| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S M de la Monte, Y K Sohn, N Ganju, J R Wand. P53- and CD95-associated apoptosis in neurodegenerative diseases. Laboratory investigation; a journal of technical methods and pathology. vol 78. issue 4. 1998-05-07. PMID:9564885. |
p53- and cd95-associated apoptosis in neurodegenerative diseases. |
1998-05-07 |
2023-08-12 |
Not clear |
| S M de la Monte, Y K Sohn, N Ganju, J R Wand. P53- and CD95-associated apoptosis in neurodegenerative diseases. Laboratory investigation; a journal of technical methods and pathology. vol 78. issue 4. 1998-05-07. PMID:9564885. |
apoptosis is likely to be an important mechanism of cell loss in neurodegenerative diseases, but the signaling cascades activated before dna fragmentation have not yet been determined. |
1998-05-07 |
2023-08-12 |
Not clear |
| S M de la Monte, Y K Sohn, N Ganju, J R Wand. P53- and CD95-associated apoptosis in neurodegenerative diseases. Laboratory investigation; a journal of technical methods and pathology. vol 78. issue 4. 1998-05-07. PMID:9564885. |
to determine whether apoptosis in other neurodegenerative diseases is mediated by similar mechanisms, p53 and cd95 expression were examined in postmortem central nervous system tissues from patients with diffuse lewy body disease (dlbd), pick's disease (pkd), progressive supranuclear palsy (psp), multiple system atrophy (msa), parkinson's disease (pd), amyotrophic lateral sclerosis (als), and down's syndrome plus alzheimer's disease (dn+ad). |
1998-05-07 |
2023-08-12 |
Not clear |
| S M de la Monte, Y K Sohn, N Ganju, J R Wand. P53- and CD95-associated apoptosis in neurodegenerative diseases. Laboratory investigation; a journal of technical methods and pathology. vol 78. issue 4. 1998-05-07. PMID:9564885. |
the results suggest that p53- or cd95-associated apoptosis may be a common mechanism of cell loss in several important neurodegenerative diseases. |
1998-05-07 |
2023-08-12 |
Not clear |
| E Schmitt, A T Sané, A Steyaert, G Cimoli, R Bertran. The Bcl-xL and Bax-alpha control points: modulation of apoptosis induced by cancer chemotherapy and relation to TPCK-sensitive protease and caspase activation. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 75. issue 4. 1998-03-30. PMID:9493953. |
defective control of apoptosis appears to play a central role in the pathogenesis of human diseases including neoplasic, autoimmune, and neurodegenerative diseases. |
1998-03-30 |
2023-08-12 |
human |
| T Ariga, W D Jarvis, R K Y. Role of sphingolipid-mediated cell death in neurodegenerative diseases. Journal of lipid research. vol 39. issue 1. 1998-03-26. PMID:9469581. |
inappropriate initiation of apoptosis has been proposed to underlie the progressive neuronal attrition associated with various neurodegenerative diseases such as alzheimer's disease (ad), parkinson's disease (pd), amyotrophic lateral sclerosis (als), and other neurological disorders that are characterized by the gradual loss of specific populations of neurons. |
1998-03-26 |
2023-08-12 |
Not clear |
| L Stefanis, R E Burke, L A Green. Apoptosis in neurodegenerative disorders. Current opinion in neurology. vol 10. issue 4. 1997-10-17. PMID:9266153. |
we review here recent reports pertaining to the issue of apoptosis in neurodegenerative diseases. |
1997-10-17 |
2023-08-12 |
human |
| J R Fraser, J Brown, M E Bruce, M Jeffre. Scrapie-induced neuron loss is reduced by treatment with basic fibroblast growth factor. Neuroreport. vol 8. issue 9-10. 1997-10-07. PMID:9243649. |
growth factor treatment of other neurodegenerative diseases has been shown to protect neurons destined for apoptosis, and several types of experimental retinopathy have been successfully treated with basic fibroblast growth factor (bfgf). |
1997-10-07 |
2023-08-12 |
Not clear |
| I Nishimoto, T Okamoto, U Giambarella, T Iwatsub. Apoptosis in neurodegenerative diseases. Advances in pharmacology (San Diego, Calif.). vol 41. 1997-09-17. PMID:9204151. |
apoptosis in neurodegenerative diseases. |
1997-09-17 |
2023-08-12 |
Not clear |
| H M Ellerby, S J Martin, L M Ellerby, S S Naiem, S Rabizadeh, G S Salvesen, C A Casiano, N R Cashman, D R Green, D E Bredese. Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 16. 1997-08-28. PMID:9236228. |
apoptosis is a fundamental process required for normal development of the nervous system and is triggered during neurodegenerative disease. |
1997-08-28 |
2023-08-12 |
Not clear |
| I Hajimohamadreza, J M Trehern. The role of apoptosis in neurodegenerative diseases. Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques. vol 48. 1997-07-24. PMID:9204683. |
the role of apoptosis in neurodegenerative diseases. |
1997-07-24 |
2023-08-12 |
Not clear |
| L Fernández-Novoa, X A Alvarez, J M Sempere, J J Miguel-Hidalgo, J Díaz, A Franco-Maside, R Cacabelo. Effects of anapsos on the activity of the enzyme Cu-Zn-superoxide dismutase in an animal model of neuronal degeneration. Methods and findings in experimental and clinical pharmacology. vol 19. issue 2. 1997-07-22. PMID:9151285. |
free radical reactions are implicated in a variety of physiological and pathological processes as aging, apoptosis and neurodegenerative diseases, and abnormalities associated with sod have been recently documented in several neurodegenerative processes. |
1997-07-22 |
2023-08-12 |
rat |
| P Popper, D B Farber, P E Micevych, K Minoofar, J M Bronstei. TRPM-2 expression and tunel staining in neurodegenerative diseases: studies in wobbler and rd mice. Experimental neurology. vol 143. issue 2. 1997-04-07. PMID:9056387. |
neuronal apoptosis has been described during development but little is known about whether apoptosis plays a role in neurodegenerative disease. |
1997-04-07 |
2023-08-12 |
mouse |
| W G Tatton, R M Chalmers-Redma. Modulation of gene expression rather than monoamine oxidase inhibition: (-)-deprenyl-related compounds in controlling neurodegeneration. Neurology. vol 47. issue 6 Suppl 3. 1997-01-15. PMID:8959986. |
in situ evidence suggests that apoptosis contributes to neuronal death in a number of neurodegenerative diseases. |
1997-01-15 |
2023-08-12 |
human |
| W G Tatton, R M Chalmers-Redma. Modulation of gene expression rather than monoamine oxidase inhibition: (-)-deprenyl-related compounds in controlling neurodegeneration. Neurology. vol 47. issue 6 Suppl 3. 1997-01-15. PMID:8959986. |
if apoptosis is critical to the progression of one or more human neurodegenerative diseases, then transcriptionally active agents such as (-)-desmethyldeprenyl may be of value in treating the diseases. |
1997-01-15 |
2023-08-12 |
human |
| A Macay. [Apoptosis in the nervous system]. Revista de neurologia. vol 24. issue 135. 1996-12-30. PMID:8974737. |
activation of apoptosis occurs also in some neurodegenerative diseases. |
1996-12-30 |
2023-08-12 |
Not clear |
| G Taglialatela, M Gegg, J R Perez-Polo, L R Williams, G M Ros. Evidence for DNA fragmentation in the CNS of aged Fischer-344 rats. Neuroreport. vol 7. issue 5. 1996-12-11. PMID:8804034. |
apoptosis has been reported to be responsible for neuronal death during development and may also be involved in some age-related neurodegenerative diseases of the cns. |
1996-12-11 |
2023-08-12 |
rat |
| C M Cagnoli, E Kharlamov, C Atabay, T Uz, H Mane. Apoptosis induced in neuronal cultures by either the phosphatase inhibitor okadaic acid or the kinase inhibitor staurosporine is attenuated by isoquinolinesulfonamides H-7, H-8, and H-9. Journal of molecular neuroscience : MN. vol 7. issue 1. 1996-12-06. PMID:8835783. |
elucidating the isoquinolinesulfonamide-sensitive mechanism may help us find new therapies for neurodegenerative diseases that involve apoptosis. |
1996-12-06 |
2023-08-12 |
rat |
| R M Sainz, J C Mayo, H Uría, M Kotler, I Antolín, C Rodriguez, A Menendez-Pelae. The pineal neurohormone melatonin prevents in vivo and in vitro apoptosis in thymocytes. Journal of pineal research. vol 19. issue 4. 1996-10-21. PMID:8789249. |
since apoptosis is a possible mechanism involved in neuronal death shown in several neurodegenerative diseases such as parkinson or alzheimer's diseases, investigative efforts should be directed to the possible role of melatonin in inhibiting cell death in tissues other that the thymus. |
1996-10-21 |
2023-08-12 |
rat |
| S C Lane, R D Jolly, D E Schmechel, J Alroy, R M Boustan. Apoptosis as the mechanism of neurodegeneration in Batten's disease. Journal of neurochemistry. vol 67. issue 2. 1996-09-19. PMID:8764595. |
this is the first inherited neurodegenerative disease involving brain and retina in which apoptosis has been established as the mechanism of neuronal and photoreceptor cell death in both humans and animal models. |
1996-09-19 |
2023-08-12 |
mouse |