| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shinichi Takahashi, Kyoko Mashim. Neuroprotection and Disease Modification by Astrocytes and Microglia in Parkinson Disease. Antioxidants (Basel, Switzerland). vol 11. issue 1. 2022-01-21. PMID:35052674. |
in parkinson disease, which is characterized by the degeneration of dopaminergic neurons resulting in dopamine depletion, the pathogenesis differs between hereditary and solitary disease forms and is often unclear. |
2022-01-21 |
2023-08-13 |
Not clear |
| Shinichi Takahashi, Kyoko Mashim. Neuroprotection and Disease Modification by Astrocytes and Microglia in Parkinson Disease. Antioxidants (Basel, Switzerland). vol 11. issue 1. 2022-01-21. PMID:35052674. |
pacemaking activity, which is a hallmark of dopaminergic neurons, is essential for the homeostatic maintenance of adequate dopamine concentrations in the synaptic cleft, but it imposes a burden on mitochondrial oxidative glucose metabolism, leading to reactive oxygen species production. |
2022-01-21 |
2023-08-13 |
Not clear |
| Lulu Tian, Murad Al-Nusaif, Xi Chen, Song Li, Weidong L. Roles of Transcription Factors in the Development and Reprogramming of the Dopaminergic Neurons. International journal of molecular sciences. vol 23. issue 2. 2022-01-21. PMID:35055043. |
in vitro and in vivo, tfs regulate the expression of tyrosine hydroxylase, a dopamine transporter, vesicular monoamine transporter 2, and l-aromatic amino acid decarboxylase, all of which are critical for dopamine synthesis and transport in dopaminergic neurons (da neurons). |
2022-01-21 |
2023-08-13 |
human |
| Adriana Trapani, Stefania Cometa, Elvira De Giglio, Filomena Corbo, Roberta Cassano, Maria Luisa Di Gioia, Sonia Trombino, Md Niamat Hossain, Sante Di Gioia, Giuseppe Trapani, Massimo Cones. Novel Nanoparticles Based on Pharmaceutics. vol 14. issue 1. 2022-01-21. PMID:35057043. |
although several bio-nanomaterials have been evaluated for encapsulation of neurotransmitter dopamine (da) or dopaminergic drugs in order to restore the da content in parkinsonian patients, the premature leakage of the therapeutic agent limits this approach. |
2022-01-21 |
2023-08-13 |
Not clear |
| Veronica Mutti, Federica Bono, Zaira Tomasoni, Leonardo Bontempi, Adele Guglielmi, Silvia Bolognin, Jens C Schwamborn, Cristina Missale, Chiara Fiorentin. Structural Plasticity of Dopaminergic Neurons Requires the Activation of the D3R-nAChR Heteromer and the PI3K-ERK1/2/Akt-Induced Expression of c-Fos and p70S6K Signaling Pathway. Molecular neurobiology. 2022-01-19. PMID:35044626. |
we have previously shown that the heteromer composed by the dopamine d3 receptor (d3r) and the nicotinic acetylcholine receptor (nachr) (d3r-nachr heteromer) is expressed in dopaminergic neurons, activated by nicotine and represents the molecular unit that, in these neurons, contributes to the modulation of critical events such as structural plasticity and neuroprotection. |
2022-01-19 |
2023-08-13 |
mouse |
| Gabriela Novak, Dimitrios Kyriakis, Kamil Grzyb, Michela Bernini, Sophie Rodius, Gunnar Dittmar, Steven Finkbeiner, Alexander Skupi. Single-cell transcriptomics of human iPSC differentiation dynamics reveal a core molecular network of Parkinson's disease. Communications biology. vol 5. issue 1. 2022-01-14. PMID:35027645. |
proteomics analysis showed a consistent alteration in proteins of dopamine metabolism, indicating a defect of dopaminergic metabolism in pink1-ile368asn neurons. |
2022-01-14 |
2023-08-13 |
human |
| Imre Kalló, Azar Omrani, Frank J Meye, Han de Jong, Zsolt Liposits, Roger A H Ada. Characterization of orexin input to dopamine neurons of the ventral tegmental area projecting to the medial prefrontal cortex and shell of nucleus accumbens. Brain structure & function. 2022-01-14. PMID:35029758. |
thus, the hypothalamic orexin system targets mnacs and to a lesser extent mpfc-projecting dopaminergic neurons of the vta and exerts facilitatory effects on both clusters of dopamine neurons. |
2022-01-14 |
2023-08-13 |
Not clear |
| Patrick D Skelton, Valerie Tokars, Loukia Parisiado. LRRK2 at Striatal Synapses: Cell-Type Specificity and Mechanistic Insights. Cells. vol 11. issue 1. 2022-01-11. PMID:35011731. |
recapitulation of the genotype in rodent models causes abnormal dopamine release and increases the susceptibility of dopaminergic neurons to insults, making lrrk2 a valuable model for understanding the pathobiology of parkinson's disease. |
2022-01-11 |
2023-08-13 |
Not clear |
| Alexia Polissidis, Effrosyni Koronaiou, Georgia Nikolopoulou, Catherine Viel, Maria Nikatou, Marios Bogiongko, S Pablo Sardi, Maria Xilouri, Kostas Vekrellis, Leonidas Stefani. A double-hit in vivo model of GBA viral microRNA-mediated downregulation and human alpha-synuclein overexpression demonstrates nigrostriatal degeneration. Neurobiology of disease. 2022-01-07. PMID:34995756. |
on the other hand, microrna (mir)-mediated gba1 downregulation (mir gba), combined with virus-mediated human as overexpression (+as), yields decreased gcase activity in the cortex, mimicking levels seen in gba1 heterozygous carriers (30-40%), increased astrogliosis and microgliosis, decreased striatal dopamine levels (50% compared to controls) and loss of nigral dopaminergic neurons (~33%)- effects that were all reversible with mir rescue. |
2022-01-07 |
2023-08-13 |
mouse |
| Saurabh Bhatia, Ahmed Al-Harrasi, Arun Kumar, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Md Khalid Anwer, Deepak Kaushik, Vineet Mittal, Sridevi Chigurupati, Pritam Babu Sharma, Lotfi Aleya, Celia Vargas-de-la-Cruz, Md Tanvir Kabi. Anti-migraine activity of freeze-dried latex obtained from Calotropis gigantea Linn. Environmental science and pollution research international. 2022-01-04. PMID:34981370. |
anti-migraine effect of calotropis gigantea freeze-dried latex by inhibition of dopamine and serotonin receptors (d1 and d2: dopamine receptors; 5-ht: serotonin receptors); yellow color represents serotonergic, and blue color indicates dopaminergic neurons. |
2022-01-04 |
2023-08-13 |
Not clear |
| Md Ashraf-Uz-Zaman, Guangchen Ji, Dalton Tidwell, Linda Yin, Smathorn Thakolwiboon, Jie Pan, Riley Junell, Zach Griffin, Sadisna Shahi, Derek Barthels, Md Sanaullah Sajib, Paul C Trippier, Constantinos M Mikelis, Hiranmoy Das, Mirla Avila, Volker Neugebauer, Nadezhda A Germa. Evaluation of Urea-Based Inhibitors of the Dopamine Transporter Using the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis. ACS chemical neuroscience. 2022-01-03. PMID:34978174. |
for conditions such as parkinson's disease and multiple sclerosis (ms), pharmacological modulation of dopamine (da) system activity is thought to have therapeutic relevance, providing the basis for using dopaminergic agents as a treatment of relevant states. |
2022-01-03 |
2023-08-13 |
Not clear |
| Eryigit Karamahmutoglu Tugba, Gulcebi Idriz Oglu Medine, Akman Ozlem, Kirik Deniz, Onat Yilmaz Fili. Prolongation of absence seizures and changes in serotonergic and dopaminergic neurotransmission by nigrostriatal pathway degeneration in genetic absence epilepsy rats. Pharmacology, biochemistry, and behavior. 2022-01-02. PMID:34974062. |
we examined the role of the nigrostriatal dopaminergic pathway in absence epilepsy through behavioral and electroencephalography (eeg) parameters, immunohistochemical, and biochemical characteristics of dopamine and serotonin in the genetic absence epilepsy rat model. |
2022-01-02 |
2023-08-13 |
rat |
| Jingjing Wu, Cheng Zhou, Tao Guo, Xiaojun Guan, Ting Gao, Xueqin Bai, Haoting Wu, Jingwen Chen, Jiaqi Wen, Xiaocao Liu, Luyan Gu, Zhe Song, Min Xuan, Quanquan Gu, Peiyu Huang, Jiali Pu, Baorong Zhang, Xiaojun Xu, Minming Zhan. Cholinergic relevant functional reactivity is associated with dopamine responsiveness of tremor in Parkinson's disease. Brain imaging and behavior. 2022-01-01. PMID:34973120. |
through investigating the alterations of cholinergic and dopaminergic network during levodopa administration, we aimed at exploring the mechanisms of differed dopamine responsiveness of parkinsonian tremor. |
2022-01-01 |
2023-08-13 |
Not clear |
| Marit F L Ruitenberg, Vincent Koppelmans, Rachael D Seidler, Judith Schomake. Novelty exposure induces stronger sensorimotor representations during a manual adaptation task. Annals of the New York Academy of Sciences. 2021-12-24. PMID:34951019. |
these effects have been attributed to novelty promoting dopamine release via mesolimbic dopaminergic pathways in the brain. |
2021-12-24 |
2023-08-13 |
human |
| Alexander K Song, Kaitlyn R Hay, Paula Trujillo, Megan Aumann, Adam J Stark, Yan Yan, Hakmook Kang, Manus J Donahue, David H Zald, Daniel O Claasse. Amphetamine-induced dopamine release and impulsivity in Parkinson disease. Brain : a journal of neurology. 2021-12-24. PMID:34951464. |
we hypothesized that parkinson disease patients with impulsive-compulsive behaviors would have greater ventral striatal dopaminergic response to dextroamphetamine, and that an inability to attenuate ventral striatal dopamine release via midbrain d2 autoreceptors would underlie this response. |
2021-12-24 |
2023-08-13 |
human |
| Allison E Hamilos, Giulia Spedicato, Ye Hong, Fangmiao Sun, Yulong Li, John Assa. Slowly evolving dopaminergic activity modulates the moment-to-moment probability of reward-related self-timed movements. eLife. vol 10. 2021-12-23. PMID:34939925. |
clues from human movement disorders have long suggested that the neurotransmitter dopamine plays a role in motor control, but how the endogenous dopaminergic system influences movement is unknown. |
2021-12-23 |
2023-08-13 |
mouse |
| Xiaodan Li, Jian Xiong, Baojian Zhang, Dongting Zhangsun, Sulan Lu. α-Conotoxin TxIB Inhibits Development of Morphine-Induced Conditioned Place Preference in Mice Frontiers in pharmacology. vol 12. 2021-12-20. PMID:34925031. |
previous studies have showed that α6β2* (* designated other subunits) nachrs are mainly distributed in dopaminergic neurons in the midbrain area, which regulates the release of dopamine. |
2021-12-20 |
2023-08-13 |
mouse |
| Kenan Steidel, Marina C Ruppert, Irina Palaghia, Andrea Greuel, Masoud Tahmasian, Franziska Maier, Jochen Hammes, Thilo van Eimeren, Lars Timmermann, Marc Tittgemeyer, Alexander Drzezga, David Pedrosa, Carsten Egger. Dopaminergic pathways and resting-state functional connectivity in Parkinson's disease with freezing of gait. NeuroImage. Clinical. vol 32. 2021-12-16. PMID:34911202. |
seed-to-voxel resting-state functional connectivity maps of the resulting dopamine depleted structures and dopaminergic midbrain regions were created and compared between both groups. |
2021-12-16 |
2023-08-13 |
Not clear |
| Steven M Graves, Sarah E Schwarzschild, Rex A Tai, Yu Chen, D James Surmeie. Mitochondrial oxidant stress mediates methamphetamine neurotoxicity in substantia nigra dopaminergic neurons. Neurobiology of disease. vol 156. 2021-12-11. PMID:34082123. |
recently, it was found that methamphetamine increases mitochondrial oxidant stress in substantia nigra pars compacta (snc) dopaminergic neurons by releasing vesicular dopamine (da) and stimulating mitochondrially-anchored monoamine oxidase (mao). |
2021-12-11 |
2023-08-13 |
mouse |
| Bárbara Coimbra, Ana Verónica Domingues, Carina Soares-Cunha, Raquel Correia, Luísa Pinto, Nuno Sousa, Ana João Rodrigue. Laterodorsal tegmentum-ventral tegmental area projections encode positive reinforcement signals. Journal of neuroscience research. vol 99. issue 11. 2021-12-11. PMID:34374447. |
the laterodorsal tegmentum (ldt) is a brainstem nucleus classically involved in rem sleep and attention, and that has recently been associated with reward-related behaviors, as it controls the activity of ventral tegmental area (vta) dopaminergic neurons, modulating dopamine release in the nucleus accumbens. |
2021-12-11 |
2023-08-13 |
rat |