| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M H Van Woert, R Jutkowitz, D Rosenbaum, M B Bower. Gilles de la Tourette's syndrome: biochemical approaches. Research publications - Association for Research in Nervous and Mental Disease. vol 55. 1977-02-24. PMID:1070064. |
this supports the hypothesis that tourette symptoms are related to an increased firing of dopaminergic neurons in the central nervous system; haloperidol relieves these symptoms by blocking dopamine receptors. |
1977-02-24 |
2023-08-11 |
Not clear |
| L L Butcher, L Bilezikjia. Acetylcholinesterase-containing neurons in the neostriatum and substantia nigra revealed after punctate intracerebral injection of di-isopropylfluorophosphate. European journal of pharmacology. vol 34. issue 1. 1977-02-24. PMID:1234757. |
although the significance of dopaminergic--cholinergic interactions in the neostriatum could not be elucidated on the basis of these histochemical data, the thesis was advanced that dopamine neurons in the pars compacta of the substantia nigra also contained ache, possibly to inactivate acetylcholine released from cholinergic fibers afferent to this neural structure. |
1977-02-24 |
2023-08-11 |
rat |
| L C Murrin, R H Rot. Dopaminergic neurons: reversal of effects elicited by gamma-butyrolactone by stimulation of the nigro-neostriatal pathway. Naunyn-Schmiedeberg's archives of pharmacology. vol 295. issue 1. 1977-02-16. PMID:12482. |
these results are also consistent with the hypothesis that gbl activates tyrosine hydroxylase and increases endogenous dopamine levels primarily by blocking impulse flow in central dopaminergic neurons. |
1977-02-16 |
2023-08-11 |
Not clear |
| S W Gumulka, V Dinnendahl, P S Schönhöfer, K Stoc. Dopaminergic stimulants and cyclic nucleotides in mouse brain. Effects of dopaminergic antagonists, cholinolytics, and GABA agonists. Naunyn-Schmiedeberg's archives of pharmacology. vol 295. issue 1. 1977-02-16. PMID:187962. |
these findings suggest that low doses of the dopaminergic antagonists may predominantly act by interfering with the release of dopamine from presynaptic stores, while high doses may act by blockade of the postsynaptic dopaminergic receptor. |
1977-02-16 |
2023-08-11 |
mouse |
| T J Crow, E C Johnstone, H A McClellean. The coincidence of schizophrenia and Parkinsonism: some neurochemical implications. Psychological medicine. vol 6. issue 2. 1977-02-16. PMID:1005563. |
these observations appear to conflict with the view that increased dopamine release in the striatum is necessary for the expression of schizophrenic psychopathology, but do not exclude the possibility that increased transmission may occur at other dopaminergic sites in the brain, for example the nucleus accumbens, tuberculum olfactorium or cerebral cortex. |
1977-02-16 |
2023-08-11 |
Not clear |
| F M Sharabi, J P Long, J G Cannon, G J Hathewa. Inhibition of the sympathetic nervous system by a series of heterocyclic congeners of dopamine. The Journal of pharmacology and experimental therapeutics. vol 199. issue 3. 1977-01-29. PMID:994020. |
a series of heterocyclic congeners of dopamine (gjh-series) with different positions of phenolic oxygens and with the possibility of cis and trans isomerism at the 4a-10b ring juncture was evaluated in vitro and in vivo for dopaminergic activity. |
1977-01-29 |
2023-08-11 |
Not clear |
| F M Sharabi, J P Long, J G Cannon, G J Hathewa. Inhibition of the sympathetic nervous system by a series of heterocyclic congeners of dopamine. The Journal of pharmacology and experimental therapeutics. vol 199. issue 3. 1977-01-29. PMID:994020. |
the results outlined in this manuscript support the hypothesis that the extended conformation of the dihydroxyhenylethylamine moiety of dopamine with a trans isomeric form is favorable for dopaminergic agonist activity. |
1977-01-29 |
2023-08-11 |
Not clear |
| L F Tseng, D A Brase, H H Lo. Dopaminergic influence on withdrawal jumping behavior in morphine-dependent mice. Research communications in chemical pathology and pharmacology. vol 15. issue 3. 1977-01-29. PMID:1033590. |
these findings indicate that there may be a decrease release of dopamine in the brain during the expression of withdrawal jumping behavior and that dopaminergic activation may be inhibitory to this behavior. |
1977-01-29 |
2023-08-11 |
mouse |
| E A Zeller, G S Couper, S V Huprikar, A M Mellow, R R Mood. Mescaline: its effects on learning rate and dopamine metabolism in goldfish (Carassius auratus). Experientia. vol 32. issue 11. 1977-01-28. PMID:991995. |
apparently, mescaline induced a release of dopamine which stimulated central dopaminergic systems. |
1977-01-28 |
2023-08-11 |
Not clear |
| H J Chiel, R J Wurtma. Suppression of amphetamine-induced hypothermia by the neutral amino acid valine. Psychopharmacology communications. vol 2. issue 3. 1977-01-28. PMID:996276. |
because dopaminergic neurons mediate the hypothermic response to amphetamine and because amphetamine's ability to produce hypothermia requires, in part, the release of newly synthesized dopamine, these observed effects of valine pretreatment support the hypothesis that treatments which alter precursor (tyrosine) availability also affect brain catecholamine synthesis. |
1977-01-28 |
2023-08-11 |
rat |
| E A Zeller, B Boshes, J Arbit, M Bieber, E R Blonsky, M Dolkart, S V Huprika. Molecular biology of neurological and psychiatric disorders. I. Effect of parkinsonism, age, sex and L-dopa on platelet monoamine oxidase. Journal of neural transmission. vol 39. issue 1-2. 1976-12-30. PMID:978197. |
dopamine, formed from l-dopa, may thus have a better chance for survival in reaching the dopaminergic receptor. |
1976-12-30 |
2023-08-11 |
human |
| A Simon, E F Van Maane. Dopamine receptors and dopaminergic nerves in the vas deferens of the rat. Archives internationales de pharmacodynamie et de therapie. vol 222. issue 1. 1976-12-30. PMID:984969. |
dopamine receptors and dopaminergic nerves in the vas deferens of the rat. |
1976-12-30 |
2023-08-11 |
rat |
| G Verde, G Oppizzi, G Colussi, G Cremascoli, L Botalla, E E Müller, F Silvestrini, P G Chiodini, A Liuzz. Effect of dopamine infusion on plasma levels of growth hormone in normal subjects and in agromegalic patients. Clinical endocrinology. vol 5. issue 4. 1976-12-03. PMID:971548. |
since dopamine does not cross the blood-brain barrier, these results, although not excluding a site of action at median eminence level, support the thesis that the inhibitory effect of dopaminergic stimulation on gh release in acromegaly possibly involves receptors present on gh-secreting cells. |
1976-12-03 |
2023-08-11 |
human |
| J G Cannon, G J Hathewa. Centrally acting emetics. 10. Rigid dopamine congeners derived from octahydrobenzo[f]quinoline. Journal of medicinal chemistry. vol 19. issue 8. 1976-11-21. PMID:184283. |
in a study of conformational requirements for certain dopaminergic agonist molecules, a series of conformationally predictable dopamine congeners related to cis- and trans-octahydrobenzo[f]quinoline was prepared. |
1976-11-21 |
2023-08-11 |
Not clear |
| H Leblanc, G C Lachelin, S Abu-Fadil, S S Ye. Effects of dopamine infusion on pituitary hormone secretion in humans. The Journal of clinical endocrinology and metabolism. vol 43. issue 3. 1976-11-01. PMID:956350. |
these data indicate that in man a dopaminergic mechanism ixists in the regulation of prl secretion and that dopamine also exerts an inhibitory effect of lh release. |
1976-11-01 |
2023-08-11 |
human |
| T J Crow, E C Johnstone, J F Deakin, A Longde. Dopamine and schizophrenia. Lancet (London, England). vol 2. issue 7985. 1976-10-29. PMID:60635. |
it is argued that the former are more closely related to actions on dopaminergic mechanisms in the "mesolimbic dopamine" system, and the latter to similar actions in the striatum. |
1976-10-29 |
2023-08-11 |
Not clear |
| T J Crow, E C Johnstone, J F Deakin, A Longde. Dopamine and schizophrenia. Lancet (London, England). vol 2. issue 7985. 1976-10-29. PMID:60635. |
although the amphetamine psychosis closely resembles paranoid schizophrenia and may be due to excess dopamine release, clinical, biochemical, and endocrine studies suggest that dopaminergic overactivity is not a necessary concomitant of schizophrenic illnesses. |
1976-10-29 |
2023-08-11 |
Not clear |
| A P Ferk. The inhibitory action of dopamine on the anterior tibialis muscle preparation antagonized by pimozide and chlorpromazine. Archives internationales de pharmacodynamie et de therapie. vol 221. issue 1. 1976-10-20. PMID:962431. |
the phenothiazine derivative, chlorpromazine (cpz, 400 mug/kg) which possesses both alpha and dopaminergic blocking properties significantly reduces the action of dopamine on skeletal muscle. |
1976-10-20 |
2023-08-11 |
cat |
| A P Ferk. The inhibitory action of dopamine on the anterior tibialis muscle preparation antagonized by pimozide and chlorpromazine. Archives internationales de pharmacodynamie et de therapie. vol 221. issue 1. 1976-10-20. PMID:962431. |
however, phentolamine (1 mg/kg), an alpha adrenergic blocker is without effect, possibly indicating that the dopaminergic blocking characteristic of cpz is responsible for decreasing the action of dopamine. |
1976-10-20 |
2023-08-11 |
cat |
| A P Ferk. The inhibitory action of dopamine on the anterior tibialis muscle preparation antagonized by pimozide and chlorpromazine. Archives internationales de pharmacodynamie et de therapie. vol 221. issue 1. 1976-10-20. PMID:962431. |
a more selective dopaminergic blocking agent, pimozide (100 and 200 mug/kg) is an effective antagonist to the paralysis caused by dopamine on the anterior tibialis muscle. |
1976-10-20 |
2023-08-11 |
cat |