| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaolin Tia. Enhancing mask activity in dopaminergic neurons extends lifespan in flies. Aging cell. vol 20. issue 11. 2021-11-20. PMID:34626525. |
this mask-induced beneficial effect requires dopaminergic transmission but cannot be recapitulated by elevating dopamine production alone in the dans. |
2021-11-20 |
2023-08-13 |
Not clear |
| Cathy K Cui, Simon J G Lewi. Future Therapeutic Strategies for Freezing of Gait in Parkinson's Disease. Frontiers in human neuroscience. vol 15. 2021-11-20. PMID:34795568. |
whilst there already exist a number of pharmacological (e.g., dopaminergic and beyond dopamine), non-pharmacological (physiotherapy and cueing, cognitive training, and non-invasive brain stimulation) and surgical approaches to freezing (i.e., dual-site deep brain stimulation, closed-loop programming), an integrated collaborative approach to future research in this complex area will be necessary to systematically investigate new therapeutic avenues. |
2021-11-20 |
2023-08-13 |
Not clear |
| Jingyi Wang, Yohan John, Helen Barba. Pathways for Contextual Memory: The Primate Hippocampal Pathway to Anterior Cingulate Cortex. Cerebral cortex (New York, N.Y. : 1991). vol 31. issue 3. 2021-11-19. PMID:33207365. |
the proximity of hippocampal terminations to d1 receptors may enable dopamine to enhance information transfer from the hippocampus to a25 and contribute to dopaminergic influence downstream on goal-directed action and emotional control by prefrontal cortices, in processes that may be disrupted by excessive dopamine release during uncontrollable stress. |
2021-11-19 |
2023-08-13 |
monkey |
| Douglas R Miller, Dylan T Guenther, Andrew P Maurer, Carissa A Hansen, Andrew Zalesky, Habibeh Khoshboue. Dopamine Transporter Is a Master Regulator of Dopaminergic Neural Network Connectivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 25. 2021-11-19. PMID:33980544. |
dopamine transporter is a master regulator of dopaminergic neural network connectivity. |
2021-11-19 |
2023-08-13 |
mouse |
| Douglas R Miller, Dylan T Guenther, Andrew P Maurer, Carissa A Hansen, Andrew Zalesky, Habibeh Khoshboue. Dopamine Transporter Is a Master Regulator of Dopaminergic Neural Network Connectivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 25. 2021-11-19. PMID:33980544. |
the dopaminergic neurons in these regions have been shown to exhibit differential sensitivity to neuronal loss and psychostimulants targeting dopamine transporter. |
2021-11-19 |
2023-08-13 |
mouse |
| Hongli Li, Yaru Feng, Ziyu Chen, Xi Jiang, Zhenyu Zhou, Jinfeng Yuan, Fei Li, Yu Zhang, Xingxu Huang, Shengjie Fan, Xiaojun Wu, Cheng Huan. Pepper component 7-ethoxy-4-methylcoumarin, a novel dopamine D2 receptor agonist, ameliorates experimental Parkinson's disease in mice and Caenorhabditis elegans. Pharmacological research. vol 163. 2021-11-18. PMID:33007422. |
parkinson's disease (pd) is a progressive neurodegenerative disease resulting from the degeneration of dopaminergic (daergic) neurons in the substantia nigra pars compacta (snpc) and subsequent deficit of dopamine in the striatum. |
2021-11-18 |
2023-08-13 |
mouse |
| Peiling Zhou, Meiping Deng, Jiashan Wu, Qinghui Lan, Huifang Yang, Changzheng Zhan. Ventral Tegmental Area Dysfunction and Disruption of Dopaminergic Homeostasis: Implications for Post-traumatic Stress Disorder. Molecular neurobiology. vol 58. issue 5. 2021-11-18. PMID:33428093. |
this article reviews recent advances in our knowledge of the relationship between dopaminergic dyshomeostasis and ptsd, including the contributions of specific dopaminergic gene variants to disease susceptibility, alterations in vta dopamine neuron activity, dysregulation of dopaminergic transmission, and potential pharmacological and psychological interventions for ptsd targeting the dopaminergic system. |
2021-11-18 |
2023-08-13 |
Not clear |
| Andrew Kayse. Dopamine and Gambling Disorder: Prospects for Personalized Treatment. Current addiction reports. vol 6. issue 2. 2021-11-17. PMID:31728265. |
to address variation in the severity of gambling disorder, this review evaluates the contribution of mesocorticolimbic dopamine neurons to potential behavioral endophenotypes, the influence of individual differences in the dopamine system on gambling and related behaviors, and the possible role for dopaminergic medications in the treatment of gambling disorder. |
2021-11-17 |
2023-08-13 |
Not clear |
| Charlotte P Magee, BaoMinh D Le, Yasmeen H Siripathane, Diana G Wilkins, Glen R Hanson, Annette E Fleckenstei. Methcathinone decreases dopamine transporter function: Role of protein kinase C. Journal of neurochemistry. vol 159. issue 1. 2021-11-17. PMID:34320222. |
methcathinone decreases dopamine transporter function: role of protein kinase c. methcathinone (mcat) is a psychostimulant of abuse that can cause both persistent striatal dopaminergic and serotonergic, as well as hippocampal serotonergic, deficits. |
2021-11-17 |
2023-08-13 |
rat |
| Emma A Honkanen, Mikael Eklund, Simo Nuuttila, Tommi Noponen, Elina Jaakkola, Elina Mäkinen, Risto Hirvilammi, Marko Seppänen, Kari Lindholm, Filip Scheperjans, Riitta Parkkola, Juho Joutsa, Andrea Varrone, Valtteri Kaasine. Dopamine transporter binding in symptomatic controls and healthy volunteers: Considerations for neuroimaging trials. NeuroImage. Clinical. vol 32. 2021-11-17. PMID:34482280. |
to evaluate possible differences between brain dopamine transporter (dat) binding in a group of symptomatic parkinsonism patients without dopaminergic degeneration and healthy individuals. |
2021-11-17 |
2023-08-13 |
human |
| Eleanor Porter, Andreas-Antonios Roussakis, Nicholas P Lao-Kaim, Paola Piccin. Multimodal dopamine transporter (DAT) imaging and magnetic resonance imaging (MRI) to characterise early Parkinson's disease. Parkinsonism & related disorders. vol 79. 2021-11-15. PMID:32861103. |
currently, in early idiopathic pd, dopamine transporter (dat)-specific imaging assesses the extent of striatal dopaminergic deficits, and conventional magnetic resonance imaging (mri) of the brain excludes the presence of significant ischaemic load in the basal ganglia as well as signs indicative of other forms of parkinsonism. |
2021-11-15 |
2023-08-13 |
Not clear |
| Aqilah M McCane, Meredyth A Wegener, Mojdeh Faraji, Maria T Rivera-Garcia, Kathryn G Wallin-Miller, Vincent D Costa, Bita Moghadda. Adolescent Dopamine Neurons Represent Reward Differently during Action and State Guided Learning. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 45. 2021-11-14. PMID:34611024. |
static characteristics of dopamine neurons, such as dopamine cell number and size, were similar in the vta and sn of both ages, but there were age-related differences in stimulated dopamine release and correlated spike activity, suggesting that differences in reward responsiveness by adolescent dopamine neurons are not because of differences in intrinsic properties of these neurons but engagement of different dopaminergic networks. |
2021-11-14 |
2023-08-13 |
rat |
| Piniel Alphayo Kambey, Ma Chengcheng, Guo Xiaoxiao, Ayanlaja Abiola Abdulrahman, Kouminin Kanwore, Iqra Nadeem, Wu Jiao, Dianshuai Ga. The orphan nuclear receptor Nurr1 agonist amodiaquine mediates neuroprotective effects in 6-OHDA Parkinson's disease animal model by enhancing the phosphorylation of P38 mitogen-activated kinase but not PI3K/AKT signaling pathway. Metabolic brain disease. vol 36. issue 4. 2021-11-12. PMID:33507465. |
we first demonstrated that amodiaquine treatment ameliorated behavioural deficits in 6-ohda parkinson's disease mouse model, and it promoted dopaminergic neurons protection signified by tyrosine hydroxylase (th) and dopamine transporter (dat) mrna; tyrosine hydroxylase (th) protein expression level and the immunoreactivity in the substantia nigra compacta. |
2021-11-12 |
2023-08-13 |
mouse |
| Tina Kazemi, Shuyan Huang, Naze G Avci, Yasemin M Akay, Metin Aka. Investigating the effects of chronic perinatal alcohol and combined nicotine and alcohol exposure on dopaminergic and non-dopaminergic neurons in the VTA. Scientific reports. vol 11. issue 1. 2021-11-12. PMID:33888815. |
the ventral tegmental area (vta) is the origin of dopaminergic neurons and the dopamine (da) reward pathway. |
2021-11-12 |
2023-08-13 |
rat |
| Mirjam Wolfschlag, Anders Håkansso. Increased risk for developing gambling disorder under the treatment with pramipexole, ropinirole, and aripiprazole: A nationwide register study in Sweden. PloS one. vol 16. issue 6. 2021-11-12. PMID:34061895. |
compared to patients with any other dopaminergic drug prescription (38.7% with gd), the diagnosis was more common in patients with a dopamine agonist prescription (69.8% with gd), resulting in an odds ratio of 3.2. |
2021-11-12 |
2023-08-13 |
Not clear |
| Fabrizio Sanna, Jessica Bratzu, Laura Angioni, Maria Pina Sorighe, Cristina Cocco, Antonio Argiolas, Maria Rosaria Meli. Oxytocin-conjugated saporin injected into the substantia nigra of male rats alters the activity of the nigrostriatal dopaminergic system: A behavioral and neurochemical study. Brain research. vol 1773. 2021-11-12. PMID:34744015. |
these results show that oxy-sap destroys nigrostriatal dopaminergic neurons expressing oxytocin receptors leading to a reduced striatal dopamine function. |
2021-11-12 |
2023-08-13 |
rat |
| Amber D Van Laar, Victor S Van Laar, Waldy San Sebastian, Aristide Merola, J Bradley Elder, Russell R Lonser, Krystof S Bankiewic. An Update on Gene Therapy Approaches for Parkinson's Disease: Restoration of Dopaminergic Function. Journal of Parkinson's disease. vol 11. issue s2. 2021-11-11. PMID:34366374. |
gene therapy is an attractive approach to impart a durable effect on neuronal function through introduction of genetic material to reestablish dopamine levels and/or functionally recover dopaminergic signaling by improving neuronal health. |
2021-11-11 |
2023-08-13 |
Not clear |
| Amber D Van Laar, Victor S Van Laar, Waldy San Sebastian, Aristide Merola, J Bradley Elder, Russell R Lonser, Krystof S Bankiewic. An Update on Gene Therapy Approaches for Parkinson's Disease: Restoration of Dopaminergic Function. Journal of Parkinson's disease. vol 11. issue s2. 2021-11-11. PMID:34366374. |
ongoing clinical gene therapy trials in pd are focused on enzymatic enhancement of dopamine production and/or the restoration of the nigrostriatal pathway to improve dopaminergic network function. |
2021-11-11 |
2023-08-13 |
Not clear |
| Serena Venezia, Walter A Kaufmann, Gregor K Wenning, Nadia Stefanov. Toll-like receptor 4 deficiency facilitates α-synuclein propagation and neurodegeneration in a mouse model of prodromal Parkinson's disease. Parkinsonism & related disorders. vol 91. 2021-11-11. PMID:34530328. |
the facilitated propagation of α-synuclein is associated with early loss of dopamine transporter (dat) signal in the striatum and loss of dopaminergic neurons in substantia nigra pars compacta of tlr4 deficient mice. |
2021-11-11 |
2023-08-13 |
mouse |
| Jing Wang, Xiao-Na Zhang, Jin-Ni Fang, Fei-Fei Hua, Jing-Yang Han, Zeng-Qiang Yuan, An-Mu Xi. The mechanism behind activation of the Nod-like receptor family protein 3 inflammasome in Parkinson's disease. Neural regeneration research. vol 17. issue 4. 2021-11-10. PMID:34472491. |
our results suggest that the atp-p2x4 receptor signaling pathway mediates nlrp3 inflammasome activation, dopaminergic neurodegeneration, and dopamine levels. |
2021-11-10 |
2023-08-13 |
rat |