| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| U K Rinn. New strategies in the treatment of early Parkinson's disease. Acta neurologica Scandinavica. Supplementum. vol 136. 1992-04-21. PMID:1801545. |
as a new treatment strategy it appears advisable to initiate the dopaminergic treatment in early parkinson's disease by using initially selegiline and a dopamine agonist and by adding levodopa when the therapeutic response is insufficient. |
1992-04-21 |
2023-08-11 |
Not clear |
| R Spanagel, A Herz, T S Shippenber. Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 6. 1992-04-17. PMID:1347943. |
employing the technique of in vivo microdialysis and the administration of highly selective opioid ligands, the present study demonstrates the existence of tonically active and functionally opposing mu and kappa opioid systems that regulate dopamine release in the nucleus accumbens, the major terminal area of a10 dopaminergic neurons. |
1992-04-17 |
2023-08-11 |
Not clear |
| R Spanagel, A Herz, T S Shippenber. Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 6. 1992-04-17. PMID:1347943. |
thus, stimulation of mu-type receptors in the ventral tegmental area, the site of origin of a10 dopaminergic neurons, increases dopamine release whereas the selective blockade of this opioid receptor type results in a significant decrease in basal dopamine release. |
1992-04-17 |
2023-08-11 |
Not clear |
| A C Linthorst, H De Lang, W De Jong, D H Verstee. Effect of the dopamine D2 receptor agonist quinpirole on the in vivo release of dopamine in the caudate nucleus of hypertensive rats. European journal of pharmacology. vol 201. issue 2-3. 1992-04-16. PMID:1686754. |
the present findings on changes in dopaminergic neurotransmission and d2 autoreceptor-mediated modulation of dopamine release in genetically hypertensive rats but not in rats with experimentally induced hypertension provide further evidence for the hypothesis that alterations in the nigrostriatal dopamine system may be involved in the initiation of the development of spontaneous hypertension. |
1992-04-16 |
2023-08-11 |
rat |
| Y Akiyama, A Ito, K Koshimura, T Ohue, S Yamagata, S Miwa, H Kikuch. Effects of transient forebrain ischemia and reperfusion on function of dopaminergic neurons and dopamine reuptake in vivo in rat striatum. Brain research. vol 561. issue 1. 1992-04-16. PMID:1797339. |
effects of transient forebrain ischemia and reperfusion on function of dopaminergic neurons and dopamine reuptake in vivo in rat striatum. |
1992-04-16 |
2023-08-11 |
rat |
| Y Akiyama, A Ito, K Koshimura, T Ohue, S Yamagata, S Miwa, H Kikuch. Effects of transient forebrain ischemia and reperfusion on function of dopaminergic neurons and dopamine reuptake in vivo in rat striatum. Brain research. vol 561. issue 1. 1992-04-16. PMID:1797339. |
to clarify functional changes of dopaminergic neurons and dopamine (da) reuptake during and after ischemia, extracellular da levels in striatum were determined using in vivo brain microdialysis in a 4-vessel occlusion model of male wistar rats with and without pharmacological interventions. |
1992-04-16 |
2023-08-11 |
rat |
| F Larrea, A Escorza, X Valencia, I Méndez, R Schiavon, G Forsbac. Reduced dopaminergic inhibition of thyrotropin release in hyperprolactinemic ovulatory women. Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion. vol 43. issue 4. 1992-04-16. PMID:1798861. |
central dopaminergic activity was investigated by the administration of the dopamine antagonist domperidone to normal women (n = 7) and women with anovulatory (n = 6) and ovulatory hyperprolactinemia (n = 2). |
1992-04-16 |
2023-08-11 |
human |
| V Leviel, B Guibert, J Mallet, N Faucon-Bigue. Induction of tyrosine hydroxylase in the rat substantia nigra by local injection of forskolin. Journal of neuroscience research. vol 30. issue 2. 1992-04-15. PMID:1686787. |
in addition, the decrease of the ratio between dopamine and its first metabolite in the cn and the sn suggested a decreased activity of the dopaminergic nigral cells. |
1992-04-15 |
2023-08-11 |
rat |
| D Casper, C Mytilineou, M Blu. EGF enhances the survival of dopamine neurons in rat embryonic mesencephalon primary cell culture. Journal of neuroscience research. vol 30. issue 2. 1992-04-15. PMID:1839162. |
fluorodeoxyuridine, an agent that is toxic to proliferating cells was able to eliminate the effect of egf on dopamine uptake, suggesting that egf may be increasing dopaminergic cell survival largely through a population of dividing cells. |
1992-04-15 |
2023-08-11 |
rat |
| M S Saporito, R E Heikkila, S K Youngster, W J Nicklas, H M Gelle. Dopaminergic neurotoxicity of 1-methyl-4-phenylpyridinium analogs in cultured neurons: relationship to the dopamine uptake system and inhibition of mitochondrial respiration. The Journal of pharmacology and experimental therapeutics. vol 260. issue 3. 1992-04-13. PMID:1312170. |
dopaminergic neurotoxicity of 1-methyl-4-phenylpyridinium analogs in cultured neurons: relationship to the dopamine uptake system and inhibition of mitochondrial respiration. |
1992-04-13 |
2023-08-11 |
Not clear |
| M S Saporito, R E Heikkila, S K Youngster, W J Nicklas, H M Gelle. Dopaminergic neurotoxicity of 1-methyl-4-phenylpyridinium analogs in cultured neurons: relationship to the dopamine uptake system and inhibition of mitochondrial respiration. The Journal of pharmacology and experimental therapeutics. vol 260. issue 3. 1992-04-13. PMID:1312170. |
the compounds that were potent and selective dopaminergic neurotoxins had high affinity for the dopamine transport system, as measured by their ability to cause dopamine release, and were similar to mpp+ in inhibiting mitochondrial respiration. |
1992-04-13 |
2023-08-11 |
Not clear |
| M S Saporito, R E Heikkila, S K Youngster, W J Nicklas, H M Gelle. Dopaminergic neurotoxicity of 1-methyl-4-phenylpyridinium analogs in cultured neurons: relationship to the dopamine uptake system and inhibition of mitochondrial respiration. The Journal of pharmacology and experimental therapeutics. vol 260. issue 3. 1992-04-13. PMID:1312170. |
this study describes the neurotoxicity of a number of analogs of mpp+ and highlights the importance of the dopamine uptake system and the ability to inhibit mitochondrial respiration as critical processes in conferring selectivity and neurotoxicity, respectively, to mpp+ and analogs, for dopaminergic neurons in culture. |
1992-04-13 |
2023-08-11 |
Not clear |
| X Z Ding, I Mocchett. Dopaminergic regulation of cholecystokinin mRNA content in rat striatum. Brain research. Molecular brain research. vol 12. issue 1-3. 1992-04-13. PMID:1312208. |
the nigrostriatal dopaminergic activity was pharmacologically changed to assess whether dopamine (da) regulates cholecystokinin (cck) mrna steady state in rat striatum. |
1992-04-13 |
2023-08-11 |
rat |
| M Savasta, F Mennicken, M Chritin, D N Abrous, C Feuerstein, M Le Moal, J P Herma. Intrastriatal dopamine-rich implants reverse the changes in dopamine D2 receptor densities caused by 6-hydroxydopamine lesion of the nigrostriatal pathway in rats: an autoradiographic study. Neuroscience. vol 46. issue 3. 1992-04-13. PMID:1532053. |
one month later animals were killed and striatal dopaminergic receptor densities were quantified using autoradiography, the dopaminergic reinnervation of the host striatum being visualized with [3h]gbr 12935, a ligand labelling dopamine uptake sites. |
1992-04-13 |
2023-08-11 |
rat |
| M A Cenci, P Kalén, R J Mandel, K Wictorin, A Björklun. Dopaminergic transplants normalize amphetamine- and apomorphine-induced Fos expression in the 6-hydroxydopamine-lesioned striatum. Neuroscience. vol 46. issue 4. 1992-04-09. PMID:1347413. |
dopamine receptor-mediated fos protein expression in the striatum has been used to monitor dopamine receptor activation at the cellular level after dopaminergic denervation and reinnervation by fetal nigral transplants. |
1992-04-09 |
2023-08-11 |
rat |
| K K Maitra, P Seth, K P Mohanakumar, D K Gangul. Supersensitivity of spinal dopaminergic receptors in rat after chronic haloperidol. Brain research bulletin. vol 28. issue 1. 1992-04-09. PMID:1540840. |
in order to examine the effect of chronic neuroleptics on spinal dopaminergic system, rats were treated with haloperidol (0.5 mg/kg ip) for 21 days and the monosynaptic mass reflex (mmr) as well as dopamine (da) metabolism were investigated. |
1992-04-09 |
2023-08-11 |
rat |
| J M Tepper, I Creese, D H Schwart. Stimulus-evoked changes in neostriatal dopamine levels in awake and anesthetized rats as measured by microdialysis. Brain research. vol 559. issue 2. 1992-04-08. PMID:1794102. |
the effect of medial forebrain bundle (mfb) stimulation on neostriatal dopamine levels was examined using in vivo microdialysis in urethane-anesthetized and awake, freely-moving rats in conjunction with single unit extracellular recordings from antidromically identified nigral dopaminergic neurons. |
1992-04-08 |
2023-08-11 |
rat |
| J M Tepper, I Creese, D H Schwart. Stimulus-evoked changes in neostriatal dopamine levels in awake and anesthetized rats as measured by microdialysis. Brain research. vol 559. issue 2. 1992-04-08. PMID:1794102. |
there was a significant correlation between the proportion of dopaminergic neurons that could be antidromically activated from the mfb and the increase in neostriatal dopamine. |
1992-04-08 |
2023-08-11 |
rat |
| N T Panagopoulos, G C Papadopoulos, N A Matsoki. Dopaminergic innervation and binding in the rat cerebellum. Neuroscience letters. vol 130. issue 2. 1992-04-08. PMID:1795884. |
in the present study, we used an antiserum against dopamine (da), and specific [3h]ligands in order to shed more light on the dopaminergic system of the rat cerebellum. |
1992-04-08 |
2023-08-11 |
mouse |
| N R Oakley, A G Hayes, M J Sheeha. Effect of typical and atypical neuroleptics on the behavioural consequences of activation by muscimol of mesolimbic and nigro-striatal dopaminergic pathways in the rat. Psychopharmacology. vol 105. issue 2. 1992-04-07. PMID:1686655. |
since dopamine d2 antagonists are believed to exert their anti-psychotic effects via an action on mesolimbic dopaminergic systems, and their ability to induce extrapyramidal side effects (eps) is thought to be due to an action on nigro-striatal dopamine systems, these results suggest that the behavioural models described can be used to predict efficacy and side-effect liability of potential neuroleptic drugs. |
1992-04-07 |
2023-08-11 |
rat |