| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Asadi Rizi, L Amjad, M Shahrani, H Amini Khoe. Investigating the Mechanisms Involved in Scopolamine-induced Memory Degradation. Archives of Razi Institute. vol 79. issue 3. 2024-12-31. PMID:39736944. |
these autoreceptors are located on dopaminergic presynaptic neurons, and their activation reduces the release of dopamine. |
2024-12-31 |
2025-01-02 |
Not clear |
| Atsushi Fujimoto, Catherine Elorette, Satoka H Fujimoto, Lazar Fleysher, Peter H Rudebeck, Brian E Rus. Pharmacological modulation of dopamine receptors reveals distinct brain-wide networks associated with learning and motivation in non-human primates. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-12-27. PMID:39730205. |
the neurotransmitter dopamine (da) has a multifaceted role in healthy and disordered brains through its action on multiple subtypes of dopaminergic receptors. |
2024-12-27 |
2024-12-30 |
human |
| Quézia Teixeira Rodrigues, Lucas Rios Drummond, Paulo Marcelo Andrade Lima, Frederico Sander Mansur Machado, Helton Oliveira Campos, Raphael Escorsim Szawka, Laura Hora Rios Leite, Cândido Celso Coimbr. Exercise performance effect of central dopamine is mediated by hypothalamic neuronal activation. Behavioural brain research. vol 480. 2024-12-26. PMID:39722282. |
thus, to evaluate the role of the central dopaminergic system in hypothalamic neuronal activation and its relationship with exercise performance, wistar rats were intracerebroventricularly injected with saline (sal) or sch-23390 (sch, dopamine d1 receptor blocker) at rest and before timed submaximal exercise (∼13 min) or exercise until fatigue. |
2024-12-26 |
2024-12-29 |
rat |
| Talita Rodrigues, Getulio Nicola Bressan, Patrícia Zorzi Juliani, Maria Eduarda Brandli da Silva, Roselei Fachinett. Ketamine impairs the performance of male mice in novel recognition object test and reduces the immunoreactivity of GAD Pharmacology, biochemistry, and behavior. 2024-12-26. PMID:39725040. |
the peroxisome proliferator-activated receptors-gamma (ppar-γ) are expressed in dopaminergic neurons of the midbrain participating in the modulation of neurotransmitters release like dopamine. |
2024-12-26 |
2024-12-29 |
mouse |
| Judy Cheng, Ellen T Koch, Daniel Ramandi, James P Mackay, Timothy P O'Leary, William Rees-Jones, Lynn A Raymon. Synaptic modulation of glutamate in striatum of the YAC128 mouse model of Huntington disease. Neurobiology of disease. 2024-12-24. PMID:39716682. |
d2 receptors are also expressed on glutamatergic cortical terminals, cholinergic interneurons, and dopaminergic terminals from substantia nigra where they suppress release of glutamate, acetylcholine and dopamine, respectively, and these cell types may contribute to early striatal dysfunction in hd. |
2024-12-24 |
2024-12-26 |
mouse |
| Aino M Kuusela, Emma A Honkanen, Elina Jaakkola, Elina Myller, Mikael Eklund, Simo Nuuttila, Kirsi-Marja Murtomäki, Tuomas Mertsalmi, Reeta Levo, Toni Ihalainen, Tommi Noponen, Tero Vahlberg, Juho Joutsa, Filip Scheperjans, Valtteri Kaasine. Striatal Dopaminergic Function and Motor Slowing in Essential Tremor Plus. Movement disorders clinical practice. 2024-12-23. PMID:39714119. |
while previous imaging studies have generally shown normal striatal dopamine transporter (dat) binding in essential tremor (et), emerging evidence suggests a partial dopaminergic mechanism in this condition and an epidemiological link between et and parkinson's disease (pd). |
2024-12-23 |
2024-12-25 |
Not clear |
| Mitchell J Vaughn, Nandini Yellamelli, R Michael Burger, Julie S Haa. Dopamine receptors D1, D2, and D4 modulate electrical synapses and excitability in the thalamic reticular nucleus. Journal of neurophysiology. 2024-12-20. PMID:39706150. |
although dopaminergic modulation of presynaptic inputs to trn has been described, the direct effect of dopamine on trn neurons and its electrical synapses is largely unknown. |
2024-12-20 |
2024-12-24 |
Not clear |
| Jin Hee Kim, Eugene Huh, Hyeyoon Eo, Jin Se Kim, Youngji Kwon, In Gyoung Ju, Yujin Choi, Hae-Jee Yoon, So-Ri Son, Dae Sik Jang, Seon-Pyo Hong, Hi-Joon Park, Myung Sook O. Tribuli Fructus alleviates 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease by suppressing neuroinflammation via JNK signaling. Metabolic brain disease. vol 40. issue 1. 2024-12-19. PMID:39699803. |
in the brains of mptp-induced pd mouse model, tf inhibited the activation of microglia and astrocytes, protected dopaminergic neurons, and increased dopamine levels. |
2024-12-19 |
2024-12-21 |
mouse |
| Thiago Ohno Bezerra, Antonio C Roqu. Dopamine facilitates the response to glutamatergic inputs in astrocyte cell models. PLoS computational biology. vol 20. issue 12. 2024-12-16. PMID:39680609. |
while glutamate released by neurons trigger ca2+ signals through ip3- and glutamate transporter-dependent mechanisms, dopamine released in distant sites activates astrocytes via dopaminergic receptors. |
2024-12-16 |
2024-12-21 |
Not clear |
| Arash Yaghoobi, Homa Seyedmirzaei, Marzie Jamaat, Moein Al. Epigenomic and clinical analyses of striatal DAT binding in healthy individuals reveal well-known loci of Parkinson's disease. Heliyon. vol 10. issue 23. 2024-12-10. PMID:39654757. |
striatal dopamine transporter (dat) binding is a sensitive and specific endophenotype for detecting dopaminergic deficits across parkinson's disease (pd) spectrum. |
2024-12-10 |
2024-12-12 |
Not clear |
| Kaili Liang, Li Yang, Jiawei Kang, Bo Liu, Ding Zhang, Liyan Wang, Wei Wang, Qing Wan. Improving treatment for Parkinson's disease: Harnessing photothermal and phagocytosis-driven delivery of levodopa nanocarriers across the blood-brain barrier. Asian journal of pharmaceutical sciences. vol 19. issue 6. 2024-12-06. PMID:39640059. |
levodopa, a key component of dopamine replacement therapy, effectively enhances dopaminergic activity. |
2024-12-06 |
2024-12-08 |
mouse |
| Jae Hoon Sul, Sol Shin, Hark Kyun Kim, Jihoon Han, Junsik Kim, Soyong Son, Jungmi Lee, Seung Hyun Baek, Yoonsuk Cho, Jeongmi Lee, Jinsu Park, Donghoon Ahn, Sunyoung Park, Leon F Palomera, Jeein Lim, Jongho Kim, Chanhee Kim, Seungsu Han, Ka Young Chung, Sangho Lee, Tae-In Kam, Yunjong Lee, Jeongyun Kim, Jae Hyung Park, Dong-Gyu J. Dopamine-conjugated extracellular vesicles induce autophagy in Parkinson's disease. Journal of extracellular vesicles. vol 13. issue 12. 2024-12-06. PMID:39641313. |
these findings collectively indicate that surface modification of evs with dopamine presents a potent strategy for targeting dopaminergic neurons in the brain. |
2024-12-06 |
2024-12-08 |
mouse |
| Kielen R Zuurbier, Rene Solano Fonseca, Sonja L B Arneaud, Jordan M Wall, Juhee Kim, Lexus Tatge, Gupse Otuzoglu, Sofia Bali, Patrick Metang, Peter M Dougla. Yin Yang 1 and guanine quadruplexes protect dopaminergic neurons from cellular stress via transmissive dormancy. Nature communications. vol 15. issue 1. 2024-12-05. PMID:39632864. |
extending observations of neurotrauma in c. elegans and mice, human dopaminergic neurons capable of surviving severe cellular challenges both decrease spontaneous activity and modulate dopamine homeostasis through the transcriptional regulator yin yang 1 (yy1). |
2024-12-05 |
2024-12-07 |
mouse |
| Kielen R Zuurbier, Rene Solano Fonseca, Sonja L B Arneaud, Jordan M Wall, Juhee Kim, Lexus Tatge, Gupse Otuzoglu, Sofia Bali, Patrick Metang, Peter M Dougla. Yin Yang 1 and guanine quadruplexes protect dopaminergic neurons from cellular stress via transmissive dormancy. Nature communications. vol 15. issue 1. 2024-12-05. PMID:39632864. |
this dopaminergic stress response has the potential to cause circuit inactivation, yet safeguards neurons by minimizing the toxic accumulation of cytosolic dopamine and inducing a state of neuronal dormancy. |
2024-12-05 |
2024-12-07 |
mouse |
| Marta Lapo Pais, Joana Crisóstomo, Antero Abrunhosa, Miguel Castelo-Branc. Central dopamine receptors: Radiotracers unveiling the Role of dopaminergic tone in obesity. Journal of molecular medicine (Berlin, Germany). 2024-12-04. PMID:39630278. |
central dopamine receptors: radiotracers unveiling the role of dopaminergic tone in obesity. |
2024-12-04 |
2024-12-06 |
Not clear |
| Hongquan Wang, Shuang Wu, Xiaodong Jiang, Wenjing Li, Qiang Li, Huiyan Sun, Yumin Wan. Acteoside alleviates salsolinol-induced Parkinson's disease by inhibiting ferroptosis via activating Nrf2/SLC7A11/GPX4 pathway. Experimental neurology. 2024-12-04. PMID:39631720. |
salsolinol (sal), i.e.1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroiso-quinoline, is a dopamine metabolite and endogenous neurotoxin that is toxic to dopaminergic neurons, and is involved in the genesis of parkinson's disease (pd). |
2024-12-04 |
2024-12-07 |
Not clear |
| Christopher I Esezobor, Girish C Bhatt, Emmanuel E Effa, Elisabeth M Hodso. Fenoldopam for preventing and treating acute kidney injury. The Cochrane database of systematic reviews. vol 11. 2024-11-28. PMID:39607014. |
fenoldopam is a short-acting benzazepine selective dopaminergic a1 (da1) receptor agonist with increased activity at the d1 receptor compared with dopamine. |
2024-11-28 |
2024-11-30 |
Not clear |
| Jintae Kim, Mi-Yoon Chan. Gene Therapy for Parkinson's Disease Using Midbrain Developmental Genes to Regulate Dopaminergic Neuronal Maintenance. International journal of molecular sciences. vol 25. issue 22. 2024-11-27. PMID:39596436. |
it is characterized by the progressive loss of dopaminergic (danergic) neurons in the substantia nigra and decreased dopamine (da) levels, which lead to both motor and non-motor symptoms. |
2024-11-27 |
2024-11-29 |
Not clear |
| Kaijie She, Naijun Yuan, Minyi Huang, Wenjun Zhu, Manshi Tang, Qingyu Ma, Jiaxu Che. Emerging role of microglia in the developing dopaminergic system: perturbation by early life stress. Neural regeneration research. 2024-11-26. PMID:39589170. |
furthermore, inflammation and oxidative stress induced by activated microglia can directly damage dopaminergic neurons, inhibiting dopamine synthesis, reuptake, and receptor activity. |
2024-11-26 |
2024-11-28 |
Not clear |
| Zu-Ming Duan, Yi-Tong Xu, Zheng Li, Jian-Xiang Pang, Jing-Juan Xu, Wei-Wei Zha. Neuromorphic Nanofluidic Sense Digitalization. Angewandte Chemie (International ed. in English). 2024-11-21. PMID:39569596. |
by inspiration of dopaminergic nerve, here a nanofluidic nerve with sense digitalization is devised by engineering a dopamine (da)-specific nanofluidic synapse as mediated by pc-12 cells to manage the robotic arm. |
2024-11-21 |
2024-11-23 |
Not clear |