. AIMS neuroscience. vol 10. issue 3. 2023-10-16. PMID:37841347. |
in individuals with parkinson's disease, the loss of dopaminergic neurons leads to a reduction in dopamine levels, which causes motor impairment and may also contribute to the cognitive deficits observed in some patients. |
2023-10-16 |
2023-11-08 |
Not clear |
| Sheila A Villa-Cedillo, Daniel Matta-Yee-Chig, Adolfo Soto-Domínguez, Humberto Rodríguez-Rocha, Aracely García-García, Carlos R Montes-de-Oca-Saucedo, María de Jesús Loera-Arias, Jesús Valdés, Odila Saucedo-Cárdena. CDNF overexpression prevents motor-cognitive dysfunction by intrastriatal CPP-based delivery system in a Parkinson's disease animal model. Neuropeptides. vol 102. 2023-10-14. PMID:37837805. |
neurotrophic factors, such as cerebral dopamine neurotrophic factor (cdnf), have shown a neuroprotective effect on dopaminergic neurons. |
2023-10-14 |
2023-11-08 |
mouse |
| Mohana Devi Subramaniam, P Aishwarya Janaki, B Abishek Kumar, Janani Gopalarethinam, Aswathy P Nair, I Mahalaxmi, Balachandar Vellingir. Retinal Changes in Parkinson's Disease: A Non-invasive Biomarker for Early Diagnosis. Cellular and molecular neurobiology. 2023-10-13. PMID:37831228. |
parkinson's disease (pd) is caused due to degeneration of dopaminergic neurons in the substantia nigra pars compacta (snpc) which leads to the depletion of dopamine in the body. |
2023-10-13 |
2023-10-15 |
Not clear |
| Hao Liu, Haibin Dong, Chunxiao Wang, Wenjuan Jia, Guangqiang Wang, Hua Wang, Lin Zhong, Lei Gon. Key Subdomains of Cerebral Dopamine Neurotrophic Factor Regulate Its Protective Function in 6-Hydroxydopamine-Lesioned PC12 Cells. DNA and cell biology. 2023-10-10. PMID:37815547. |
cerebral dopamine neurotrophic factor (cdnf) is a unique neurotrophic factor (ntf) that has shown significant neuroprotective and neurorestorative functions on midbrain dopaminergic neurons. |
2023-10-10 |
2023-10-15 |
human |
| Xuanxiang Jin, Xiaoli Si, Xiaoguang Lei, Huifang Liu, Anwen Shao, Lingfei L. Disruption of Dopamine Homeostasis Associated with Alteration of Proteins in Synaptic Vesicles: A Putative Central Mechanism of Parkinson's Disease Pathogenesis. Aging and disease. 2023-10-10. PMID:37815908. |
vestigial dopaminergic cells in pd have selectivity for a sub-class of hypersensitive neurons with the nigrostriatal dopamine (da) tract. |
2023-10-10 |
2023-10-15 |
Not clear |
| Xiu-Ying He, Ru-Rong Wang, Ting-Hua Wan. The role of immune cells in the course of Parkinson's disease. Ibrain. vol 7. issue 2. 2023-10-03. PMID:37786903. |
the pathological manifestations mainly consist of α-synuclein accumulation, degeneration and death of dopaminergic neurons, and insufficient dopamine secretion. |
2023-10-03 |
2023-10-07 |
Not clear |
| G Cappelletti, E V Carsana, G Lunghi, S Breviario, C Vanetti, A B Di Fonzo, E Frattini, M Magni, S Zecchini, M Clerici, M Aureli, C Fenizi. SARS-CoV-2 hampers dopamine production in iPSC-derived dopaminergic neurons. Experimental and molecular pathology. 2023-09-29. PMID:37775022. |
sars-cov-2 hampers dopamine production in ipsc-derived dopaminergic neurons. |
2023-09-29 |
2023-10-07 |
human |
| Laoise Casserly, Daniel R Garton, Ana Montaño-Rodriguez, Jaan-Olle Andresso. Analysis of Acute and Chronic Methamphetamine Treatment in Mice on Gdnf System Expression Reveals a Potential Mechanism of Schizophrenia Susceptibility. Biomolecules. vol 13. issue 9. 2023-09-28. PMID:37759827. |
the increase in presynaptic striatal dopamine is the main dopaminergic abnormality in schizophrenia (scz). |
2023-09-28 |
2023-10-07 |
mouse |
| Paola Briñez-Gallego, Dennis Guilherme da Costa Silva, Ana Paula Horn, Mariana Appel Hor. Effects of curcumin to counteract levodopa-induced toxicity in zebrafish. Journal of toxicology and environmental health. Part A. 2023-09-28. PMID:37767720. |
currently, treatment of pd has focused on increasing dopamine levels, using a dopamine precursor, levodopa (l-dopa) or stimulation of dopaminergic receptors. |
2023-09-28 |
2023-10-07 |
zebrafish |
| Jingbo Wang, Sabitha Joseph, Siv Vingill, Ekrem Dere, Lars Tatenhorst, Anja Ronnenberg, Paul Lingor, Christian Preisinger, Hannelore Ehrenreich, Jörg B Schulz, Judith Stegmülle. Loss of the parkinsonism-associated protein FBXO7 in glutamatergic forebrain neurons in mice leads to abnormal motor behavior and synaptic defects. Journal of neurochemistry. 2023-09-27. PMID:37753846. |
nex-cre;fbxo7fl/fl mice revealed an increase in striatal dopamine concentrations, changes in the glutamatergic, gabaergic and dopaminergic pathways, astrogliosis and microgliosis and little or no neuronal loss in the striatum. |
2023-09-27 |
2023-10-07 |
mouse |
| Li He, Huihui Zheng, Jilong Qiu, Hong Chen, Huan Li, Yuejiao Ma, Yingying Wang, Qianjin Wang, Yuzhu Hao, Yueheng Liu, Qian Yang, Xin Wang, Manyun Li, Huixue Xu, Pu Peng, Zejun Li, Yanan Zhou, Qiuxia Wu, Shubao Chen, Xiaojie Zhang, Tieqiao Li. Effects of Multiple High-Dose Methamphetamine Administration on Enteric Dopaminergic Neurons and Intestinal Motility in the Rat Model. Neurotoxicity research. 2023-09-27. PMID:37755670. |
the edns were assessed by measuring the expression of two dopaminergic neuronal markers, dopamine transporter (dat) and tyrosine hydroxylase (th), at the transcriptional and protein levels. |
2023-09-27 |
2023-10-07 |
rat |
| Jingjing Song, Yang Zhao, Xiaoqian Shan, Yongyin Luo, Nan Hao, Lan Zha. Active ingredients of Chinese medicine with immunomodulatory properties: NF-κB pathway and Parkinson's disease. Brain research. 2023-09-25. PMID:37748570. |
it has been found that an increasing number of active ingredients in chinese medicines, such as flavonoids, alkaloids, saponins, terpenoids, phenols and phenylpropanoids, have anti-inflammatory properties that can regulate neuroglia cell activation and ameliorate neuroinflammation through the nf-κb pathway, and increase dopamine release or protect dopaminergic neurons for neuroprotection to improve behavioural dysfunction in pd. |
2023-09-25 |
2023-10-07 |
Not clear |