| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Lappalainen, J Hietala, M Koulu, B Sjöholm, E Syvälaht. Effects of acute administration of SCH 23390 on dopamine and serotonin turnover in major dopaminergic areas and mesencephalic raphe nuclei--comparison with ritanserin. Progress in neuro-psychopharmacology & biological psychiatry. vol 15. issue 6. 1992-02-13. PMID:1722342. |
the effects of acute administration of sch 23390 (0.05 and 0.25 mg/kg s.c.), a dopamine d-1 receptor antagonist having also a moderate serotonin-s2 (5-ht-2) receptor blocking activity, and ritanserin (0.5 mg/kg), a specific 5-ht-2 antagonist, on dopamine (da) and serotonin (5-ht) turnover were investigated in dopaminergic (nucleus caudatus, nucleus accumbens, substantia nigra, a10 area) and serotonergic (nucleus raphe dorsalis and nucleus raphe medialis) rat brain nuclei. |
1992-02-13 |
2023-08-11 |
rat |
| M Yoshida, G Damsma, H C Fibiger, H Yokoo, K Mizoguchi, M Tanak. Central dopaminergic neurons: immunohistochemistry and in vivo monitoring of dopamine release correlated to behavior. The Japanese journal of psychiatry and neurology. vol 45. issue 2. 1992-02-13. PMID:1762260. |
central dopaminergic neurons: immunohistochemistry and in vivo monitoring of dopamine release correlated to behavior. |
1992-02-13 |
2023-08-11 |
Not clear |
| N B Mercuri, F Stratta, P Calabresi, G Bernard. Nomifensine but not amantadine increases dopamine-induced responses on rat substantia nigra zona compacta neurons. Neuroscience letters. vol 131. issue 2. 1992-02-12. PMID:1662338. |
while our results provide electrophysiological evidence for an inhibition of the dopamine uptake system by nomifensine, they do not support a dopaminergic mechanism for the actions of amantadine in the substantia nigra zona compacta. |
1992-02-12 |
2023-08-11 |
rat |
| W G Tatton, C E Greenwood, P T Salo, N A Seniu. Transmitter synthesis increases in substantia nigra neurons of the aged mouse. Neuroscience letters. vol 131. issue 2. 1992-02-12. PMID:1722294. |
counts of nigrostriatal dopaminergic neurons in c57bl mice identified using immunocytochemistry, fluoro-gold retrograde axonal transport and nissl staining were combined with measures of striatal dopamine and dopa after saline, pargyline or nsd-1015 treatment. |
1992-02-12 |
2023-08-11 |
mouse |
| W G Tatton, C E Greenwood, P T Salo, N A Seniu. Transmitter synthesis increases in substantia nigra neurons of the aged mouse. Neuroscience letters. vol 131. issue 2. 1992-02-12. PMID:1722294. |
on average, 68% of the dopaminergic nigrostriatal neurons died between ages 8 and 104 weeks and there was a 3-fold increase in dopamine synthesis per average neuron in the aged mice. |
1992-02-12 |
2023-08-11 |
mouse |
| A W Spira, D Parkinso. Effects of dark-rearing on the retinal dopaminergic system in the neonatal and postnatal guinea pig. Brain research. Developmental brain research. vol 62. issue 1. 1992-02-12. PMID:1760868. |
to appraise the extent of light responsivity of the retinal dopaminergic system in the early postnatal period, dopamine content (da) of retinas of cycling-light-reared and dark-reared guinea pigs was determined. |
1992-02-12 |
2023-08-11 |
Not clear |
| M E Reith, A E Jacobson, K C Rice, M Benuck, I Zimany. Effect of metaphit on dopaminergic neurotransmission in rat striatal slices: involvement of the dopamine transporter and voltage-dependent sodium channel. The Journal of pharmacology and experimental therapeutics. vol 259. issue 3. 1992-02-07. PMID:1662274. |
effect of metaphit on dopaminergic neurotransmission in rat striatal slices: involvement of the dopamine transporter and voltage-dependent sodium channel. |
1992-02-07 |
2023-08-11 |
rat |
| J A Angulo, H Coirini, M Ledoux, M Schumache. Regulation by dopaminergic neurotransmission of dopamine D2 mRNA and receptor levels in the striatum and nucleus accumbens of the rat. Brain research. Molecular brain research. vol 11. issue 2. 1992-02-06. PMID:1661813. |
regulation by dopaminergic neurotransmission of dopamine d2 mrna and receptor levels in the striatum and nucleus accumbens of the rat. |
1992-02-06 |
2023-08-11 |
rat |
| J A Angulo, H Coirini, M Ledoux, M Schumache. Regulation by dopaminergic neurotransmission of dopamine D2 mRNA and receptor levels in the striatum and nucleus accumbens of the rat. Brain research. Molecular brain research. vol 11. issue 2. 1992-02-06. PMID:1661813. |
likewise, unilateral dopamine depletion due to 6-hydroxydopamine (6-ohda) lesions of mesencephalic dopaminergic neurons resulted in decreased levels of d2 receptor mrna by day 8 post-lesion in the ipsilateral mcpu, acpu and the nac. |
1992-02-06 |
2023-08-11 |
rat |
| J A Angulo, H Coirini, M Ledoux, M Schumache. Regulation by dopaminergic neurotransmission of dopamine D2 mRNA and receptor levels in the striatum and nucleus accumbens of the rat. Brain research. Molecular brain research. vol 11. issue 2. 1992-02-06. PMID:1661813. |
the results demonstrate that midbrain dopaminergic innervation exerts tonic effects on the levels of dopamine d2 receptor and mrna in the caudate-putamen and the nucleus accumbens of the rat. |
1992-02-06 |
2023-08-11 |
rat |
| B Meister, M Schultzberg, H C Hemmings, P Greengard, M Goldstein, T Hökfel. Dopamine- and adenosine-3',5'-monophosphate (cAMP)-regulated phosphoprotein of 32 kDa (DARPP-32) in the adrenal gland: immunohistochemical localization. Journal of the autonomic nervous system. vol 36. issue 1. 1992-01-27. PMID:1721636. |
it has been shown that dopamine and dopaminergic agonists inhibit catecholamine release from chromaffin cells and aldosterone secretion from cells in the adrenal cortex. |
1992-01-27 |
2023-08-11 |
mouse |
| M C Garrett, P Soares-da-Silv. Increased cerebrospinal fluid dopamine and 3,4-dihydroxyphenylacetic acid levels in Huntington's disease: evidence for an overactive dopaminergic brain transmission. Journal of neurochemistry. vol 58. issue 1. 1992-01-22. PMID:1309230. |
increased cerebrospinal fluid dopamine and 3,4-dihydroxyphenylacetic acid levels in huntington's disease: evidence for an overactive dopaminergic brain transmission. |
1992-01-22 |
2023-08-11 |
Not clear |
| G M Friehs, R G Parker, L S He, S J Haines, D A Turner, T J Ebne. Lesioning of the striatum reverses motor asymmetry in the 6-hydroxydopamine rodent model of parkinsonism. Journal of neural transplantation & plasticity. vol 2. issue 2. 1992-01-22. PMID:1684115. |
suggested explanations for the decrease in induced rotational behavior with radiofrequency lesions include a decrease in the number of striatal dopamine receptors following cell destruction and lesion-induced recovery of host dopaminergic afferents. |
1992-01-22 |
2023-08-11 |
rat |
| A Elverfors, H Nissbrand. Reserpine-insensitive dopamine release in the substantia nigra? Brain research. vol 557. issue 1-2. 1992-01-22. PMID:1720998. |
dopamine (da) is synthesized and released not only from the terminals of the nigrostriatal dopaminergic pathway, but also from the dendrites in the substantia nigra (sn). |
1992-01-22 |
2023-08-11 |
Not clear |
| G L Bernardini, X Gu, D C Germa. Nucleus A10 dopaminergic neurons in inbred mouse strains: firing rate and autoreceptor sensitivity are independent of the number of cells in the nucleus. Brain research bulletin. vol 27. issue 2. 1992-01-13. PMID:1742603. |
it was observed that the autoreceptors on mouse dopaminergic neurons exhibit pharmacological properties of dopamine autoreceptors; activation of the autoreceptor produced a marked inhibition (50-70%) in cell firing rate by quinpirole (10(-8) m), ly-141865 (10(-7) m), (+)-3-(3-hydroxyphenyl)-n-n-propyl-piperidine (10(-6) m), propyl-norapomorphine (10(-5) m) and dopamine (10(-4) m), and this inhibition was blocked or reversed by specific dopamine d2 receptor antagonists [(-) sulpiride and spiroperidol, 10(-6) m]. |
1992-01-13 |
2023-08-11 |
mouse |
| M T Martin-Iverso. Chronic treatment with D1 and D2 dopamine receptor agonists: combined treatments interact to differentially affect brain levels of monoamines. Naunyn-Schmiedeberg's archives of pharmacology. vol 344. issue 3. 1992-01-09. PMID:1683687. |
in addition, recent hypotheses of the possible pathogenesis of this disorder have suggested that metabolism of dopamine by monoamine oxidase in the presynaptic terminal may contribute to the loss of dopaminergic cells, through the production of reactive by-products. |
1992-01-09 |
2023-08-11 |
rat |
| E Arenas, J Alberch, J Marsa. Dopaminergic system mediates only delta-opiate inhibition of endogenous acetylcholine release evoked by glutamate from rat striatal slices. Neuroscience. vol 42. issue 3. 1992-01-02. PMID:1683474. |
furthermore, these results suggest that the inhibition by delta-opiate agonists could be the result of dopamine release from dopaminergic terminals and its action on d2 receptors. |
1992-01-02 |
2023-08-11 |
rat |
| T M Shih, T A Koviak, B R Capaci. Anticonvulsants for poisoning by the organophosphorus compound soman: pharmacological mechanisms. Neuroscience and biobehavioral reviews. vol 15. issue 3. 1991-12-31. PMID:1683477. |
we also found that at anticonvulsant doses biperiden and trihexyphenidyl each significantly reversed the effects of soman on striatal levels of dopac and hva, the metabolites of dopamine, and have concluded that in addition to actions on muscarinic receptors, the anticonvulsant effects of these anticholinergics in soman poisoning may be partially related to their actions on the striatal dopaminergic system. |
1991-12-31 |
2023-08-11 |
rat |
| S Sigala, P Rizzonelli, E Zanelli, A Forgione, C Missale, P Span. Low doses of l-sulpiride down-regulate striatal and cortical dopamine receptors and beta-adrenoceptors. European journal of pharmacology. vol 199. issue 2. 1991-12-30. PMID:1683290. |
taken together these data suggest that cortical noradrenergic terminals may be endowed with dopamine d2 receptors controlling norepinephrine release and that blockade of this dopaminergic inhibitory modulation may be involved in the antidepressant effects of l-sulpiride. |
1991-12-30 |
2023-08-11 |
Not clear |
| J L Góngora-Alfaro, S Hernández-López, D Martínez-Fong, J L Brassart, J Aceve. Activation of nigral M1 and M2 muscarinic receptors produces opposing effects on striatal 3,4-dihydroxyphenylacetic acid measured by in vivo voltammetry. Brain research. vol 554. issue 1-2. 1991-12-26. PMID:1933315. |
these results indicate the existence of two types of muscarinic receptors on dopaminergic neurons, whose activation produces opposing effects on dopamine metabolism in neostriatum. |
1991-12-26 |
2023-08-11 |
rat |