| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Ham, A Eilers, J Whitfield, S J Neame, B Sha. c-Jun and the transcriptional control of neuronal apoptosis. Biochemical pharmacology. vol 60. issue 8. 2000-10-31. PMID:11007936. |
there has been considerable interest in the molecular mechanisms of apoptosis in mammalian neurons because this form of neuronal cell death is important for the normal development of the nervous system and because inappropriate neuronal apoptosis may contribute to the pathology of human neurodegenerative diseases. |
2000-10-31 |
2023-08-12 |
mouse |
| A R Saha, N N Ninkina, D P Hanger, B H Anderton, A M Davies, V L Buchma. Induction of neuronal death by alpha-synuclein. The European journal of neuroscience. vol 12. issue 8. 2000-10-19. PMID:10971650. |
however, there is growing evidence that neuronal apoptosis in the absence of obvious pathological deposits could have a serious impact on the pathogenesis of neurodegenerative diseases. |
2000-10-19 |
2023-08-12 |
Not clear |
| V Máximo, M Sobrinho-Simõe. Hürthle cell tumours of the thyroid. A review with emphasis on mitochondrial abnormalities with clinical relevance. Virchows Archiv : an international journal of pathology. vol 437. issue 2. 2000-10-02. PMID:10993269. |
the molecular and enzymatic abnormalities of mitochondria in oxyphilic / oncocytic / hürthle cells and their respective tumours are reviewed in a series of sections: "mitochondria, ageing, neurodegenerative diseases and cancer", "mitochondrial abnormalities in hürthle cells and hürthle cells tumours", "mitochondrion-related alterations in tumours with and without hürthle cell/oncocytic features", "true and secondary oxyphilia", and "bcl-2 expression, apoptosis and necrosis in hürthle cell tumours and tumour-like lesions". |
2000-10-02 |
2023-08-12 |
Not clear |
| M Shimura, Y Osawa, A Yuo, K Hatake, F Takaku, Y Ishizak. Oxidative stress as a necessary factor in room temperature-induced apoptosis of HL-60 cells. Journal of leukocyte biology. vol 68. issue 1. 2000-08-17. PMID:10914494. |
taken together with the reports that some burkitt lymphoma cells showed apoptosis when exposed at low temperature followed by rewarming, and that hepatocytes or liver endothelial cells are susceptible to cold-induced apoptosis through the ros function, we propose that studying the mechanism of rt-induced apoptosis of hl-60 cells may provide a therapeutic strategy for pathological conditions involving ros, such as neurodegenerative diseases and ischemia. |
2000-08-17 |
2023-08-12 |
Not clear |
| S Afford, S Randhaw. Apoptosis. Molecular pathology : MP. vol 53. issue 2. 2000-07-19. PMID:10889903. |
in humans, dysregulation of apoptosis can result in inflammatory, malignant, autoimmune, and neurodegenerative diseases. |
2000-07-19 |
2023-08-12 |
Not clear |
| G S Robertson, S J Crocker, D W Nicholson, J B Schul. Neuroprotection by the inhibition of apoptosis. Brain pathology (Zurich, Switzerland). vol 10. issue 2. 2000-06-06. PMID:10764048. |
consistent with the proposal that apoptosis plays a central in role human neurodegenerative disease, caspase-3 activation has recently been observed in stroke, spinal cord trauma, head injury and alzheimer's disease. |
2000-06-06 |
2023-08-12 |
mouse |
| M S Beer, J A Stanton, K Salim, M Rigby, R P Heavens, D Smith, G Mcalliste. EDG receptors as a therapeutic target in the nervous system. Annals of the New York Academy of Sciences. vol 905. 2000-06-05. PMID:10818448. |
edg receptors located in brain neuronal cells might, for example, influence apoptosis and be involved in cell rescue following ischemic damage or during the early stages of progressive neurodegenerative diseases. |
2000-06-05 |
2023-08-12 |
Not clear |
| H W Ko, K S Han, E Y Kim, B R Ryu, W J Yoon, Y K Jung, S U Kim, B J Gwa. Synergetic activation of p38 mitogen-activated protein kinase and caspase-3-like proteases for execution of calyculin A-induced apoptosis but not N-methyl-d-aspartate-induced necrosis in mouse cortical neurons. Journal of neurochemistry. vol 74. issue 6. 2000-06-02. PMID:10820206. |
we examined the possibility that p38 mitogen-activated protein kinase and caspase-3 would be activated for execution of apoptosis and excitotoxicity, the two major types of neuronal death underlying hypoxicischemic and neurodegenerative diseases. |
2000-06-02 |
2023-08-12 |
mouse |
| F G Blankenberg, J F Tait, H W Straus. Apoptotic cell death: its implications for imaging in the next millennium. European journal of nuclear medicine. vol 27. issue 3. 2000-05-18. PMID:10774891. |
thereafter an outline is provided of the role of apoptosis in the pathophysiology of clinical disorders including stroke, neurodegenerative diseases, pulmonary inflammatory diseases, myocardial ischemia and inflammation, myelodysplastic disorders, organ transplantation, and oncology, in which imaging may play a critical role in diagnosis and patient management. |
2000-05-18 |
2023-08-12 |
human |
| C L Wellington, M R Hayde. Caspases and neurodegeneration: on the cutting edge of new therapeutic approaches. Clinical genetics. vol 57. issue 1. 2000-04-28. PMID:10733228. |
unregulated apoptosis underlies many pathological conditions, including neurodegenerative diseases. |
2000-04-28 |
2023-08-12 |
Not clear |
| L F Jarskog, J H Gilmor. Developmental expression of Bcl-2 protein in human cortex. Brain research. Developmental brain research. vol 119. issue 2. 2000-04-11. PMID:10675772. |
apoptosis is essential for normal human neurodevelopment and is increasingly recognized for its role in various neurodegenerative diseases such as alzheimer's and parkinson's diseases. |
2000-04-11 |
2023-08-12 |
human |
| G W Glazner, M P Mattso. Differential effects of BDNF, ADNF9, and TNFalpha on levels of NMDA receptor subunits, calcium homeostasis, and neuronal vulnerability to excitotoxicity. Experimental neurology. vol 161. issue 2. 2000-03-29. PMID:10686066. |
calcium influx through n-methyl-d-aspartate (nmda) receptors can result in neuronal apoptosis or necrosis and may play a pivotal role in neuronal death in many different neurodegenerative diseases. |
2000-03-29 |
2023-08-12 |
Not clear |
| H R Warne. Apoptosis: a two-edged sword in aging. Anticancer research. vol 19. issue 4B. 2000-02-15. PMID:10652562. |
of particular importance are the roles of apoptosis in reducing cancer incidence, and in promoting neurodegenerative disease. |
2000-02-15 |
2023-08-12 |
Not clear |
| F Terro, F Esclaire, C Yardin, J Hugo. N-methyl-D-aspartate receptor blockade enhances neuronal apoptosis induced by serum deprivation. Neuroscience letters. vol 278. issue 3. 2000-02-15. PMID:10653015. |
neuronal apoptosis a hallmark of brain development could also be involved in neurodegenerative diseases. |
2000-02-15 |
2023-08-12 |
rat |
| J V Leonard, A H Schapir. Mitochondrial respiratory chain disorders II: neurodegenerative disorders and nuclear gene defects. Lancet (London, England). vol 355. issue 9201. 2000-02-15. PMID:10665569. |
the mitochondrion's role in apoptosis and its contribution to the pathogenesis of neurodegenerative diseases are also covered. |
2000-02-15 |
2023-08-12 |
Not clear |
| N Canu, C Barbato, M T Ciotti, A Serafino, L Dus, P Calissan. Proteasome involvement and accumulation of ubiquitinated proteins in cerebellar granule neurons undergoing apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 2. 2000-02-09. PMID:10632588. |
the finding that the proteasomes are early involved in apoptosis and that ubiquitinated proteins accumulate during this process prospect granule neurons as a model system aimed at correlating these events with neurodegenerative diseases. |
2000-02-09 |
2023-08-12 |
Not clear |
| P S Sastry, K S Ra. Apoptosis and the nervous system. Journal of neurochemistry. vol 74. issue 1. 2000-01-18. PMID:10617101. |
apoptosis is now recognized as a normal feature in the development of the nervous system and may also play a role in neurodegenerative diseases and aging. |
2000-01-18 |
2023-08-12 |
Not clear |
| J Y Follézou, J Emerit, F Bricair. [Neuro-degenerative diseases: role of reactive oxygen species and of apoptosis]. Presse medicale (Paris, France : 1983). vol 28. issue 30. 1999-11-09. PMID:10544701. |
neuron death: major progress in our understanding of the pathophysiology of neurodegenerative diseases has greatly benefited from the convergence between work devoted to reactive oxygen species (including nitric oxide) and programmed cell death, or apoptosis, and exitotoxicity. |
1999-11-09 |
2023-08-12 |
mouse |
| J Y Follézou, J Emerit, F Bricair. [Neuro-degenerative diseases: role of reactive oxygen species and of apoptosis]. Presse medicale (Paris, France : 1983). vol 28. issue 30. 1999-11-09. PMID:10544701. |
other chronic conditions: based on evidence from the mouse model, apoptosis, excitotoxicity and oxygenated free radicals could play a causal role in other neurodegenerative diseases including hiv-related encephalopathy, parkinsonís disease and alzheimerís disease. |
1999-11-09 |
2023-08-12 |
mouse |
| A M Gleckman, Z Jiang, Y Liu, T W Smit. Neuronal and glial DNA fragmentation in Pick's disease. Acta neuropathologica. vol 98. issue 1. 1999-09-24. PMID:10412801. |
evidence from other neurodegenerative diseases has suggested that dna damage and apoptosis may play a major role in cellular degeneration and death. |
1999-09-24 |
2023-08-12 |
Not clear |